Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 6
102
Views
24
CrossRef citations to date
0
Altmetric
Research Article

Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/ insect cell system

, , , , &
Pages 345-356 | Published online: 22 Sep 2008

References

  • BAUER, E., Guo, Z., UENG, Y. F., BELL, L. C., ZELDIN, L. and GUENGERICH, F. P., 1995, Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology, 8, 136–142.
  • BURKE, M. D. and MAYER, R. T., 1983, Inherent specificities of purified cytochromes P450 and P448 toward biphenyl hydroxylation and ethoxyresorufin deethylation. Chemical and Biological Interactions, 45, 243–258.
  • BUYERS, J. T. M., SHou, M., HARDWICK, J. P., KORZEKWA, K. R. and GONZALEZ, F. J., 1995, cDNA-directed expression of human cytochrome P450 CYP1A1 using baculovirus. Drug Metabolism and Disposition, 23, 696–701.
  • CASCORBI, I., BROCKMOLLER, J. and ROOTS, I., 1996, A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Research, 56, 4965–4969.
  • CHEN, L., BUTERS, J. T. M., HARDWICK, J. P., TAMURA, S., PENMAN, T. W., GONZALEZ, F. J. and CRESPI, C. L., 1997, Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system. Drug Metabolism and Disposition, 25, 399–405.
  • GAUTIER, J. C., LECOEUR, S., COSME, J., PERRET, A., URBAN, P., BEAUNE, P. and POMPON, D., 1996, Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast. Pharmacogenetics, 6, 489–499.
  • GONZALEZ, F. J. and KORZEKWA, K. R., 1995, Cytochromes P450 expression systems. Annual Review of Pharmacology and Toxicology, 35, 369–390.
  • GUENGERICH, F. P. and SHIMADA, T., 1998, Activation of procarcinogens by human cytochrome P450 enzymes. Mutation Research, 400, 201–213.
  • HAYASHI, S., WATANABE, J., NAKACHI, K. and KAWAJIRI, K., 1991, Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P4501A1 gene. Journal of Biochemistry, 110, 407–411.
  • HOLDER, G., YAGI, H., DANSETTE, P., JERINA, D. M., LEVIN, W., Lu, A. Y. H. and CONNEY, A. H., 1974, Effects of inducers and epoxide hydrolase on the metabolism of benzo[a]pyrene by liver microsomes and a reconstituted system: Analysis by high-pressure liquid chromatography. Proceedings of the National Academy of Sciences, USA, 72, 4356–4360.
  • HOULSTON, R. S., 2000, CYP1A1 polymorphisms and lung cancer risk: a meta-analysis. Pharmacogenetics, 10, 105–114.
  • HUG, C., CHERN, H., CHANG, K., CHENG, C., Hsu, S. and SHEN, C., 1999, Cancer Research, 59, 4870–4875.
  • INGELMAN-SUNDBERG, M., DALY, A. K., OSCARSON, M. and NEBERT, D. W., 2000, Human cytochrome P450 (GYP) genes: recommendations for the nomenclature of alleles. Pharmacogenetics, 10, 91–93.
  • JAISWAL, A. K., GONZALEZ, F. J. and NEBERT, D. W., 1985, Human dioxin-inducible cytochrome Pi-450: complementary DNA and amino acid sequence. Science, 228, 80–83.
  • KIM, J. H., STANSBURY, K. H., WALKER, N. J., TRUSH, M. A., STRICKLAND, P. T. and SUTTER, T. R., 1998, Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis, 19, 1847–1853.
  • NEBERT, D. W., INGELMAN-SUNDBERG, M. and DALY, A. K., 1999, Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metabolism Reviews, 31, 467–487.
  • ONG, C. E., MINERS, J. O., BIRKETT, D. J. and BHASKER, C. R., 1998, Baculovirus-mediated expression of cytochrome P4502C8 and human NADPH-cytochrome P450 reductase: optimization of protein expression. Xenobiotica, 28, 137–152.
  • PAINE, M. J. I., GILHAM, D., ROBERTS, G. C. K. and WOLF, C. R., 1996, Functional high level expression of cytochrome P4502D6 using baculoviral expression systems. Archives of Biochemistry and Biophysics, 328, 143–150.
  • PERSSON, I., JOHANSSON, I. and INGELMAN-SUNDBERG, M., 1997, In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochemical and Biophysical Research Communications, 231, 227–230.
  • SATO, M., SATO, T., Izumo, T. and AMAGASA, T., 1999, Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. Carcinogenesis, 20, 1927–1931.
  • SCHWARZ, D., KISSELEV, P., SCHUNCK, W. H., CHERNOGOLOV, A., BOIDOL, W., CASCORBI, I. and ROOTS, I., 2000, Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics, 10, 519–530.
  • SELKIRK, J. K., CROY, R. G. and GELBOIN, H. V., 1974, Benzo[a]pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography. Science, 184, 169–171.
  • SHIMADA, T., MARTIN, M. V., PRUESS-SCHWARTZ, D., MARNETT, L. J. and GUENGERICH, F. P., 1989, Roles of individual human cytochrome P450 enzymes in the bioactivation of benzo[a]pyrene, 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Research, 49, 6304–6312.
  • SUOU, M., KORZEKWA, K. R., CRFSPI, C. L., GONZALEZ, F. J. and GELBOIN, H. V., 1994, The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol. Molecular Carcinogenesis, 10, 159–168.
  • TAMURA, S., KORZEKWA, K. R., KIMURA, S., GELBOIN, H. V. and GONZALEZ, F. J., 1992, Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase. Archives of Biochemistry and Biophysics, 293, 219–223.
  • TAN, Y., PATTEN, C. J., SMITH, T. and YANG, C. S., 1997, Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system. Archives of Biochemistry and Biophysics, 342, 82–91.
  • WANG, M. H., PATTEN, C. J., YANG, G. Y., PARANAWITHANA, S. R., TAN, Y. and YANG, C. S., 1996, Expression and coupling of human cytochrome P450 2E1 and NADPH-cytochrome P450 oxidoreductase in dual expression and co-infection systems with baculovirus in insect cells. Archives of Biochemistry and Biophysics, 334, 380–388.
  • WERLINDER, V., ZHUKOV, A. and INGELMAN-SUNDBERG, M., 1998, Posttranslational regulation of cytochromes P4501A1 and 1A2. Paper presented at the 12th International Symposium on Microsomes and Drug Oxidations, 20–24 July, Montpellier, abst. 370.
  • YASUKOCHI, Y. and MASTERS, B. S. S., 1976, Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. Journal of Biological Chemistry, 251, 5337–5344.
  • ZHANG, Z. Y., PASCO, M. J., HUANG, L., GUENGERICH, F. P. and KAMINSKY, L. S., 1996, Characterization of purified human recombinant cytochrome P4501A1-11e462 and -Va1462: assessment of a role for the rare allele in cancerogenesis. Cancer Research, 56, 3926–3933.
  • Zuuxov, A. and INGELMAN-SUNDBERG, M., 1999, Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase. Biochemical Journal, 340 (Pt 2), 453–458.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.