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Original Articles

Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide

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Pages 55-66 | Received 18 Mar 2023, Accepted 16 Aug 2023, Published online: 06 Sep 2023

References

  • Polat G, Ugan RA, Çadırcı E, et al. Sepsis and septic shock: current treatment strategies and new approaches. Eurasian J Med. 2017;49(1):53–58. doi: 10.5152/eurasianjmed.2017.17062.
  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). Jama. 2016;315(8):801–810. doi: 10.1001/jama.2016.0287.
  • Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet. 2005;365(9453):63–78. doi: 10.1016/S0140-6736(04)17667-8.
  • Deutschman CS, Neligan PJ. Evidence-based practice of critical care e-book. 2nd Ed. U.S.A: Elsevier Health Sciences; 2015. p. 249–262.
  • Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420(6917):885–891. doi: 10.1038/nature01326.
  • Mollnes TE, Christiansen D, Brekke OL. Espevik THypothesis: combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory response. In Current topics in complement II. In Lambris JD, Eds. New York: Springer; 2008. p. 243–253.
  • Yorgancı K. Pathophysiology of sepsis. J Int Care. 2005;5(2):80–84.
  • Yalçın A, Gürsoy B. Immunopathogenesis of sepsis. J Harran Univ Facult Med. 2008;5(3):25–29.
  • Hotchkiss RS, Moldawer LL, Opal SM, et al. And septic shock. Nat Rev Dis Primers. 2016;2(1):16045. doi: 10.1038/nrdp.2016.45.
  • Karabulut H, Gülay MS. Antioxidants. Mehmet Akif Ersoy Univ J Facult Vet Med. 2016;1(1):65–76.
  • Kaymak C, Basar H, Sardas S. Reactive oxygen species (ROS) generation in sepsis. FABAD J Pharma Sci. 2011;36:41–47.
  • Fidan H, Koca U, Ergür B, et al. The effects of N-acetylcysteine on kidney apoptosis in a rat intra-abdominal sepsis model. Turkey Clin J Med Sci. 2012;32(6):1653–1659.
  • Remick DG. Pathophysiology of sepsis. Am J Pathol. 2007;170(5):1435–1444. doi: 10.2353/ajpath.2007.060872.
  • Bagshaw SM, George C, Bellomo R. Early acute kidney injury and sepsis: a multicentre evaluation. Critical Care. 2008;12(2):R47. doi: 10.1186/cc6863.
  • Mete B. Kidney and liver in sepsis IU Cerrahpaşa faculty of medicine continuing medical education activities in the light of current ınformation sepsis symposium statement. 2006;51:p. 35–43.
  • Reinhart K, Bayer O, Brunkhorst F, et al. Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med. 2002;30(5 Suppl): s 302–312. doi: 10.1097/00003246-200205001-00021.
  • Schouten M, Wiersinga WJ, Levi M, et al. Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol. 2008;83(3):536–545. doi: 10.1189/jlb.0607373.
  • Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood J Am Soc Hematol. 2003;101(10):3765–3777. doi: 10.1182/blood-2002-06-1887.
  • Kavoussi R. Pregabalin: from molecule to medicine. Eur Neuropsychopharmacol. 2006;16:S128–S133. doi: 10.1016/j.euroneuro.2006.04.005.
  • Ha KY, Carragee E, Cheng I, et al. Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells. J Korean Med Sci. 2011;26(3):404–411. doi: 10.3346/jkms.2011.26.3.404.
  • Alles SR, Cain SM, Snutch TP. Pregabalin as a pain therapeutic: beyond calcium channels. Front Cell Neurosci. 2020;14:83. doi: 10.3389/fncel.2020.00083.
  • Song SK, Karl IE, Ackerman JJ, et al. Increased intracellular ca+2: a critical link in the pathophysiology of sepsis? Proc Natl Acad Sci U S A. 1993;90(9):3933–3937. doi: 10.1073/pnas.90.9.3933.
  • Aslankoç R, Savran M, Özmen Ö, et al. Hippocampus and cerebellum damage in sepsis induced by lipopolysaccharide in aged rats-Pregabalin can prevent damage. Biomed Pharmacother. 2018;108:1384–1392. doi: 10.1016/j.biopha.2018.09.162.
  • Asci H, Ozmen O, Erzurumlu Y, et al. Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity. Biotechnic Histochem. 2021;96(5):364–375. doi: 10.1080/10520295.2020.1810315.
  • Özmen Ö, Topsakal S. Pregabalin ameliorates lipopolysaccharide-induced pancreatic inflammation in aged rats. Endocr Metab Immune Disord Drug Targets. 2019;19(8):1141–1147. doi: 10.2174/1871530319666190306095532.
  • Abu-Rish EY, Mansour AT, Mansour HT, et al. Pregabalin inhibits in vivo and in vitro cytokine secretion and attenuates spleen inflammation in lipopolysaccharide/concanavalin, A-induced murine models of inflammation. Sci Rep. 2020;10(1):4007. doi: 10.1038/s41598-020-61006-1.
  • Günyeli I, Saygın M, Özmen Ö. The impact of the sepsis on female urogenital system: the role of pregabalin. Arch Gynecol Obstetr. 2019;300(4):1067–1082.
  • Ayaz G, Halici Z, Albayrak A, et al. Evaluation of 5-HT7 receptor trafficking on In vivo and In vitro model of lipopolysaccharide (LPS)-ınduced ınflammatory cell ınjury in rats and LPS-Treated A549 cells. Biochem Genet. 2017;55(1):34–47. doi: 10.1007/s10528-016-9769-2.
  • Ben‐Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia. 2004;45(s6):13–18. doi: 10.1111/j.0013-9580.2004.455003.x.
  • Meymandi MS, Sepehri G, Abdolsamadi M, et al. The effects of co-administration of pregabalin and vitamin E on neuropathic pain induced by partial sciatic nerve ligation in male rats. Inflammopharmacology. 2017;25(2):237–246. doi: 10.1007/s10787-017-0325-4.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103–1111. doi: 10.1016/j.clinbiochem.2005.08.008.
  • Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37(2):112–119. doi: 10.1016/j.clinbiochem.2003.10.014.
  • James RW, Leviev I, Righetti A. Smoking is associated with reduced serum paraoxonase activity and concentration in coronary artery disease patients. Circulation. 2000;101(19):2252–2257. doi: 10.1161/01.cir.101.19.2252.
  • Kösecik M, Erel O, Sevinc E, et al. Increased oxidative stress in childrenexposed to passive smoking. Int J Cardiol. 2005;100(1):61–64. doi: 10.1016/j.ijcard.2004.05.069.
  • Lima J, Skare TL, Malafaia O, et al. Sepsis inducing syndrome of multiple organ dysfunction: an experimental study in rats. ABCD, Arq Bras Cir Dig. 2011;24(2):95–102. doi: 10.1590/S0102-67202011000200002.
  • Lee RP, Wang D, Lin NT, et al. Physiological and chemical indicators for early and late stages of sepsis in conscious rats. J Biomed Sci. 2002;9(6):613–621. doi: 10.1007/BF02254989.
  • Pereira RS, Bertoncheli CM, Adefegha SA, et al. Sepsis induced by cecal ligation and perforation (CLP) alters nucleotidase activities in platelets of rats. Microb Pathog. 2017;111:345–351. doi: 10.1016/j.micpath.2017.08.047.
  • Tsirigotis P, Chondropoulos S, Frantzeskaki F, et al. Thrombocytopenia in critically ill patients with severe sepsis/septic shock: prognostic value and association with a distinct serum cytokine profile. J Crit Care. 2016;32:9–15. doi: 10.1016/j.jcrc.2015.11.010.
  • Benediktsson S, Frigyesi A, Kander T. Routine coagulation tests on ICU admission are associated with mortality in sepsis: an observational study. Acta Anaesthesiol Scand. 2017;61(7):790–796. doi: 10.1111/aas.12918.
  • Mihajlovic D, Lendak D, Mitic G, et al. Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in sepsis. Turk J Med Sci. 2015;45(1):93–98. doi: 10.3906/sag-1309-64.
  • Jiang Y, Jiang FQ, Kong F, et al. Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study. Ann Intensive Care. 2019;9(1):67. doi: 10.1186/s13613-019-0542-7.
  • Bellomo R, Kellum JA, Ronco C, et al. Acute kidney injury in sepsis. Intensive Care Med. 2017;43(6):816–828. doi: 10.1007/s00134-017-4755-7.
  • Zhang Z. Biomarkers, diagnosis and management of sepsis-induced acute kidney injury: a narrative review. Heart, Lung and Vessels. 2015;7(1):64.
  • Dellepiane S, Marengo M, Cantaluppi V. Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies. Crit Care. 2016;20(1):61. doi: 10.1186/s13054-016-1219-3.
  • Kamar C, Ali A, Altun D, et al. Evaluation of risk factors and development of acute kidney injury in aneurysmal subarachnoid hemorrhage, head injury, and severe sepsis/septic shock patients during ICU treatment. Turkish J Trauma Emerg Surg. 2017;23(1):39–45.
  • Atikeler G, Çıracı MZ, Kocabıyık M, et al. Effect of vitamin D on free radical metabolism in renal tissues of septic rats. Turkish J Biochem. 2016;41(5):316–321. doi: 10.1515/tjb-2016-0046.
  • Akdemir FNE, Tanyeli A. The antioxidant effect of fraxin against acute organ damage in polymicrobial sepsis model induced by cecal ligation and puncture. Turkish J Sci. 2019;4(1):22–29.
  • Benli E, Ayyildiz SN, Cirrik S, et al. The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study. Int Braz J Urol. 2017;43(2):345–355. doi: 10.1590/S1677-5538.IBJU.2016.0075.
  • Ismy J, Syukri M, Emril DR, et al. The effect of superoxide dismutase on ınhibition of acute kidney ınjury ınduced by sepsis based on kidney tissue histology and murine sepsis score. Sci World J. 2021;2021:1–7. doi: 10.1155/2021/1827296.
  • Liu L, Song Y, Zhao M, et al. Protective effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced acute kidney injury in a rat model of sepsis. Int Urol Nephrol. 2015;47(10):1745–1752. doi: 10.1007/s11255-015-1070-5.
  • İlçe F, Gök G, Pandır D. Acute effects of lipopolysaccharide (LPS) in kidney of rats and preventive role of vitamin E and sodium selenite. Hum Exp Toxicol. 2019;38(5):547–560. doi: 10.1177/0960327118817106.
  • Chen Y, Luan L, Wang C, et al. Dexmedetomidine protects against lipopolysaccharide-induced early acute kidney injury by inhibiting the iNOS/NO signaling pathway in rats. Nitric Oxide. 2019;85:1–9. doi: 10.1016/j.niox.2019.01.009.
  • Kiyonaga N, Moriyama T, Kanmura Y. Effects of landiolol in lipopolysaccharide-induced acute kidney injury in rats and in vitro. Shock. 2019;52(5):e117–e123. doi: 10.1097/SHK.0000000000001306.
  • Garofalo AM, Lorente-Ros M, Goncalvez G, et al. Histopathological changes of organ dysfunction in sepsis. Intensive Care Med Exp. 2019;7(Suppl 1):45. doi: 10.1186/s40635-019-0236-3.
  • Fani F, Regolisti G, Delsante M, et al. Advances in the pathogenetic mechanisms of sepsis-associated acute kidney injury. J Nephrol. 2018;31(3):351–359. doi: 10.1007/s40620-017-0452-4.
  • Anderberg SB, Luther T, Frithiof R. Physiological aspects of toll‐like receptor 4 activation in sepsis‐induced acute kidney injury. Acta Physiol. 2017;219(3):573–588. doi: 10.1111/apha.12798.
  • Shimokawa T, Yoneda K, Yamagata M, et al. Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats. Eur J Pharmacol. 2020;871:172917. doi: 10.1016/j.ejphar.2020.172917.
  • Özkök E, Yorulmaz H, Ateş G, et al. The impact of pretreatment with simvastatin on kidney tissue of rats with acute sepsis. Physiol Int. 2017;104(2):158–170. doi: 10.1556/2060.104.2017.2.8.
  • Koc F, Tekeli MY, Kanbur M, et al. The effects of chrysin on lipopolysaccharide‐induced sepsis in rats. J Food Biochem. 2020;44(9):e13359. doi: 10.1111/jfbc.13359.
  • Jin YH, Li ZT, Chen H, et al. Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-kappaB/iNOS signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23(11):5020–5025.

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