169
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer

, , , , , , , , , , , , & show all
Pages 73-85 | Received 27 Dec 2022, Accepted 26 Aug 2023, Published online: 27 Sep 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660.
  • Guanghui R, Xiaoyan H, Shuyi Y, et al. An efficient or methodical review of immunotherapy against breast cancer. J Biochem Mol Toxicol. 2019;33(8):e22339. doi: 10.1002/jbt.22339.
  • Gu-Trantien C, Loi S, Garaud S, et al. CD4+ follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest. 2013;123(7):2873–2892. doi: 10.1172/JCI67428.
  • Li L, Wang W, Pan H, et al. Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer. J Transl Med. 2017;15(1):23. doi: 10.1186/s12967-017-1124-9.
  • Raphael I, Nalawade S, Eagar TN, et al. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine. 2015;74(1):5–17. doi: 10.1016/j.cyto.2014.09.011.
  • Golstein P, Griffiths GM. An early history of T cell-mediated ­cytotoxicity. Nat Rev Immunol. 2018;18(8):527–535. doi: 10.1038/s41577-018-0009-3.
  • Zhang Y, Zhang Z. The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol. 2020;17(8):807–821. doi: 10.1038/s41423-020-0488-6.
  • Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol. 2005;5(4):296–306. doi: 10.1038/nri1592.
  • Castell-Rodríguez A, Piñón-Zárate G, Herrera-Enríquez M, et al. Dendritic cells: location, function, and clinical implications. In: Ghosh A, editor. Biology of myelomonocytic cells. London, UK: IntechOpen; 2017. p. 21–50.
  • Mastelic-Gavillet B, Balint K, Boudousquie C, et al. Personalized dendritic cell vaccines – recent breakthroughs and encouraging clinical results. Front Immunol. 2019;10:766. doi: 10.3389/fimmu.2019.00766.
  • Ardavín C, Amigorena S, Reis e Sousa C. Dendritic cells: immunobiology and cancer immunotherapy. Immunity. 2004;20(1):17–23. doi: 10.1016/s1074-7613(03)00352-2.
  • Becerril S, Rodríguez A, Catalán V, et al. Functional relationship between leptin and nitric oxide in metabolism. Nutrients. 2019;11(9):2129. doi: 10.3390/nu11092129.
  • Mattioli B, Straface E, Quaranta MG, et al. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol. 2005;174(11):6820–6828. doi: 10.4049/jimmunol.174.11.6820.
  • Francisco V, Pino J, Gonzalez-Gay MA, et al. Adipokines and inflammation: is it a question of weight? Br J Pharmacol. 2018;175(10):1569–1579. doi: 10.1111/bph.14181.
  • Procaccini C, Jirillo E, Matarese G. Leptin as an immunomodulator. Mol Aspects Med. 2012;33(1):35–45. doi: 10.1016/j.mam.2011.10.012.
  • Abella V, Scotece M, Conde J, et al. Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol. 2017;13(2):100–109. doi: 10.1038/nrrheum.2016.209.
  • Mattioli B, Straface E, Matarrese P, et al. Leptin as an immunological adjuvant: enhanced migratory and CD8+ T cell stimulatory capacity of human dendritic cells exposed to leptin. FASEB J. 2008;22(6):2012–2022. doi: 10.1096/fj.07-098095.
  • Naylor C, Petri WA. Leptin regulation of immune responses. Trends Mol Med. 2016;22(2):88–98. doi: 10.1016/j.molmed.2015.12.001.
  • White SJ, Taylor MJ, Hurt RT, et al. Leptin-based adjuvants: an innovative approach to improve vaccine response. Vaccine. 2013;31(13):1666–1672. doi: 10.1016/j.vaccine.2013.01.032.
  • Masoumi J, Jafarzadeh A, Tavakoli T, et al. Inhibition of apelin/APJ axis enhances the potential of dendritic cell-based vaccination to modulate TH1 and TH2 cell-related immune responses in an animal model of metastatic breast cancer. Adv Med Sci. 2022;67(1):170–178. doi: 10.1016/j.advms.2022.02.006.
  • Balog JÁ, Hackler LJr, Kovács AK, et al. Single cell mass cytometry revealed the immunomodulatory effect of cisplatin via downregulation of splenic CD44+, IL-17A+ MDSCs and promotion of circulating IFN-γ+ myeloid cells in the 4T1 metastatic breast cancer model. Int J Mol Sci. 2019;21(1):170. doi: 10.3390/ijms21010170.
  • Jadidi-Niaragh F, Atyabi F, Rastegari A, et al. CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. J Control Release. 2017;246:46–59. doi: 10.1016/j.jconrel.2016.12.012.
  • Basu A, Albert GK, Awshah S, et al. Identification of immunogenic MHC class II human HER3 peptides that mediate anti-HER3 CD4+ Th1 responses and potential use as a cancer vaccine. Cancer Immunol Res. 2022;10(1):108–125. doi: 10.1158/2326-6066.CIR-21-0454.
  • Zhang R, Yuan F, Shu Y, et al. Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models. Cancer Immunol Immunother. 2020;69(1):135–145. doi: 10.1007/s00262-019-02448-z.
  • Liu L, Wang Y, Miao L, et al. Combination immunotherapy of MUC1 mRNA nano-vaccine and CTLA-4 blockade effectively inhibits growth of triple negative breast cancer. Mol Ther. 2018;26(1):45–55. doi: 10.1016/j.ymthe.2017.10.020.
  • Yazdani M, Gholizadeh Z, Nikpoor AR, et al. Ex vivo dendritic cell-based (DC) vaccine pulsed with a low dose of liposomal antigen and CpG-ODN improved PD-1 blockade immunotherapy. Sci Rep. 2021;11(1):14661. doi: 10.1038/s41598-021-94250-0.
  • Wculek SK, Amores-Iniesta J, Conde-Garrosa R, et al. Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen. J Immunother Cancer. 2019;7(1):100. doi: 10.1186/s40425-019-0565-5.
  • Özverel CS, Uyanikgil Y, Karaboz İ, et al. Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice. Immunopharmacol Immunotoxicol. 2020;42(4):346–357. doi: 10.1080/08923973.2020.1775644.
  • Tan C, Reddy V, Dannull J, et al. Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model. J Transl Med. 2013;11(1):148. doi: 10.1186/1479-5876-11-148.
  • Zhang SN, Choi IK, Huang JH, et al. Optimizing DC vaccination by combination with oncolytic adenovirus coexpressing IL-12 and GM-CSF. Mol Ther. 2011;19(8):1558–1568. doi: 10.1038/mt.2011.29.
  • Hahn T, Alvarez I, Kobie JJ, et al. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int J Cancer. 2006;118(9):2220–2231. doi: 10.1002/ijc.21616.
  • Baldo BA. Immune- and non-immune-mediated adverse effects of monoclonal antibody therapy: a survey of 110 approved antibodies. Antibodies (Basel). 2022;11(1):17–58. doi: 10.3390/antib11010017.
  • Saffari F, Jafarzadeh A. Development of anti-rituximab antibodies in rituximab-treated patients: related parameters and consequences. Indian J Med Res. 2022;155(3 and 4):335–346. doi: 10.4103/ijmr.IJMR_312_19.
  • Lam QLK, Liu S, Cao X, et al. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol. 2006;36(12):3118–3130. doi: 10.1002/eji.200636602.
  • Li J, Yao Q, Liu D. Hydrodynamic cell delivery for simultaneous establishment of tumor growth in mouse lung, liver and kidney. Cancer Biol Ther. 2011;12(8):737–741. doi: 10.4161/cbt.12.8.16442.
  • Pulaski BA, Ostrand-Rosenberg S. Mouse 4T1 breast tumor model. Curr Protoc Immunol. 2001;Chapter 20(1):Unit 20.2. doi: 10.1002/0471142735.im2002s39.
  • Moraes-Vieira PM, Larocca RA, Bassi EJ, et al. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol. 2014;44(3):794–806. doi: 10.1002/eji.201343592.
  • Macia L, Delacre M, Abboud G, et al. Impairment of dendritic cell functionality and steady-state number in obese mice. J Immunol. 2006;177(9):5997–6006. doi: 10.4049/jimmunol.177.9.5997.
  • Khalife E, Khodadadi A, Talaeizadeh A, et al. Overexpression of regulatory T Cell-Related markers (FOXP3, CTLA-4 and GITR) by peripheral blood mononuclear cells from patients with breast cancer. Asian Pac J Cancer Prev. 2018;19(11):3019–3025. doi: 10.31557/APJCP.2018.19.11.3019.
  • Fernández-Riejos P, Najib S, Santos-Alvarez J, et al. Role of leptin in the activation of immune cells. Mediators Inflamm. 2010;2010:568343–568348. doi: 10.1155/2010/568343.
  • Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394(6696):897–901. doi: 10.1038/29795.
  • Batra A, Okur B, Glauben R, et al. Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo. Endocrinology. 2010;151(1):56–62. doi: 10.1210/en.2009-0565.
  • Sheikhi A, Jafarzadeh A, Kokhaei P, et al. Whole tumor cell vaccine adjuvants: comparing IL-12 to IL-2 and IL-15. Iran J Immunol. 2016;13(3):148–166.
  • Jafarzadeh A, Larussa T, Nemati M, et al. T cell subsets play an important role in the determination of the clinical outcome of Helicobacter pylori infection. Microb Pathog. 2018;116:227–236. doi: 10.1016/j.micpath.2018.01.040.
  • Tomasicchio M, Semple L, Esmail A, et al. An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells. Cancer Immunol Immunother. 2019;68(1):71–83. doi: 10.1007/s00262-018-2238-5.
  • Qi C-J, Ning Y-L, Han Y-S, et al. Autologous dendritic cell vaccine for estrogen receptor (ER)/progestin receptor (PR) double-negative breast cancer. Cancer Immunol Immunother. 2012;61(9):1415–1424. doi: 10.1007/s00262-011-1192-2.
  • Saucillo DC, Gerriets VA, Sheng J, et al. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol. 2014;192(1):136–144. doi: 10.4049/jimmunol.1301158.
  • Rescigno M, Martino M, Sutherland CL, et al. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med. 1998;188(11):2175–2180. doi: 10.1084/jem.188.11.2175.
  • Kaisho T, Takeuchi O, Kawai T, et al. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol. 2001;166(9):5688–5694. doi: 10.4049/jimmunol.166.9.5688.
  • Verhasselt V, Buelens C, Willems F, et al. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. Journal of Immunology (Baltimore, Md: 1950). 1997;158(6):2919–2925. doi: 10.4049/jimmunol.158.6.2919.
  • Kalaiyarasu S, Bhatia S, Mishra N, et al. Elevated level of pro inflammatory cytokine and chemokine expression in chicken bone marrow and monocyte derived dendritic cells following LPS induced maturation. Cytokine. 2016;85:140–147. doi: 10.1016/j.cyto.2016.06.022.
  • Xu L, Kwak M, Zhang W, et al. Time-dependent effect of E. coli LPS in spleen DC activation in vivo: alteration of numbers, expression of co-stimulatory molecules, production of pro-inflammatory cytokines, and presentation of antigens. Mol Immunol. 2017;85:205–213. doi: 10.1016/j.molimm.2017.02.017.
  • Showalter LE, Czerniecki BJ, Kodumudi K, et al. Murine dendritic cells grown in Serum-Free culture show potent therapeutic activity when loaded with novel Th epitopes in an orthotopic model of HER2pos breast cancer. Vaccines (Basel). 2021;9(9):1037. doi: 10.3390/vaccines9091037.
  • Czerniecki BJ, Koski GK, Koldovsky U, et al. Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer Res. 2007;67(4):1842–1852. doi: 10.1158/0008-5472.CAN-06-4038.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.