1,707
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

The potential role of hydrogen sulfide in regulating macrophage phenotypic changes via PINK1/parkin-mediated mitophagy in sepsis-related cardiorenal syndrome

, , , , , & show all
Pages 139-151 | Received 14 Mar 2023, Accepted 04 Nov 2023, Published online: 16 Nov 2023

References

  • Kotecha A, Vallabhajosyula S, Coville HH, et al. Cardiorenal syndrome in sepsis: a narrative review. J Crit Care. 2018;43:122–127. doi: 10.1016/j.jcrc.2017.08.044.
  • Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862–874. doi: 10.1038/nri3552.
  • Pfalzgraff A, Weindl G. Intracellular lipopolysaccharide sensing as a potential therapeutic target for sepsis. Trends Pharmacol Sci. 2019;40(3):187–197. doi: 10.1016/j.tips.2019.01.001.
  • Shapouri-Moghaddam A, Mohammadian S, Vazini H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425–6440. doi: 10.1002/jcp.26429.
  • Gordon S, Pluddemann A, Martinez Estrada F. Macrophage heterogeneity in tissues: phenotypic diversity and functions. Immunol Rev. 2014;262(1):36–55. doi: 10.1111/imr.12223.
  • Carestia A, Mena HA, Olexen CM, et al. Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice. Cell Rep. 2019;28(4):896–908 e5. Jul 23 doi: 10.1016/j.celrep.2019.06.062.
  • Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. 2019;176(1–2):11–42. doi: 10.1016/j.cell.2018.09.048.
  • Mantzarlis K, Tsolaki V, Zakynthinos E. Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies. Oxid Med Cell Longev. 2017;2017:5985209–5985210. doi: 10.1155/2017/5985209.
  • Xu Y, Shen J, Ran Z. Emerging views of mitophagy in immunity and autoimmune diseases. Autophagy. 2020;16(1):3–17. doi: 10.1080/15548627.2019.1603547.
  • Zhou H, Ren J, Toan S, et al. Role of mitochondrial quality surveillance in myocardial infarction: from bench to bedside. Ageing Res Rev. 2021;66:101250. doi: 10.1016/j.arr.2020.101250.
  • Eiyama A, Okamoto K. PINK1/parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol. 2015;33:95–101. doi: 10.1016/j.ceb.2015.01.002.
  • Zhang J, Ney PA. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ. 2009;16(7):939–946. doi: 10.1038/cdd.2009.16.
  • Lampert MA, Orogo AM, Najor RH, et al. BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation. Autophagy. 2019;15(7):1182–1198. doi: 10.1080/15548627.2019.1580095.
  • Dilek N, Papapetropoulos A, Toliver-Kinsky T, et al. Hydrogen sulfide: an endogenous regulator of the immune system. Pharmacol Res. 2020;161:105119. doi: 10.1016/j.phrs.2020.105119.
  • Beltowski J. Hydrogen sulfide in pharmacology and medicine–an update. Pharmacol Rep. 2015;67(3):647–658. doi: 10.1016/j.pharep.2015.01.005.
  • Yagdi E, Cerella C, Dicato M, et al. Garlic-derived natural polysulfanes as hydrogen sulfide donors: friend or foe? Food Chem Toxicol. 2016;95:219–233. doi: 10.1016/j.fct.2016.07.016.
  • Wu Y, Hu Y, Zhou H, et al. Organosulfur compounds induce cytoprotective autophagy against apoptosis by inhibiting mTOR phosphorylation activity in macrophages. Acta Biochim Biophys Sin. 2018;50(11):1085–1093. doi: 10.1093/abbs/gmy114.
  • Li S, Yang G, Zhu X, et al. Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces Colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. Oncol Rep. 2017;38(3):1637–1644. doi: 10.3892/or.2017.5849.
  • Wen YD, Zhu YZ. The pharmacological effects of S-propargyl-cysteine, a novel endogenous H2S-Producing compound. Handb Exp Pharmacol. 2015;230:325–336. doi: 10.1007/978-3-319-18144-8_16.
  • Wang Q, Liu HR, Mu Q, et al. S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway. J Cardiovasc Pharmacol. 2009;54(2):139–146. doi: 10.1097/FJC.0b013e3181ac8e12.
  • Wang Q, Wang XL, Liu HR, et al. Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production. Antioxid Redox Signal. 2010;12(10):1155–1165. May 15 doi: 10.1089/ars.2009.2947.
  • Wang M, Tang W, Xin H, et al. S-propargyl-cysteine, a novel hydrogen sulfide donor, inhibits inflammatory hepcidin and relieves anemia of inflammation by inhibiting IL-6/STAT3 pathway. PLoS One. 2016;11(9):e0163289. doi: 10.1371/journal.pone.0163289.
  • Sidhapuriwala JN, Hegde A, Ang AD, et al. Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS One. 2012;7(3):e32574. doi: 10.1371/journal.pone.0032574.
  • Virzi GM, Breglia A, Castellani C, et al. Lipopolysaccharide in systemic circulation induces activation of inflammatory response and oxidative stress in cardiorenal syndrome type 1. J Nephrol. 2019;32(5):803–810. doi: 10.1007/s40620-019-00613-2.
  • Li T, Chu X, Xin D, et al. H2S prevents peripheral immune cell invasion, increasing [Ca(2+)]i and excessive phagocytosis following hypoxia-ischemia injury in neonatal mice. Biomed Pharmacother. 2021;135:111207. doi: 10.1016/j.biopha.2020.111207.
  • Maciel E, Neves BM, Martins J, et al. Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling Cascades. Cell Signal. 2019;61:30–38. doi: 10.1016/j.cellsig.2019.04.015.
  • Deretic V, Levine B. Autophagy balances inflammation in innate immunity. Autophagy. 2018;14(2):243–251. doi: 10.1080/15548627.2017.1402992.
  • Pasquier B. Autophagy inhibitors. Cell Mol Life Sci. 2016;73(5):985–1001. doi: 10.1007/s00018-015-2104-y.
  • Kowald A, Hamann A, Zintel S, et al. A systems biological analysis links ROS metabolism to mitochondrial protein quality control. Mech Ageing Dev. 2012;133(5):331–337. doi: 10.1016/j.mad.2012.03.008.
  • Wang Y, Jasper H, Toan S, et al. Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury. Redox Biol. 2021;45:102049. doi: 10.1016/j.redox.2021.102049.
  • Patoli D, Mignotte F, Deckert V, et al. Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis. J Clin Invest. 2020;130(11):5858–5874. doi: 10.1172/JCI130996.
  • Delano MJ, Ward PA. Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest. 2016;126(1):23–31. doi: 10.1172/JCI82224.
  • Pouokam E, Althaus M. Epithelial electrolyte transport physiology and the gasotransmitter hydrogen sulfide. Oxid Med Cell Longev. 2016;2016:4723416–4723413. doi: 10.1155/2016/4723416.
  • Kim MJ, Yoo YC, Kim HJ, et al. Aged black garlic exerts anti-inflammatory effects by decreasing no and proinflammatory cytokine production with less cytoxicity in LPS-stimulated raw 264.7 macrophages and LPS-induced septicemia mice. J Med Food. 2014;17(10):1057–1063. doi: 10.1089/jmf.2013.3043.
  • Rousta AM, Mirahmadi SM, Shahmohammadi A, et al. S-allyl cysteine, an active ingredient of garlic, attenuates acute liver dysfunction induced by lipopolysaccharide/d-galactosamine in mouse: underlying mechanisms. J Biochem Mol Toxicol. 2020;26:e22518. doi: 10.1002/jbt.22518.
  • Yang G, Sun S, Wang J, et al. S-Allylmercaptocysteine targets Nrf2 in osteoarthritis treatment through NOX4/NF-kappaB pathway. Drug Des Devel Ther. 2020;14:4533–4546. doi: 10.2147/DDDT.S258973.
  • Lee DY, Li H, Lim HJ, et al. Anti-inflammatory activity of sulfur-containing compounds from garlic. J Med Food. 2012;15(11):992–999. doi: 10.1089/jmf.2012.2275.
  • Zhu X, Jiang X, Li A, et al. S-allylmercaptocysteine attenuates cisplatin-induced nephrotoxicity through suppression of apoptosis, oxidative stress, and inflammation. Nutrients. 2017;9(2):166. Feb 20 doi: 10.3390/nu9020166.
  • Schepetkin IA, Kirpotina LN, Khlebnikov AI, et al. Neutrophil immunomodulatory activity of natural organosulfur compounds. Molecules. 2019;24(9):1809. doi: 10.3390/molecules24091809.
  • Duan H, Li L, Shen S, et al. Hydrogen sulfide reduces cognitive impairment in rats after subarachnoid hemorrhage by ameliorating neuroinflammation mediated by the TLR4/NF-kappaB pathway in microglia. Front Cell Neurosci. 2020;14:210. doi: 10.3389/fncel.2020.00210.
  • Shibutani ST, Saitoh T, Nowag H, et al. Autophagy and autophagy-related proteins in the immune system. Nat Immunol. 2015;16(10):1014–1024. doi: 10.1038/ni.3273.
  • Ho J, Yu J, Wong SH, et al. Autophagy in sepsis: degradation into exhaustion? Autophagy. 2016;12(7):1073–1082. doi: 10.1080/15548627.2016.1179410.
  • Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 2013;20(1):31–42. doi: 10.1038/cdd.2012.81.
  • Sun Y, Yao X, Zhang QJ, et al. Beclin-1-dependent autophagy protects the heart during sepsis. Circulation. 2018;138(20):2247–2262. Nov 13 doi: 10.1161/CIRCULATIONAHA.117.032821.
  • Zhong Z, Umemura A, Sanchez-Lopez E, et al. NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria. Cell. 2016;164(5):896–910. doi: 10.1016/j.cell.2015.12.057.
  • Zhu H, Toan S, Mui D, et al. Mitochondrial quality surveillance as a therapeutic target in myocardial infarction. Acta Physiol. 2021;231(3):e13590. doi: 10.1111/apha.13590.
  • Sun D, Wang J, Toan S, et al. Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance. Angiogenesis. 2022;25(3):307–329. doi: 10.1007/s10456-022-09835-8.