MODE-OF-ACTION?BASED DOSIMETERS FOR INTERSPECIES EXTRAPOLATION OF VINYL ACETATE INHALATION RISK

REFERENCES

• Bogdanffy, M. S., and Taylor, M. L. 1993. Kinetics of carboxylesterase-mediated hydrolysis of the nasal carcinogen vinyl acetate. Drug Metab. Dispos. 21:1107–1111.
   PubMed Web of Science ®Google Scholar
• Bogdanffy, M. S., Randall, H. W., and Morgan, K. T. 1986. Histochemical localization of aldehyde dehydrogenase in the respiratory tract of the Fischer-344 rat. Toxicol. Appl. PharmacoL 82:560–567.
   PubMed Web of Science ®Google Scholar
• Bogdanffy, M. S., Randall, H. W., and Morgan, K. T. 1987. Biochemical quantitation and h istochemi-cal localization of carboxylesterase in the nasal passages of the Fischer-344 rat and B6C3F1 mouse. ToxicoL Appl. Pharmacol. 88:183–194.
   PubMed Web of Science ®Google Scholar
• Bogdanffy, M. S., Dreef-van der Meulen, H. C., Beems, R. B., Feron, V. J., Rickard, R. W., Cascieri, T. C., Tyler, T. R., and Vinegar, M. B. 1994. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam. Appl. Toxicol. 23: 215–229.
   Google Scholar
• Bogdanffy, M. S., Gladnick, N. L., Kegelman, T., and Frame, S. R. 1997. Cell proliferation responses in rat nasal epithelium following repeated exposures to vinyl acetate vapor. InhaL ToxicoL 9:331–350.
   Web of Science ®Google Scholar
• Bogdanffy, M. S., Sarangapani, R., Kimbell, J. S., Frame, S. R., and Plowchalk, D. R. 1998. Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique. Toxicol. Sci. 46:235–246.
   PubMed Web of Science ®Google Scholar
• Bogdanffy, M. S., Manning, L. A., and Sarangapani, R. 1999a. High-affinity nasal extraction of vinyl acetate is carboxylesterase dependent. Inhal. Toxicol. 11:927–941.
   PubMed Web of Science ®Google Scholar
• Bogdanffy, M. S., Sarangapani, R., Plowchalk, D. R., Jarabek, A., and Andersen, M. E. 1999b. A bio-logically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxic-ity. ToxicoL ScL 51:19–35.
   PubMed Web of Science ®Google Scholar
• Casanova-Schmitz, N., David, R. M., and Heck, H. d'A. 1984. Oxidation of formaldehyde and acetaldehyde by NAD'-dependentdehydrogenases in rat nasal mucosal homogenates. Biochem. PharmacoL 33:1137–1142.
   Google Scholar
• Cohen, S. M., and Ellwein, L. B. 1991. Genetic errors, cell proliferation and carcinogenesis. Cancer Res. 51:6493–6505.
   PubMed Web of Science ®Google Scholar
• Dellarco, V. L. 1988. A mutagenicity assessment of acetaldehyde Mutat. Res. 195:1–20.
   Google Scholar
• Fedtke, N., and Wiegand, H. J. 1990. Hydrolysis of vinyl acetate in human blood. Arch. ToxicoL 64: 428–429.
   PubMed Web of Science ®Google Scholar
• Feldman, M. Y. 1979. Reactions of nucleic acids and nucleoproteins with formaldehyde. Prog. Nucleic Acid Res. Mol. Biol. 13:1–49.
   Google Scholar
• Frederick, C. B., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. 1998. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapola-tion of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152:211–231.
   PubMed Web of Science ®Google Scholar
• Frighi, V., Ng, L. L., Lewis, A., and Dhar, H. 1991. Na/Fr antiport and buffering capacity of human polymorphonuclear and mononuclear leucocytes. Clin. ScL 80:95–99.
   PubMed Web of Science ®Google Scholar
• Goldsmith, D. J., and Hilton, P. J. 1992. Relationship between intracellular proton buffering capacity and intracellular pH. Kidney Int. 41:43–49.
   PubMed Web of Science ®Google Scholar
• He, S. M., and Lambert, B. 1985. Induction and persistence of SCE-inducing damage in human lym-phocytes exposed to vinyl acetate and acetaldehyde in vitro. Mutat. Res. 158:201–208.
   PubMed Web of Science ®Google Scholar
• He, S. M., and Lambert, B. 1990. Acetaldehyde-induced mutation at the HPRT locus in human lym-phocytes in vitro. Environ. MoL Mutagen. 16:57–63.
   PubMed Web of Science ®Google Scholar
• International Agency for Cancer Research. 1995. Dry cleaning, some chlorinated solvents and other industrial chemicals. IARC Monogr. Eval. Carcinogen. Risks Hum. 63:443–465.
   PubMedGoogle Scholar
• Knowles, S. E., Jarret, I. G., Owen, H. F., and Ballard, F. J. 1974. Production and utilization of acetate in mammals. Biochem. J. 142:401–411.
   PubMed Web of Science ®Google Scholar
• Kuykendall, J. R., and Bogdanffy, M. S. 1992a. Efficiency of DNA-histone crosslinking induced by saturated and unsaturated aldehydes in vitro. Mutat. Res. 283:131–136.
   PubMed Web of Science ®Google Scholar
• Kuykendall, J. R., and Bogdanffy, M. S. 1992b. Reaction kinetics of DNA-histone crosslinking by vinyl acetate and acetaldehyde. Carcinogenesis13:2095–2100.
   PubMed Web of Science ®Google Scholar
• Kuykendall, J. R., and Bogdanffy, M. S. 1994. Formation and stability of acetaldehyde-induced crosslinks between poly-lysine and poly-deoxyguanosine. Mutat. Res. 311:49–56.
   PubMed Web of Science ®Google Scholar
• Kuykendall, J. R., Taylor, M. L. and Bogdanffy, M. S. 1993. Cytotoxicity and DNA-protein crosslink formation in rat nasal tissues exposed to vinyl acetate are carboxylesterase-mediated. Toxicol. Appl. PharmacoL 123:283–292.
   PubMed Web of Science ®Google Scholar
• Laib, R. J., and Bolt, H. M. 1986. Vinyl acetate, a structural analog of vinyl carbamate, fails to induce enzyme-altered foci in rat liver. Carcinogenesis 7:841–843.
   PubMed Web of Science ®Google Scholar
• Lam, C. W., Casanova, M., and Heck, H. d'A. 1986. Decreased extractability of DNA from proteins in the rat nasal mucosa after acetaldehyde exposure. Fundam. Appl. Toxicol. 6: 541–550.
   Google Scholar
• Lambert, B., Chen, Y., He, S. M., and Sten, M. 1985. DNA-crosslinks in human leucocytes treated with vinyl acetate and acetaldehyde in vitro. Mutat. Res. 146:301–303.
   PubMedGoogle Scholar
• La Pointe, M. S., and Baffle, D. 1996. Regulation of intracellular pH and the Na'/H* antiporter in vas-cular smooth muscle. In Contemporary endocrinology of the vasculature, ed. J. R. Sowers, pp. 301–323. Totowa, NJ: Humana Press.
   Google Scholar
• Miller, R. R., Auers, J. A., Jersey, G. C., and McKenna, M. J. 1981. Inhalation toxicity of acrylic acid. Fundam. AppL Toxicol. 1:271–277.
   PubMedGoogle Scholar
• Miller, R. R., Hermann, E. A., Young, J. T., Calhoun, L. L., and Kastl, P. E. 1984. Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition and short-term vapor inhalation toxicity studies. Toxicol. AppL Pharmacol. 75:521–530.
   PubMed Web of Science ®Google Scholar
• Miller, R. R., Young, J. T., Kociba, R. J., Keyes, D. G., Bodner, K. M., Calhoun, L. L., and Ayres, J. A. 1985. Chronic toxicity and oncogenicity bioassay of inhaled ethyl acrylate in Fischer 344 rats and B6C3F1 mice. Drug Chem. Toxicol. 8:1–42.
   PubMed Web of Science ®Google Scholar
• Moolgavkar, S. H., and Luebeck, G. 1990. Two event model for carcinogenesis: Biological, mathe-matical, and statistical considerations. Risk Anal. 10:323–341.
   PubMed Web of Science ®Google Scholar
• Morita, T. 1995. Low pH leads to sister-chromatid exchanges and chromosomal aberrations and its clastogenicity is S-dependent. Mutat. Res. 344:301–308.
   Google Scholar
• Morita, T., Takeda, K., and Okumura, K. 1990. Evaluation of clastogenicity of formic acid, acetic acid and lactic acid on cultured mammalian cells. Mutat. Res. 268:297–305.
   Google Scholar
• Morris, J. B., Hasset, D. N., and Blanchard, K. T. 1993. A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vinyl acetate vapors. Toxicol. Appl. PharmacoL 123:120–129.
   PubMed Web of Science ®Google Scholar
• National Toxicology Program. 1992. NTP Technical Report on Studies of Formic Acid Administered by Inhalation to F344/N Rats and B6C3F1 Mice. Research Triangle Park, NC: NIH Publication 92–3342.
   Google Scholar
• Nedergaard, M., Goldman, S. A., Desai, S., and Pulsinelli, W. A. 1991. Acid-induced death in neu-rons and glia. J. Neurosci. 11(8):2489–2497.
   PubMed Web of Science ®Google Scholar
• Norppa, H., Tursi, F., Pfaffli, P., Maki-Paakkanen, J., and Jarventaus, H. 1985. Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells. Cancer Res. 45:4816–4821.
   PubMed Web of Science ®Google Scholar
• Obe, G., Natarajan, A. T., Meyers, M., and Den Hertog, A. 1979. Induction of chromosomal aberra-tions in peripheral lymphocytes of human blood in vitro, and of SCEs in bone-marrow cells of mice in vivo by ethanol and its metabolite acetaldehyde. Mutat. Res. 68:291–294.
   PubMed Web of Science ®Google Scholar
• Obe, G., and Ristow, H. 1977. Acetaldehyde, but not ethanol, induces sister chromatid exchanges in Chinese hamster ovary cells in vitro. Mutat. Res. 56:211–213.
   Web of Science ®Google Scholar
• Ohba, Y., Morimitsu, U., and Watariai, A. 1979. Reaction of formaldehyde with calf-thymus nucleo-h istone. Eur. J. Biochem. 100:285–293.
   PubMedGoogle Scholar
• Plowchalk, D. R., Andersen, M. E., and Bogdanffy, M. S. 1997. Physiologically-based modeling of vinyl acetate uptake, metabolism and intracellular pH changes in the rat nasal cavity. Toxicol. AppL PharmacoL 142:286–400.
   Web of Science ®Google Scholar
• Reininghaus, W., Hoestner, A., and Klimisch, H. K. 1991. Chronic toxicity and oncogenicity bioassay of inhaled methyl acrylate and n-butyl acrylate in Sprague-Dawley rats. Food Chem. Toxicol. 29:329–339.
   PubMed Web of Science ®Google Scholar
• Rhomberg, L., Dellarco, V. L., Siegel-Scott, C., Dearfield, K. L., and Jacobson-Kram, D. 1990. Quantitative estimation of the genetic risk associated with the induction of heritable transloca-tions at low-dose exposure: Ethylene oxide as an example. Environ. Mol. Mutagen. 16: 104–125.
   Google Scholar
• Segel, I. H. 1976. Biochemical calculations. New York: John Wiley and Sons.
   Google Scholar
• Simon, P., Epe, B., Muetzel, P., Schiffmann, D., Wild, P., Ottenwalder, H., Gedtke, N., Both, H. M., and Henschler, D. 1986. Synthesis and genotoxicity of acetoxyoxirane, the epoxide of vinyl acetate. J. Biochem. Toxicol. 1:43–55.
   PubMedGoogle Scholar
• Simon, P., Filser, J. G., and Bolt, H. M. 1985a. Metabolism and pharmacokinetics of vinyl acetate. Arch. Toxicol. 57:191–195.
   PubMed Web of Science ®Google Scholar
• Simon, P., Ottenwalder, H., and Bolt, H. M. 1985b. Vinyl acetate: DNA-binding assay in vivo. Toxicol. Lett. 27:115–120.
   PubMed Web of Science ®Google Scholar
• Sipi, P., Jarventaus, H., and Norppa, H. 1992. Sister-chromatid exchanges induced by vinyl esters and respective carboxylic acids in cultured human lymphocytes. Mutat. Res. 279:75–82.
   PubMed Web of Science ®Google Scholar
• Subramaniam, R., Richardson, R. B., Morgan, K. T., Kimbell, J. S., and Guilmette, R. A. 1997. Com-putational fluid dynamic simulations of inspiratory airflow in the human nose and nasopharynx. lnhal. Toxicol. 10:473–502.
   Google Scholar
• Thornton-Manning, J. R., and Dahl, A. R. 1997. Metabolic capacity of nasal tissue. lnterspecies com-parisons of xenobiotic-metabolizing enzymes. Mutat. Res. 380: 43–59.
   Google Scholar
• Tobey, N. A., Reddy, S. P., Keku, T. O., Cragoe, E. J., and Orlando, R. C. 1992. Studies of pH, in rabbit esophageal basal and squamous epithelial cells in culture. Gastroenterology 103:830–839.
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency. 1996. Proposed guidelines for carcinogen risk assessment. Fed. Reg. 61(79):17959–18011.
   Google Scholar