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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 5
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Research Article

USE OF A STRATIFIED OXIDATIVE STRESS MODEL TO STUDY THE BIOLOGICAL EFFECTS OF AMBIENT CONCENTRATED AND DIESEL EXHAUST PARTICULATE MATTER

Ning Li Department of Medicine, University of California Los Angeles, Los Angeles, California, USA
,
Seongheon Kim Department of Environmental Health Sciences, University of California Los Angeles, Los Angeles, California, USA
,
Meiying Wang Department of Medicine, University of California Los Angeles, Los Angeles, California, and Southern California Particulate Center and Supersite, Los Angeles, California, USA
,
John Froines Department of Environmental Health Sciences, University of California Los Angeles, Los Angeles, California, and Southern California Particulate Center and Supersite, Los Angeles, California, USA
,
Constantinos Sioutas University of Southern California, Civil and Environmental Engineering, Los Angeles, California, and Southern California Particulate Center and Supersite, Los Angeles, California, USA
&
Andre Nel Department of Medicine, University of California Los Angeles, Los Angeles, California, and Southern California Particulate Center and Supersite, Los Angeles, California, USA
Pages 459-486 | Published online: 01 Oct 2008

  • Alam, J., Stewart, D., Touchard, C, Boinapally, S., Choi, A. M., and Cook, J. L. 1999. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J. Biol. Chem. 274:26071-26078.
  • Alam, J., Wicks, C., Stewart, D., Gong, P., Touchard, C., Otterbein, S., Choi, A. M., Burow, M. E., and Tou, J. 2000. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J. Biol. Chem. 275: 27694-27702.
  • Alien, J. O., Hughes, L. S., Salmon, L. G., Mayo, P. R., Johnson, R. J., and Cass, G. R. 2000. Characterization and evolution of primary and secondary aerosols during PM2.5 and PM10 episodes in the South Coast Air Basin. Report A-22 to the Coordinating Research Council, Alpharetta, GA.
  • Anderson, M. E. 1985. Tissue glutathione. In Handbook of methods for oxygen radical research, ed. R. A. Greenwald, p. 317. Boca Raton, FL: CRC Press.
  • Bates, D., Pope, C., Thun, M., Namboodiri, M., Dockery, D., Evans, J., Speizer, F., and Heath, C. 1995. Particulate air pollution as a predictor of mortality in a prospective cohort study of US adults. Am. J. Respir. Clin. Care Med. 151:669-674.
  • Bayram, H., Devalia, J. L., Sapsford, R. J., Ohtoshi, T., Miyabara, Y., Sagai, M., and Davies, R. J. 1998. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. CeII MoI. Biol. 108:441-448.
  • Becker, S., Soukup, J. M., Gilmour, M. I., and Devlin, R. B. 1996. Stimulation of human and rat alveolar macrophages by urban air participates: Effects on oxidant radical generation and cytokine production. Toxicol. Appl. Pharmacol. 141:637-648.
  • Chan, K., and Kan, Y. W. 1999. Nrf2 is essential for protection against acute pulmonary injury in mice. Pmc. Natl. Acad. Sci. USA. 96:12731-12736.
  • Choi, A. M., and Alam, J. 1996. Heme oxygenase-1 : Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. 7. Respir. CeII MoI. Biol. 15:9-19.
  • Chow, J. C, Watson, J. G., Fujita, E. M., Lu, Z., and Lawson, D. R. 1994. Temporal and spatial variations of PM2.5 and PM10 aerosol in the Southern Californien Air Quality Study. Atmos. Environ. 28:2061-2080.
  • Diaz-Sanchez, D., Tsien, A., Fleming, J., and Saxon, A. 1997. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances in vivo nasal ragweed-specific IgE and shows cytokine production to a TH2-type pattern. J. ImmunoL 158:2406-2413.
  • Diaz-Sanchez, D., Jyrala, M., Ng, D., NeI, A. E., and Saxon, A. 2000. In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines, Rantes, MIP-1 a and MCP-3 in humans. Clin. ImmunoL 97:140-148.
  • Dick, C. A. J., Stone, V., Brown, D. M., Watt, M., Cherrie, J. W., Howarth, S., Seaton, A., and Donaldson, K. 2000. Toxic and inflammatory effects of filters frequently used for the collection of airborne particulate matter. Atmos. Environ. 34:2587-2592.
  • Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., and Speizer, F. E. 1993. An association between air pollution and mortality in six U.S. cities. N. Engl.J. Med. 329:1753-1759.
  • Federal Register. 1997. National ambient air quality standards for particulate matter; Final rule. 62:38,652-38,752.
  • Folkard, S. G., Westwick, J., and Millar, A. B. 1997. Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics, Eur. Respir. J. 10:2097-2104.
  • Ghio, A. J., and Samet, J. M. 1998. Metals and air pollution particles. In Air pollution and health, eds. S. T. Holgate, J. M. Samet, H. S. Koren, and R. L. Maynard, vol. 30, pp. 635-651. San Diego: Academic Press.
  • Gilmour, P. S., Brown, D. M., Lindsay, T. G., Beswick, P. H., MacNee, W., and Donaldson, K. 1996. Adverse health effects of PM10 particles: Involvement of iron in generation of hydroxyl radical. Occup. Environ. Med. 53:817-822.
  • Goldsmith, C, Frevert, C, lmrich, A., Sioutas, C., and Kobzik, L. 1997. Alveolar macrophage interaction with air pollution particulates. Environ. Health Perspect. 105:1191-1195.
  • Griffith, O. W. 1980. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106:207.
  • Hiura, T. S., Kaszubowski, M., Li, N., and NeI, A. E. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and apoptosis in macrophages. J. ImmunoL 163:55825590.
  • Hiura, T. S., Li, N., Kaplan, R., Horwitz, M., Seagrave, J., and NeI, A. E. 2000. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from DEP. J Immunol. 165:2703-2711.
  • Horvath, I., DonnelIy, L. E., Kiss, A., Pared!, P., Kharitonov, S. A., and Barnes, P. J. 1998. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: A new marker of oxidative stress. Thorax 53:668-672.
  • ltoh, K., Wakabayashi, N., Katoh, Y., lshii, T., lgarashi, K., Engel, J. D., and Yamamoto, M. 1999. Keapl represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13:76-86.
  • Junge, C. E. 1977. Basic considerations about trace constituents in the atmosphere as related to the fate of global pollutants. In Fate of pollutants in the air and water environment, ed. I. H. Suffet, part 1, vol. 8, pp. 7-9. New York: Wiley-lnterscience.
  • Kataoka, K., Noda, M., and Nishizawa, M. 1994. Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. MoI. Cell. Boil. 14: 700-712.
  • Keyse, S. M., and Tyrrell, R. M. 1989. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide and sodium arsenite. Proc. Natl. Acad. Sci. USA 86:99-103.
  • Kirn, S., Jaques, P., Chang, M., and Sioutas, C. 2001 a. Versatile aerosol concentration enrichment system (VACES) for simultaneous in-vivo and in-vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles. Part I: Development and laboratory characterization. J. Aerosol Sci. 11:1281-1297.
  • Kirn, S., Jaques, P., Chang M., and Sioutas, C. 2001 b. Versatile aerosol concentration enrichment system (VACES) for simultaneous in-vivo and in-vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles. Part II: Field evaluation. J. Aerosol Sci. 11:1299-1314.
  • Kumagai, Y., Arimoto, T., Shinyashiki, M., Shimojo, N., Nakai, Y., Yoshikawa, T., and Sagai, M. 1997. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Free Radical BoiI. Med. 22:479-487.
  • Kyriakis, J. M., Banerjee, P., Nikolakaki, E., DaI, T., Ruble, E. A., Ahmad, M. F., Avruch, J., and Woodgett, J. R. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156-160.
  • Lakshminarayanan V., Drab-Welss, E. A., and Roebuck, K. A. 1998. H2O2 and tumor necrosis factora induce differential binding of the redox-responsive transcription factors AP-I and NF-kB to the interleukin 8 promoter in endothelial and epithelial cells. J. Boil. Chem. 49:32670-32678.
  • Lander, M. 1997. An essential role for free radicals and derived species in signal transduction. FASEB J. 11:118-124.
  • Li, N., Venkatesan, M. I., Miguel, A., Kaplan, R., Gujuluva, C., Alam, J., and NeI, A. 2000. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J. ImmunoL 165:3393-3401.
  • Li, X. Y, Gilmour, P. S., Donaldson, K., and Mac Nee, W. 1996. Free radical activity and proinflammatory effects of paniculate air pollution(PMIO) in vivo and in vitro. Thorax 51:1216-1222.
  • MacNee, W., and Donaldson, K. 1998. Particulate air pollution: injurious and protective mechanisms in the lung. In Air pollution and health, eds. S. T. Holgate, J. M. Samet, H. S. Koren, and R. L. Maynard, vol. 30, pp. 653-672. San Diego: Academic Press.
  • Maines, M. D. 1997. The heme oxygenase system: A regulator of second messenger gases. Annu. Rev. Pharmacol. Txicol. 37:517-554.
  • Marple, V. A., Rubow, K. L., and Behm, S. M. 1991. A microorifice uniform deposit impactor (MOUDI): description, calibration and use. Aerosol Sci. Technol. 14:436-446.
  • Misra, C, Geller, M., Sioutas, C, and Solomon, P. 2001. Development and evaluation of a continuous coarse particle monitor. J. Air. Waste Manage. Assoc., in press.
  • Monks, T. J., Hanzlik, R. P., Cohen, G. M., Ross, D., and Graham, D. G. 1992. Quinone chemistry and toxicity. Toxicol. Appl. Pharmacol. 112:2-16.
  • Mori, N., Mukaida, N., Ballard, D. W., Matsushima, K., and Yamamoto, N. 1998. Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-I and nuclear factor-kB like sites. Cancer Res. 58:3993-4000.
  • National Research Council. 1998. Research priorities for airborne paniculate matter: I-Immediate priorities and a long-range research portfolio. Washington, DC: National Academy of Sciences.
  • NeI, A. E., Diaz-Sanchez, D., Ng, D., Hiura, T., and Saxon, A. 1998. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J. Allergy Clin. Immunol. 102:539-554.
  • NeI, A. E., Diaz-Sanchez, D., and Li, N. 2001. The role of particulate pollutants in pulmonary inflammation and asthma: Evidence for the involvement of organic chemicals and oxidative stress. Curr. Opin. PuIm. Med. 7:20-26.
  • Ng, D., Kokot, N., Hiura, T., Paris, M., Saxon, A., and NeI, A. 1998. Macrophage activation by polycyclic aromatic hydrocarbons: Evidence for the involvement of stress-activated protein kinases, AP-I and anti-oxidant response element. J. lmmunol. 161:942-951.
  • Nightingale, J. A., Maggs, R., Cullinan, P., Donnellely, L. E., Rogers, D. F., Kinnersley, R., Chung, K. F., Barnes, P. J., Ashmore, M., and Newman-Taylor, A. 2000. Airway inflammation after controlled exposure to diesel exhaust particulates. Am. J. Respir. Crit. Care Med. 162:161-166.
  • Oberdörster, G. 2001. Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health 74:1-8.
  • O'Brien, P. J. 1991. Molecular mechanisms of quinonecytotoxicity. Chem. Biol. Interact. 80:1-41.
  • Ohtoshi, T., Takizawa, H., Okazaki, H., Kawasaki, S., Takeuchi, N., Ohta, K., and lto, K. 1998. Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J. Allergy Clin. ImmunoL 101:778-785.
  • Otterbein, L. E., KoIIs, J. K., Mantell, L. L., Cook, J. L., Alam, J., and Choi, A. M. 1999. Exogenous administration of hemeoxygenase-1 by gene transfer provides protection against hyperoxiainduced lung injury. J. Clin. Invest. 103:1047-1054.
  • Pankow, J. F. 1987. Review and comparative analysis of theories of partitioning between the gas and aerosol particulate phases in the atmosphere. Atmos. Environ. 22:2275-2283.
  • Penning, T. M., Burczynski, M. E., Hung, C. F., McCoull, K. D., Palackal, N. T., and Tsuruda, L. S. 1999. Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: Generation of reactive and redox active o-quinones. Chem. Res. Toxicol. 12:1-18.
  • Pope, C. A., Thun, M. J., Namboodiri, M. M., Dockery, D. W., Evans, J. S., Speizer, F. E., and Heath, C. W., Jr. 1995. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am.). Respir. Crif. Care Med. 151:669-674.
  • Prestera, T., Talalay, P., Alam, J., Ahn, Y. I., Lee, P. J., and Choi, A. M. 1995. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE). MoI. Med. 1:827-837.
  • Rahman, I., Li, X. Y., Donaldson, K., Harrison, D. J., and MacNee, W. 1995. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. Am. J. Physiol. 269: L285-292.
  • Salvi, S. S., Nordenhall, C, Blomberg, A., Rudell, B., Pourazar, J., Kelly, F. J., Wilson, S., Sandstrom, T., Holgate, S. T., and Frew, A. J. 2000. Acute exposure to diesel exhaust increases IL-8 and GROalpha production in healthy human airways. Am. J. Respir. Crit. Care Med. 161:550-557.
  • Sarnat, J. A., Schwartz, J., and Suh, H. H. 2001. Fine particulate air pollution and mortality in 20 U.S. cities. N. Engl.j. Med. 344:1253-1254.
  • Sen, C, and Packer, L. 1996. Antioxidant and redox regulation of gene transcription. FASEB J. 10: 709-720.
  • Shuetzle, D., Lee, F. S., Prater, T. J., and Tejada, S. B. 1981. The identification of polynuclear aromatic hydrocarbon derivatives in mutagenic fractions of diesel particulate extracts. Int. Environ. Anal. Chem. 9:93-144.
  • Sioutas, C, Koutrakis, P., Ferguson, S. T., and Burton, R. M. 1995. Development and evaluation of a prototype ambient particle concentrator for inhalation exposure studies, lnhal. Toxicol. 7:633-644.
  • Takizawa, H., Ohtoshi, T., Kawasaki, S., Kohyama, T., Desaki, M., Kasama, T., Kobayashi, K., Nakahara, K., Yamamoto, K., Matsushima, K., and Kudoh, S. 1999. Diesel exhaust particles induce NF-KB activation in human bronchial epithelial cells in vitro: Importance in cytokine transcription. J. Clin. Allergy ImmunoL 162:4705-4711.
  • Tietze, F. 1969. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 27: 502.
  • Venkatesan, M. I., Brenner, S., Ruth, E., Bonilla, J., and Kaplan, I. R. 1980. Hydrocarbons in agedated sediment cores from two basins in southern California Bight. Geochim. Cosmochim. Acta 44:789.
  • Wall, S. M., John, W., and Ondo, J. L. 1988. Measurement of aerosol size distributions for nitrate and major ionoc species. Atmos. Environ. 22:1649-1656.
  • Willeke, K., Lin, X., and Grinshpun, S. A. 1998. Improved aerosol collection by combined impaction and centrifugal motion. Aerosol Sci. Technol. 28:439-456.
  • Willis, D., Moore, A. R., Frederick, R., and Willoughby, D. A. 1996. Hemeoxygenase: A novel target for the modulation of the inflammatory response. Nature Med. 2:87-90.
  • Yamada, N., Yamaya, M., Okinaga, S., Nakayama, K., Sekizawa, K., Shibahara, S., and Sasaki, H. 2000. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am. J. Hum. Genet. 66:187-195.
  • Zucker, B. A., Draz, A. M., and Muller, M. 2000. Comparison of filtration and impingement for sampling airborne endotoxins. J. Aerosol Sd. 31:751-755.

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