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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 3
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Research Article

QUANTIFICATION OF FIBROSIS IN THE LUNGS OF RATS USING A MORPHOMETRIC METHOD

E. E. McConnell ToxPath, Inc., Raleigh, North Carolina, USA
&
J. M. G. Davis Institute of Occupational Medicine, Edinburgh, Scotland
Pages 263-272 | Published online: 01 Oct 2008

  • Hesterberg, T. W., Miiller, W. C., McConnell, E. E., Chevalier, J., Hadley, J., Bernstein, D. M., Thevenaz, P., and Anderson, R. 1993. Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats. Fundam. Appl. Toxicol. 20:464-476.
  • Mast, R. W., McConnell, E. E., Anderson, R., Chavalier, J., Kotin, P., Bernstein, D. M., Thevenaz, P., Glass, L. R., Miiller, W. C., and Hesterberg, T. W. 1995a. Studies on the chronic toxicity (inhalation) of four types of refractory ceramic fiber in male Fischer 344 rats, lnhal. Toxicol. 7:425-467.
  • Mast, R. W., McConnell, E. E., Hesterberg, T. W., Chevalier, J., Kotin, P., Thevenax, P., Bernstein, D. M., Glass, LR., Miiller, W., and Anderson, R. 1995b. A multiple dose chronic inhalation toxicity study of size-separated kaolin refractory ceramic fiber (RCF) in male Fischer 344 rats, lnhal. Toxicol. 7:469-502.
  • Maxim, L. D., and McConnell, E. E. 2001. lnterspecies comparisons of the toxicity of asbestos and synthetic vitreous fibers: A weight-of-the-evidence approach. Regul. Toxicol. Pharmacol. 33:319-342.
  • McConnell, E. E., Wagner, J. C., Skidmore, J. W., and Moore, J. A. 1984. A comparative study of the fibrogenic and carcinogenic effects of UICC Canadian chrysotile B asbestos and glass microfibre (JM100). In Biological effects of man-made mineral fibres. Report of a WHO/lARC meeting, pp. 234-252. Copenhagen: WHO.
  • McConnell, E. E., Kamstrup, O., Musselman, R., Hesterberg, T. W., Chevalier, J., Miiller, W. C., and Thevenaz, P. 1994. Chronic inhalation study of size-separated rock and slag wool insulation fibers in Fischer 344/N rats, lnhal. Toxicol. 6:571-614.
  • McConnell, E. E., Axten, C., Hesterberg, T. W., Chevalier, J., Miiller, W., Everitt, J., Oberdörster, G., Chase, G. R., Thevenaz, P., and Kotin, P. 1999. Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the Syrian golden hamster. Part 2. Results of chronic exposure. lnhal. Toxicol. 11:785-836.
  • Wagner, J. C., Berry, G., and Skidmore, J. W. 1974. The effects of the inhalation of asbestos in rats. Br. J. Cancer29:252-269.

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