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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 3
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Research Article

SHORT-TERM INHALATION TOXICITY OF POLYISOCYANATE AEROSOLS IN RATS: COMPARATIVE ASSESSMENT OF IRRITANT-THRESHOLD CONCENTRATIONS BY BRONCHOALVEOLAR LAVAGE

Jürgen Pauluhn Institute of Toxicology, Bayer AG, Wuppertal, Germany
Pages 287-301 | Published online: 01 Oct 2008

  • Deutsche Forschungsgemeinschaft. 2000. List of MAK and BAT values 2000. Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. Report No. 36. Weinheim, Germany: Wiley-VCH.
  • Dunlap, K. L., Sandridge, R. L., and Keller, J. 1976. Determination of isocyanates in working atmosphere by high performance liquid chromatography. Anal. Chem. 48:497-499.
  • European Economic Community. 1986. Directive 86/609/EEC. Guideline of the Council dated November 24, 1986 on the Reconciliation of Legal and Administrative Regulations of the Member Countries for the Protection of Animals used for Studies and other Scientific Purposes. /. fur. Commun. Legal Spec. L 358, 29.
  • Ferguson, J. S., Schaper, M., and Alarie, Y. 1987. Pulmonary effects of a polyisocyanate aerosol: Hexamethylene diisocyanate trimer (HDIt) or Desmodur-N (Des-N). Toxicol. Appl. Pharmacol. 89:332-346.
  • Feron, V. J., Kittel, B., Kuper, C. F., Ernst, H., Rittinghausen, S., Muhle, H., Koch, W., Gamer, A., Mal left, A. K., and Hoffmann, H. D. 2001. Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: Combination of findings from two bioassays. Arch. Toxicol. 75:159-175.
  • Henderson, R. F. 1989. Bronchoalveolar lavage: A tool for assessing the health status of the lung. In Concepts in inhalation toxicology, eds. R. O. McClellan and R. F. Henderson, pp. 415-444. New York: Hemisphere.
  • Janko, M., McCarthy, K., Fajer, M., and van Raalte, J. 1992. Occupational exposure to 1,6-hexamethylene diisocyanate-based poly isocyanates in the state of Oregon, 1980-1990. Am. Ind. Hyg. Assoc. 53:331-338.
  • Jugg, B., Jenner, J., and Rice, P. 1999. The effect of perfluoroisobutene and phosgene on rat lavage fluid surfactant phospholipids. Hum. Exp. Toxicol. 18:659-668.
  • Nieman, G. F. 1985. Current concepts of lung-fluid balance. Respir. Care 30:1062-1076.
  • Organization for Economic Cooperation and Development. 1983. Publication of the German version of the OECD Principles of Good Laboratory Practice (GLP). Bundesanzeiger 35(42a).
  • Pauluhn, J. 1994. Validation of an improved nose-only exposure system for rodents. J. Appl. Toxicol. 14:55-62.
  • Pauluhn, J. 2000a. Acute inhalation toxicity of polymeric diphenyl-methane-4,4'-diisocyanate (MDI) in rats: Time course of changes in bronchoalveolar lavage. Arch. Toxicol. 74:257-269.
  • Pauluhn, J. 2000b. Inhalation toxicity of 1,6-hexamethylene diisocyanate-homopolymer (HDI-IC) aerosol: Results of single inhalation exposure studies. Toxicol. Sd. 58:173-181.
  • Pauluhn, J., and Mohr, U. 2001. Inhalation toxicity of 1,6-hexamethylene diisocyanate-homopolymers (HDI-IC and HDI-BT): Results of subacute and subchronic repeated exposure inhalation exposure studies, lnhal. Toxicol. 13:513-532.
  • Pauluhn, J., Emura, M., Mohr, U., Popp, A., and Rosenbruch, M. 1999. Two-week inhalation toxicity of polymeric diphenyl-methane-4,4'-diisocyanate (PMDI) in rats: Analysis of biochemical and morphological markers of early pulmonary response, lnhal. Toxicol. 11:1143-1163.
  • Persson, C. G. A., Erjefält, J. S., Andersson, M., Greiff, I., and Svensson, C. 1996. Extravasation, laminapropria flooding and lumenal entry of bulk plasma exudate in mucosal defence, inflammation, and repair. Pulmon. Pharmacol. 9:129-139.
  • Persson, C. G. A., Erjefält, J. S., Greiff, l., Erjefält, I., Korsgren, M., Linden, M., Sundler, F., Andersson, M., and Svensson, C. 1998. Contribution of plasma-derived molecules to mucosal immune defence, disease and repair in the airways. Scant. J. Immunol 47:302-313.
  • Reuzel, P. G. J., Kuper, C. F., Feron, V. J., Appelman, L. M., and Loser, E. 1994a. Acute, subacute, and subchronic inhalation toxicity studies of respirable polymeric methylene diphenyl diiso- cyanate (polymeric MDI) aerosol in rats. Fundam. Appl. Toxicol. 22:186-194.
  • Reuzel, P. G., Arts, J. H., Lomax, L. G., Kuijpers, M. H., Kuper, C. F., Gembardt, C., Feron, V. J., and Löser, E. 1994b. Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats. Fundam. Appl. Toxicol. 22:195-210.
  • Silk, S. J., and Hardy, H. L. 1983. Control limits for isocyanates. Ann. Occup. Hyg. 27:333-339.
  • Valentin!, J. E., Wong, K.-L., and Alarie, Y. 1983. Single-tracer technique to evaluate pulmonary edema and its application to detect the effect of hexamethylene diisocyanate trimer aerosol exposure. Toxicol. Appl. Pharmacol. 69:461-470.
  • Vesterberg, O., Palmberg, L., and Larsson, K. 2001. Albumin, transferrin and Oj-macroglobulin in bronchoalveolar lavage fluid following exposure to organic dust in healthy subjects. Int. Arch. Occup. Environ. Health 74:249-254.
  • Weyel, D. A., Rodney, B. S., and Alarie, Y. 1982. Sensory irritation, pulmonary irritation, and acute lethality of a polymeric isocyanate and sensory irritation of 2,6-toluene diisocyanate. Toxicol. Appl. Pharmacol. 64:423-430.
  • Wiener, F., Carlson, R. W., Puri, V. K., and Weil, M. H. 1983. Mathematical model to study fluid and protein transfer in pulmonary edema in man. Crit. Care Med. 11:132-141.

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