Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 6
29
Views
9
CrossRef citations to date
0
Altmetric
Research Article

EFFECTS OF INHALED OZONE ON PULMONARY IMMUNE CELLS CRITICAL TO ANTIBACTERIAL RESPONSES IN SITU

, , , , , , & show all
Pages 599-619 | Published online: 01 Oct 2008

  • Amoruso, M. A., Witz, G., and Goldstein, B. D. 1981. Decreased Superoxide anion radical production by rat alveolar macrophages following inhalation of ozone or nitrogen dioxide. Life Sci. 28:2215-2221.
  • Aranyi, C., Vana, S. C., Thomas, P. T., Bradof, J. N., Fenters, J. D., Graham, J. A., and Miller, F. J. 1983. Effects of subchronic exposure to a mixture of O3, SO2, and (NH4)2SO4 on host defenses of mice. J. Toxicol. Environ. Health 12:55-71.
  • Bancroft, G. J., Sheehan, K. C., Schreiber, R. D., and Unanue, E. R. 1989. Tumor necrosis factor is involved in the T-cell-independent pathway of macrophage activation in SCID mice. J. Immunol. 143:127-130.
  • Becker, S., Jordan, R. L., Orlando, G. S., and Koren, H. S. 1989. In vitro ozone exposure inhibits mitogen-induced lymphocyte proliferation and IL-2 production.J. Toxicol. Environ. Health 26:469-483.
  • Becker, S., Madden, M. C, Newman, S. L., Devlin, R. B., and Koren, H. S. 1991. Modulation of human alveolar macrophage properties by ozone exposure in vitro. Toxicol. Appl. Pharmacol. 110:403-415.
  • Bilyk, N., and Holt, P. G. 1995. Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations. Immunology 86:231-237.
  • Burleson, G. R., and Keyes, L. L. 1989. Natural killer activity in Fisher-344 rat lungs as a method to assess pulmonary immunocompetence: Immune suppression by phosgene inhalation, lmmunopharmacol. Immunotoxicol. 11:4211-443.
  • Chang, L. Y., Huang. Y., Stockstill, B. L, Graham, J. A., Grase, E. C, Menache, M. G. Miller, F. J., Costa, D. L., and Crapo, J. D. 1992. Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. Toxicol. Appl. Pharmacol. 115:241-252.
  • Chen, L. C., Qu, Q., Amdur, M., and Schlesinger, R. B. 1993. Alteration of pulmonary macrophage pH following inhalation exposure to sulfuric acid/ozone mixtures. Toxicol. Appl. Pharmacol. 121: 138-143.
  • Christian, D. L., Chen, L. L, Scannell, C. H., Ferrando, R. E., Welch, B. S., and Balmes, J. R. 1998. Ozone-induced inflammation is attenuated with multiday exposure. Am. J. Respir. Crit. Care Med. 158:532-537.
  • Coffin, D. L., Gardner, D. E., Holzman, R. S., and Wolock, F. J. 1968. Influence of ozone on pulmonary cells. Arch. Environ. Health 16:633-636.
  • Cohen, M. D., Chen, C. M., and Wei, C. I. 1989. Decreased resistance to Listeria monocytogenes in mice following vanadate exposure: Effects upon the function of macrophages. Int. J. lmmunopharmacol. 11:285-292.
  • Cohen, M. D., Yang, Z., Qu, Q., Schlesinger, R. B., and Zelikoff, J. T. 1996a. Vanadium affects macrophage interferon-? binding and -inducible responses. Toxicol. Appl. Pharmacol. 138:110-120.
  • Cohen, M. D., Zelikoff, J. T., Qu, Q., and Schlesinger, R. B. 1996b. Effects of ozone upon macrophage-interferon interactions. Toxicology 114:243-252.
  • Cohen, M. D., Becker, S., Devlin, R., Schlesinger, R. B., and Zelikoff, J. T. 1997. Effects of vanadium upon polyl:C-induced responses in rat lung and alveolar macrophages. J. Toxicol. Environ. Health 51:591-608.
  • Cohen, M. D., Zelikoff, J. T., Chen, L. C., and Schlesinger, R. B. 1998. Immunotoxicologic effects of inhaled chromium: Role of particle solubility and co-exposure to ozone. Toxicol. Appl. Pharmacol. 152:30-40.
  • Cohen, M. D., Sisco, M., Li, Y., Zelikoff, J. T., and Schlesinger, R. B. 2001. Ozone-induced modulation of cell-mediated immune responses in the lungs. Toxicol. Appl. Pharmacol. 171:71-84.
  • Donaldson, K., Brown, G. M., Brown, D. M., Slight, J., Maclaren, W. M., and Davis, J. M. 1991. Leukocyte-mediated epithelial injury in ozone-exposed rat lung. HEI Research Report Number 44. Cambridge, MA: Health Effects Institute.
  • Dormans, J. A., Boere, A. J., Van Loveren, H., Rombout, P. J., Marra, M., and van Bree, L 1996. Age-related toxicity in rat lungs following acute and repeated ozone exposure, lnhal. Toxicol. 8:903-925.
  • Driscoll, K. E., Vollmuth, T. A., and Schlesinger, R. B. 1986. Early alveolar clearance of particles in rabbits undergoing acute and subchronic exposure to ozone. Fundam. Appl. Toxicol. 7:264-271.
  • Flesch, I. E., Barsig, J., and Kaufmann, S. H. 1998. Differential chemokine response of murine macrophages stimulated with cytokines and infected with Listeria monocytogenes. Int. Immunol. 10: 757-765.
  • Gardner, D. E., Leweis, T. R., Alpert, S. M., Hurst, D. J., and Coffin, D. L. 1972. The role of tolerance in pulmonary defense mechanisms. Arch. Environ. Health 25:432-438.
  • Hurst, D. J., Gardner, D. E., and Coffin, D. L. 1970. Effect of ozone on acid hydrolases of the pulmonary alveolar macrophage. J. Reticuloendothel. Soc. 8:288-301.
  • Ibrahim, A. L., Zee, Y. C, and Osebold, J. W. 1976. The effects of ozone on the respiratory epithelium and alveolar macrophages of mice. Proc. Soc. Exp. Biol. Med. 152:483-488.
  • Jakab, G. F. 1993. The toxicologie interactions resulting from inhalation of carbon black and acrolein on pulmonary antibacterial and antiviral defenses. Toxicol. Appl. Pharmacol. 121:167-175.
  • Koike, E., Kobayashi, T., Nelson, D. J., McWilliam, A. S., and Holt, P. G. 1998. Effect of ozone on alveolar macrophage-mediated immunosuppressive activity in rats. Toxicol. Sci. 41:217-223.
  • Koike, E., Kobayashi, T., Murakami, M., McWilliam, A. S., and Holt, P. G. 1999. Mechanisms of ozone-induced inhibitory effect of bronchoalveolar lavage fluid on alveolar macrophage-mediated immunosuppressive activity in rats. J. Leukocyte Biol. 66:75-82.
  • Lafranconi, W. M., Spall, R. D., Sipes, I. G., Duhamel, R. C, Meezan, E., and Brendel, K. 1983. Rapid isolation of type Il pneumocytes with magnetic removal of macrophages. Exp. Lung Res. 4:191-204.
  • Lang, D. S., Jorres., R. A., Mucke, M., Siegfried, W., and Magnussen, H. 1998. Interactions between human bronchoepithelial cells and lung fibroblasts after ozone exposure in vitro. Toxicol. Lett. 96-97:13-24.
  • Lefford, M. J., Amell, L., and Warner, S. 1978. Listeria pneumonitis: Induction of immunity after airborne infection with Listeria monocytogenes. Infect. Immun. 22:746-751.
  • Lillehoj, H. S., Malek, T. R., and Shevach, E. M. 1984. Differential effect of cyclosporin A on expression of T and B lymphocyte activation antigens. J. Immunol. 133:244-250.
  • Lum, H., Tyler, W. S., Hyde, D. M., and Plopper, C. G. 1983. Morphometry of in situ and lavaged pulmonary alveolar macrophages from control and ozone-exposed rats. Exp. Lung Res. 5:61-78.
  • MacLean, J. A., Xia, W., Pinto, C. E., Zhao, L., Liu, H. W., and Kradin, R. L. 1996. Sequestration of inhaled paniculate antigens by lung phagocytes. A mechanism for effective inhibition of pulmonary cell-mediated immunity. Am. J. Pathol. 148:657-666.
  • North, R. J., Dunn, P. L., and Conlan, J. W. 1997. Murine listeriosis as a model of antimicrobial defense. Immunol. Rev. 158:27-36.
  • Paine, R., Mody, C. H., Chavis, A., Spahr, M. A., Turka, L. A., and Toews, G. B. 1991. Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. Am. J. Respir. CeII MoI. BioI. 5:221-229.
  • Rusznak, C., Devailia, J. L., Sapsfor, R. J., and Davies, R. J. 1996. Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium. Eur. Respir. J. 9:2298-2305.
  • Ryan, L. 2000. Ozone. In Pulmonary immunotoxicology, eds. M. D. Cohen, J. T. Zelikoff, and R. B. Schlesinger, pp. 301-336. Boston: Kluwer.
  • Strickland, D., Kees, U. R., and Holt, P. G. 1996. Regulation of T-cell activation in the lung: Alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction. Immunology 87:250-258.
  • Tepper, J. S., Costa, D. L., and Lehmann, J. R. 1993. Extrapolation of animal data to humans: Homology of pulmonary physiological responses with ozone exposure. In Toxicology of the lung, 2nd ed., eds. D. E. Gardner, J. D. Crapo, and R. O. McClellan, pp. 217-251. New York: Raven Press.
  • Unanue, E. R. 1996. Macrophages, NK cells, and neutrophils in the cytokine loop of Listeria resistance. Res. Immunol. 147:499-505.
  • Unanue, E. R. 1997. Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response. Immunol. Rev. 158:11-25.
  • Unanue, E. R. 1998. Interrelationships among macrophages, natural killer cells, and neutrophils in early stages of Listeria resistance. Curr. Opin. Immunol. 9:35-43.
  • U.S. Environmental Protection Agency. 1996. Air quality criteria for ozone and related photochemical oxidants. EPA/600/P-93/0041F. Washington, DC: U.S. Environmental Protection Agency, Office of Research and Development.
  • van Loveren, H., Rombout, P. J. A., Wagenaar, S. S., Walvoort, H. C., and Vos, J. G. 1988. Effects of ozone on the defense to a respiratory Listeria monocytogenes infection in the rat. Suppression of macrophage function and cellular immunity and aggravation of histopathology in lung and liver during infection. Toxicol. Appl. Pharmacol. 94:374-393.
  • van Loveren, H., Steerenberg, P. A., Garssen, J., and van Bree, L. 1996. Interaction of environmental chemicals with respiratory sensitization. Toxicol. Lett. 86:163-167.
  • Wagner, R. D., Maroushek, N. M., Brown, J. F., and Czuprynski, C. Z. 1994. Treatment with antiinterleukin-10 monoclonal antibody enhances early resistance to, but impairs complete clearance of, Listeria monocytogenes infection in mice. Infect. Immun. 62:2345-2353.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.