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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 6
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Research Article

OZONE-INDUCED DNA SINGLE STRAND-BREAKS IN GUINEA PIG TRACHEOBRONCHIAL EPITHELIAL CELLS IN VIVO

Shiaw-Fen Ferng Department of Health and Safety, School of Health and Human Performance, Indiana State University, Terre Haute, Indiana, USA
Pages 621-633 | Published online: 01 Oct 2008

  • Afifi, A. A., and Clark, V. A. 1996. Computer-aided multivariate statistics, 3rd ed. New York: Chapman and Hall.
  • Alpert, S. E., Kramer, C. M., Hayes, M. M., and Dennery, P. A. 1990. Morphologic injury and lipid peroxidation in monolayer cultures of rabbit trachea! epithelium exposed in vitro to ozone. J. Toxicol. Environ. Health 30(4):287-304.
  • APHA lntersociety Committee. 1972. Recommended method for analysis of nitrogen dioxide content of the atmosphere (Griess-Saltzman reaction). In Methods of air sampling and analysis, ed. M. Katz, 2nd ed., pp. 527-534. Washington, DC: American Public Health Association.
  • Bermúdez, E., Castro, C. E., and Mustafa M. G. 1990. Ozone and nitrogen dioxide cause DNA strand breaks in rat lung cells. Free Radical. BioI. Med. 9:114.
  • Bermúdez, E., Ferng, S.-F., Castro, C. E., and Mustafa, M. G. 1999. DNA strand breaks caused by exposure to ozone and nitrogen dioxide. Environ. Res. 81:72-80.
  • Birnboim, H. C. 1990. Fluorometric analysis of DNA unwinding to study strand breaks and repair in mammalian cells. Methods Enzymol. 186:550-555.
  • Birnboim, H. C., and Jevcak, J. J. 1981. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res. 41:1889-1892.
  • Boat, T. F., and Cheng, P. W. 1980. Biochemistry of airway mucus secretions. Fed. Proc. 39:3067-3074.
  • Boorman, G. A., Sills, R. C, Grumbein, S., Hailey, R., Miller, R. A., and Herbert, R. A. 1995. Long-term toxicity studies of ozone in F344/N rats and B6C3F1 mice. Toxicol. Lett. 82-83:301-306.
  • Borek C., Ong, A., and Zaider, M. 1989. Ozone activates transforming genes in vitro and acts as a synergistic co-carcinogen with gamma-rays only if delivered after radiation. Carcinogenesis 10: 1549-1551.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
  • Clements, J. A. 1971. Comparative lipid chemistry of lungs. Arch. Intern. Med. 127:387-389.
  • Dixon, W. J., and Massey, E. J., Jr. 1983. Introduction to statistical analysis, 4th ed., pp. 369-419. New York: McGraw-Hill.
  • Evans, M. J. 1984. Oxidant gases. Environ. Health Perspect. 55:85-95.
  • Ferng, S.-F., Castro, C. E., Afifi, A. A., Bermudez, E., and Mustafa, M. G. 1997. Ozone-induced DNA strand breaks in guinea pig tracheobronchial epithelial cells. J. Toxicol. Environ. Health 51:353-367.
  • Guerrero, R. R., Rounds, D. E., Olson, R. S., and Hackney, J. D. 1979. Mutagenic effects of ozone on human cells exposed in vivo and in vitro based on sister chromatid exchange analysis. Environ. Res. 18:336-346.
  • Hamelin, C., and Chung, Y. S. 1989. Repair of ozone-induced DNA lesions in Escherichia coli B cells. Mutat. Res. 214(2):253-255.
  • Hamelin, C., Sarhan, F., and Shung, Y. S. 1978. Induction of deoxyribonucleic acid degradation in Escherichia coli by ozone. Experientia 34:1578-1579.
  • Hasset, C., Mustafa, M. G., Coulson, W. F., and Elashoff, R. M. 1985. Murine lung carcinogenesis following exposure to ambient ozone concentrations. JNCI 75:771-777.
  • Hu, P. C., Miller, F. J., Daniels, M. J., Hatch, G. E., Graham, J. A., Gardner, D. E., and Selgrade, M. K. 1982. Protein accumulation in lavage fluid following ozone exposure. Environ. Res. 29: 377-388.
  • Kennedy, C. H., Hatch, G. E., Salde, R., and Mason, R. P. 1990. Application of the EPR spin-trapping technique to the detection of radicals produced in vivo during the inhalation exposure of rats to ozone. Free Radical Biol. Med. 9:114.
  • Last, J. A., Warren, D. L., Pecquet-Goat, E., and Witschi, H. P. 1987. Modification of lung tumor development in mice by ozone. JNCI 78:149-158.
  • Lee, J. G., Madden, M. C, Reed, W., Adler, K., and Devlin, R. 1996. The use of the single cell gel electrophoresis assay in detecting DNA single strand breaks in lung cells in vitro. Toxicol. Appl. Pharmacol. 141:195-204.
  • Lee, J. G., Madden, M. C, Hatch, G., Peden, D., Adler, K., and Devlin, R. 1997. Ozone-induced DNA single strand breaks in human and guinea pig lung cells in vivo, lnhal. Toxicol. 9:811-828.
  • Lum, H., Schwartz, L. W., Dungworth, D. L., and Tyler, W. S. 1978. A comparative study of cell renewal after exposure to ozone or oxygen: Response of terminal bronchiolar epithelium in the rat. Am. Rev. Respir. Dis. 118:335-345.
  • Mckenzie, W. H., Knelson, J. H., Rummo, N. J., and House, D. E. 1977. Cytogenetic effects of inhaled ozone in man. Mutat. Res. 48:95-102.
  • McWilliams, R. S., Cross, W. G., Kaplan, J. G., and Birnboim, H. C. 1983. Rapid rejoining of DNA strand breaks in resting human lymphocytes after irradiation by low doses of 60Co ? rays or 14.6-MeV neutrons. Radiat. Res. 94:499-507.
  • Menzel, D. B. 1976. The role of free radicals in the toxicity of air pollutants (nitrogen oxides and ozone). In Free radicals in biology, ed. W. A. Pryor, vol. II, pp. 181-201. New York: Academic Press.
  • Merz, T., Bender, M., Kerr, H., and KuIIe, T. 1975. Observations of aberrations in chromosomes of lymphocytes from human subjects exposed to ozone at concentrations of 0.5 ppm for 6 and 10 hours. Mutat. Res. 31:299-302.
  • Miller, F. J., Menzel, D. B., and Coffin, D. L. 1978. Similarity between man and laboratory animals in regional pulmonary deposition of ozone. Environ. Res. 17:84-101.
  • Miller, F. J., Overton, J. H., Jaskot, R. H., and Menzel, D. B. 1985. A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of the ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol. Appl. Pharmacol. 79:11-27.
  • Morgan, A. R., and Pulleyblank, D. E. 1974. Native and denatured DNA cross-linked and palindromic DNA and circular covalently-closed DNA analyzed by a sensitive fluorometric procedure. Biochem. Biophys. Res. Commun. 61:396-403.
  • Mudd, J. B., and Freeman, B. A. 1977. Reaction of ozone with biological membranes. In Biochemical effects of environmental pollutants, ed. S. D. Lee, pp. 97-133. Ann Arbor, Ml: Ann Arbor Science.
  • Mustafa, M. G. 1990. Biochemical basis of ozone toxicity. Free Radical Biol. Med. 9(3):245-265.
  • Mustafa, M. G., and Lee, S. D. 1976. Pulmonary biochemical alterations resulting from ozone exposure. Ann. Occ. Hyg. 19:17-26.
  • Neter, J., Wasserman, W., and Kutner, M. H. 1985. Applied linear statistical models, 2nd ed., p. 582. Homewood, IL: Irwin.
  • Pryor, W. A., and Church, D. F. 1991. Aldehydes, hydrogen peroxide and organic radicals as mediators of ozone toxicity. Free Radical Biol. Med. 11:41-46.
  • Pryor, W. A., Lightsey, J. W., and Church, D. F. 1982. Reaction of nitrogen dioxide with alkenes and polyunsaturated fatty acids: Addition and hydrogen abstraction mechanisms. J. Am. Chem. Soc. 104:6685-6692.
  • Pryor, W. A., Dooley, M. M., and Church, D. F. 1983. Mechanisms for the reaction of ozone with biological molecules: The source of the toxic effects of ozone. In The biomedical effects of ozone and related photochemical oxidants, eds. S. D. Lee, M. G. Mustafa, and M. A. Mehlman, pp. 7-19. Princeton, NJ: Princeton Scientific.
  • Pryor, W. A., Das, B., and Church, D. F. 1991. The oxonation of unsaturated fatty acids: Aldehydes and hydrogen peroxide as products and possible mediators of ozone toxicity. Chem Res. Toxicol. 4:341-348.
  • Pryor, W. A., Squadrito, G. L., and Friedman, M. 1995. A cascade mechanism to explain the toxicity of ozone. Free Radical BioI. Med. 19:935-941.
  • Rasmussen, R. E. 1986. Inhibition of DNA replication by ozone in Chinese hamster V79 cells. J. Toxicol. Environ. Health 17:119-128.
  • Rithidech, K., Hotchkiss, J. A., Griffith, W. C., Henderson, R. F., and Brooks, A. L. 1990. Chromosome damage in rat pulmonary alveolar macrophages following ozone inhalation. Mutat. Res. 241:67-73.
  • Rydberg, B. 1975. The rate of strand separation in alkali of DNA of irradiated mammalian cells. Radiat. Res. 61:274-287.
  • Sills, R. C, Hong, H. L., Greenwell, A., Herbert, R. A., Boorman, G. A., and Devereux, T. R. 1995. Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months. Carcinogenesis 16:1623-1628.
  • Steinberg, J. J., Gleeson, J. L., and Gil, D. 1990. The pathobiology of ozone-induced damage. Arch. Environ. Health 45(2):80-87.
  • Stephens, R. J., Freeman, G., and Evans, M. J. 1972. Early response of lungs to low levels of nitrogen dioxide. Arch. Environ. Health 24:160-179.
  • Van der Zee, J., Van Beek, E., Dubbelman, T. M., and Van Steveninck, J. 1987a. Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA. Biochem. J. 247(1):69-72.
  • Van der Zee, J., Dubbelman, T. M., and Van Steveninck, J. 1987b. The role of hydroxyl radicals in the degradation of DNA by ozone. Free Radical Res. Commun. 2(4-6):279-284.
  • Zelac, R. E., Cromroy, H. L., Bolch, W. E., Dunanvant, B. G., and Bevis, H. A. 1971a. Inhaled ozone as a mutagen. I. Chromosome aberrations induced in Chinese hamster lymphocytes. Environ. Res. 4:262-282.
  • Zelac, R. E., Cromroy, H. L., Bolch, W. E., Dunanvant, B. G., and Bevis, H. A. 1971b. Inhaled ozone as a mutagen. II. Effect on the frequency of chromosome aberrations observed in irradiated Chinese hamsters. Environ. Res. 4:325-342.

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