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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 7
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Research Article

EFFECTS OF DIESEL EXHAUST ENRICHED CONCENTRATED PM2.5 IN OZONE PREEXPOSED OR MONOCROTALINE-TREATED RATS

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Pages 721-743 | Published online: 01 Oct 2008

  • Adamson, I. Y. R., Prieditis, H., and Vincent, R. 1999a. Pulmonary toxicity of an atmospheric paniculate sample is due to the soluble fraction. Toxicol. Appl. Pharmacol. 157: 43-50.
  • Adamson, I. Y. R., Vincent, R., and Bjarnason, S. G. 1999b. Cell injury and interstitial inflammation in rat lung after inhalation of ozone and urban particulates. Am. J. Respir. Cell MoI. Biol. 20: 1067-- 1072.
  • Baker, M. A., Cerniglia, G. J., and Zaman, A. 1990. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal. Biochem. 190: 360-365.
  • Bennett, W. D., Zeman, K. L, Kim, C, and Mascarella, J. 1997. Enhanced deposition of fine particles in COPD patients spontaneously breathing at rest, lnhal. Toxicol. 9(1):1-14.
  • Blomberg, B., Sainsbury, C., Rudell, B., Frew, A. J., Holgate, S. T., Sandstrom, T., and Kelly, F. J. 1998. Nasal cavity lining fluid ascorbic acid concentration increases in health human volunteers following short term exposure to diesel exhaust. Free Radical Res. 28(1): 59-67.
  • Bolarin, D. M., Bhalla, D. K., and Kleinman, M. T. 1997. Effects of repeated exposures of geriatric rats to ozone and particle containing atmospheres: an analysis of bronchoalveolar lavage and plasma proteins, lnhal. Toxicol. 9: 423-434.
  • Brunekreef, B., Dockery, D. W., and Krzyzanowski, M. 1995. Epidemiologic studies on short-term effects of low levels of major ambient air pollution components. Environ. Health Perspect. 103: 3-- 13.
  • Churg, A., Brauer, M., and Keeling, B. 1996. Ozone enhances the uptake of mineral particles by tracheobronchial epithelial cells in organ culture. Am. J. Respir. Crit. Care Med. 153(4): 1230--1233.
  • Costa, D. L., Lehmann, J. R., Frazier, L T., Doerfler, D., and Ghio, A. 1994. Pulmonary hypertension: A possible risk factor in particulate toxicity. Am. J. Respir. Crit. Care Med. 149: A840.
  • Creutzenberg, O., Bellmann, B., Klingebiel, R., Heinrich, U., and Muhle, H. 1995. Phagocytosis and chemotaxis of rat alveolar macrophages after a combined or separate exposure to ozone and carbon black. Exp. Toxicol. Pathol. 47: 202-206.
  • Dockery, D. W., and Pope, C. A. III. 1994. Acute respiratory effects of particulate air pollution. Annu. Rev. Public Health 15: 107-132.
  • Dockery, D. W., Pope, C. A. Ill, Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. C, and Speier, F. E. 1993. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329: 1753-1759.
  • Dormans, J. A. M. A., Boere, A. J. F., Van Loveren H., Rombout, P. J. A., Marra, M., and Van Bree, L. 1996. Age-related toxicity in rat lungs following acute and repeated ozone exposure, lnhal. Toxicol. 8: 903-925.
  • Fujimaki, H., Nohara, O., lchinose, T., Watanabe, N., and Saito, S. 1994. IL-4 production in mediasti- nal lymph node cells in mice intratracheally instilled with diesel exhaust particulates and antigen.Toxicology 92: 261-268.
  • Gamble, J. F. 1998. PM2.5 and mortality in long-term prospective cohort studies: Cause-effect or statistical associations? Environ. Health Perspect. 106: 535-549.
  • Gerrity, T. R. 1995. Regional deposition of gases and particles in the lung: Implications for mixtures. Toxicology 105: 327-334.
  • Ghio, A. J., Richards, J. H., Carter, J. D., and Madden, M. C. 2000. Accumulation of iron in the rat lung after trachea! instillation of diesel Particles. Toxicol. Pathol. 28: 619-627.
  • Health Effects Institute. 1994. HEI strategic research plan for vehicle emission and fuels. Draft report, April 25. Cambridge, MA: Health Effects Institute.
  • Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, O., Bellmann, B., Koch, W., and Levsen, K. 1995. Chronic inhalation exposure of Wistar rats and two different strain of mice to diesel engine exhaust, carbon black and titanium oxide, lnhal. Toxicol. 7: 533-556.
  • Hemenway, D. R., Clarke, R., Frank, R., and Jakab, G. J. 1996. Factors governing the mass loading of aerosolized carbon black particles with acid sulfates, inhalation exposure and alveolar macrophage phagocytic function, lnhal. Toxicol. 8: 679-694.
  • lchinose, T., Furuyama, A., and Sagai, M. 1995. Biological effects of diesel exhaust particles (DEP). II. Acute toxicity of DEP introduced into the lung by intratracheal instillation. Toxicology 99:153-- 167.
  • Jakab, G. J., and Hemenway, D. R. 1994. Concomittant exposure to carbon black particulates enhances ozone-induced lung inflammation and suppression of alveolar macrophage phagocytosis. J. Toxicol. Environ. Health 41 (2): 221-231.
  • Johnson, N. F., Hotchkiss, J. A., Harkema, J. R., and Henderson, R. F. 1990. Proliferative responses of rat nasal epithelia to ozone. Toxicol. Appl. Pharmacol. 103: 143-155.
  • Kodavanti, U. P., Jackson, M., Gardner, S. Y., Watkinson, W. P., Campen, M. J., Richards, J., and Costa, D. L. 1997. Particle induced lung injury in hypertensive rats. Am. J. Respir. Crit. Care Med. 155: A247.
  • Kodavanti, U. P., Costa D. L., and Bromberg P. A. 1998. Rodent models of cardiopulmonary disease: Their potential applicability in studies of air pollutant susceptibility. Environ. Health Perspect. 106(1): 111-130.
  • Kodavanti, U. P., Mebane, R., Ledbetter, A., Krantz, T., McGee, J., Jackson, M. C, Walsh, L., Milliard, H., Chen, B. Y., Richards, J., and Costa, D. L. 2000. Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Toxicol. Sci. 54: 441-- 451.
  • Last, J. W., and Warren, D. L. 1987. Synergistic interaction between nitrogen dioxide and respir- able aerosols of sulfuric acid or sodium chloride on rat lungs. Toxicol. Appl. Pharmacol. 90(1): 34-42.
  • Last, J. A., Hyde, D. M., Guth, D. J., and Warren, D. L. 1986. Synergistic interaction of ozone and res- pirable aerosols on rat lungs. I. Importance of aerosol acidity. Toxicology 39: 247-257.
  • Lim, H. B., lchinose, T., Miyabara, Y., Takano, H., Kumagai, Y., Shimojyo, N., Devalia, J. L., and Sagai, M. 1998. Involvement of Superoxide and nitric oxide on airway inflammation and hyperre- sponsiveness induced by diesel exhaust particles in mice. Free Radical Biol. Med. 25(6): 635-644.
  • Madden, M. C, Richards, J., Daily, L. A., Hatch, G., and Ghio, A. J. 2000. Effect of ozone on diesel exhaust particle toxicity in rat lung. Toxicol. Appl. Pharmacol. 168(2): 140-148.
  • Meyrick, B. 1991. Structure function correlates in the pulmonary vasculature during acute lung injury and chronic pulmonary hypertension. Toxicol. Pathol. 19: 447-457.
  • Nagai, A., Kakuta, Y., Ozawa, Y., Uno, H., Yasui, S., Konno, K., Kata, A., and Kagawa, J. 1996. Alveolar destruction in guinea pigs chronically exposed to diesel engine exhaust. A light and electron microscopic morphometry study. Am. J. Respir. Crit. Care Med. 153: 724-730.
  • Nikula, K. J., Snipes, M. B., Barr, E. B., Griffith, W. C, Henderson, R. F., and Mauderley, J. L 1995. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rat. Fundam. Appl. Toxicol. 25: 80-94.
  • Ohta, K., Yamashita, N., Tajima, M., Miyasaki, T., Nakano, J., Nakajima, M., lshii, A., Horiuchi, T., Mano, K., and Miyamoto, T. 1999. Diesel exhaust paniculate induces airway hyperresponsiveness in a murine model: Essential role of GM-CSF. J. Allergy Clin. Immunol. 104(5): 1024-1030.
  • Popp, J. A., and Monteiro-Riviere, N. A. 1985. Macroscopic, microscopic and ultrastructural anatomy of the nasal cavity, rat. In Respiratory system, eds. T. C. Jones, U. Mohr, and R. D. Hunt, p. 3. Berlin: Springer Verlag.
  • Rajini, P., and Witschi, H. 1995. Cumulative labelling indices in epithelial cell populations of the respiratory tract after exposure to ozone at low concentrations. Toxicol. Pharmacol. 130: 32-40.
  • Robinovitch, M. 1991. Investigational approaches to pulmonary hypertension. Toxicol. Pathol. 19: 458-469.
  • Rudell, B., Sandström, T., Stjernberg, N., and Kolmodin-Hedman, B. 1990. Controlled diesel exhaust exposure in an exposure chamber. Pulmonary effects investigated with bronchoalveolar lavage. J. Aerosol Sd. 21: 411-414.
  • Rudell, B., Ledin, M. G, Hammarström, U., Stjernberg, N., Lundbäck, B., and Sandström, T. 1996. Effects on symptoms and lung function in humans experimentally exposed to diesel exhaust. Occup. Environ. Med. 53: 658-662.
  • Sagai, M., Saito, H., lchinose, T., Kodama, M., and Mori, Y. 1994. Biological effects of diesel exhaust particles. I. In vitro production of Superoxide and in vivo toxicity in mouse. Free Radical Biol. Med. 14: 37-47.
  • Sagai, M., Furuyama, A., and lchinose, T. 1996. Biological effects of diesel exhaust particles (CDP). III. Pathogenesis of asthma like symptoms in mice. Free Radical Biol. Med. 21 (2): 199-209.
  • Saldiva, P. H. N., Pope, C. A., Schwartz, J., Dockery, D. W., Lichtenfels, A. J., Salge, J. M., Barone, I., and Böhm, G. M. 1995. Air pollution and mortality in elderly people: A time-series study in Sao Paolo, Brazil. Arch. Environ. Health 50: 159-163.
  • Salvi, S., Blomberg, A., Rudell, B., Kelly, F., Sandström, T., Holgate, S. T., and Frew, A. 1999. Acute inflammatory responses in the airways and peripheral blood following short term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159: 702-709.
  • Sioutas, G, Koutrakis, P., Godleski, J. J., Ferguson, S. T., Kim, C. S., and Burton, R. M. 1997. Fine particle concentrators for inhalation exposures-Effect of particle size and composition. J. Aerosol Sd. 28: 1057-1071.
  • Stephens, R. J., Sloan, M. F., Evans, M. J., and Freeman, G. 1973. Early responses of lung to low levels of ozone. Am. J. Pathol. 74: 31-58.
  • Thurston, G. D. 1996. A critical review of PM10-mortality time-series studies J. Expos. Anal. Environ. Epidemiol. 6: 3-21.
  • Van Bree, L, and Cassee, F. R. 2000. Toxicity of ambient air PM10. National Institute off Public Health and the Environment, Bilthoven, the Netherlands, (RIVM) report 650010 015, May.
  • Vincent, R., Bjarnason, S. G., Adamson, I. Y. R., Hedgecock, G, Kumarathasan, P., Guenette, J., Potvin, M., Goegan, P., and Bouthillier, L. 1997. Acute pulmonary toxicity of urban paniculate matter and ozone. Am. J. Pathol. 151: 1563-1570.
  • Von Clauss. A. 1957. Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 17: 237-246.
  • Warren, D. L., Guth, D. J., and Last, J. A. 1986. Synergistic interaction of ozone and respirable aerosols on rat lungs. II. Synergy between ammonium sulfate aerosol and various concentrations of ozone. Toxicol. Appl. Pharmacol. 84(3): 470-479.
  • Wordley, J., Walters, S., and Ayres, J. G. 1997. Short term variations in hospital admissions and mortality and paniculate air pollution. Occup. Environ. Med. 54: 108-116.
  • Zomer, G., and Jacquemijns, M. 2001. Application of novel acridan esters as chemiluminogenic signal reagents in immunoassay. In Chemiluminescence in analytical chemistry, eds. A. M. GarciaCampana and W. R. G. Bayens, pp. 530-549. New York: Marcel Dekker.

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