Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 11
48
Views
29
CrossRef citations to date
0
Altmetric
Research Article

AEROSOL TRANSPORT AND DEPOSITION IN A TRIPLE BIFURCATION BRONCHIAL AIRWAY MODEL WITH LOCAL TUMORS

, , &
Pages 1111-1133 | Published online: 01 Oct 2008

  • AEA Technology. 1998. CFX-4.3: Solver. Oxfordshire, UK: CFX International.
  • Beers, M. H., and Birkow, R., eds. 1999. The Merck manual of diagnosis and therapy, 17th ed. Whitehouse Station, NJ: Merck & Co.
  • Clift, R. J., Grace, R., and Weber, M. E. 1978. Bubbles, drops, and particles. New York: Academic Press.
  • Comer, J. K., Kleinstreuer, C., Hyun, S., and Kim, C. S. 2000. Aerosol transport and deposition in sequentially bifurcating airways. J. Biomech. Eng. 122:152-158.
  • Comer, J. K., Kleinstreuer, C., and Zhang, Z. 2001a. Flow structures and particle deposition patterns in double bifurcation airway models. Part I. Airflow fields. J. Fluid Mech. 435:25-54.
  • Comer, J. K., Kleinstreuer, C., and Kim, C. S. 2001b. Flow structures and particle deposition patterns in double bifurcation airways models. Part II: Aerosol transport and deposition. J. Fluid Mech. 435:55-80.
  • Delarue, N. C, and Eschapasse, H., eds. 1985. Lung cancer. Philadelphia: W. B. Saunders.
  • Health Alliance Cancer Services. 2001. About lung cancer [online], http://www.health-alliance.com/ cancer/lung/general.html (8 September).
  • Katz, I. M., and Martonen, T.B. 1999. A numerical study of particle motion within the human larynx and trachea. J. Aerosol Sd. 30:173-183.
  • Kirn, C. S. 1989. Aerosol deposition in the lung with obstructed airways. J. Aerosol Med. 2:111-120.
  • Kim, C. S., Brown, L. K., Lewars, G. G., and Sackner, M. A. 1983. Deposition of aerosol particles and flow resistance in mathematical and experimental airway models.J. Appl. Physiol. 55:154-163.
  • Kim, C. S., Eldridge, M. A., Garcia, L., and Wanner, A. 1989. Aerosol deposition in the lung with asymmetric airways obstruction: in vivo observation. J. Appl. Physiol. 67:2579-2585.
  • Kim, C. S., Fisher, D. M., Lutz, D. J., and Gerrity, T. R. 1994. Particle deposition in bifurcating airway models with varying airway geometry. J. Aerosol Sci. 25:567-581.
  • Kim, C. S., and Iglesias, A. J. 1989. Deposition of inhaled particles in bifurcating airway models: I. lnspiratory deposition. J. Aerosol Med. 2:1-14.
  • Kim, C. S., Lewars, G. A., Eldridge, M. A., and Sackner, M. A. 1984. Deposition of aerosol particles in a straight tube with an abrupt obstruction. J. Aerosol Sei. 15:167-176.
  • Lee, J. W., Goo, J. H., and Chung, M. K. 1996. Characteristics of inertia! deposition in a double bifurcation. J. Aerosol Sd. 27:119-138.
  • Luomanen, R. K. J., and Watson, W. L. 1968. Autopsy findings. In Lung cancer: A study for five thousand Memorial Hospital cases, ed. W. L. Watson, pp. 504-510. St Louis, MO: C. V. Mosby.
  • Michaelides, E. E. 1997. Review-The transient equation of motion for particles, bubbles and droplets. J. Fluids Eng. 119:233-247.
  • Mitchell, J. D., Mathisen, D. J., Wright, C. D., Wain, J. C, Donahue, D. M., Allan, J. S., Moncure, A. C, and Grillo·, H. C. 2001. Resection for bronchogenic carcinoma involving the carina: Long-term results and effect of nodal status on outcome. J. Thorac. Cardiovasc. Surg. 121:465-471.
  • Mulshine, J. L., De Luca, L. M., and Dedrick, R. L. 1998. Regional delivery of retinoids: A new approach to early lung cancer intervention. In Clinical and biological basis of lung cancer prevention, eds. Y. Martinet, F. R. Hirsch, N. Martinet, J. M. Vignaud, and J. L. Mulshine, pp. 273-283. Boston: Birkhauser Verlag.
  • Oho, K., and Amemiya, R. 1980. Practical fiberoptic bronchoscopy. Tokyo: Igaku-Shoin.
  • Rhie, C. M., and Chow, W. L. 1983. Numerical study of turbulent flow past an airfoil with trailing edge separation. AIAA J. 21:1527-1534.
  • Schlesinger, R. B., and Lippmann, M. 1978. Selective particle deposition and bronchogenic carcinoma. Environ. Res. 15:424-431.
  • Segal, R. A., Martonen, T. B., Kim, C. S., and Shearer M. 2002. Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients, lnhal. Toxicol. 14:705-720.
  • Segal, R. A., Guan, X., Shearer, M., and Martonen, T. B. 2000. Mathematical model of airflow in the lungs of children. I. Effects of tumor sizes and locations. J. Theor. Med. 2:199-213.
  • Simoff, M. J. 2001. Endobronchial management of advanced lung cancer. Cancer Control 8:337-343.
  • Tatsumura, T., Koyama, S., Tsujimoto, M., Kitagawa, M., and Kagamimori, S. 1993. Further study of nebulisation chemotherapy, a new chemotherapeutic method in the treatment of lung carcinomas: fundamental and clinical. Br. J. Cancer 68:1146-1149.
  • Torosian, M. H., ed. 1999. Integrated cancer management: Surgery, medical oncology and radiation oncology. New York: Marcel Dekker.
  • Wassermann, K., Eckel, H. E., Michel, O., and Muller, R. P. 1996. Emergency stenting of malignant obstruction of the upper airways: Long-term follow-up with two types of silicone prostheses. J. Thorac. Cardiovasc. Surg. 112:859-866.
  • Weibel, E. R. 1963. Morphometry of the human lung. New York: Academic Press.
  • Zhang, Z., and Kleinstreuer, C. 2001. Effect of particle inlet distribution on deposition in a triple bifurcation lung airway model. 7. Aerosol Med. 14:13-29.
  • Zhang, Z., Kleinstreuer, C, and Kim, C. S. 2000. Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways. J. Med. Eng. Technol. 24:192-202.
  • Zhang, Z., Kleinstreuer, C., and Kim, C. S. 2001. Flow structure and particle transport in a triple bifurcation airway model. J. Fluids Eng. 123:320-330.
  • Zhang, Z., Kleinstreuer, C., and Kim, C. S. 2002a. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model, J. Aerosol Sci. 33:257-281.
  • Zhang, Z., Kleinstreuer, C., and Kim, C. S. 2002b. Computational analysis of micron-particle deposition in a human triple bifurcation airway model. Comput. Methods Biomech. Biomed. Eng. 5:135-147.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.