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Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 1
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Research Article

Inflammatory and Cytotoxic Potential of the Airborne Particle Material Assessed by Nasal Lavage and Cell Exposure Methods

Marjut Roponen Department of Environmental Health, National Public Health Institute, Kuopio, Finland
,
Mika Toivola Department of Environmental Health, National Public Health Institute, Kuopio, Finland
,
Sari Alm Department of Environmental Health, National Public Health Institute, Kuopio, Finland
,
Aino Nevalainen Department of Environmental Health, National Public Health Institute, Kuopio, Finland
,
Juha Jussila Department of Environmental Health, National Public Health Institute, Kuopio, Finland
&
Maija-Riitta Hirvonen Department of Environmental Health, National Public Health Institute, Kuopio, Finland
Pages 23-38 | Published online: 01 Oct 2008

  • Dales, R. E., Zwanenburg, H., Burnett, R., and Franklin, C. A. 1991. Respiratory health effects of home dampness and molds among Canadian children. Am. J. Epidemiol. 134:196-203.
  • Dillon, H. K., Miller, J. D., Sorenson, W. G., Douwes, J., and Jacobs, R. R. 1999. Review of methods applicable to the assessment of mold exposure to children. Environ. Health Perspect. 107(suppl. 3): 473:480.
  • Dormans, J. A., van Bree, L., Boere, A. J., Marra, M., and Rombout, P. J. 1999. Interspecies differences in time course of pulmonary toxicity following repeated exposure to ozone. Inhal. Toxicol. 11: 309-329.
  • Douwes, J., Wouters, I, Dobbeld, H., van Zwieten. L., Steerenberg, P., Doekes, G., and Heederik, D. 2000. Upper airway inflammation assessed by nasal lavage in compost workers: A relation with bio-aerosol exposure. Am. J. Ind. Med. 37:459-468.
  • Fleming, H., Little, F., Schnurr, D., Avila, P., Wong, H., Liu, J., Yagi, s., and Boushey, H. 1999. Rhinovirus-16 colds in healthy and in asthmatic subjects. Am. J. Respir. Crit. Care Med. 160:100-108.
  • Green, L. C., Wagner, D.A., Glogowski, J., Skipper, P. L., Wishnok, J. S., and Tannenbaum, S. R. 1982. Analysis of nitrate, nitrite and 15NInitrate in biological fluids. Anal. Biochem. 126:131-138.
  • Hirvonen, M.-R., Nevalainen, A., Makkonen, N., Mönkkönen, J., and Savolainen, K. 1997. Induced production of nitric oxide, tumor necrosis factor, and interleukin-6 in RAW 264.7 macrophages by Streptomycetes from indoor air of moldy houses. Arch. Environ, Health 6:426-432.
  • Hirvonen, M.-R., Ruotsalainen, M., Roponen, M., Hyvärinen, A., Husman, T., Kosma, V.-M., Komulainen, H., Savolainen, K., and Nevalainen, A. 1999. Nitric oxide and proinflammatory cytokines in nasal lavage fluid assiciated with symptoms and exposure to moldy building microbes. Am. J. Respir. Crit. Care Med. 160:1943-1946.
  • Hirvonen, M.-R., Suutari, M., Ruotsalainen, M., Lignell, U., and Nevalainen, A. 2001. Effect of growth medium on potential of Streptomyces anulatus spores to induce inflammatory responses and cytotoxicity in RAW/264.7 macrophages. Inhal. Toxicol. 13:55-68.
  • Huttunen, K., Jussila, J., Hirvonen, M.-R., livanainen, E., and Katila, M.-L. 2001. Comparison of mycobacteria-induced cytotoxicity and inflammatory responses in human and mouse cell lines. Inhal. Toxicol. 13:977-991.
  • Huttunen, K., Hyvärinen, A., Nevalainen, A., Komulainen, H., and Hirvonen, M.-R. 2003. More intense production of proinflammatory mediators by indoor air bacteria than fungal spores in mouse and human cell lines. Environ. Health Perspect. In Press.
  • Jesch, N. K., Dörger, M., Enders, G., Riedaer, G., Vogelmeier, C., Messmer, K., and Krombach, F. 1997. Expression or inducible nitric oxide synthase and formation of nitric oxide by alveolar macrophages: An interspecies its comparison. Environ. Health Perspect. 105:1297-1300.
  • Jussila, J., Komulainen, H., Huttunen, K., Roponen, M., Mälinen, A., Hyvärinen, A., Kosma, V.-M., Pelkonen, J., and Hirvonon, M, R. 2001. Inflammatory responses in mice after intratracheal instillation of spores of Streptomyces californifus isolated from indoor air of a moldy building. Toxicol. Appl. Pharmacol. 171:61-69.
  • Mosmann, T, 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
  • Murtoniemi, T., Nevalainen, A., Suutari, M., Toivola, M., Komulainen, H., and Hirvonen, M.-R. 2001. Induction of cytotoxicity and production of inflammatory mediators in RAW264.7 macrophages by spores grown on Six different plasterboards. Inhal. Toxicol. 13:233-247.
  • Pasanen, A.-L. 2001. A review: Fungal exposure assessment in indoor environment. Indoor Air 1:87-98.
  • Peat, J. K., Dickerson, J., and Li, J. 1998. Effects of damp and mould in the home on respiratory health: A review of the literature. Allergy 53:120-128.
  • Peltola, J., Andersson, M. A., Haahtela, T., Mussalo-Rauhamaa, H., Rainey, F. A., Kroppenstedt, R. M., Samson, R. A., and Salkinoja-Salonene, M. S. 2001. Toxic-metabolite-producing bacteria and fungus in an indoor environment. Appl. Environ. Microbiol. 67:3269-3274.
  • Pirhonen, I., Nevalainen, A., Husman, T., and Pekkanen, J. 1996. Home dampness, moulds and their influence on respiratory infections and symptoms in adults in Finland. Eur. Respir. J. 9:2618-2622.
  • Roponen, M., Kiviranta, J., Seuri, M., Tukiainen, H., Myllykangas-Luosujärvi, R., and Hirvonen with rheumatic and respiratory disorders. Eur. Respir. J, 18:542-548.
  • Roponen, M., Toivola, M., Meklin, T., Ruotsalainen, M., Komulainen, H., Nevalainen, A., and Hirvonen M.-R., 2001b. Differences in inflammatory responses and Cytotoxicity in RAW264.7 macrophages induced by Streptomyces anulates grown on different building materials. Indoor Air 11:179-184.
  • Shahan, T. A., Sorenson, W. G., Paulauskis, J. D., Morey, R., and D. M., 1998. Concentration- and time-dependent upregulation and release of the cytokines MIP-2, KC, TNF, and MIP-1 alpha in rat alveolar macrophages by fungal spores implicated in airway inflammation. Am. J. Respir. Cell Mol. Biol. 18:435-440.
  • Steerenberg, P. A., Fischer, P. H., Gmelig Meyling, F., Willighagen, J., Geerse, E., van de Vliet, H., Ameling, C., Boink, A. B. T. I., van Bree, L., and Loveren, H. 1996. Nasal lavage as a tool for health effect assesssment of photochemical air pollution. Hum. Exp. Toxicol. 15:111-119.
  • Toivola, M., Alm, S., Reponen, T., Kolari, S., and Nevalainen, A. 2002. Personal exposures and microenvironmental concentrations of particles and bioaerosols. J. Environ. Monit. 4:166-174.

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