Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 1
Submit an article Journal homepage
286
Views
276
CrossRef citations to date
0
Altmetric
Research Article

The Role of Free Radicals in the Toxic and Inflammatory Effects of Four Different Ultrafine Particle Types

Colin A. J. Dick School of Health and Life Sciences, Napier University, Edinburgh, United Kingdom
,
David M. Brown School of Health and Life Sciences, Napier University, Edinburgh, United Kingdom
,
Ken Donaldson School of Health and Life Sciences, Napier University, Edinburgh, United Kingdom
&
Vicki Stone School of Health and Life Sciences, Napier University, Edinburgh, United Kingdom
Pages 39-52 | Published online: 01 Oct 2008

  • Beck-Speier, I., Dayal, N., Karg, E., Maier, K. L., Roth, C., Ziesenis, A., and Heyder, J. 2001. Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. Environ. Health Perspect. 109:613-618.
  • Brown, D. M., Stone, V., Findlay, P., MacNee, W., and Donaldson, K. 2000. Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components. Occup. Environ. Med. 57:685-691.
  • Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., and Donaldson, K. 2001. Size dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 175:191-199.
  • Bucher, J. R., Hailey, J. R., Roycroft, J. R., Haseman, J. K., Sills R. C., Grumbein, S. L., Mellick, P. W., and Chou B. J. 1999. Inhalation toxicity and carcinogenicity studies of cobalt sulfate. Toxicol. Sci. 49:56-67.
  • Carter, J. D., Ghio, A. J., Samet, J. M., and Devlin, R. B. 1997. Cytokine production by human airway cells after exposure to an air pollution particle is metal dependent. Toxicol. Appl. Pharmacol. 146:180-188.
  • Costa, D. L., and Dreher, K. L. 1997. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in health and compromised animal models. Environ. Res. 105:1053-1060.
  • Dennekamp, M., Howarth, S., Dick, C. A. J., Cherrie, J., Donaldson, K., and Seaton, A. 2001. Ultrafine particles and nitrogen dioxide generated by gas and electric cooking. Occup. Environ. Med. 58:511-516.
  • Department of Health. 1993. Advisory group on the medical aspects of air pollution episodes. Third report: Oxides of nitrogen, London: Her Majesty's Stationary Office.
  • Donaldson, K., Li, X. Y., and MacNee, W. 1998. Ultrafine (nanometre) particle mediated lung injury. J. Aerosol Sci. 29:553-560.
  • Donaldson, K., Beswick, P. H., and Gilmour, P. 1996. Free radical activity associated with the surface of particles: a unifying factor in determining biological activity? Toxicol. Lett. 88:293-298.
  • Donaldson, K., Brown, D. B., Mltchell, C., Dineva, M., Beswick, P. H. Gilmour, P., and MacNee, W. 1997. Free radical activity of PM10: Iron mediated generation of hydroxyl radicals. Environ. Health Perspect. 105:1285-1289.
  • Driscoll, K.E. 2000. TNF and MIP2: Role in particle-induced inflammation and regulation by oxidative stress. Toxicol. Lett. 112-113:177-184.
  • Ferin, J., Oberdorster, G., and Penney, D. P. 1992. Pulmonary retention of ultrafine particles in rats. Am. J. Respir. Cell Mol. Biol. 6:535-542.
  • Gilmour, P. S., Brown, D. M., Beswick, P. H., MacNee, W., Rahman, I., and Donaldson, K. 1997. Free radical activity of industrial fibres: Role of iron in oxidative stress and activation of transcription factors. Environ. Health Perspect. 105:1313-1317.
  • Grattagliano, I., Weiland, P., Schanz, C., and Lauterburg, B. H. 1995. Disposition of glutathione monoethyl ester in the rat: glutathione ester is a show release form of extracellular glutathione. J. Clin. Exp. Ther. 272:484-488.
  • Halliwell, B., and Gutteridge, J. M. C. 1989. Free radicals in biology and medicine, 2nd ed., pp. 1-39. Oxford, UK: Clarendon Press.
  • Jimenez, L, A., Thompson, J., Brown, D. A., Rahman, I., Antonicelli, F., Duffin, R., Drost, E. M., Hay, R. T., Donaldson, K., and MacNee, W. 2000. Activation of NF?B by PM10 occurs via an iron mediated mechanism in the absence of I?B degradation. Toxicol. Appl. Pharmacol. 166:101-110.
  • Lay, J. C., Bennett, W. D., Ghio, A. J., Bromberg, P. A., Costa, D. L., Kim, C. S., Koren, H. S., and Devlin, R. B. 1999. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. Am. J. Respir. Cell Mol. Biol. 20:631-642.
  • Li, X. Y., Gilmour, P. S., Donaldson, K., and MacNee, W. 1996. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. Thorax 51:1216-1222.
  • Li, X. Y., Brown, D., Smith, S., MacNee, W., and Donaldson, K. 1999. Short term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats. Inhal. Toxicol. 11:709-731.
  • Lundborg, M., Johansson, A., Lastbom, L., and Camner, P. 1999. Ingested aggregates of ultrafine carbon particles and interferon-? impair rat alveolar macrophage function. Environ. Res. A 81:309-315.
  • MacNee, W., Bridgeman, M. M. E., Marsden, M., Drost, E., Lannan, S., Selby, C., and Donaldson, K. 1991. The effects of N-acetylcysteine and glutathione on smoke-induced changes in lung phagocytes and epithelial cells. Am. J. Med. 91:60S-66S.
  • Nolan, R. P., Langer, A. M., Weisman, I., and Herson, G. B. 1987. Surface character and membranolytic activity of rutile and anatase: two titanium dioxide polymorphs. Br. J. Ind. Med. 44:687-698.
  • Oberdorster, G. 1996. Significance of particle parameters in the evaluation of exposure dose-response relationships of inhaled particles. Particulate Sci. Technol. 14:135-151.
  • Pahl, H. L., and Baeuerle, P. A. 1997. The ER-overload response: activation of NF?B. Trends Cell Biol. 22:63-67.
  • Peters, A., Wichmann, E. H., Tuch, T., Heinrich, J., and Heyder, J. 1997. Respiratory effects are associated with the number of ultrafine particles. Am. J. Respir. Crit. Care Med. 155:1376-1383.
  • Rahman, I., and MacNee, W. 2000. Oxidative stress and regulation of glutathione in lung inflammation. Eur. Respir. J. 16:534-554.
  • Rahman, I., Mulier, B., Gilmour, P. S., Watchorn, T., Donaldson, K., Jeffery, P. K., and MacNee, W. 2001. Oxidant mediated Lung epithelial cell tolerance: The role of intracellular glutathione and nuclear factor kappa B. Biochem. Pharmacol. 62:787-794.
  • Rice, T. M., Clarke, R. W., Godleski, J. J., Mutairi, E. Al., Jiang, N. F., Hauser, R., and Paulauskis, J. D. 2001. Differential ability of transition metals to induce pulmonary inflammation. Toxicol. Appl. Pharmacol. 177:46-53.
  • Schreck, R., Albermann, K. A. J., and Baeuerele, P. A. 1992. Nuclear factor ?B: An oxidative stress-responsive transcription factor of eukaryotic cells (A review). Free Radical Res. Common. 17:221-237.
  • Seaton, A., MacNee, W., Donaldson, K., and Godden, D. 1995. Particulate air pollution and acute health effects. Lancet 345:176-178.
  • Serita, F., Kyono, H., and Seki, Y. 1999. Pulmonary clearance and lesions in rats after a single inhalation of ultrafine metallic nickel at dose levels comparable to the threshold limit value. Ind. Health 37:353-363.
  • Soukup, J. M., and Becker, S. 2001. Human alveolar macrophages responses to air pollution particulates are associated with insoluble components of coarse material, including particulate endotoxin. Toxicol. Appl. Pharmacol. 171:20-26.
  • Stone, V., Shaw, J., Brown, D. M., MacNee, W., Faux, S. P., and Donaldson, K. 1998. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicol. In Vitro 12:649-659.
  • Stone, V., Tuinman, M., Vamvakopoulos, J. E., Shaw, J., Brown, D., Petterson, S., Faux, S. P., Borm, P., MacNee, W., Michaelangeli, F., and Donaldson, K. 2000. Increased calcium influx in a monolytic cell line on exposure to ultrafine carbon black. Eur. Respir. J. 15:297-303.
  • Tran, C. L., Buchanan, D., Cullen, R. T., Searl, A., Jones, A. D., and Donaldson, K. 2000. Inhalation of poorly soluble particles II. Influence of particle surface area on inflammation and clearance. Inhal. Toxicol. 12:1113-1126.
  • Zhang, Q., Kusaka, Y., Sato, K., Nakakuki, N., Kohyama, N., and Donaldson, K. 1998a. Differences in the extent of inflammation caused by intracheal exposure to three ultrafine metals: Role of free radicals. J. Toxicol. Environ. Health A 53:423-438.
  • Zhang, Q., Kusaka, Y., Sato, K., Mo, Y., Fukuda, M., and Donaldson, K. 1998b. Toxicity of ultrafine nickel particles in lungs after intratracheal instillation. J. Occup. Health 40:171-176.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.