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Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 12
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Research Article

Calibration Study on Subchronic Inhalation Toxicity of Man-Made Vitreous Fibers in Rats

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Pages 1147-1177 | Published online: 01 Oct 2008

  • Bellmann, B., Muhle, H., Creutzenberg, O., Dasenbrock, C., Klipper, R., MacKenzie, J. C., Morrow, P., and Mermelstein, R. 1991. Lung clearance and retention of toner, utillizing a tracer technique, during chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17:300-331.
  • Bellmann, B., Muhle, H., Creutzenberg, O., and Mermelstein, R. 1992. Irreversible pulmonary changes induced in rat lung by dust overload. Environ. Health Perspect. 97:189-191.
  • Bellmann, B., Muhle, H., Kamstrup, O., and Draeger, U. F. 1994. Investigation of the biodurability of man-made vitreous fibers in rat lungs. Environ. Health Perspect. 102(suppl. 5):185-189.
  • Bellmann, B., Muhle, H., Creutzenberg, O., Ernst, H., Brown, R. C., and Sebastien, P. 2001. Effects of nonfibrous particles on ceramic fiber (RCF1) toxicity in rats, Inhal. Toxicol. 13:877-901.
  • Bellmann, B., Muhle, H., Ernst, H., Pohlmann, G., Sebastien, P., and Brown, R. C. 2002. Subchronic studies on man-made vitreous fibres: Kinetics of inhaled particles. Ann. Occup. Hyg. 46(suppl. 1): 166-169.
  • Bernstein, D. M., Morscheidt, C., Tiesler, H., Grimm, H. G., Thévenaz, P., and Teichert, U. 1995. Evaluation of the biopersistence of commercial and experimental fibers following inhalation, Inhal. Toxicol. 7:1031-1058.
  • Bernstein, D. M., Morscheidt, C., Grimm, H. G., Thévenaz, P., and Teichert, U. 1996. Evaluation of soluble fibers using the inhalation biopersistence model, a nine-fiber comparison, Inhal. Toxicol. 8:345-385.
  • Brown, R. C., Bellmann, B., Muhle, H., Ernst, H., Pohlmann, G., and Sebastien, P. 2002. Subchronic studies on man-made vitreous fibres: Toxicity results. Ann. Occup. Hyg. 46(suppl. 1):102-104.
  • Cullen, T. R., Searl, A., Buchanan, D., Davis, J. M. G., Miller, B. G., and Jones, A. D. 2000. Pathogenicity of a special-purpose glass microfiber (E glass) relative to another glass microfiber and amosite asbestos, Inhal. Toxicol. 12:959-977.
  • ECB/TM 16 (97) rev. 1 : Subchronic inhalation toxicity of synthetic mineral fibres in rats. 1999. In Methods tor the determination of the hazardous properties for human health of man made mineral fibres (MMMF). European Commission Joint Research Centre, report EUR 18748 EN (1999), eds. D. M. Bernstein and J. M. Riego Sintes. http://ecb.jrc.it/testing-methods
  • ECB/TM 26 rev. 7: Biopersistence of fibres. Short term exposure by inhalation. 1999. In Methods tor the determination of the hazardous properties tor human health of man made mineral fibres (MMMF). European Commission Joint Research Centre, report EUR 18748 EN 1999, eds. D. M. Bernstein and J. M. Riego Sintes. http://ecb.jrc.it/testing-methods
  • Harris, R. L., and Fraser, D. A. 1976. A model for deposition of fibres in the human respiratory system. Am. Ind. Hyg. Assoc. 37 :73-89.
  • Henderson, R. F., Mauderly, J. L., Pickrell, J. A., Hahn, F. F., Muhle, H., and Rebar, A. H. 1987. Comparative study of bronchoalveolar lavage fluid: Effect of species, age and method of lavage. Exp. Lung Res. 13:329-342.
  • Hesterberg, T. W., Hart, G. A., Chevalier, J., Miller, W. C., Hamilton, R. D., Bauer, J., and Thevenaz, P. 1998a. The importance of fiber biopersistence and lung dose in determining the chronic inhalation effects of X607, RCF1, and chrysotile asbestos in rats. Toxicol. Appl. Pharmacol. 153:68-82.
  • Hesterberg, T. W., Chase, G., Axten, C., Miller, W. C., Musselman, R. P., Kamstrup, O., Hadley, J., Morscheidt, C., Bernstein, D. M., and Thevenaz, P. 1998b. Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation. Toxicol. Appl. Pharmacol. 151 : 262-275.
  • Kamstrup, O., Davis, J. M. G., Ellehauge, A., and Guldberg, M. 1998 The biopersistence and pathogenicity of man-made vitreous fibres after short- and long-term inhalation. Ann. Occup. Hyg. 42: 191-199.
  • Mast, R. W., Maxim, L. D., Utell, M. J., and Walker, A. M. 2000a. Refractory ceramic fiber: Toxicology, epidemiology, and risk analysis-A review, Inhal. Toxicol. 12:359-399.
  • Mast, R. W., Yu, C. P., Oberdörster, G., McConnell, E. E., and Utell, M. J. 2000b. A retrospective review of the carcinogenicity of relfractory ceramic fiber in two chronic Fischer 344 rat inhalation studies: An assessment of the MTD and implications for risk assessment, Inhal. Toxicol. 12:1141-1172.
  • Maxim, L. D., Allshouse, J. N., Kelly, W. P., Walters, T., and Waugh, R. 1997. A multiyear workplacemonitoring program for refractory ceramic fibers: Findings and conclusions. Regul. Toxicol. Pharmacol. 26:156-171.
  • McConnell, E. E., and Davis, J. M. 2002. Quantification of fibrosis in the lungs of rats using a morphometric method, Inhal. Toxicol. 14:263-272.
  • McConnell, E. E., Wagner, J. C., Skidmore, J. W., and Moore J. A. 1984. A comparative study of the fibrogenic and carcinogenic effects of UICC Canadian chrysotile B asbestos and glass microfibre (JM 100). In Biological effects of man-made mineral fibres, vol. 2, pp. 234-252. Proc. WHO/IARC Conference, Copenhagen, 20-22 April 1982. Geneva: World Health Organization.
  • McConnell, E. E., Kamstrup, O., Musselman, R., Hesterberg, T. W., Chevalier, J., Muller, W. C., and Thevenaz, P. 1994. Chronic inhalation study of size-separated rock and slag wool insulation fibers in Fischer 344/N rats, Inhal. Toxicol. 6:571-614.
  • Morrow, P. E. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam. Appl. Toxicol. 10:369-384.
  • Morrow, P. E., Muhle, H., and Mermelstein, R. 1991. Chronic inhalation study findings as a basis for proposing a new occupational dust exposure limit. J. Am. Coll. Toxicol. 10:279-290.
  • Morrow, P. E. 1992. Dust overloading of the lungs: Update and appraisal. Toxicol. Appl. Pharmacol. 113:1-12.
  • Mosmann, T. R., Bond, M. W., Coffmann, R. L., Ohara, J., and Paul, W. E. 1986. T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc. Natl. Acad. Sci. USA 83:5654-5658.
  • Muhle, H., and Bellmann, B. 1995. Biopersistence of man-made vitreous fibres. Ann. Occup. Hyg. 39: 655-660.
  • Muhle, H., Bellmann, B., and Heinrich, U. 1988. Overloading of lung clearance chronic exposure of experimental animals to particles. Ann. Occup. Hyg. 32:141-147.
  • Muhle, H., Bellmann, B., Creutzenberg, O., Dasenbrock, C, Ernst, H., Kilpper, R., MacKenzie, J. C., Morrow, P., Mohr, U., Takenaka, S., and Mermelstein, R. 1991. Pulmonary response to toner upon chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17:280-299.
  • Vu, V., Barrett, J. C., Roycroft, J., Schuman, L, Dankovic, D., Baron, P., Marionen, T., Pepelko, W., and Lai, D. 1996. Workshop report: Chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles. Regul. Toxicol. Pharmacol. 24:202-212.
  • World Health Organization. 1985. Reference methods for measuring airborne man made mineral fibres (MMMF). Copenhagen: WHO Regional Office for Europe.

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