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Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 12
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Research Article

Repeated Exposure to Isoprene Oxidation Products Causes Enhanced Respiratory Tract Effects in Multiple Murine Strains

Annette C. Rohr Electric Power Research Institute, Palo Alto, California, USA
,
Stephanie A. Shore Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
&
John D. Spengler Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Pages 1191-1207 | Published online: 01 Oct 2008

  • Alarie, Y. 1973. Sensory irritation by airborne chemicals. CRC Crit. Rev. Toxicol. 2:299-363.
  • Alarie, Y. 1998. Computer-based bioassay for evaluation of sensory irritation of airborne chemicals and its limit of detection. Arch. Toxicol. 72:277-282.
  • American Society for Testing and Materials. 1984. Standard test method far estimating sensory irritancy of airborne chemicals. Philadelphia, PA: ASTM. Designation E981 -84.
  • Atkinson, R., Aschmann, S. M., Arey, J., and Shorees, B. 1992. Formation of OH radicals in the gas phase reactions of O3 with a series of monoterpenes and related compounds at 296 ± 2 K. Int. J. Chem. Kinet, 22:871-888.
  • Boylstein, L. A., Anderson, S. J., Thompson, R. D., and Alarie, Y. 1995. Characterization of the effect of an airborne mixture of chemicals on the respiratory tract and smoothing polynomial spline analysis of the data. Arch. Toxicol. 69:579-589.
  • Boylstein, L. A., Luo, J., Stock, M. F., and Alarie, Y. 1996. An attempt to define a just detectable effect for airborne chemicals on the respiratory tract in mice. Arch. Toxicol. 70:567-578.
  • Calogirou, A., Larsen, B. R., and Kotzias, D. 1999. Gas-phase terpene oxidation products: A review. Atmos. Environ. 33:1423-1439.
  • Clausen, P. A., Wilkins, C. K., Wolkoff, P., and Nielsen, G. D. 2001. Chemical and biological evaluation of a reaction mixture of R-(+)-limonene/ozone: Formation of strong airway irritants. Environ. Int, 27:1-12.
  • Di Pauli, R. 1972. Genetics of the immune response. I. Differences in the specificity of antibodies to lipopolysaccharides among different strains of mice. J. lmmunol. 109:394-400.
  • Dockery, D. W., Pope, C. A. Ill, Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., and Speizer, F. E. 1993. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329:1753-1759.
  • Fehsenfeld, F., Calvert, J., Fall, R., Goldan, P., Guenther, A. B., Hewitt, C. N., Lamb, B., Liu, S., Trainer, M., Westberg, H., and Zimmerman, P. 1992. Emissions of volatile organic compounds from vegetation and the implications for atmospheric chemistry. Global Biogeochem. Cycles 6(4): 389-430.
  • Fenske, J. D., and Paulson, S. E. 1999. Human breath emissions of VOCs. J. Air Waste Manage. Assoc. 49(5):594-598.
  • Gagnaire, F., Micillino, J. C., Bonnet, P., Simon, P., and de Ceaurriz, J. 1988. Toluene diisocyanateinduced airway responsiveness to intravenous acetylcholine: A study on single and repeated exposure in guinea pigs. Toxicol. Lett. 44:273-280.
  • Grosjean, D., Williams, E. L. Ill, and Seinfeld, J. H. 1992. Atmospheric oxidation of selected terpenes and related carbonyls: Gas-phase carbonyl products. Environ. Sci. Technol. 26(8):1526-1533.
  • Hakola, H., Arey, J., Aschmann, S. M., and Atkinson, R. 1994. Product formation from the gas-phase reactions of OH radicals and O3 with a series of monoterpenes. J. Atmos. Chem. 18:75-102.
  • Hamelmann, E., Schwarze, J., Takeda, K., Oshiba, A., Larsen, G. L., Irvin, C. G., and Gelfand, E. W. 1997. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 156:766-775.
  • Jang, M., and Kamens, R. M. 1999. Newly characterized products and composition of secondary aerosols from the reaction of á-pinene with ozone. Atmos. Environ. 33:459-474.
  • Kamens, R. M., Gery, M. W., Jeffries, H. E., Jackson, M., and Cole, E. I. 1982. Ozone-isoprene reactions: Product formation and aerosol potential. Int. J. Chem. Kinet. 14:955-975.
  • Kane, L. E., and Alarie, Y. 1977. Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice. Am. Ind. Hyg. Assoc. J. 38:509-521.
  • Kleeberger, S. R., Bassett, D. J. P., Jakab, G. J., and Levitt, R. C. 1990. A genetic model for evaluation of susceptibility to ozone-induced inflammation. Am. J. Physiol. 258(6, Pt 1):L313-320.
  • Kleeberger, S. R., Zhang, L-Y., and Jakab, G. J. 1997. Differential susceptibility to oxidant exposure in inbred strains of mice: Nitrogen dioxide versus ozone, lnhal. Toxicol. 9:601-621.
  • Kleeberger, S. R., Reddy, S., Zhang, L. Y., and Jedlicka, A. E. 2000. Genetic susceptibility to ozoneinduced lung hyperpermeability: Role of toll-like receptor 4. Am. J. Respir. Cell. MoI. Biol. 22(5): 620-627.
  • Lamb, B., Guenther, A., Gay, D., and Westberg, H. 1987. A national inventory of biogenic hydrocarbons emissions. Atmos. Environ. 21:1695-1705.
  • Levitt, R. C., and Mitzner, W. 1988. Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB J. 2:2605-2608.
  • Long, C. M., Suh, H. H., and Koutrakis, P. 2000. Characterization of indoor particle sources using continuous mass and size monitors. J. Air Waste Manage. Assoc. 50(7):1236-1250.
  • McDonnell, W. F., Kehrl, H. R., Abdul-Salaam, S., Ives, P. J., Folinsbee, L. J., Devlin, R. B., O'Neil, J. J., and Horstman, D. H. 1991. Respiratory response of humans exposed to low levels of ozone for 6.6 hours. Arch. Environ. Health 46:145-150.
  • Murphy, D. J. 1994. Safety pharmacology of the respiratory system-Techniques and study design. Drug Dev. Res. 32(4):237-246.
  • Paulson, S. E., Flagan, R. C., and Sienfeld, J. H. 1992. Atmospheric photooxidation of isoprene part II: The ozone-isoprene reaction. Int. J. Chem. Kinet. 24:103-125.
  • Pauluhn, J., Eben, A., and Kimmerle, G. 1990. Functional, biochemical, and histopathological evidence of airway-obstruction in rats following a 4-hour acute inhalation exposure to normal-butyl isocyanate. Exp. Pathol. 40(4):197-203.
  • Petak, F., Habre, W., Donati, Y. R., Hantos, Z., and Barazzone-Argiroffo, C. 2001. Hyperoxia-induced changes in mouse lung mechanics: Forced oscillations vs. barometric plethysmography. J. Appl. Physiol. 90(6):2221-2230.
  • Pope, C. A. Ill, Burnett, R. T., Thun, M. J., CaIIe, E. E., Krewski, D., lto, K., and Thurston, G. D. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc. 287:1132-1141.
  • Roehrs, J. D., Rogers, W. R., and Johanson, W. G. 1981. Bronchial reactivity to inhaled methacholine in cigarette smoking baboons. J. Appl. Physiol. 50:754-760.
  • Rohr, A. C., Wilkins, C. K., Clausen, P. A., Hammer, M., Nielsen, G. D., Spengler, J. D., and Wolkoff, P. 2002. Terpene/ozone reaction products: Effects on conducting and upper airways and their reversibility in mice, lnhal. Toxicol. 14(7):663-684.
  • Rohr, A. C., Weschler, C., Koutrakis, P., and Spengler, J. D. 2003. Generation and quantification of ultrafine particles through terpene/ozone reaction in a chamber setting. Aerosol Sci. Tech. 37:65-78.
  • Samet, J. M., Dominici, F., Curriero, F. C., Coursac, I., and Zeger, S. L. 2000. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N. Engl. J. Med. 343:1742-1749.
  • Sangha, G. K., and Alarie, Y. 1979. Sensory irritation by toluene diisocyanate in single and repeated exposures. Toxicol. Appl. Pharmacol. 50:533-547.
  • Sarwar, G., Corsi, R., Allen, D., and Weschler, C. 2003. The significance of secondary organic aerosol formation and growth in buildings: Experimental and computational evidence. Atmos. Environ. 37: 1365-1381.
  • Sauer, F., Schäfer, C., Neeb, P., Horie, O., and Moortgat, G. K. 1999. Formation of hydrogen peroxidein the ozonolysis of isoprene and simple alkenes under humid conditions. Atmos. Environ. 33: 229-241.
  • Shore, S. A., Kariya, S. T., Anderson, K., Skornik, W., Feldman, H. A., Pennington, J., Godleski, J., and Drazen, J. M. 1987. SO2-Induced bronchitis in dogs. Effects on airway responsiveness to inhaled and intravenous methacholine. Am. Rev. Respir. Dis. 135:840-847.
  • Tankersley, C. G., Fitzgerald, R. S., and Kleeberger, S. R. 1994. Differential control of ventilation among inbred strains of mice. Am. J. Physiol. 267(Regul. Integrative Comp. Physiol. 36):R1371-R1377.
  • Tankersley, C. G., Fitzgerald, R. S., Levitt, R. C., Mitzner, W. A., Ewart, S. L, and Kleeberger, S. R. 1997. Genetic control of differential baseline breathing pattern. J. Appl. Physiol. 82(3):874-881.
  • Tepper, J. S., Blanchard, J. D., and Pfeiffer, J. W. 1997. Validation of noninvasive measures of bronchoconstriction in mice. Am. J. Respir. Crit. Care Med. 155:A160.
  • Vijayaraghavan, R., Schaper, M., Thompson, R., Stock, M. F., and Alarie, Y. 1993. Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch. Toxicol. 67:478-490.
  • Vijayaraghavan, R., Schaper, M. Thompson, R., Stock, M. F., Boylstein, L. A., Luo, J. E., and Alarie, Y. 1994. Computer-assisted recognition and quantification of the effects of airborne chemicals acting at different areas of the respiratory tract in mice. Arch. Toxicol. 68:490-499.
  • Wainman, T., Zhang, J., Weschler, C. J., and Lioy, P. J. 2000. Ozone and limonene in indoor air: A source of submicron particle exposure. Environ. Health Perspect. 108(12): 1139-1145.
  • Weschler, C. J., and Shields, H. C. 1997. Potential reactions among indoor pollutants. Atmos. Environ. 31(21):3487-3495.
  • Weschler, C. J., and Shields, H. C. 1999. Indoor ozone/terpene reactions as a source of indoor particles. Atmos. Environ. 33(15):2301-2312.
  • Wesselkamper, S. C., Chen, L. C., Kleeberger, S. R., and Gordon, T. 2001. Genetic variability in the development of pulmonary tolerance to inhaled pollutants in inbred mice. Am. J. Physiol. Lung Cell. MoI. Physiol. 281 (5):1200-1209.
  • Wilkins, C. K., Clausen, P. A., Wolkoff, P., Larsen, S. T., Hammer, M., Larsen, K., Hansen, V., and Nielsen, G. D. 2001. Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide. Environ. Health Perspect. 109(9):937-941.
  • Wolkoff, P., and Nielsen, G. D. 2001. Organic compounds in indoor air-Their relevance for indoor air quality? Atmos. Environ. 35:4407-4417.
  • Wolkoff, P., Clausen, P. A., Jensen, B., Nielsen, G. D., and Wilkins, C. K. 1997. Are we measuring the relevant indoor pollutants? Indoor Air 7:92-106.
  • Wolkoff, P., Clausen, P. A., Wilkins, C. K., and Nielsen, G. D. 2000. Formation of strong irritants in terpene/ozone mixtures. Indoor Air 10(2):82-91.
  • Xu, J. Y., Zhao, M. W., and Liao, S. L. 2000. Establishment and pathological study of models of chronic obstructive pulmonary disease by SO2 inhalation method. Chin. Med. J. 113(3):213-216.
  • Zhang, L.-Y., Levitt, R. C., and Kleeberger, S. R. 1995. Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice. Exp. Lung Res. 1:503-518.

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