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Inhalation Toxicology
International Forum for Respiratory Research
Volume 16, 2004 - Issue 5
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Research Article

Toxicokinetics of Propylene Glycol Mono-t-Butyl Ether Following Intravenous or Inhalation Exposure in Rats and Mice

Jeffrey A. Dill Battelle, Toxicology Northwest, Richland, Washington, USACorrespondence[email protected]
,
Alfred F. Fuciarelli Battelle, Toxicology Northwest, Richland, Washington, USA
,
Kyeonghee M. Lee Battelle, Toxicology Northwest, Richland, Washington, USA
,
Kathleen M. Mellinger Battelle, Toxicology Northwest, Richland, Washington, USA
,
Leo T. Burka National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
&
Joseph H. Roycroft National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Pages 271-290 | Published online: 19 Oct 2008

REFERENCES

  • American Ink Maker. 1985. PTB solvent from ARCO. Am. Ink Maker. December: 153
  • Boatman R. J.. 2001. Glycol ethers: Ethers of propylene, butylenes glycols, and other glycol derivatives. Patty's toxicology, 5th ed., E., Bingham, B., Cohrssen, C. H., Powell. vol. 7: pp. 271–395, New York, John Wiley & Sons
  • Borghoff S. J., Short B. G., Swenberg J. A.. 1990. Biochemical mechanisms and pathobiology of alpha 2μ-globulin nephopathy. Annu. Rev. Pharmacol. Toxicol.. 30: 349–367. [PUBMED], [INFOTRIEVE]
  • Davies B., Morris T.. 1993. Physiological parameters in laboratory animals and humans. Pharmacol. Res.. 10: 1093–1095
  • Dittmer D. S., Altman P. L.. 1961; Blood and other body fluids. Washington, DC, Federation of American Societies for Experimental Biology
  • Gradinaru D., Suleman F. G., Leclerc S., Heydel J. M., Grillasca J. P., Magdalou J., Minn A.. 1999. UDP-glucuronosyltransferase in the rat olfactory bulb: Identification of the UGT1A6 isoform and age-related changes in 1-naphthol glucuronidation. Neurochem. Res.. 24: 995–1000. [CROSSREF], [PUBMED], [INFOTRIEVE]
  • Guthie D. H.. 1987. Coalescent interaction determines proper latex film formation. Modern Paint Coatings. November: 60–62
  • Hard G. C., Rodgers J. S., Baetcke K. P., Richards W. L., McGaughy R. E., Valcovic L. R.. 1993. Hazard evaluation of chemicals that cause accumulation of α2μ-globulin, hyaline droplet nephopathy, and tubule neophasia in the kidneys of male rats. Environ. Health Perspect.. 99: 313–349. [PUBMED], [INFOTRIEVE]
  • Heckman R. A.. 1986. Using P-series glycol ethers in water-reducible coatings. Modern Paint Coatings. November: 36–42
  • Hinderling P. H.. 1997. Red blood cells: A neglected compartment in pharmacokinetics and pharmacodynamics. Pharmacol. Rev.. 49: 279–295. [PUBMED], [INFOTRIEVE]
  • Kessler D. G.. 1989. Regulations bring new products and services. CPI Purchasing. October: 46–53
  • Klaassen C. D., Liu L., Dunn R. T., II. 1998. Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Chem. Biol. Interact.. 109: 299–313. [CROSSREF], [PUBMED], [INFOTRIEVE]
  • Lehman-McKeeman L. D., Caudill D., Takigiku R., Schneider R. E., Young J. A.. 1990. Comparative disposition of d-limonene in rats and mice: Relevance of male-rat-specific nephrotoxicity. Toxicol. Lett.. 53: 193–195. [CROSSREF], [PUBMED], [INFOTRIEVE]
  • Liu L., Klaassen C. D.. 1996. Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases. J. Pharmacol. Exp. Ther.. 279: 386–391. [PUBMED], [INFOTRIEVE]
  • Miller R. R.. 1987. Metabolism and disposition of glycol ethers. Drug Metab. Rev.. 18: 1–22. [PUBMED], [INFOTRIEVE]
  • Miller R. R., Hermann E. A., Young J. T., Landry T. D., Calhoun L. L.. 1984. Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: Metabolism, disposition, and subchronic inhalation toxicity studies. Environ. Health. Perspect.. 57: 233–239. [PUBMED], [INFOTRIEVE]
  • Nakagomi M., Suzuki E., Kitashima M., Iida S., Abe M., Matsuki Y., Kaneko K.. 1997. Sex difference in the metabolism of pirmenol in rats. Biol. Pharmacol. Bull.. 20: 1279–1284
  • National Toxicology Program, 1994; Chemical disposition in mammals: The metabolism and disposition of propylene glycol t-butyl ether in the male Fischer 344 rat (Final report), NIEHS Contract N01-ES-85320. Research Triangle Park, NC, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health
  • National Toxicology Program, 2003; Toxicology and carcinogenesis studies of propylene glycol mono t-butyl ether (CAS No. 57018–52-7) in F/344 rats and B6C3F1 mice (inhalation studies), NTP Technical Rep. No. 515 (Draft). Research Triangle Park, NC, NTP
  • Nudy L. R., Johnston W. A.. 1990. PTB: A safe, effective solvent for hard surface cleaners. Household and Personal Products Industry. April: 90–92
  • Perry R. H., Green D. W., Maloney J. O., 1984; Perry's chemical engineer's handbook, 6th ed., pp. 66–67, New York, McGraw-Hill
  • Runge-Morris M. A.. 1994. Sulfotransferase gene expression in rat hepatic and extrahepatic tissues. Chem. Biol. Interact.. 92: 67–76. [CROSSREF], [PUBMED], [INFOTRIEVE]
  • van, Bezooijen C. F.. 1984. Influence of age-related changes in rodent liver morphology and physiology on drug metabolism-a review. Mech. Ageing Dev. 25: 1–22
  • Welling P. G.. 1986; Pharmacokinetics. pp. 145–149, Washington, DC, American Chemical Society
  • Williams T. M., Borghoff S. J.. 2001. Characaterization of tert-butyl alcohol binding to alpha2μ-globuling in F-344 rats. Toxicol. Sci.. 62: 228–235. [CROSSREF], [PUBMED], [INFOTRIEVE]

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