Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue sup1
467
Views
95
CrossRef citations to date
0
Altmetric
Research Article

Importance of Size and Composition of Particles for Effects on Cells In Vitro

, , , , , , , & show all
Pages 17-22 | Received 20 Jun 2006, Accepted 01 Nov 2006, Published online: 20 Oct 2008

REFERENCES

  • Agopyan N., Li L., Yu S., Simon S. A. Negatively charged 2- and 10-μ m particles activate vanilloid receptors, increase cAMP, and induce cytokine release. Toxicol. Appl. Pharmacol. 2003; 186: 63–76
  • Barrett E. G., Johnston C., Oberdorster G., Finkelstein J. N. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress. Am. J. Physiol. Lung Cell Mol. Physiol. 1999; 276: L979–L988
  • Becher R., Hetland R. B., Refsnes M., Dahl J. E., Dahlman H. J., Schwarze P. E. Rat lung inflammatory responses after in vivo and in vitro exposure to various stone particles. Inhal. Toxicol. 2001; 13: 789–805
  • Becker S., Mundandhara S., Devlin R. B., Madden M. Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: Further mechanistic studies. Toxicol. Appl. Pharmacol. 2005; 207: 269–275
  • Brown D. M., Wilson M. R., MacNee W., Stone V., Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 2001; 175: 191–199
  • Clouter A., Brown D., Hohr D., Borm P., Donaldson K. Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates. Toxicol. Sci. 2001; 63: 90–98
  • Duffin R., Gilmour P. S., Schins R. P., Clouter A., Guy K., Brown D. M., MacNee W., Borm P. J., Donaldson K., Stone V. Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappaB activation. Toxicol. Appl. Pharmacol. 2001; 176: 10–17
  • Dybing E., Lovdal T., Hetland R. B., Lovik M., Schwarze P. E. Respiratory allergy adjuvant and inflammatory effects of urban ambient particles. Toxicology. 2004; 198: 307–314
  • Fenoglio I., Croce A., DiRenzo F., Tiozzo R., Fubini B. Pure-silica zeolites (porosils) as model solids for the evaluation of the physicochemical features determining silica toxicity to macrophages. Chem. Res. Toxicol. 2000; 13: 489–500
  • Fubini B., Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Biol. Med. 2003; 34: 1507–1516
  • Hamoir J., Nemmar A., Halloy D., Wirth D., Vincke G., Vanderplasschen A., Nemery B., Gustin P. Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: Role of size and surface properties. Toxicol. Appl. Pharmacol. 2003; 190: 278–285
  • Hetland R. B., Refsnes M., Myran T., Johansen B. V., Uthus N., Schwarze P. E. Mineral and/or metal content as critical determinants of particle-induced release of IL-6 and IL-8 from A549 cells. J. Toxicol. Environ. Health A 2000; 60: 47–65
  • Hetland R. B., Myhre O., Lag M., Hongve D., Schwarze P. E., Refsnes M. Importance of soluble metals and reactive oxygen species for cytokine release induced by mineral particles. Toxicology 2001a; 165: 133–144
  • Hetland R. B., Schwarze P. E., Johansen B. V., Myran T., Uthus N., Refsnes M. Silica-induced cytokine release from A549 cells: Importance of surface area versus size. Hum. Exp. Toxicol. 2001b; 20: 46–55
  • Hetland R., Cassee F., Lag M., Refsnes M., Dybing E., Schwarze P. Cytokine release from alveolar macrophages exposed to ambient particulate matter: Heterogeneity in relation to size, city and season. Part. Fibre Toxicol. 2005; 2(4)
  • Hext P. M., Tomenson J. A., Thompson P. Titanium dioxide: Inhalation toxicology and epidemiology. Ann. Occup. Hyg. 2005; 49: 461–472
  • Hohr D., Steinfartz Y., Schins R. P., Knaapen A. M., Martra G., Fubini B., Borm P. J. The surface area rather than the surface coating determines the acute inflammatory response after instillation of fine and ultrafine TiO2 in the rat. Int. J. Hyg. Environ. Health 2002; 205: 239–244
  • Huang Y. C., Li Z., Harder S. D., Soukup J. M. Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. Inhal. Toxicol. 2004; 16: 863–878
  • Kamp D. W., Weitzman S. A. The molecular basis of asbestos induced lung injury. Thorax. 1999; 54: 638–652
  • Kleinman M. T., Sioutas C., Chang M. C., Boere A. J., Cassee F. R. Ambient coarse and fine particle suppression of alveolar macrophage functions. Toxicol. Lett. 2003; 137: 151–158
  • Mondal K., Haskill J. S., Becker S. Adhesion and pollution particle-induced oxidant generation is neither necessary nor sufficient for cytokine induction in human alveolar macrophages. Am. J. Respir. Cell Mol Biol. 2000; 22: 200–208
  • Nygaard U. C., Samuelsen M., Aase A., Lovik M. The capacity of particles to increase allergic sensitization is predicted by particle number and surface area, not by particle mass. Toxicol. Sci. 2004; 82: 515–524
  • Nygaard U. C., Alberg T., Bleumink R., Aase A., Dybing E., Pieters R., Lovik M. Ambient air particles from four European cities increase the primary cellular response to allergen in the draining lymph node. Toxicology 2005; 207: 241–254
  • Ovrevik J., Myran T., Refsnes M., Lag M., Becher R., Hetland R. B., Schwarze P. E. Mineral particles of varying composition induce differential chemokine release from epithelial lung cells: Importance of physico-chemical characteristics. Ann. Occup. Hyg. 2005; 49: 219–231
  • Ovrevik J., Hetland R. B., Schins R. P., Myran T., Schwarze P. E. Iron release and ROS generation from mineral particles are not related to cytokine release or apoptosis in exposed A549 cells. Toxicol. Lett. 2006; 165: 31–38
  • Refsnes M., Hetland R. B., Ovrevik J., Sundfor I., Schwarze P. E., Lag M. Different particle determinants induce apoptosis and cytokine release in primary alveolar macrophages. Part. Fibre Toxicol. 2006; 3: 10
  • Renwick L. C., Brown D., Clouter A., Donaldson K. Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup. Environ. Med. 2004; 61: 442–447
  • Schwarze P. E., Ovrevik J., Lag M., Refsnes M., Nafstad P., Hetland R. B., Dybing E. Particulate matter properties and health effects: Consistency of epidemiological and toxicological studies?. Hum. Exp. Toxicol. 2006; 25: 559–579
  • Shi X., Ding M., Chen F., Wang L., Rojanasakul Y., Vallyathan V., Castranova V. Reactive oxygen species and molecular mechanism of silica-induced lung injury. J. Environ. Pathol. Toxicol. Oncol. 2001; 20: 85–93, (suppl. 1)
  • Shukla A., Gulumian M., Hei T. K., Kamp D., Rahman Q., Mossman B. T. Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. Free Radical Biol. Med. 2003; 34: 1117–1129
  • Steerenberg P. A., van Amelsvoort L., Lovik M., Hetland R. B., Alberg T., Halatek T., Bloemen H. J., Rydzynski K., Swaen G., Schwarze P., Dybing E., Cassee F. R. Relation between sources of particulate air pollution and biological effect parameters in samples from four European cities: An exploratory study. Inhal. Toxicol. 2006; 18: 333–346
  • Veronesi B., Haar C. d., Lee L., Oortgiesen M. The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 2002; 178: 144–154
  • Warheit D. B., Webb T. R., Sayes C. M., Colvin V. L., Reed K. L. Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicol. Sci. 2006; 91: 227–236

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.