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Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue sup1
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Research Article

Does Inhalation of Ultrafine Particles Cause Pulmonary Vasular Effects in Humans?

Pages 75-79 | Received 16 Jan 2007, Accepted 26 Mar 2007, Published online: 20 Oct 2008

REFERENCES

  • Anderson G. J., Roswit W. T., Holtzman M. J., Hogg J. C., Van Eeden S. F. Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion. J. Appl. Physiol. 2001; 91: 1084–1090
  • Batalha J. R., Saldiva P. H., Clarke R. W., Coull B. A., Stearns R. C., Lawrence J., Murthy G. G., Koutrakis P., Godleski J. J. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ. Health Perspect. 2002; 110: 1191–1197
  • Beckett W. S., Chalupa D. F., Pauly-Brown A., Speers D. M., Stewart J. C., Frampton M. W., Utell M. J., Huang L.-S., Cox C., Zareba W., Oberdörster G. Comparison of inhaled ultrafine vs. fine zinc oxide particles in healthy adults: A human inhalation study. Am. J. Respir. Crit. Care Med. 2005; 171: 1129–1135
  • Brown D. M., Wilson M. R., MacNee W., Stone V., Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 2001; 175: 191–199
  • Chalupa D. C., Morrow P. E., Oberdörster G., Utell M. J., Frampton M. W. Ultrafine particle deposition in subjects with asthma. Environ. Health Perspect. 2004; 112: 879–882
  • Chalupa D. F., Gibb F. R., Morrow P. E., Oberdörster G., Riesenfeld E., Gelein R., Utell M. J., Frampton M. W. A facility for controlled human exposures to ultrafine particles. Crucial issues in inhalation research—Mechanistic, clinical and epidemiologic, U. Heinrich, U. Mohr. ILSI Press, Washington, DC 2002; 241–253
  • Daigle C. C., Chalupa D. C., Gibb F. R., Morrow P. E., Oberdörster G., Utell M. J., Frampton M. W. Ultrafine particle deposition in humans during rest and exercise. Inhal. Toxicol. 2003; 15: 539–552
  • Dick C. A., Brown D. M., Donaldson K., Stone V. The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhal. Toxicol. 2003; 15: 39–52
  • Doerschuk C. M. Neutrophil emigration in the lungs. Therapeutic targets in airway inflammation, T. Eissa, D. P. Huston. Marcel Dekker, New York 2003; 249–280
  • Dominici F., Peng R. D., Bell M. L., Pham L., McDermott A., Zeger S. L., Samet J. M. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. J. Am. Med. Assoc. 2006; 295: 1127–1134
  • Elder A., Gelein R., Silva V., Feikert T., Opanashuk L., Carter J., Potter R., Maynard A., Ito Y., Finkelstein J., Oberdorster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ. Health Perspect. 2006; 114: 1172–1178
  • Frampton M. W., Pietropaoli A. P., Morrow P. E., Utell M. J. Human clinical studies of airborne pollutants. Toxicology of the lung, D. E. Gardner. CRC Press, Boca Raton, FL 2006a; 29–82
  • Frampton M. W., Stewart J. C., Oberdörster G., Morrow P. E., Chalupa D., Pietropaoli A. P., Frasier L. M., Speers D. M., Cox C., Huang L.-S., Utell M. J. Inhalation of carbon utrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ. Health Perspect. 2006b; 114: 51–58
  • Geiser M., Rothen-Rutishauser B., Kapp N., Schurch S., Kreyling W., Schulz H., Semmler M., Im Hof V., Heyder J., Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 2005; 113: 1555–1560
  • Godleski J. J. Responses of the heart to ambient particle inhalation. Clin. Occup. Environ. Med. 2006; 5: 849–864
  • ICRP. Human respiratory tract model for radiological protection. International Commission on Radiological Protection, Elsevier Science Ltd, Tarrytown, NY 1994, Publication no. 66
  • Künzli N., Jerrett M., Mack W. J., Beckerman B., LaBree L., Gilliland F., Thomas D., Peters J., Hodis H. N. Ambient air pollution and atherosclerosis in Los Angeles. Environ. Health Perspect. 2005; 113: 201–206
  • Markos J., Doerschuk C. M., English D., Wiggs B. R., Hogg J. C. Effect of positive end-expiratory pressure on leukocyte transit in rabbit lungs. J. Appl. Physiol. 1993; 74: 2627–2633
  • Markos J., Hooper R. O., Kavanagh-Gray D., Wiggs B. R., Hogg J. C. Effect of raised alveolar pressure on leukocyte retention in the human lung. J. Appl. Physiol. 1990; 69: 214–221
  • Mills N. L., Amin N., Robinson S. D., Anand A., Davies J., Patel D., de la Fuente J. M., Cassee F. R., Boon N. A., Macnee W., Millar A. M., Donaldson K., Newby D. E. Do inhaled carbon nanoparticles translocate directly into the circulation in humans?. Am. J. Respir. Crit. Care Med. 2006; 173: 426–431
  • Nemmar A., Hoet P. H., Vanquickenborne B., Dinsdale D., Thomeer M., Hoylaerts M. F., Vanbilloen H., Mortelmans L., Nemery B. Passage of inhaled particles into the blood circulation in humans. Circulation 2002; 105: 411–414
  • Phalen R. F., Oldham M. J. Aerosol dosimetry considerations. Clin. Occup. Environ. Med. 2006; 5: 773–784
  • Pietropaoli A. P., Frampton M. W., Hyde R. W., Morrow P. E., Oberdörster G., Cox C., Speers D. M., Frasier L. M., Chalupa D. C., Huang L.-S., Utell M. J. Pulmonary function, diffusing capacity and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal. Toxicol. 2004a; 16: 59–72, (suppl. 1)
  • Pietropaoli A. P., Frampton M. W., Oberdörster G., Cox C., Huang L.-S., Marder V., Utell M. J. Blood markers of coagulation and inflammation in healthy human subjects exposed to carbon ultrafine particles. Effects of air contaminants on the respiratory tract—Interpretations from molecular to meta analysis, U. Heinrich. INIS Monographs, Fraunhofer IRB Verlag, StuttgartGermany 2004b; 181–194
  • Schwartz J. Long-term effects of exposure to particulate air pollution. Clin. Occup. Environ. Med. 2006; 837–848
  • Utell M. J., Frampton M. W. Particles and mortality: A clinical perspective. Inhal. Toxicol. 1995; 7: 645–655
  • Utell M. J., Frampton M. W., Zareba W., Devlin R. B., Cascio W. E. Cardiovascular effects associated with air pollution: Potential mechanisms and methods of testing. Inhal. Toxicol. 2002; 14: 1231–1247
  • van Eeden S. F., Granton J., Hards J. M., Moore B., Hogg J. C. Expression of the cell adhesion molecules on leukocytes that demarginate during acute maximal exercise. J. Appl. Physiol. 1999; 86: 970–976
  • Xia T., Kovochich M., Nel A. The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clin. Occup. Environ. Med. 2006; 5: 817–836

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