Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue sup1
131
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Risk Assessment for Biopersistent Granular Particles

&
Pages 199-204 | Received 17 Aug 2006, Accepted 01 Nov 2006, Published online: 20 Oct 2008

REFERENCES

  • Barnhart M. I., Chen S., Salley S. O., Puro H. Untrastructure and morphometry of the alveolar lung of guinea pigs chtonically exposed to diesel engine exhaust: six month's experience. J. Appl. Toxicol. 1981; 1: 88–103
  • Bellmann B., Muhle H., Creutzenberg O., Dasenbrock C., Klipper R., Mckenzie J. C., Morrow P., Mermelstein R. Lung clearance and retention of tonner, utilizing a tracer technique, during chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 1991; 17: 300–331
  • Bermudez E., Mangum J. B., Wong B. A., Ashgarian B., Wong B. A., Reverdy E. E., Janszen D. B., Hext P. M., Warheit D. B., Everitt J. I. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol. Sci. 2002; 70: 86–89
  • Borm P., Shins R. P. F., Albrecht C. A. Inhaled particles and lung. Part B. Paradigms and assessment. Int. J. Cancer 2004; 110: 3–14
  • Borm P. J., Schins R., Donaldson K., Driscoll K., Hartwig A., Kuempel E., Oberdorster G., Speit G. Toxicity of fibers and particulates. Report of a Workshop held in Munich, Germany, October 26–27 2000. Inhal. Toxicol. 2001; 13: 737–754
  • Borm P. J., Höhr D., Steinfartz Y., Zeitträger I., Albrecht C. Chronic inflammation and tumor formation in rats after intratracheal inflammation of high doses of coal dusts, titanium dioxides and quartz. Inhal. Toxicol. 2000; 12: 225–231, (suppl. 3)
  • Castranova V. Particulates and the airways: Basic biological mechanisms of pulmonarypathogenicity. Appl. Occup. Environ. Hyg. 1998; 13(8)613–616
  • Deutsche Forschungsgemeinschaft. List of MAK and BAT values 2006. Willey-VCH Verlag GmbH & Co. 2006
  • de Visser K., Korets L., Coussens L. De novo cacinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 2005; 7: 411–423
  • Driscoll K. E. Role of inflammation in the development of rat lung tumors in response zo chronic particle exposure. Inhal. Toxicol. 1996; 8: 139–153, (suppl.)
  • Driscoll K. E., Deyo L. C., Howard B. W., Hassenbein D. G., Bertram T. Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar type II cells. Carcinogenesis 1997; 18: 423–430
  • Erst H., Rittinghausen S., Bartsch W., Creutzenberg O., Dasenbrock C., Görlitz B., Hecht M., Kairies U., Muhle H., Müller M., Heirich U., Pott F. Pulmonary inflammation in rats after intratracheal instillation of quartz, amorphous SiO2, carbon black, and coal dust and the influence of poly-2-vinylpyridine-N-oxide (PVNO). Exp. Toxicol. Pathol. 2002; 54: 109–126
  • Greim H. General threshold limit value for dust. Occup. Toxicants 1997; 14: 239–270
  • Greim H., Borm P. H., Schins R., Donaldson K., Driscoll K., Hatwig A., Kuempel E., Oberdöster G., Speit G. Toxicity of fibres and particles. Report of the workshop held in Munich, Germany, 26–27 October 2000. Inhal. Toxicol. 2001; 13(9)737–754
  • Henderson R. F., Pickerl J. A., Jones R. K., Sun J. D., Benson J. M., Mauderly J. L., McCleland R. O. Response of rodents to inhaled diluted diesl exhaust: biochemical and cytological changes in bronchoalveolar lavage fluid and in lung tissue. Fundam. Appl. Toxicol. 1988; 11: 546–567
  • Hext P. M., Warheit D. B., Mangum J., Asgharian B., Wong B., Bermudez E., Everitt J. Comparison of the pulmonary responses to inhaled pigmentary and ultrafine titanium dioxide particles in the rat, mouse and hamster. Ann. Occup. Hyg. 2002; 46: 191–196
  • Heinrich U., Fuhst R., Rittinghausen S., Creutzenberg O., Bellmann B., Koch W., Levsen K. Chronic inhalation exposure of Wistar rats and 2 different strains of mice to diesel-engine exhaust, carbon black, and titanium dioxide. Inhal. Toxicol. 1995; 7(4)533–556
  • Institute for Environment and Health. Approaches to predicting toxicity from occupational exposure to dusts. An appraisal of low-toxicity dusts. Page Bros, Norwich 1999, Report R11
  • ILSI. The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report—Risk Science Institute workshop. Inhal. Toxicol. 2000; 12: 1–17
  • Ishihara Y., Kagawa J. Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesl exhaust: Analysis of various biological markers in pulmonary alveolar lavage fluid and circulation blood. Inhal. Toxicol. 2002; 14: 1049–1067
  • Ishihara Y., Kagawa J. Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation. Inhal. Toxicol. 2003; 15: 473–492
  • Ishinishi N., Kuwabara N., Nagase S., Suzuki T., Ishiwata S., Kohno T. Carcinogenic and mutagenic effects of diesel engine exhaust, N. Ishinishi, A. Loizumi, R. O. McCleland. Elsevier Science, New York 1986; 329–348
  • Katabami M., Disaka-Akita H., Honma K., Saitoh Y., Kimura K., Ushida Y., Mikami H., Ohsaki Y., Kawakami Y., Kikuchi K. Pneumoconiosis-related lung cancers: Preferential occurrence from diffuse interstitial fibrosis-type pneomoconiosis. Am. J. Respir. Crit. Care Med. 2000; 152: 295–300
  • Kato A., Nagai A., Kagawa J. Morphological changes in rat lung after long-term exposure to diesel emissions. Inhal. Toxicol. 2000; 12: 469–490
  • Knaapen A., Borm P., Albrecht C., Schins R. Inhaled particles and lung cancer. Part A. Mechanisms. Int. J. Cancer 2004; 109: 799–809
  • Lee K. P., Trichimowicz H. J., Reinhardt C. F. Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years. Toxicol. Appl. Pharmacol. 1985; 79: 179–192
  • Marx J. Inflammation and cancer: The link grows stronger. Science 2004; 306: 966–968
  • Mauderly J. L., Jones R. K., Griffith W. C., Henderson R. F., McCleland R. O. Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. Appl. Toxicol. 1987; 9: 208–221
  • Morrow P. E. Possible mechanisms to explain dust overloading of the lungs. Fundam. Appl. Toxicol. 1988; 10: 369–384
  • Muhle H., Creuzenberg O., Bellmann B., Heinrich U., Mermelstein R. Dust overload of lungs: Investigation of various materials, species differences and irreversibility of effects. J. Aerosol Med. 1990; 3: 111–128, (suppl. 1)
  • Muhle H., Bellmann B., Creutzenberg O., Dasenbrock C., Ernst H., Kilpper R., Mackenzie J. C., Morrow P., Mohr U., Takenaka S., Mermelstein R. Pulmonary response to toner upon chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 1991; 17: 280–299
  • Oberdöster G. Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health 2001; 74: 1–8
  • Pott F., Roller A. Carcinogenicity of poorly soluble particles in rats—In man too?. ILSI Monographs, Washington, DC 2000
  • Pott F., Roller M. Untersuchungen zur Kanzerogenität granulärer Stäube an Ratten-Ergebnisse und Interpretationen. Kurzbericht über das Projjekt F1843 der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin. 2003, Accessed 28 August 2003
  • Pott F., Roller K. Carcinogenicity study with nineteen granular dusts in rats. Eur. J. Oncol. 2005; 10(4)249–281
  • Pott F., Roller M. Lung tumour risk estimates from rat studies with not specifically toxic granular dusts. Ann. NY Acad. Sci. 2006; 1076: 266–280
  • Tran C. L., Buchanan R. T., Cullen R. T., Searl A., Jones A. D., Donaldson K. Inhalation of poorly soluble particles.II. Influence of particle surface area on inflammation and clearance. Inhal. Toxicol. 2000; 12: 1113–1126

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.