Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue 11
465
Views
70
CrossRef citations to date
0
Altmetric
Research Article

Mathematical Analysis of Particle Deposition in Human Lungs: An Improved Single Path Transport Model

&
Pages 925-939 | Received 26 Feb 2007, Accepted 19 May 2007, Published online: 06 Oct 2008

REFERENCES

  • Asgharian B., Hofmann W., Bergmann R. Particle deposition in a multi-path model of the human lung. Aerosol Sci. Technol. 2001; 34: 332–339
  • Beeckmans J. M. The deposition of aerosols in the respiratory tract: I. Mathematical analysis and comparison with experimental data. Can. J. Physiol. Pharmacol. 1965; 43: 157–172
  • Chan T. L., Lippmann M. Experimental measurements and empirical modeling of the regional deposition of inhaled particles in humans. Am. Ind. Hyg. Assoc. J. 1980; 41: 399–408
  • Cheng Y. S. Aerosol deposition in the extrathoracic region. Aerosol Sci. Technol. 2003; 37: 659–671
  • Darquenne C., Paiva M. One-dimensional simulation of aerosol transport and deposition in the human lung. J. Appl. Physiol. 1994; 77: 2889–2898
  • Edwards D. A. The macrotransport of aerosol particles in the lung: aerosol deposition phenomena. J. Aerosol Sci., 1995; 26: 293–317
  • Egan M. J., Nixon W. A model of aerosol deposition in the lung for use in inhalation dose assessments. Radiat. Protect. Dosim. 1985; 11: 15–17
  • Fuchs N. A. The mechanics of aerosols. Macmillan, New York 1964
  • Gerrity T. R., Lee P. S., Hass F. J., Marinelli A., Werner P., Lourenco R. V. Calculated deposition of inhaled particles in the airway generations of normal subjects. J. Appl. Physiol. 1979; 47: 867–873
  • Goo J., Kim C. S. Theoretical analysis of particle deposition in human lungs considering stochastic variations of airway morphology. J. Aerosol Sci. 2003; 34: 585–602
  • Heyder J., Armbruster L., Gebhart J., Grein E., Stahlhofen W. Total deposition of aerosol particles in the human respiratory tract for nose and mouth breathing. J. Aerosol Sci. 1975; 6: 311–328
  • Heyder J., Gebhart J., Rudolf G., Schiller C. F., Stahlhofen W. Deposition of particles in the human respiratory tract in the size range 0.005–15 μ m. J. Aerosol Sci. 1986; 17: 811–825
  • Hofmann W., Koblinger L. Monte-Carlo modeling of aerosol deposition in human lungs. Part II: Deposition fractions and their sensitivity to parameter variations. J. Aerosol Sci. 1990; 21: 675–688
  • Hughes J. M. B., Hoppin F. G., Mead J. Effect of lung inflation on bronchial length and diameter in excised lungs. J. Appl. Physiol. 1972; 32: 25–35
  • Ingham D. B. Diffusion of aerosols from a stream flowing through a cylindrical tube. J. Aerosol Sci. 1975; 6: 125–132
  • Jaques P. A., Kim C. S. Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women. Inhal. Toxicol. 2000; 12: 715–731
  • Kim C. S. Methods of calculating lung delivery and deposition of aerosol particles. Respir. Care 2000; 45: 695–711
  • Kim C. S., Brown L. K., Lewars G. G., Sackner M. A. Deposition of aerosol particles and flow resistance in mathematical and experimental airway models. J. Appl. Physiol. 1983; 55: 154–163
  • Kim C. S., Fisher D. M. Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Sci. Technol. 1999; 31: 198–220
  • Kim C. S., Hu S. C., Dewitt P., Gerrity T. R. Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. J. Appl. Physiol. 1996; 81: 2203–2213
  • Kim C. S., Hu S. C. Regional deposition of inhaled particles in human lungs: Comparison between men and women. J. Appl. Physiol. 1998; 84: 1834–1844
  • Kim C. S., Hu S. C. Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: Empirical equations for sex and breathing pattern. J. Appl. Physiol. 2006; 101: 401–412
  • Kim C. S., Iglesias A. J. Deposition of inhaled particles in bifurcating airway models: I. Inspiratory deposition. J. Aerosol Med. 1989; 2: 1–14
  • Kim C. S., Iglesias A. J., Garcia L. Deposition of inhaled particles in bifurcating airway models: II. Expiratory deposition. J. Aerosol Med. 1989; 2: 15–27
  • Kim C. S., Jaques P. A. Respiratory dose of inhaled ultrafine particles in healthy adults. Philos. Trans. R. Soc. Lond. A 2000; 358: 2693–2705
  • Kim C. S., Jaques P. A. Analysis of total respiratory deposition of inhaled ultrafine particles in adult subjects at various breathing patterns. Aerosol Sci. Technol. 2004; 38: 525–540
  • Landahl H. D. On the removal of air-borne droplets by the human respiratory tract: I. The lung. Bull. Math. Biophy. 1950; 12: 43–56
  • Martonen T. B. Mathematical model for the selective deposition of inhaled pharmaceuticals. J. Pharm. Sci. 1993; 82: 1191–1199
  • Patankar S. V. Numerical heat transfer and fluid flow. Hemisphere, New York 1980
  • Stahlhofen W., Gebhart J., Heyder J. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 1980; 41: 385–398
  • Stahlhofen W., Rudolf G., James A. C. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 1989; 2: 285–308
  • Taulbee D. B., Yu C. P. A theory of aerosol deposition in the human respiratory tract. J. Appl. Physiol. 1975; 38: 77–85
  • Thiagrajan V., Yu C. P. Sedimentation from aerosol flows in finite tubes in random orientation. J. Aerosol Sci. 1978; 9: 543–546
  • Ultman J. S. Gas transport in the conducting airways. Gas mixing and distribution in lung. Marcel Dekker, New York 1985; 63–136
  • Weibel E. R. Morphology of human lung. Academic Press, New York 1963
  • Yeh H., Schum G. M. Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 1980; 42: 461–480
  • Yu C. P. Exact analysis of aerosol deposition during steady breathing. Powder Technol. 1978; 21: 55–62

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.