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Inhalation Toxicology
International Forum for Respiratory Research
Volume 28, 2016 - Issue 8
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Research Article

Differential expression of pro-inflammatory and oxidative stress mediators induced by nitrogen dioxide and ozone in primary human bronchial epithelial cells

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Pages 374-382 | Received 10 Mar 2016, Accepted 28 Apr 2016, Published online: 20 May 2016

References

  • Ayyagari VN, Januszkiewicz A, Nath J. (2004). Pro-inflammatory responses of human bronchial epithelial cells to acute nitrogen dioxide exposure. Toxicology 197:149–64.
  • Ayyagari VN, Januszkiewicz A, Nath J. (2007). Effects of nitrogen dioxide on the expression of intercellular adhesion molecule-1, neutrophil adhesion, and cytotoxicity: studies in human bronchial epithelial cells. Inhal Toxicol 19:181–94.
  • Azari MR, Esmaeilzadeh M, Mehrabi Y, Salehpour S. (2011). Monitoring of occupational exposure of mild steel welders to ozone and nitrogen oxides. Tanaffos 10:54–9.
  • Ballinger CA, Cueto R, Squadrito G, et al. (2005). Antioxidant-mediated augmentation of ozone-induced membrane oxidation. Free Radic Biol Med 38:515–26.
  • Bauer RN, Muller L, Brighton LE, et al. (2015). Interaction with epithelial cells modifies airway macrophage response to ozone. Am J Respir Cell Mol Biol 52:285–94.
  • Bayram H, Sapsford RJ, Abdelaziz MM, Khair OA. (2001). Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients in vitro. J Allergy Clin Immunol 107:287–94.
  • Blomberg A, Krishna MT, Bocchino V, et al. (1997). The inflammatory effects of 2 ppm NO2 on the airways of healthy subjects. Am J Respir Crit Care Med 156:418–24.
  • Carbone U, Montuori P, Novi C, Triassi M. (2014). Respiratory function in power plant workers exposed to nitrogen dioxide. Occup Med (Lond) 64:644–6
  • Connor LM, Ballinger CA, Albrecht TB, Postlethwait EM. (2004). Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitro. Am J Physiol Lung Cell Mol Physiol 286:L1169–78.
  • Devalia JL, Campbell AM, Sapsford RJ, et al. (1993). Effect of nitrogen dioxide on synthesis of inflammatory cytokines expressed by human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol 9:271–8.
  • Devlin RB, Duncan KE, Jardim M, et al. (2012). Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects. Circulation 126:104–11.
  • Devlin RB, Horstman DP, Gerrity TR, et al. (1999). Inflammatory response in humans exposed to 2.0 ppm nitrogen dioxide. Inhal Toxicol 11:89–109.
  • Devlin RB, Mcdonnell WF, Becker S, et al. (1996). Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: a comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure. Toxicol Appl Pharmacol 138:176–85.
  • Devlin RB, Mcdonnell WF, Mann R, et al. (1991). Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol 4:72–81.
  • Devlin RB, Mckinnon KP, Noah T, et al. (1994). Ozone-induced release of cytokines and fibronectin by alveolar macrophages and airway epithelial cells. Am J Physiol 266:L612–19.
  • Gauderman WJ, Gilliland GF, Vora H, et al. (2002). Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med 166:76–84.
  • Hatch GE, Duncan KE, Diaz-Sanchez D, et al. (2014). Progress in assessing air pollutant risks from in vitro exposures: matching ozone dose and effect in human airway cells. Toxicol Sci 141:198–205.
  • Horstman DH, Folinsbee LJ, Ives PJ, et al. (1990). Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm . N Engl J Med 142:1158–63.
  • Jerrett M, Burnett RT, Pope CA, Ii, et al. (2009). Long-term ozone exposure and mortality. N Engl J Med 360:1085–95.
  • Johnston CJ, Oberdorster G, Finkelstein JN. (2001). Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures. Inhal Toxicol 13:689–702.
  • Johnston CJ, Reed CK, Avissar NE, et al. (2000). Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice. Inhal Toxicol 12:187–203.
  • Kleeberger SR, Zhang LY, Jakab GJ. (1997). Differential susceptibility to oxidant exposure in inbred strains of mice: Nitrogen dioxide versus ozone. Inhal Toxicol 9:601–21.
  • Koren HS, Devlin RB, Becker S, et al. (1991). Time-dependent changes of markers associated with inflammation in the lungs of humans exposed to ambient levels of ozone. Toxicol Pathol 19:406–11.
  • Krishna MT, Madden J, Teran LM, et al. (1998). Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. Eur Respir J 11:1294–300.
  • Lee K, Yanagisawa Y, Spengler JD, Nakai S. (1994). Carbon monoxide and nitrogen dioxide exposures in indoor ice skating rinks. J Sports Sci 12:279–83.
  • Li Z, Tighe RM, Feng F, et al. (2013). Genes of innate immunity and the biological response to inhaled ozone. J Biochem Mol Toxicol 27:3–16.
  • Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402–8.
  • Mcconnell R, Berhane K, Gilliland F, et al. (2002). Ozone induces a proinflammatory response in primary human bronchial epithelial cells through mitogen-activated protein kinase activation without nuclear factor-κB activation. Lancet 359:386–91.
  • Mccullough SD, Duncan KE, Swanton SM, et al. (2014). Ozone induces a proinflammatory response in primary human bronchial epithelial cells through mitogen-activated protein kinase activation without nuclear factor-kappaB activation. Am J Respir Cell Mol Biol 51:426–35.
  • Mcdonnell WF, Abbey DE, Nishino N, Lebowitz MD. (1999). Long-term ambient ozone concentration and the incidence of asthma in nonsmoking adults: the AHSMOG Study. Environ Res 80:110–21.
  • Mcdonnell WF, Kehrl HR, Abdul-Salaam S, et al. (1991). Respiratory response of humans exposed to low levels of ozone for 6.6 hours. Arch Environ Health 46:145–50.
  • Mckinnon KP, Madden MC, Noah TL, Devlin RB. (1993). In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line. Toxicol Appl Pharmacol 118:215–23.
  • Park JW, Taube C, Swasey C, et al. (2004). Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. Am J Respir Cell Mol Biol 30:830–6.
  • Pavelchak N, Church L, Roerig S, et al. (1999). Silo gas exposure in New York state following the dry growing season of 1995. Appl Occup Environ Hyg 14:34–8.
  • Pelham TW, Holt LE, Moss MA. (2002). Exposure to carbon monoxide and nitrogen dioxide in enclosed ice arenas. Occup Environ Med 59:224–33.
  • Persinger RL, Poynter ME, Ckless K, Janssen-Heininger YM. (2002). Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Mol Cell Biochem 234–5:71–80.
  • Peters JM, Avol E, Gauderman WJ, et al. (1999). A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med 159:768–75.
  • Postlethwait EM, Bidani A. (1994). Mechanisms of pulmonary NO2 absorption. Toxicology 89:217–37.
  • Rietjens IM, Poelen MC, Hempenius RA, et al. (1986). Toxicity of ozone and nitrogen dioxide to alveolar macrophages: comparative study revealing differences in their mechanism of toxic action. J Toxicol Environ Health 19:555–68.
  • Ross AJ, Dailey LA, Brighton LE, Devlin RB. (2007). Transcriptional profiling of mucociliary differentiation in human airway epithelial cells. Am J Respir Cell Mol Biol 37:169–85.
  • Rusznak C, Devalia JL, Sapsford RJ, Davies RJ. (1996). Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium. Eur Respir J 9:2298–305.
  • Ryter SW, Alam J, Choi AM. (2006). Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86:583–650.
  • Sandstrom T. (1995). Respiratory effects of air pollutants: experimental studies in humans. Eur Respir J 8:976–95.
  • Sunil VR, Patel-Vayas K, Shen J, et al. (2012). Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicol Appl Pharmacol 263:195–202.
  • Sunil VR, Vayas KN, Massa CB, et al. (2013). Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics. Toxicol Sci 133:309–19.
  • Takahashi Y, Takahashi S, Yoshimi T, et al. (1997). Increases in the mRNA levels of gamma-glutamyltransferase and heme oxygenase-1 in the rat lung after ozone exposure. Biochem Pharmacol 53:1061–4.
  • Tighe RM, Li Z, Potts EN, et al. (2011). Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J Immunol 187:4800–8.
  • Vagaggini B, Paggiaro PL, Giannini D, et al. (1996). Effect of short-term NO2 exposure on induced sputum in normal, asthmatic and COPD subjects. Eur Respir J 9:1852–7.
  • WHO. (2005). Air quality guidelines: global update [Online]. Available from: http://www.euro.who.int/__data/assets/pdf_file/0005/78638/E90038.pdf [Last accessed: 10 Feb 2015].
  • Wiegman CH, Li F, Clarke CJ, et al. (2014). A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model. Clin Sci (Lond) 126:425–40.

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