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Inhalation Toxicology
International Forum for Respiratory Research
Volume 29, 2017 - Issue 7
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Research Article

Pulmonary toxicity following acute coexposures to diesel particulate matter and α-quartz crystalline silica in the Sprague-Dawley rat

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Pages 322-339 | Received 20 Apr 2017, Accepted 26 Jul 2017, Published online: 01 Oct 2017

References

  • Abe S, Takizawa H, Sugawara I, Kudoh S. (2000). Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitro. Am J Respir Cell Mol Biol. 22:296–303.
  • Antonini JM, Van Dyke K, Ye Z, et al. (1994). Introduction of luminol-dependent chemiluminescence as a method to study silica inflammation in the tissue and phagocytic cells of rat lung. Environ Health Perspect. 102 Suppl 10:37–42.
  • Antonini JM, Yang HM, Ma JY, et al. (2000). Subchronic silica exposure enhances respiratory defense mechanisms and the pulmonary clearance of Listeria monocytogenes in rats. Inhal Toxicol. 12:1017–36.
  • API. (2014). Oil and natural gas stimulate American economic and job growth. Online: American Petroleum Institute; Available from: http://www.api.org/∼/media/Files/Policy/Jobs/Oil-Gas-Stimulate-Jobs-Economic-Growth/API-State-Vendor-Survey-Findings-Report.pdf.
  • Bayram H, Devalia JL, Sapsford RJ, et al. (1998). The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol. 18:441–8.
  • Beamer CA, Holian A. (2008). Silica suppresses toll-like receptor ligand-induced dendritic cell activation. FASEB J. 22:2053–63.
  • Beatty TK, Shimshack JP. (2011). School buses, diesel emissions, and respiratory health. J Health Econ. 30:987–99.
  • Beckett W, Abraham J, Becklake M, et al. (1997). Adverse effects of crystalline silica exposure. Am J Respir Crit Care Med. 155:8.
  • Beckwith R. (2011). Proppants: where in the world. J Petrol Technol. 63:36–41.
  • Blackford JA, Jr., Antonini JM, Castranova V, Dey RD. (1994). Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils. Am J Respir Cell Mol Biol. 11:426–31.
  • Brandt EB, Myers JMB, Acciani TH, et al. (2015). Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J Allergy Clin Immunol. 136:295–303.e7.
  • Brandt EB, Kovacic MB, Lee GB, et al. (2013). Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol. 132:1194–204.e2.
  • Breitenstein M, Esswein EJ, Snawder J. (2011). NIOSH field effort to assess chemical exposures in oil and gas workers: health hazards in hydraulic fracturing. Proceedings of the NIOSH Intramural Science Conference.
  • Brown B. (2012). Hydrofrac sand in Wisconsin. University of Wisconsin Extension - Monroe County: WGaNH Survey.
  • Burchiel SW, Lauer FT, McDonald JD, Reed MD. (2004). Systemic immunotoxicity in AJ mice following 6-month whole body inhalation exposure to diesel exhaust. Toxicol Appl Pharmacol. 196:337–45.
  • Cassel SL, Eisenbarth SC, Iyer SS, et al. (2008). The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA. 105:9035–40.
  • Castranova V, Bowman L, Reasor MJ, et al. (1985). The response of rat alveolar macrophages to chronic inhalation of coal dust and/or diesel exhaust. Environ Res. 36:405–19.
  • Castranova V, Jones T, Barger M, et al. (1990). Pulmonary responses of guinea pigs to consecutive exposures to cotton dust. In: Jacobs R, Wakelyn P, Domelsmith L, (eds). Proceedings of the 14th Cotton Dust Research Conference; National Cotton Council.
  • Castranova V, Ma JY, Yang HM, et al. (2001). Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection. Environ Health Perspect. 109 Suppl 4:609–12.
  • Castranova V, Vallyathan V. (2000). Silicosis and coal workers' pneumoconiosis. Environ Health Perspect. 108 Suppl 4:675–84.
  • CDHS. (2002). Diesel engine exhaust health hazard advisory. In: Health hazard advisory California Department of Public Health: hazard evaluation system and information service; p. 1–6.
  • Certificate of Analysis Standard Reference Material 2975. (2013). Diesel particulate matter (Industrial Forklift). 2013 ed. Gaithersburg, MD: National Institute of Standards and Technology, US Department of Commerce; p. 11.
  • Co DO, Hogan LH, Il-Kim S, Sandor M. (2004). T cell contributions to the different phases of granuloma formation. Immunol Lett. 92:135–42.
  • Costa D, Fubini B, Giamello E, Volante M. (1991). A novel type of active site at the surface of crystalline SiO2(a-quartz) and its possible impact on pathogenicity. Can J Chem. 69:1427–34.
  • Cowie RL. (1994). The epidemiology of tuberculosis in gold miners with silicosis. Am J Respir Crit Care Med. 150:1460–2.
  • Creutzenberg O, Hansen T, Ernst H, et al. (2008). Toxicity of a quartz with occluded surfaces in a 90-day intratracheal instillation study in rats. Inhal Toxicol. 20:995–1008.
  • Dalal NS, Shi XL, Vallyathan V. (1990). ESR spin trapping and cytotoxicity investigations of freshly fractured quartz: mechanism of acute silicosis. Free Radic Res Commun 9:259–66.
  • Dauber JH, Rossman MD, Pietra GG, et al. (1980). Experimental silicosis: morphologic and biochemical abnormalities produced by intratracheal instillation of quartz into guinea pig lungs. Am J Pathol. 101:595–612.
  • Deshazo R. (1982). Current concepts about the pathogenesis of silicosis and asbestosis. J. Allergy Clin Immunol. 70:41–9.
  • Diaz-Sanchez D, Garcia MP, Wang M, et al. (1999). Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa. J Allergy Clin Immunol. 104:1183–8.
  • Dostert C, Petrilli V, Van Bruggen R, et al. (2008). Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (New York, NY). 320:674–7.
  • Esswein EJ, Breitenstein M, Snawder J, et al. (2013). Occupational exposures to respirable crystalline silica during hydraulic fracturing. J Occup Environ Hyg. 10:347–56.
  • Fubini B, Hubbard A. (2003). Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med. 34:1507–16.
  • Garshick E, Laden F, Hart JE, et al. (2004). Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect. 12:1539–43.
  • Gasse P, Riteau N, Charron S, et al. (2009). Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med. 179:903–13.
  • Gauderman WJ, Avol E, Gilliland F, et al. (2004). The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 351:1057–67.
  • Ghio AJ, Jaskot RH, Hatch GE. (1994). Lung injury after silica instillation is associated with an accumulation of iron in rats. Am J Physiol. 267:L686–92.
  • Ghio AJ, Smith CB, Madden MC. (2012a). Diesel exhaust particles and airway inflammation. Curr Opin Pulm Med. 18:144–50.
  • Ghio AJ, Sobus JR, Pleil JD, Madden MC. (2012b). Controlled human exposures to diesel exhaust. Swiss Med Wkly. 142:w13597.
  • Gwinn MR, Leonard SS, Sargent LM, et al. (2009). The role of p53 in silica-induced cellular and molecular responses associated with carcinogenesis. J Toxicol Environ Health A. 72:1509–19.
  • Hart JE, Eisen EA, Laden F. (2012). Occupational diesel exhaust exposure as a risk factor for chronic obstructive pulmonary disease. Curr Opin Pulm Med. 18:151–4.
  • Heppleston AG. (1982). Silicotic fibrogenesis: a concept of pulmonary fibrosis. Ann Occup Hyg. 26:449–62.
  • Hesterberg TW, Long CM, Bunn WB, et al. (2009). Non-cancer health effects of diesel exhaust: a critical assessment of recent human and animal toxicological literature. Crit Rev Toxicol. 39:195–227.
  • Hnizdo E. (2003). Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence. Occup Environ Med. 60:237–43.
  • Huaux F, Louahed J, Hudspith B, et al. (1998). Role of interleukin-10 in the lung response to silica in mice. Am J Respir Cell Mol Biol. 18:51–9.
  • HSE. (2012). Control of diesel engine exhaust emissions in the workplace. In: HSG187. 3rd ed. London, UK: Crown Copyright. p. 1–21.
  • IARC. (2012). Online/lancet: World Health Organization: International Agency for Research on Cancer.
  • Ichinose T, Furuyama A, Sagai M. (1995). Biological effects of diesel exhaust particles (DEP). II. Acute toxicity of DEP introduced into lung by intratracheal instillation. Toxicology. 99:153–67.
  • ICRP. (1994). Human respiratory tract model for radiological protection: a report of a task group of the International Commission on Radiological Protection. Ann ICRP. 24:1–482.
  • Iyer R, Hamilton RF, Li L, Holian A. (1996). Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol. 141:84–92.
  • Joshi GN, Goetjen AM, Knecht DA. (2015). Silica particles cause NADPH oxidase-independent ROS generation and transient phagolysosomal leakage. Mol Biol Cell. 26:3150–64.
  • Jung EJ, Avliyakulov NK, Boontheung P, et al. (2007). Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis. Proteomics. 7:3906–18.
  • Kachuri L, Villeneuve PJ, Parent ME, et al. (2014). Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men. Int J Cancer. 135:138–48.
  • Kachuri L, Villeneuve PJ, Parent ME, et al. (2016). Workplace exposure to diesel and gasoline engine exhausts and the risk of colorectal cancer in Canadian men. Environ Health. 15:4.
  • Kajiwara T, Ogami A, Yamato H, et al. (2007). Effect of particle size of intratracheally instilled crystalline silica on pulmonary inflammation. J Occup Health. 49:88–94.
  • Kawasaki H. (2015). A mechanistic review of silica-induced inhalation toxicity. Inhal Toxicol. 27:363–77.
  • Kim BG, Lee PH, Lee SH, et al. (2016). Long-term effects of diesel exhaust particles on airway inflammation and remodeling in a mouse model. Allergy Asthma Immunol Res. 8:246–56.
  • Langley RJ, Kalra R, Mishra NC, et al. (2004). A biphasic response to silica: I. Immunostimulation is restricted to the early stage of silicosis in lewis rats. Am J Respir Cell Mol Biol. 30:823–9.
  • Le Vee M, Jouan E, Lecureur V, Fardel O. (2016). Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells. Toxicol Appl Pharmacol. 290:74–85.
  • Lee S, Suh GY, Ryter SW, Choi AM. (2016). Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease. Am J Respir Cell Mol Biol. 54:151–60.
  • Liao CM, Wu BC, Cheng YH, et al. (2015). Ceramics manufacturing contributes to ambient silica air pollution and burden of lung disease. Environ Sci Pollut Res Int. 22:15067–79.
  • Liu Y, Rong Y, Steenland K, et al. (2014). Long-term exposure to crystalline silica and risk of heart disease mortality. Epidemiology (Cambridge, Mass). 25:689–96.
  • Lucking AJ, Lundback M, Barath SL, et al. (2011). Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation. 23:1721–8.
  • Ma JY, Ma JK. (2002). The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymes. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 20:117–47.
  • Ma JY, Young SH, Mercer RR, et al. (2014). Interactive effects of cerium oxide and diesel exhaust nanoparticles on inducing pulmonary fibrosis. Toxicol Appl Pharmacol. 278:135–47.
  • Maciejewska A. (2014). Health effects of occupational exposure to crystalline silica in the light of current research results. Medycyna Pracy. 65:799–818.
  • Madden MC, Richards JH, Dailey LA, et al. (2000). Effect of ozone on diesel exhaust particle toxicity in rat lung. Toxicol Appl Pharmacol. 68:140–8.
  • Madl AK, Donovan EP, Gaffney SH, et al. (2008). State-of-the-science review of the occupational health hazards of crystalline silica in abrasive blasting operations and related requirements for respiratory protection. J Toxicol Environ Health B Crit Rev. 11:548–608.
  • Mauderly JL, Snipes MB, Barr EB, et al. (1994). Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: neoplastic and nonneoplastic lung lesions. Res Rep. 1994/10:1–75. discussion 77–97.
  • McCreanor J, Cullinan P, Nieuwenhuijsen MJ, et al. (2007). Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med. 57:2348–58.
  • McDonald JD, Zielinska B, Sagebiel JC, McDaniel MR. (2002). Characterization of fine particle material in ambient air and personal samples from an underground mine. Aerosol Sci Tech. 36:1033–44.
  • Mercer RR, Russell ML, Crapo JD. (1994). Alveolar septal structure in different species. J Appl Physiol. 77:1060–6.
  • Migliaccio CT, Hamilton RF, Jr, Holian A. (2005). Increase in a distinct pulmonary macrophage subset possessing an antigen-presenting cell phenotype and in vitro APC activity following silica exposure. Toxicol Appl Pharmacol. 205:168–76.
  • Mosser DM, Zhang X. (2008). Activation of murine macrophages. Curr Protoc Immunol. 83:14.2.1–14.2.8.
  • Mundandhara SD, Becker S, Madden MC. (2006). Effects of diesel exhaust particles on human alveolar macrophage ability to secrete inflammatory mediators in response to lipopolysaccharide. Toxicol In Vitro. 20:614–24.
  • Nightingale JA, Maggs R, Cullinan P, et al. (2000). Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med. 162:161–6.
  • Ohtoshi T, Takizawa H, Okazaki H, et al. (1998). Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J Allergy Clin Immunol. 101:778–85.
  • OSHA/MSHA. 2013. Diesel exhaust/diesel particulate matter. United States Department of Labor. Available from: https://www.osha.gov/dts/hazardalerts/diesel_exhaust_hazard_alert.html. [Last accessed: 07 Aug 2017].
  • Ovrevik J, Lag M, Schwarze P, Refsnes M. (2004). p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells. Toxicol Sci. 81:480–90.
  • OSHWiki Contributors. 2017. Workplace exposure to dusts and aerosols ? diesel exhaust [Internet]. OSHWiki; 2017 May 30, 15:01 UTC. Available from: https://oshwiki.eu/index.php?title=Workplace_exposure_to_dusts_and_aerosols_-_diesel_exhaust&oldid=247433. [Last accessed: 2 Aug 2017].
  • Pasula R, Britigan BE, Turner J, Martin WJ. 2nd. (2009). Airway delivery of silica increases susceptibility to mycobacterial infection in mice: potential role of repopulating macrophages. J Immunol. 182:7102–9.
  • Peeters PM, Eurlings IM, Perkins TN, et al. (2014). Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs. Part Fibre Toxicol. 11:58.
  • Pierdominici M, Maselli A, Cecchetti S, et al. (2014). Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function. Part Fibre Toxicol. 11:74.
  • Porter DW, Ye J, Ma J, et al. (2002). Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage. Inhal Toxicol. 14:349–67.
  • Prieditis H, Adamson IY. (1996). Alveolar macrophage kinetics and multinucleated giant cell formation after lung injury. J Leukoc Biol. 59:534–8.
  • Pronk A, Coble J, Stewart PA. (2009). Occupational exposure to diesel engine exhaust: a literature review. J Expo Sci Environ Epidemiol. 19:443–57.
  • Provoost S, Maes T, Willart MA, et al. (2010). Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells. J Immunol. 184:426–32.
  • QDNRM. (2014). Guidance note for management of diesel engine exhuast in metalliferous mines. In: QGN 21. 1st ed. Mining and Quarrying Safety and Health Act of 1999. Australia: Queensland Government; p. 1–26.
  • Riteau N, Gasse P, Fauconnier L, et al. (2010). Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med. 182:774–83.
  • Roberts RR, Mercer RR, Chapman RS, et al. (2012). Pulmonary toxicity, distribution, and clearance of intratracheally instilled silicon nanowires in rats. J Nanomater. 12:17.
  • Robertson S, Gray GA, Duffin R, et al. (2012). Diesel exhaust particulate induces pulmonary and systemic inflammation in rats without impairing endothelial function ex vivo or in vivo. Part Fibre Toxicol. 9:9.
  • Rocha-Parise M, Santos LM, Damoiseaux JG, et al. (2014). Lymphocyte activation in silica-exposed workers. Int J Hyg Environ Health. 17:586–91.
  • Sagai M, Furuyama A, Ichinose T. (1996). Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radic Biol Med. 21:199–209.
  • Sagai M, Saito H, Ichinose T, et al. (1993). Biological effects of diesel exhaust particles. I. in vitro production of superoxide and in vivo toxicity in mouse. Free Radic Biol Med. 14:37–47.
  • Sager TM, Wolfarth MW, Andrew M, et al. (2014). Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model. Nanotoxicology. 8:317–27.
  • Salvi S, Blomberg A, Rudell B, et al. (1999). Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med. 159:702–9.
  • Satpathy SR, Jala VR, Bodduluri SR, et al. (2015). Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth. Nat Commun. 6:7064.
  • Sellamuthu R, Umbright C, Li S, et al. (2011). Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. Inhal Toxicol. 223:927–37.
  • Sellamuthu R, Umbright C, Roberts JR, et al. (2013). Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. J Appl Toxicol. 33:301–12.
  • Sherson D, Lander F. (1990). Morbidity of pulmonary tuberculosis among silicotic and nonsilicotic foundry workers in Denmark. J Occup Med. 32:110–13.
  • Shi X, Mao Y, Danie LN, et al. (1995). Generation of reactive oxygen species by quartz particles and its implication for cellular damage. Appl Occup Environl Hyg. 10:1138–44.
  • Shoemaker DA, Pretty JR, Ramsey DM, et al. (1995). Particle activity and in vivo pulmonary response to freshly milled and aged alpha-quartz. Scand J Work Environ Health. 21 Suppl 2:15–18.
  • Siegel PD, Saxena RK, Saxena QB, et al. (2004). Effect of diesel exhaust particulate (DEP) on immune responses: contributions of particulate versus organic soluble components. J Toxicol Environ Health Part A. 67:221–31.
  • Singh P, DeMarini DM, Dick CA, et al. (2004). Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice. Environ Health Perspect. 112:820–5.
  • Steerenberg PA, Zonnenberg JA, Dormans JA, et al. (1998). Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp Lung Res. 24:85–100.
  • Sun B, Wang X, Ji Z, et al. (2015). NADPH oxidase-dependent NLRP3 inflammasome activation and its important role in lung fibrosis by multiwalled carbon nanotubes. Small. 11:2087–97.
  • SUVA DoOM. (2013). Grenzwerte am Arbeitsplatz. In: 1903d online: SUVA. p. 1–150. Database Name 2013. Lucerne, Switzerland: OSHwiki. Available from: https://oshwiki.eu/wiki/Workplace_exposure_to_dusts_and_aerosols_-_diesel_exhaust.
  • TERA. (2014). Occupational exposure limit evaluation: diesel particulate matter. 9 October 2014. Cincinnati, OH: Toxicology Excellence for Risk Assessment.
  • Tomaru M, Matsuoka M. (2011). The role of mitogen-activated protein kinases in crystalline silica-induced cyclooxygenase-2 expression in A549 human lung epithelial cells. Toxicol Mech Methods. 21:513–9.
  • Totlandsdal AI, Lag M, Lilleaas E, et al. (2015). Differential proinflammatory responses induced by diesel exhaust particles with contrasting PAH and metal content. Environ Toxicol. 30:188–96.
  • Underwood E. (1970). Quantitative stearology. Philippines: Addison-Wesley Publishing Company.
  • Vallyathan V, Castranova V, Pack D, et al. (1995). Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals. Am J Respir Crit Care Med. 152:1003–9.
  • Vallyathan V, Mega JF, Shi X, Dalal NS. (1992). Enhanced generation of free radicals from phagocytes induced by mineral dusts. Am J Respir Cell Mol Biol. 6:404–13.
  • Vattanasit U, Navasumrit P, Khadka MB, et al. (2014). Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles. Int J Hygiene Environ Health. 17:23–33.
  • Wong O, Morgan RW, Kheifets L, et al. (1985). Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. British journal of industrial. Medicine. 42:435–48.
  • Yang HM, Antonini JM, Barger MW, et al. (2001). Diesel exhaust particles suppress macrophage function and slow the pulmonary clearance of Listeria monocytogenes in rats. Environ Health Perspect. 109:515–21.
  • Yang HM, Barger MW, Castranova V, et al. (1999). Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage activity. J Toxicol Environ Health. 58:261–78.
  • Yassin A, Yebesi F, Tingle R. (2005). Occupational exposure to crystalline silica dust in the United States, 1988-2003. Environ Health Perspect. 113:255–60.
  • Yin XJ, Dong CC, Ma JY, et al. (2007). Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles. J Toxicol Environ Health A. 70:820–8.
  • Yin XJ, Schafer R, Ma JY, et al. (2002). Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). I. Effects of DEPs on early pulmonary responses. Environ Health Perspect. 110:1105–11.
  • Zhao H, Ma JK, Barger MW, et al. (2009). Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles. J Toxicol Environ Health Part A. 72:560–70.
  • Zhou F, Li S, Jia W, et al. (2015). Effects of diesel exhaust particles on microRNA-21 in human bronchial epithelial cells and potential carcinogenic mechanisms. Mol Med Rep. 12:2329–35.

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