The severity of lung injury and metabolic disorders induced by ambient PM_2.5 exposure is associated with cumulative dose

References

• Brauner EV, Forchhammer L, Moller P, et al. (2008). Indoor particles affect vascular function in the aged: an air filtration-based intervention study. Am J Respir Crit Care Med 177:419–25.
   PubMed Web of Science ®Google Scholar
• Cachon BF, Firmin S, Verdin A, et al. (2014). Proinflammatory effects and oxidative stress within human bronchial epithelial cells exposed to atmospheric particulate matter (PM(2.5) and PM(>2.5)) collected from Cotonou, Benin. Environ Pollut 185:340–51.
   PubMed Web of Science ®Google Scholar
• Chen R, Zhao A, Chen H, et al. (2015). Cardiopulmonary benefits of reducing indoor particles of outdoor origin: a randomized, double-blind crossover trial of air purifiers. J Am Coll Cardiol 65:2279–87.
   PubMedGoogle Scholar
• Choe SS, Huh JY, Hwang IJ, et al. (2016). Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front Endocrinol (Lausanne) 7:30.
   PubMed Web of Science ®Google Scholar
• de Hartog JJ, Ayres JG, Karakatsani A, et al. (2010). Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients. Occup Environ Med 67:2–10.
   PubMed Web of Science ®Google Scholar
• Du XH, Jiang S, Zeng XJ, et al. (2018). Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE-/- mice. Toxicology Letters 290:123–32. English.
   PubMed Web of Science ®Google Scholar
• Falcon-Rodriguez CI, Osornio-Vargas AR, Sada-Ovalle I, Segura-Medina P. (2016). Aeroparticles, Composition, and Lung Diseases. Front Immunol 7:3.
   PubMed Web of Science ®Google Scholar
• Hamra GB, Guha N, Cohen A, et al. (2014). Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ Health Perspect 122:906–11.
   PubMed Web of Science ®Google Scholar
• Hinton DM, Myers MJ, Raybourne RA, et al. (2003). Immunotoxicity of aflatoxin B1 in rats: effects on lymphocytes and the inflammatory response in a chronic intermittent dosing study. Toxicol Sci 73:362–77.
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature 444:860–7.
   PubMed Web of Science ®Google Scholar
• Jin Y, Wu W, Zhang W, et al. (2017). Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice. Environ Toxicol 32:1121–34.
   PubMed Web of Science ®Google Scholar
• Lai L, Ghebremariam YT. (2016). Modulating DDAH/NOS Pathway to discover vasoprotective insulin sensitizers. J Diabetes Res 2016:1982096.
   PubMedGoogle Scholar
• Lentsch AB, Czermak BJ, Bless NM, Ward PA. (1998). NF-kappaB activation during IgG immune complex-induced lung injury: requirements for TNF-alpha and IL-1beta but not complement. Am J Pathol 152:1327–36.
   PubMed Web of Science ®Google Scholar
• Li R, Kou X, Xie L, et al. (2015). Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats. Environ Sci Pollut Res Int 22:20167–76.
   PubMed Web of Science ®Google Scholar
• Liu C, Bai Y, Xu X, et al. (2014). Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Part Fibre Toxicol 11:27.
   PubMed Web of Science ®Google Scholar
• Liu C, Fonken LK, Wang A, et al. (2014). Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Part Fibre Toxicol 11:53.
   PubMed Web of Science ®Google Scholar
• Liu C, Xu X, Bai Y, et al. (2014). Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice. Environ Health Perspect 122:17–26.
   PubMed Web of Science ®Google Scholar
• Lumeng CN, Bodzin JL, Saltiel AR. (2007). Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175–84.
   PubMed Web of Science ®Google Scholar
• Luo B, Shi H, Wang L, et al. (2014). Rat lung response to PM2.5 exposure under different cold stresses. Int J Environ Res Public Health 11:12915–26.
   PubMed Web of Science ®Google Scholar
• MacNee W, Donaldson K. (2003). Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD. Eur Respir J Suppl 40:47s–51s.
   PubMedGoogle Scholar
• Michael S, Montag M, Dott W. (2013). Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter. Environ Pollut 183:19–29.
   PubMed Web of Science ®Google Scholar
• Mikrou A, Kalimeris KA, Lilis I, et al. (2016). Molecular studies of the immunological effects of the sevoflurane preconditioning in the liver and lung in a rat model of liver ischemia/reperfusion injury. Mol Immunol 72:1–8. English.
   PubMed Web of Science ®Google Scholar
• Osornio-Vargas AR, Serrano J, Rojas-Bracho L, et al. (2011). In vitro biological effects of airborne PM(2).(5) and PM(1)(0) from a semi-desert city on the Mexico-US border. Chemosphere 83:618–26.
   PubMed Web of Science ®Google Scholar
• Ouchi N, Parker JL, Lugus JJ, Walsh K. (2011). Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11:85–97.
   PubMed Web of Science ®Google Scholar
• Park HK, Cheng KC, Tetteh AO, et al. (2017). Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study. J Asthma 54:341–6.
   PubMed Web of Science ®Google Scholar
• Pun VC, Kazemiparkouhi F, Manjourides J, Suh HH. (2017). Long-Term PM2.5 exposure and respiratory, cancer, and cardiovascular mortality in older US adults. Am J Epidemiol 186:961–9.
   PubMed Web of Science ®Google Scholar
• Sese L, Nunes H, Cottin V, Sanyal S, et al. (2018). Role of atmospheric pollution on the natural history of idiopathic pulmonary fibrosis. Thorax. 73:145–150.
   PubMed Web of Science ®Google Scholar
• Shao D, Du Y, Liu S, et al. (2017). Cardiorespiratory responses of air filtration: A randomized crossover intervention trial in seniors living in Beijing: Beijing Indoor Air Purifier study, BIAPSY. Sci Total Environ 603-604:541–9.
   PubMed Web of Science ®Google Scholar
• Snow SJ, De Vizcaya-Ruiz A, Osornio-Vargas A, et al. (2014). The effect of composition, size, and solubility on acute pulmonary injury in rats following exposure to Mexico city ambient particulate matter samples. J Toxicol Environ Health A 77:1164–82.
   PubMed Web of Science ®Google Scholar
• Sun Q, Wang A, Jin X, et al. (2005). Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 294:3003–10.
   PubMed Web of Science ®Google Scholar
• Sun Q, Yue P, Deiuliis JA, et al. (2009). Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538–46.
   PubMed Web of Science ®Google Scholar
• Tsou CL, Peters W, Si Y, et al. (2007). Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117:902–9.
   PubMed Web of Science ®Google Scholar
• van der Lans AAJJ, Boon MR, Haks MC, et al. (2015). Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects. Physiol Rep 3:e12394. English.
   PubMed Web of Science ®Google Scholar
• Wang X, Jiang S, Liu Y, et al. (2017). Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats. Sci Total Environ 592:41–50.
   PubMed Web of Science ®Google Scholar
• Wang Y, Bao S, Wang S, et al. (2017). Local and regional contributions to fine particulate matter in Beijing during heavy haze episodes. Sci Total Environ 580:283–96.
   PubMed Web of Science ®Google Scholar
• Weichenthal S, Mallach G, Kulka R, et al. (2013). A randomized double-blind crossover study of indoor air filtration and acute changes in cardiorespiratory health in a First Nations community. Indoor Air 23:175–84.
   PubMed Web of Science ®Google Scholar
• Xing YF, Xu YH, Shi MH, Lian YX. (2016). The impact of PM2.5 on the human respiratory system. J Thorac Dis 8:E69–74.
   PubMed Web of Science ®Google Scholar
• Xu X, Liu C, Xu Z, et al. (2011). Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicol Sci 124:88–98.
   PubMed Web of Science ®Google Scholar
• Xu Z, Xu X, Zhong M, et al. (2011). Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues. Part Fibre Toxicol 8:20.
   PubMed Web of Science ®Google Scholar
• Zhang N, Han B, He F, et al. (2017). Chemical characteristic of PM2.5 emission and inhalational carcinogenic risk of domestic Chinese cooking. Environ Pollut 227:24–30.
   PubMed Web of Science ®Google Scholar