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Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 9-10
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Letters to the Editor

Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

H. J. Clewell IIIa Research Triangle Park, Ramboll US Corporation, Charlotte, North Carolina, USACorrespondence[email protected]
,
J. L. Campbella Research Triangle Park, Ramboll US Corporation, Charlotte, North Carolina, USA
,
C. Van Landinghamb Ramboll US Corporation, Monroe, Louisiana, USA
,
A. Franzenb Ramboll US Corporation, Monroe, Louisiana, USA
,
M. Yoonc ToxStrategies, Inc., Cary, North Carolina, USA
,
D. E. Doddd Research Triangle Park, The Hamner Institutes for Health Sciences, North Carolina, USA
,
M. E. Andersend Research Triangle Park, The Hamner Institutes for Health Sciences, North Carolina, USA
&
P. R. Gentryc ToxStrategies, Inc., Cary, North Carolina, USA
 show all
Pages 369-371 | Received 21 Aug 2020, Accepted 21 Aug 2020, Published online: 08 Sep 2020

References

  • Allen BC, Van Landingham C, Yang Y, Youk AO, Marsh GM, Esmen N, Gentry PR, Clewell HJ, III, Himmelstein MW. 2014. A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene. Regul Toxicol Pharmacol. 70(1):203–213.
  • Andersen ME, Clewell HJ, III, Gargas ML, Smith FA, Reitz RH. 1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol Appl Pharmacol. 87(2):185–205.
  • Haley T. 1978. Chloroprene (2-chloro-1, 3-butadiene)-what is the evidence for its carcinogenicity? Clin Toxicol. 13(2):153–170.
  • Himmelstein MW, Carpenter SC, Hinderliter PM. 2004. Kinetic modeling of beta-chloroprene metabolism: I. in vitro rates in liver and lung tissue fractions from mice, rats, hamsters, and humans. Toxicol Sci. 79(1):18–27.
  • Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM. 2004. Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. Toxicol Sci. 79(1):28–37.
  • Munter T, Cottrell L, Golding BT, Watson WP. 2003. Detoxication pathways involving glutathione and epoxide hydrolase in the in vitro metabolism of chloroprene. Chem Res Toxicol. 16(10):1287–1297.
  • Plugge H, Jaeger RJ. 1979. Acute inhalation toxicity of 2-chloro-1,3-butadiene (chloroprene): effects on liver and lung. Toxicol Appl Pharmacol. 50(3):565–572.
  • Sax SN, Gentry PR, Van Landingham CV, Clewell HJ, Mundt KA. 2020. Extended analysis and evidence integration of chloroprene as a human carcinogen. Risk Anal. 40(2):294–318.
  • USEPA. 2000. Vinyl chloride: CASRN 75-01-4. Washington (DC): United States Environmental Protection Agency.

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