Is individual genetic susceptibility a link between silica exposure and development or severity of silicosis? A systematic review

References

• Allen RJ, Guillen-Guio B, Oldham JM, Ma S-F, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, et al. 2020. Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 201(5):564–574.
   PubMed Web of Science ®Google Scholar
• Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM, Guillen-Guio B, Ma SF, Okamoto T, John AE, et al. 2017. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respir Med. 5(11):869–880.
   PubMed Web of Science ®Google Scholar
• Arcangeli G, Cupelli V, Giuliano G. 2001. Effects of silica on human lung fibroblast in culture. Sci Total Environ. 270(1–3):135–139.
   PubMed Web of Science ®Google Scholar
• Arranz M, Munro J, Osborne S, Collier D, Kerwin R. 2000. Difficulties in replication of results. Lancet. 356(9238):1359–1360.
   PubMed Web of Science ®Google Scholar
• Barboza CEG, Winter DH, Seiscento M, Santos U, de P, Terra Filho M. 2008. Tuberculose e silicose: epidemiologia, diagnóstico e quimioprofilaxia. J Bras Pneumol. 34(11):959–966.
   PubMedGoogle Scholar
• Barnes H, Goh NSL, Leong TL, Hoy R. 2019. Silica-associated lung disease: an old-world exposure in modern industries. Respirology. 24(12):1165–1175.
   PubMed Web of Science ®Google Scholar
• Bizzarri C, Beccari AR, Bertini R, Cavicchia MR, Giorgini S, Allegretti M. 2006. ELR + CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets. Pharmacol Ther. 112(1):139–149.
   PubMed Web of Science ®Google Scholar
• Borges VM, Falcão H, Leite-Júnior JH, Alvim L, Teixeira GP, Russo M, Nóbrega AF, Lopes MF, Rocco PM, Davidson WF, et al. 2001. FAS Ligand Triggers Pulmonary Silicosis. J Exp Med. 194(2):155–164.
   PubMed Web of Science ®Google Scholar
• Carnevale F, Baldasseroni A. 2005. A long-lasting pandemic: diseases caused by dust containing silica: Italy within the international context. Med Lav. 96(2):169–176.
   Google Scholar
• Castranova V. 2004. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species. Free Radic Biol Med. 37(7):916–925.
   PubMed Web of Science ®Google Scholar
• Chapman RW, Phillips JE, Hipkin RW, Curran AK, Lundell D, Fine JS. 2009. CXCR2 antagonists for the treatment of pulmonary disease. Pharmacol Ther. 121(1):55–68.
   PubMed Web of Science ®Google Scholar
• Cheepsattayakorn A, Cheepsattayakorn R. 2018. Silicosis: biomarkers and pathogenesis. J Lung, Pulm Respir Res. 5(5):151–153.
   Google Scholar
• Chen S, Shen Z, Liu Z, Gao L, Han Z, Yu S, Kang M. 2019. IL-1RA suppresses esophageal cancer cell growth by blocking IL-1α. J Clin Lab Anal. 33(6):e22903.
   PubMed Web of Science ®Google Scholar
• Chen Y, Chen J, Dong J, Liu W. 2005. Antifibrotic effect of interferon gamma in silicosis model of rat. Toxicol Lett. 155(3):353–360.
   PubMed Web of Science ®Google Scholar
• Chen Y, Fan XY, Jin YL, Yao SQ, Yun X, Hua ZB, Shen FH. 2014a. Association between polymorphisms of interleukin-17A and interleukin-17F genes and silicosis susceptibility in chinese han people. Asian Pacific J Cancer Prev. 15(20):8775–8778.
   PubMedGoogle Scholar
• Chen Y, Li C, Weng D, Song L, Tang W, Dai W, Yu Y, Liu F, Zhao M, Lu C, et al. 2014b. Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice. Toxicol Appl Pharmacol. 275(1):62–72.
   Web of Science ®Google Scholar
• Choi BG, Hong JY, Hong JR, Hur MS, Kim SM, Lee YW, Choe YB, Ahn KJ. 2019. The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population. Sci Rep. 9(1):18921.
   PubMedGoogle Scholar
• Chu M, Ji X, Chen W, Zhang R, Sun C, Wang T, Luo C, Gong J, Zhu M, Fan J, et al. 2014. A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese. Hum Mol Genet. 23(23):6385–6394.
   PubMed Web of Science ®Google Scholar
• Chu M, Wu S, Wang W, Yu Y, Zhang M, Sang L, Tian T, Lu Y, Yuan W, Huang Q, et al. 2019. Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case–control study. Occup Environ Med. 76(3):169–174.
   PubMed Web of Science ®Google Scholar
• Corbett EL, Mozzato-Chamay N, Butterworth AE, De Cock KM, Williams BG, Churchyard GJ, Conway DJ. 2002. Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners. Am J Respir Crit Care Med. 165(5):690–693.
   PubMed Web of Science ®Google Scholar
• Dai W, Liu F, Li C, Lu Y, Lu X, Du S, Chen Y, Weng D, Chen J. 2016. Blockade of Wnt/β -Catenin pathway aggravated silica-induced lung inflammation through tregs regulation on th immune responses. Mediators Inflamm. 2016:6235614–6235614.
   PubMed Web of Science ®Google Scholar
• Davis GS, Pfeiffer LM, Hemenway DR. 1999. Expansion of interferon-gamma-producing lung lymphocytes in mouse silicosis. Am J Respir Cell Mol Biol. 20(4):813–824.
   PubMed Web of Science ®Google Scholar
• Deiteren K, Hendriks D, Scharpé S, Lambeir AM. 2009. Carboxypeptidase M: multiple alliances and unknown partners. Clin Chim Acta. 399(1–2):24–39.
   PubMed Web of Science ®Google Scholar
• Deng CW, Zhang XX, Lin JH, Huang LF, Qu YL, Bai C. 2017. Association between genetic variants of transforming growth factor-β1 and susceptibility of pneumoconiosis: a meta-analysis. Chin Med J. 130(3):357–364.
   PubMed Web of Science ®Google Scholar
• Di Giuseppe M, Gambelli F, Hoyle GW, Lungarella G, Studer SM, Richards T, Yousem S, McCurry K, Dauber J, Kaminski N, et al. 2009. Systemic inhibition of NF-κB activation protects from silicosis. PLoS One. 4(5):e5689.
   PubMed Web of Science ®Google Scholar
• Fang GF, Fan XY, Shen FH. 2011. The relationship between polymorphisms of interleukin-4 gene and silicosis. Biomed Environ Sci. 24(6):678–682.
   PubMed Web of Science ®Google Scholar
• Farrar MA, Schreiber RD. 1993. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol. 11(1):571–611.
   PubMedGoogle Scholar
• Fernández Álvarez R, Martínez González C, Quero Martínez A, Blanco Pérez JJ, Carazo Fernández L, Prieto Fernández A. 2015. Guidelines for the diagnosis and monitoring of silicosis. Arch Bronconeumol. 51(2):86–93.
   PubMed Web of Science ®Google Scholar
• Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, et al. 2013. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 45(6):613–620.
   PubMed Web of Science ®Google Scholar
• Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. 2009. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 10(3):241–247.
   PubMed Web of Science ®Google Scholar
• Franklin BS, Mangan MS, Latz E. 2016. Crystal formation in inflammation. Annu Rev Immunol. 34(1):173–202.
   PubMedGoogle Scholar
• Goswami T, Bhattacharjee A, Babal P, Searle S, Moore E, Li M, Blackwell JM. 2001. Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter. Biochem J. 354(3):511–519.
   PubMedGoogle Scholar
• Greenberg MI, Waksman J, Curtis J. 2007. Silicosis: a review. Dis Mon. 53(8):394–416.
   PubMed Web of Science ®Google Scholar
• Gu C, Wu L, Li X. 2013. IL-17 family: cytokines, receptors and signaling. Cytokine. 64(2):477–485.
   PubMed Web of Science ®Google Scholar
• Guo J, Gu N, Chen J, Shi T, Zhou Y, Rong Y, Zhou T, Yang W, Cui X, Chen W. 2013. neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. Arch Toxicol. 87(11):1963–1973.
   PubMed Web of Science ®Google Scholar
• Hajeer A H, Hutchinson IV. 2000. TNF-alpha gene polymorphism: clinical and biological implications. Microsc Res Tech. 50(3):216–228.
   PubMed Web of Science ®Google Scholar
• Hassani E, Bagheri M, Rad IA, Mohebbi I. 2017. Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis. Toxicol Ind Health. 33(9):673–680.
   PubMed Web of Science ®Google Scholar
• Helmig S, Grossmann M, Wübbeling J, Schneider J. 2012. Interleukin gene polymorphisms in pneumoconiosis. Int J Mol Med. 30(2):401–408.
   PubMed Web of Science ®Google Scholar
• Herseth J, Refsnes M, Låg M, Hetland G, Schwarze P. 2008. IL-1beta as a determinant in silica-induced cytokine responses in monocyte-endothelial cell co-cultures. Hum Exp Toxicol. 27(5):387–399.
   PubMed Web of Science ®Google Scholar
• Holscher C. 2004. The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases. Med Microbiol Immunol. 193(1):1–17.
   PubMed Web of Science ®Google Scholar
• Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier J-P, Vink A, Phan SH, Renauld J-C, Lison D. 2002. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol. 169(5):2653–2661.
   PubMed Web of Science ®Google Scholar
• Huber O, Petersen I. 2015. 150th anniversary series: desmosomes and the hallmarks of cancer. Cell Commun Adhes. 22(1):15–28.
   PubMed Web of Science ®Google Scholar
• Jiang PR, Cao Z, Qiu ZL, Pan JW, Zhang N, Wu YF. 2015. Plasma levels of TNF-$α$and MMP-9 in patients with silicosis. Eur Rev Med Pharmacol Sci. 19(9):1716–1720.
   PubMed Web of Science ®Google Scholar
• Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZC, Cho MH, Castaldi PJ, et al. 2016. A chronic obstructive pulmonary disease susceptibility gene, FAM13A, regulates protein stability of β-catenin. Am J Respir Crit Care Med. 194(2):185–197.
   PubMed Web of Science ®Google Scholar
• Jiménez-Sousa MÁ, Medrano LM, Liu P, Almansa R, Fernández-Rodríguez A, Gómez-Sánchez E, Rico L, Heredia-Rodríguez M, Gómez-Pesquera E, Tamayo E, et al. 2017. IL-1B rs16944 polymorphism is related to septic shock and death. Eur J Clin Invest. 47(1):53–62.
   PubMed Web of Science ®Google Scholar
• Jin Z, Chung JW, Mei W, Strack S, He C, Lau GW, Yang J. 2015. Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. Mol Biol Cell. 26(6):1160–1173.
   PubMed Web of Science ®Google Scholar
• Jones JT, Qian X, van der Velden JLJ, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, et al. 2016. Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells. Redox Biol. 8:375–382.
   PubMed Web of Science ®Google Scholar
• Joshi AD, Fong DJ, Oak SR, Trujillo G, Flaherty KR, Martinez FJ, Hogaboam CM. 2009. Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis. Am J Respir Crit Care Med. 179(8):705–716.
   PubMed Web of Science ®Google Scholar
• Kawaguchi M, Takahashi D, Hizawa N, Suzuki S, Matsukura S, Kokubu F, Maeda Y, Fukui Y, Konno S, Huang SK, et al. 2006. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J Allergy Clin Immunol. 117(4):795–801.
   PubMed Web of Science ®Google Scholar
• Kawasaki H. 2015. A mechanistic review of silica-induced inhalation toxicity. Inhal Toxicol. 27(8):363–377.
   PubMed Web of Science ®Google Scholar
• Keane MP, Belperio JA, Moore TA, Moore BB, Arenberg DA, Smith RE, Burdick MD, Kunkel SL, Strieter RM. 1999. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. J Immunol. 162(9):5511–5518.
   PubMed Web of Science ®Google Scholar
• Kips JC, Tournoy KG, Pauwels RA. 2001. New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5. Eur Respir J. 17(3):499–506.
   PubMed Web of Science ®Google Scholar
• Kong SW, Lee I-H, Leshchiner I, Krier J, Kraft P, Rehm HL, Green RC, Kohane IS, MacRae CA. 2015. Summarizing polygenic risks for complex diseases in a clinical whole-genome report. Genet Med. 17(7):536–544.
   PubMed Web of Science ®Google Scholar
• Kroeger KM, Carville KS., Abraham LJ 1997. The -308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol Immunol. 34:391–399.
   PubMed Web of Science ®Google Scholar
• Kumar NM, Rabadi NH, Sigurdson LS, Schünemann HJ, Lwebuga-Mukasa JS. 1996. Induction of interleukin-1/and interleukin-8 mRNAs and proteins by TGFβ1 in rat lung alveolar epithelial cells. J Cell Physiol. 169(1):186–199.
   PubMed Web of Science ®Google Scholar
• Kurniawidj LM. 2014. Silicosis and its progress influenced by genetic variation on TNF-alpha locus- 308, TNF-alpha and IL-10 cytokine on cement factory workers in Indonesia. Pakistan J of Biolog Sci. 17(3):419–423.
   PubMedGoogle Scholar
• Leung CC, Yu ITS, Chen W. 2012. Silicosis. Lancet. 379(9830):2008–2018.
   PubMed Web of Science ®Google Scholar
• Li W, Kumar RK, O'Grady R, Velan GM. 1992. Role of lymphocytes in silicosis: regulation of secretion of macrophage-derived mitogenic activity for fibroblasts. Int J Exp Pathol. 73(6):793–800.
   PubMed Web of Science ®Google Scholar
• Li Z, Xue J, Yan S, Chen P, Chen L. 2013. Association between Tumor Necrosis Factor-??: 308G/A gene polymorphism and silicosis susceptibility: a meta-analysis. PLoS One. 8(10):e76614.
   PubMed Web of Science ®Google Scholar
• Little J, Higgins JPT, Ioannidis JPA, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, et al. 2009. STrengthening the REporting of Genetic Association Studies (STREGA)— an extension of the STROBE statement. PLoS Med. 6(2):e1000022.
   Web of Science ®Google Scholar
• Liu T, Li L, Fu C, Liu H, Chen D, Tang F. 2012. Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles. Biomaterials. 33(7):2399–2407.
   PubMed Web of Science ®Google Scholar
• Lopes-Pacheco M. 2012. Silicose: Mecanismos De Atuação Da Partícula De Sílica No Tecido Pulmonar. Início Arquivos. 4:36–43.
   Google Scholar
• Mariani TJ, Roby JD, Mecham RP, Parks WC, Crouch E, Pierce RA. 1996. Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-β as a mediator of fibrosis. Am J Pathol. 148(1):151–164.
   PubMed Web of Science ®Google Scholar
• Mathai SK, Pedersen BS, Smith K, Russell P, Schwarz MI, Brown KK, Steele MP, Loyd JE, Crapo JD, Silverman EK, et al. 2016. Desmoplakin variants are associated with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 193(10):1151–1160.
   PubMed Web of Science ®Google Scholar
• McCanlies E, Landsittel DP, Yucesoy B, Vallyathan V, Luster ML, Sharp DS. 2002. Significance of genetic information in risk assessment and individual classification using silicosis as a case model. Ann Occup Hyg. 46(4):375–381.
   PubMed Web of Science ®Google Scholar
• Menezes Fsnrhb da RG, Neves G. d CG, Menezes JG. 2010. O mapa de exposição à sílica no Brasil. Ministério da Saúde. 1–94. Available from: http://bvsms.saude.gov.br/bvs/publicacoes/mapa_exposicao_silica_brasil.pdf
   Google Scholar
• Mohebbi I, Abdi Rad I, Bagheri M. 2010. Association of angiotensin-1-converting enzyme gene variations with silicosis predisposition. Inhal Toxicol. 22(13):1110–1115.
   PubMed Web of Science ®Google Scholar
• Mohebbi I, Rad IA, Bagheri M. 2013. Interleukin-18, interleukin-8, and CXCR2 and the risk of silicosis. Toxicol Ind Health. 29(9):830–837.
   PubMed Web of Science ®Google Scholar
• Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, et al. 2019. Resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 200(2):199–208.
   PubMed Web of Science ®Google Scholar
• Morrison C, Davey G. 2009. Assessment of respiratory function in patients with podoconiosis. Trans R Soc Trop Med Hyg. 103(3):315–317.
   PubMed Web of Science ®Google Scholar
• Mossman BT, Churg A. 1998. Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med. 157(5 Pt 1):1666–1680.
   PubMed Web of Science ®Google Scholar
• Mozzato-Chamay N, Corbett EL, Bailey RL, Mabey DC, Raynes J, Conway DJ. 2001. Polymorphisms in the IkappaB-alpha promoter region and risk of diseases involving inflammation and fibrosis. Genes Immun. 2(3):153–155.
   PubMed Web of Science ®Google Scholar
• Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, Taniguchi H, Kubo M, Kamatani N, Nakamura Y. 2008. A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet. 45(10):654–656.
   PubMed Web of Science ®Google Scholar
• Nardi J, Nascimento S, Göethel G, Gauer B, Sauer E, Fão N, Cestonaro L, Peruzzi C, Souza J, Garcia SC. 2018. Inflammatory and oxidative stress parameters as potential early biomarkers for silicosis. Clin Chim Acta. 484:305–313.
   PubMed Web of Science ®Google Scholar
• Noth I, Zhang Y, Ma S-F, Flores C, Barber M, Huang Y, Broderick SM, Wade MS, Hysi P, Scuirba J, et al. 2013. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med. 1(4):309–317.
   PubMed Web of Science ®Google Scholar
• Ohtsuka Y, Wang X-T, Saito J, Ishida T, Munakata M. 2006. Genetic linkage analysis of pulmonary fibrotic response to silica in mice. Eur Respir J. 28(5):1013–1019.
   PubMed Web of Science ®Google Scholar
• Ortiz LA, DuTreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG. 2007. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA. 104(26):11002–11007.
   PubMed Web of Science ®Google Scholar
• Paul WE. 2015. History of interleukin-4. Cytokine. 75(1):3–7.
   PubMed Web of Science ®Google Scholar
• Pavlick KP, Laroux FS, Fuseler J, Wolf RE, Gray L, Hoffman J, Grisham MB. 2002. Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease. Free Radic Biol Med. 33(3):311–322.
   PubMed Web of Science ®Google Scholar
• Piguet PF, Vesin C, Grau GE, Thompson RC. 1993. Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine. 5(1):57–61.
   PubMed Web of Science ®Google Scholar
• Pridgeon C, Bugeon L, Donnelly L, Straschil U, Tudhope SJ, Fenwick P, Lamb JR, Barnes PJ, Dallman MJ. 2011. Regulation of IL-17 in chronic inflammation in the human lung. Clin Sci. 120(12):515–524.
   PubMed Web of Science ®Google Scholar
• Qu Y, Tang Y, Cao D, Wu F, Liu J, Lu G, Zhang Z, Xia Z. 2007. Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners. Int J Hyg Environ Health. 210(6):679–689.
   PubMed Web of Science ®Google Scholar
• Rabolli V, Badissi AA, Devosse R, Uwambayinema F, Yakoub Y, Palmai-Pallag M, Lebrun A, De Gussem V, Couillin I, Ryffel B, et al. 2014. The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles. Part Fibre Toxicol. 11(1):69.
   PubMedGoogle Scholar
• Rad IA, Mohebbi I, Bagheri M. 2012. Molecular Evaluation of the IFN γ +874, TNF α -308, and IL-1Ra VNTR Sequences in Silicosis. Maedica. 7(1):20–24.
   PubMedGoogle Scholar
• Reséndiz-Hernandez JM, Falfan-Valencia R. 2018. Genetic polymorphisms and their involvement in the regulation of the inflammatory response in asthma and COPD. Adv Clin Exp Med. 27(1):125–133.
   PubMed Web of Science ®Google Scholar
• Roney N, Faroon O, Williams M, Jones DG, Klotzbach JM, Kawa M, Zaccaria K. 2019. Toxicological profile for silica.
   Google Scholar
• Salum KCR, Castro MCS, Moreira VB, Nani ASF, Kohlrausch FB. 2020. Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects. Am J Ind Med. 63(1):74–84.
   PubMed Web of Science ®Google Scholar
• Schroder K, Hertzog PJ, Ravasi T, Hume DA. 2004. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 75(2):163–189.
   PubMed Web of Science ®Google Scholar
• Sharma N, Kundu D, Dhaked S, Das A. 2016. Silicosis and silicotuberculosis in India. Bull World Health Organ. 94(10):777–778.
   PubMed Web of Science ®Google Scholar
• Shiraishi Y, Kimura A, Kimura H, Ohmori T, Takahashi M, Takeshita K. 2020. Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice. J Orthop Sci. S0949-2658(20)30124-X. DOI:10.1016/j.jos.2020.04.006
   Google Scholar
• Song L, Weng D, Dai W, Tang W, Chen S, Li C, Chen Y, Liu F, Chen J. 2014. Th17 can regulate silica-induced lung inflammation through an IL-1β-dependent mechanism. J Cell Mol Med. 18(9):1773–1784.
   PubMed Web of Science ®Google Scholar
• Srivastava KD, Rom WN, Jagirdar J, Yie T-A, Gordon T, Tchou-Wong K-M. 2002. Crucial Role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice. Am J Respir Crit Care Med. 165(4):527–533.
   PubMed Web of Science ®Google Scholar
• Stanilova S, Miteva L, Prakova G. 2007. Interleukin-12B-3′UTR polymorphism in association with IL-12p40 and IL-12p70 serum levels and silicosis severity. Int J Immunogenet. 34(3):193–199.
   PubMed Web of Science ®Google Scholar
• Stanilova S, Miteva L, Prakova G. 2008. IL-12Bpro and GSTP1 polymorphisms in association with silicosis. Tissue Antigens. 71(2):169–174.
   PubMed Web of Science ®Google Scholar
• Stranger BE, Stahl EA, Raj T. 2011. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics. 187(2):367–383.
   PubMed Web of Science ®Google Scholar
• Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F. 1992. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 51(1):197–205.
   PubMed Web of Science ®Google Scholar
• Umare VD, Pradhan VD, Rajadhyaksha AG, Patwardhan MM, Ghosh K, Nadkarni AH. 2017. Impact of TNF-α and LTα gene polymorphisms on genetic susceptibility in Indian SLE patients. Hum Immunol. 78(2):201–208.
   PubMed Web of Science ®Google Scholar
• Vanhee D, Gosset P, Boitelle A, Wallaert B, Tonnel AB. 1995. Cytokines and cytokine network in silicosis and coal workers’ pneumoconiosis. Eur Respir J. 8(5):834–842.
   PubMed Web of Science ®Google Scholar
• Vanhee D, Gosset P, Wallaert B, Voisin C, Tonnel AB. 1994. Mechanisms of fibrosis in coal workers ’ pneumoconiosis increased production of platelet-derived growth factor. Insulin-like growth factor type I, and transforming growth factor ∼ and relationship to disease severity. Comparat Study. 150(4):1049–1055.
   Google Scholar
• Wagner GR. 1997. Asbestosis and silicosis. Lancet. 349(9061):1311–1315.
   PubMed Web of Science ®Google Scholar
• Wang T, Secombes CJ. 2015. The evolution of IL-4 and IL-13 and their receptor subunits. Cytokine. 75(1):8–13.
   PubMed Web of Science ®Google Scholar
• Wang T, Yang J, Ji X, Chu M, Zhang R, Dai J, Jin G, Hu Z, Shen H, Ni C. 2015. Pathway analysis for a genome-wide association study of pneumoconiosis. Toxicol Lett. 232(1):284–292.
   PubMed Web of Science ®Google Scholar
• Wang T, Li Y, Zhu M, Yao W, Wu H, Ji X, Hu Z, Shen H, Fan X, Ni C. 2018a. Association analysis identifies new risk loci for coal workers’ pneumoconiosis in Han Chinese Men. Toxicol Sci. 163(1):206–213.
   PubMed Web of Science ®Google Scholar
• Wang W, Yu Y, Wu S, Sang L, Wang X, Qiu A, Yu X, Li J, Zhang L, Yi M, et al. 2018b. The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population. Gene. 661:196–201.
   PubMed Web of Science ®Google Scholar
• Wang W, Yu Y, Xiao J, Gao Y, Sang L, Lian Y, Lu Y, Tian T, Zhuang X, Han L, et al. 2018c. A Novel variant of desmoplakin is potentially associated with silicosis risk. DNA Cell Biol. 37(11):925–931.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wu B, Zhang M, Miao H, Sun J. 2020. Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis. BMC Cardiovasc Disord. 20(1):278.
   PubMed Web of Science ®Google Scholar
• Wang YW, Lan JY, Yang LY, Wang De J, Kuang J. 2012. TNF-α and IL-1RA polymorphisms and silicosis susceptibility in Chinese workers exposed to silica particles: a case-control study. Biomed Environ Sci. 25(5):517–525.
   PubMed Web of Science ®Google Scholar
• Weng S, Wang L, Rong Y, Liu Y, Wang X, Guan H, Chen W. 2015. Effects of the interactions between dust exposure and genetic polymorphisms in Nalp3, Caspase-1, and IL-1$β$on the risk of silicosis: a case-control study. PLoS One. 10(10):e0140952.
   PubMed Web of Science ®Google Scholar
• Williams AO, Flanders KC, Saffiotti U. 1993. Immunohistochemical localization of transforming growth factor-β1in rats with experimental silicosis, alveolar type II hyperplasia, and lung cancer. Am J Pathol. 142(6):1831–1840.
   PubMed Web of Science ®Google Scholar
• Williams AO, Saffiotti U. 1995. Transforming growth factor β1, ras and p53 in silica-induced fibrogenesis and carcinogenesis. Scand J Work Environ Health. 21(2):30–34.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2007. The global occupational health network. Gohnet Newsl. 1–32. Available from: https://www.who.int/occupational_health/publications/newsletter/en/
   Google Scholar
• Wu F, Qu Y, Tang Y, Cao D, Sun P, Xia Z. 2008a. Lack of association between cytokine gene polymorphisms and silicosis and pulmonary tuberculosis in Chinese iron miners. J Occup Health. 50(6):445–454.
   PubMed Web of Science ®Google Scholar
• Wu F, Xia Z, Qu Y, Tang Y, Cao D, Sun P, Christiani DC. 2008b. Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. Am J Ind Med. 51(11):843–851.
   PubMed Web of Science ®Google Scholar
• Wu M-F, Shu C-C, Wang J-Y, Yan B-S, Lai H-C, Chiang B-L, Wu LS-H, Yu C-J. 2019. NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1β response and host susceptibility. Sci Rep. 9(1):12534.
   PubMedGoogle Scholar
• Yang L, Liu X, Wu G, Chen L. 2018. Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population. Inhal Toxicol. 30(6):213–217.
   PubMed Web of Science ®Google Scholar
• Yucesoy B, Johnson VJ, Kissling GE, Fluharty K, Kashon ML, Slaven J, Germolec D, Vallyathan V, Luster MI. 2008. Genetic susceptibility to progressive massive fibrosis in coal miners. Eur Respir J. 31(6):1177–1182.
   PubMed Web of Science ®Google Scholar
• Yucesoy B, Vallyathan V, Landsittel DP, Sharp DS, Matheson J, Burleson F, Luster MI. 2001a. Polymorphisms of the IL-1 gene complex in coal miners with silicosis. Am J Ind Med. 39(3):286–291.
   PubMed Web of Science ®Google Scholar
• Yucesoy B, Vallyathan V, Landsittel DP, Sharp DS, Weston A, Burleson GR, Simeonova P, McKinstry M, Luster MI. 2001b. Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. Toxicol Appl Pharmacol. 172(1):75–82.
   PubMed Web of Science ®Google Scholar
• Zhang M, Peng L-L, Ji X-L, Yang H-B, Zha R-S, Gui G-P. 2019. Tumor necrosis factor gene polymorphisms are associated with silicosis: a systemic review and meta-analysis. Biosci Rep. 39(2):BSR20181896.
   Google Scholar
• Zhao M-M, Cui J-Z, Cui Y, Li R, Tian Y-X, Song S-X, Zhang J, Gao J-L. 2013. Therapeutic effect of exogenous bone marrow-derived mesenchymal stem cell transplantation on silicosis via paracrine mechanisms in rats. Mol Med Rep. 8(3):741–746.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Kang Y, Zhang Z, Liu J. 2014. IL-1RA +2018 polymorphism and the susceptivity to pneumoconiosis: a meta-analysis. Int J Clin Exp. Med. 7(8):2204–2208.
   Google Scholar
• Ziskind M, Jones RN, Weill H. 1976. Silicosis. Am Rev Respir Dis. 113(5):643–665.
   PubMedGoogle Scholar