Development of a non-target strategy for evaluation of potential biological effects of inhalable aerosols generated during purposeful room conditioning using an in vitro inhalation model

References

• Asgharian B, Hofmann W, Bergmann R. 2001. Particle deposition in a multiple-path model of the human lung. Aerosol Sci Technol. 34(4):332–339. doi: 10.1080/02786820151092478.
   Web of Science ®Google Scholar
• Baron PA, Willeke K. 2001. Aerosol measurement: principles, techniques, and applications. 2nd ed. Hoboken (NJ): John Wiley and Sons.
   Google Scholar
• Bedner E, Li X, Gorczyca W, Melamed MR, Darzynkiewicz Z. 1999. Analysis of apoptosis by laser scanning cytometry. Cytometry. 35(3):181–195. doi: 10.1002/(sici)1097-0320(19990301)35:3 < 181::aid-cyto1 > 3.0.co;2-5.
   PubMedGoogle Scholar
• Berridge MV, Herst PM, Tan AS. 2005. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotchnol Annu Rev. 11:127–152. doi: 10.1016/S1387-2656(05)11004-7.
   PubMedGoogle Scholar
• Bukowy‑Bieryłło Z. 2021. Long‑term differentiating primary human airway epithelial cell cultures: how far are we? Cell Commun Signal. 19:63. doi: 10.1186/s12964-021-00740-z.
   PubMed Web of Science ®Google Scholar
• Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C. 1993. A new method for the cytofluorometric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1). Biochem Biophys Res Commun. 197(1):40–45. doi: 10.1006/bbrc.1993.2438.
   PubMed Web of Science ®Google Scholar
• DIN 38409-18:1981-02. 1981. German standard methods for the analysis of water. Waste water and sludge; Summary action and material characteristic parameters (Group H); Determination of hydrocarbons (H 18).
   Google Scholar
• Di Ianni E, Erdem JS, Møller P, Mønster Sahlgren N, Poulsen SS, Knudsen KB, Zienolddiny S, Saber AT, Wallin H, Vogel U, et al. 2021. In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT. Part Fibre Toxicol. 18(1):25. doi: 10.1186/s12989-021-00413-2.
   PubMed Web of Science ®Google Scholar
• Dreier DA, Denslow ND, Martyniuk CJ. 2019. Computational in vitro toxicology uncovers chemical structures impairing mitochondrial membrane potential. J Chem Inf Model. 59(2):702–712. doi: 10.1021/acs.jcim.8b00433.
   PubMed Web of Science ®Google Scholar
• Dwivedi AM, Upadhyay S, Johanson G, Ernstgård L, Palmberg L. 2018. Inflammatory effects of acrolein, crotonaldehyde and hexanal vapors on human primary bronchial epithelial cells cultured at air-liquid interface. Toxicol in Vitro. 46:219–228. doi: 10.1016/j.tiv.2017.09.016.
   PubMed Web of Science ®Google Scholar
• FDA. 2022. Generally Recognized as Safe (GRAS). [last assessed 2022 Apr 28]. https://www.fda.gov/food/food-ingredients-packaging/generally-recognized-safe-gras.
   Google Scholar
• Gindele JA, Kiechle T, Benediktus K, Birk G, Brendel M, Heinemann F, Wohnhaas CT, LeBlanc M, Zhang H, Strulovici-Barel Y, et al. 2020. Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture. Sci Rep. 10(1):6257. doi: 10.1038/s41598-020-63345-5.
   PubMed Web of Science ®Google Scholar
• Grundström G, Borrebaeck CA. 2019. Skin sensitization testing—what’s next? Int J Mol Sci. 20(3):666. doi: 10.3390/ijms20030666.
   PubMedGoogle Scholar
• Hartung T. 2018. Perspectives on in vitro to in vivo extrapolations. Appl In Vitro Toxicol. 4(4):305–316. doi: 10.1089/aivt.2016.0026.
   PubMedGoogle Scholar
• Guan X, Peng J-R, Yuan L, Wang H, Wei Y-H, Leng X-S. 2004. A novel, rapid strategy to form dendritomas from human dendritic cells and hepatocellular carcinoma cell line HCCLM3 cells using mature dendritic cells derived from human peripheral blood CD14+ monocytes within 48 hours of in vitro culture. World J Gastroenterol. 10(24):3564–3568. doi: 10.3748/wjg.v10.i24.3564.
   PubMed Web of Science ®Google Scholar
• Guertler A, Kraemer A, Roessler U, Hornhardt S, Kulka U, Moertl S, Friedl AA, Illig T, Wichmann E, Gomolka M. 2011. The WST survival assay: an easy and reliable method to screen radiation-sensitive individuals. Radiat Prot Dosimetry. 143(2–4):487–490. doi: 10.1093/rpd/ncq515.
   PubMed Web of Science ®Google Scholar
• Hallagan JB, Hall RL, Drake J. 2020. The GRAS provision - the FEMA GRAS program and the safety and regulation of flavors in the United States. Food Chem Toxicol. 138:111236. doi: 10.1016/j.fct.2020.111236.
   PubMed Web of Science ®Google Scholar
• Kamal A, Nayak VL, Bagul C, Vishnuvardhan MVPS, Mallareddy A. 2015. Investigation of the mechanism and apoptotic pathway induced by 4b cinnamido linked podophyllotoxins against human lung cancer cells A549. Apoptosis. 20(11):1518–1529. doi: 10.1007/s10495-015-1173-6.
   PubMed Web of Science ®Google Scholar
• Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G. 1976. A continuous tumor cell-line from a human lung carcinoma with properties of type-II alveolar epithelial cells. Int J Cancer. 17(1):62–70. doi: 10.1002/ijc.2910170110.
   PubMed Web of Science ®Google Scholar
• Ligasová A, Koberna K. 2021. DNA dyes—highly sensitive reporters of cell quantification: comparison with other cell quantification methods. Molecules. 26(18):5515. doi: 10.3390/molecules26185515.
   PubMed Web of Science ®Google Scholar
• Lim SK, Yoo J, Kim H, Lim YM, Kim W, Shim I, Kim HR, Kim P, Eom IC. 2021. Prediction of acute inhalation toxicity using cytotoxicity data from human lung epithelial cell lines. J Appl Toxicol. 41(7):1038–1049. doi: 10.1002/jat.4090. Epub 2020 Oct 21. PMID: 33085125.
   Google Scholar
• Lou J, Wang W, Lu H, Wang L, Zhu L. 2021. Increased disinfection byproducts in the air resulting from intensified disinfection during the COVID-19 pandemic. J Hazard Mater. 418:126249. doi: 10.1016/j.jhazmat.2021.126249.
   PubMed Web of Science ®Google Scholar
• Majtnerova P, Capek J, Petira F, Handl J, Rousar T. 2021. Quantitative spectrofluorometric assay detecting nuclear condensation and fragmentation in intact cells. Sci Rep. 11(1):11921. doi: 10.1038/s41598-021-91380-3.
   PubMed Web of Science ®Google Scholar
• Malmborg A, Borrebaeck CAK. 2017. Testing human skin and respiratory sensitizers—what is good enough? Int J Mol Sci. 18(2):241. doi: 10.3390/ijms18020241.
   PubMed Web of Science ®Google Scholar
• Mennecier G, Torres LN, Cogliati B, Sanches DS, Mori CM, Latorre AO, Chaible LM, Mackowiak II, Nagamine MK, Da Silva TC, et al. 2014. Chronic exposure of lung alveolar epithelial type II cells to tobacco-specific carcinogen NNK results in malignant transformation: a new in vitro lung carcinogenesis model. Mol Carcinog. 53(5):392–402. doi: 10.1002/mc.21987.
   PubMed Web of Science ®Google Scholar
• Nardone LL, Andrews SB. 1979. Cell line A549 as a model of the type II pneumocyte. Biochim Biophys Acta. 573(2):276–295. doi: 10.1016/0005-2760(79)90061-4.
   PubMedGoogle Scholar
• Person RJ, Tokar EJ, Xu Y, Orihuela R, Olive Ngalame NN, Waalkes MP. 2013. Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells. Toxicol Appl Pharmacol. 273(2):281–288. doi: 10.1016/j.taap.2013.06.013.
   PubMed Web of Science ®Google Scholar
• Ritter D, Bitsch A, Elend M, Schuchardt S, Hansen T, Brodbeck C, Knebel J, Fuchs A, Gronewold C, Fautz R. 2018. Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process. Appl In Vitro Toxicol. 4(2):180–192. doi: 10.1089/aivt.2017.0036.
   Google Scholar
• Ritter D, Knebel J. 2014. Investigations of the biological effects of airborne and inhalable substances by cell-based in vitro methods: fundamental improvements to the ALI concept. Advances in Toxicology Volume. 2014:1–11. Article ID doi: 10.1155/2014/185201.
   Google Scholar
• Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. 1997. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 411(1):77–82. doi: 10.1016/s0014-5793(97)00669-8.
   PubMed Web of Science ®Google Scholar
• Schmid O, Cassee FR. 2017. On the pivotal role of dose for particle toxicology and risk assessment: exposure is a poor surrogate for delivered dose. Part Fibre Toxicol. 14(1):52. doi: 10.1186/s12989-017-0233-1.
   PubMedGoogle Scholar
• Selo MA, Sake JA, Kim K-J, Ehrhardt C. 2021. In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives. Adv Drug Deliv Rev. 177:113862. doi: 10.1016/j.addr.2021.113862.
   PubMed Web of Science ®Google Scholar
• Slater TF, Sawyer B, Straeuli U. 1963. Studies on succinate-tetrazolium reductase systems. III. Points of coupling of four different tetrazolium salts. Biochim Biophys Acta. 77:383–393. doi: 10.1016/0006-3002(63)90513-4.
   PubMed Web of Science ®Google Scholar
• Srivastava S, Zhao X, Manay A A, Chen Q. 2021. Effective ventilation and air disinfection system for reducing coronavirus disease 2019 (COVID-19) infection risk in office buildings. Sustain Cities Soc. 75:103408. doi: 10.1016/j.scs.2021.103408.
   PubMed Web of Science ®Google Scholar
• Stockert JC, Horobin RW, Colombo LL, Blázquez-Castro A. 2018. Tetrazolium salts and formazan products in cell biology: viability assessment, fluorescence imaging, and labeling perspectives. Acta Histochem. 120(3):159–167. doi: 10.1016/j.acthis.2018.02.005.
   PubMed Web of Science ®Google Scholar
• Stokke T, Steen HB. 1986. Binding of Hoechst 33258 to chromatin in situ. Cytometry. 7(3):227–234. doi: 10.1002/cyto.990070302.
   PubMedGoogle Scholar
• Upadhyay S, Palmberg L. 2018. Air-liquid interface: relevant in vitro models for investigating air pollutant-induced pulmonary toxicity. Toxicol Sci. 164(1):21–30. doi: 10.1093/toxsci/kfy053.
   PubMed Web of Science ®Google Scholar
• Vlaskin MS. 2022. Review of air disinfection approaches and proposal for thermal inactivation of airborne viruses as a life-style and an instrument to fight pandemics. Appl Therm Eng. 202:117855. doi: 10.1016/j.applthermaleng.2021.117855.
   PubMed Web of Science ®Google Scholar
• Zuliani T, Duval R, Jayat C, Schnebert S, André P, Dumas M, Ratinaud M-H. 2003. Sensitive and reliable JC-1 and TOTO-3 double staining to assess mitochondrial transmembrane potential and plasma membrane integrity: interest for cell death investigations. Cytometry A. 54(2):100–108. doi: 10.1002/cyto.a.10059.
   PubMedGoogle Scholar