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Inhalation Toxicology
International Forum for Respiratory Research
Volume 35, 2023 - Issue 13-14
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Research Articles

Vaping product exposure system (VaPES): a novel in vitro aerosol deposition system

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Pages 324-332 | Received 16 May 2023, Accepted 20 Nov 2023, Published online: 06 Dec 2023

References

  • Adamson J, Thorne D, Zainuddin B, Baxter A, McAughey J, Gaça M. 2016. Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems. Chem Cent J. 10(1):74.
  • Basáñez T, Majmundar A, Cruz TB, Allem J-P, Unger JB. 2019. E-cigarettes are being marketed as “vitamin delivery” devices. Am J Public Health. 109(2):194–196. doi: 10.2105/ajph.2018.304804.
  • Belushkin M, Tafin Djoko D, Esposito M, Korneliou A, Jeannet C, Lazzerini M, Jaccard G. 2020. Selected harmful and potentially harmful constituents levels in commercial e-cigarettes. Chem Res Toxicol. 33(2):657–668. doi: 10.1021/acs.chemrestox.9b00470.
  • Bennett WD, Clapp PW, Holbrook LT, Zeman KL. 2022. Respiratory tract deposition of e-cigarette particles. Compr Physiol. 12(4):3823–3832. eng. doi: 10.1002/cphy.c210038.
  • Brian CK, Mike V, Jennifer M, Jeremy S. 2023. E-cigarette use among early adolescent tobacco cigarette smokers: testing the disruption and entrenchment hypotheses in two longitudinal cohorts. Tob Control. doi: 10.1136/tc-2022-057717.
  • Clapp PW, Lavrich KS, van Heusden CA, Lazarowski ER, Carson JL, Jaspers I. 2019. Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function. Am J Physiol Lung Cell Mol Physiol. 316(3):L470–L486. doi: 10.1152/ajplung.00304.2018.
  • Darquenne C. 2012. Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv. 25(3):140–147. doi: 10.1089/jamp.2011.0916.
  • Delaval M, Egli D, Schüpfer P, Benarafa C, Geiser M, Burtscher H. 2019. Novel instrument to generate representative e-cigarette vapors for physicochemical particle characterization and in-vitro toxicity. J Aerosol Sci. 129:40–52. doi: 10.1016/j.jaerosci.2018.11.011.
  • Delnevo C, Giovenco DP, Hrywna M. 2020. Rapid proliferation of illegal pod-mod disposable e-cigarettes. Tob Control. 29(e1):e150–e151. doi: 10.1136/tobaccocontrol-2019-055485.
  • Ding Y, Weindl P, Lenz A-G, Mayer P, Krebs T, Schmid O. 2020. Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems. Part Fibre Toxicol. 17(1):44. doi: 10.1186/s12989-020-00376-w.
  • Escobar YH, Nipp G, Cui T, Petters SS, Surratt JD, Jaspers I. 2020. In vitro toxicity and chemical characterization of aerosol derived from electronic cigarette humectants using a newly developed exposure system. Chem Res Toxicol. 33(7):1677–1688. doi: 10.1021/acs.chemrestox.9b00490.
  • Fadus MC, Smith TT, Squeglia LM. 2019. The rise of e-cigarettes, pod mod devices, and JUUL among youth: factors influencing use, health implications, and downstream effects. Drug Alcohol Depend. 201:85–93. doi: 10.1016/j.drugalcdep.2019.04.011.
  • Floyd EL, Queimado L, Wang J, Regens JL, Johnson DL. 2018. Electronic cigarette power affects count concentration and particle size distribution of vaping aerosol. PLOS One. 13(12):e0210147. doi: 10.1371/journal.pone.0210147.
  • Forest V, Mercier C, Pourchez J. 2022. Considerations on dosimetry for in vitro assessment of e-cigarette toxicity. Respir Res. 23(1):358. doi: 10.1186/s12931-022-02286-1.
  • Fulcher ML, Gabriel S, Burns KA, Yankaskas JR, Randell SH. 2005. Well-differentiated human airway epithelial cell cultures. Methods Mol Med. 107:183–206. In eng doi: 10.1385/1-59259-861-7:183.
  • Gaiha SM, Lin C, Lempert LK, Halpern-Felsher B. 2022. Use patterns, flavors, brands, and ingredients of nonnicotine e-cigarettes among adolescents, young adults, and adults in the United States. JAMA Netw Open. 5(5):e2216194-e2216194. doi: 10.1001/jamanetworkopen.2022.16194.
  • Geiss O, Bianchi I, Barrero-Moreno J. 2016. Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours. Int J Hyg Environ Health. 219(3):268–277. doi: 10.1016/j.ijheh.2016.01.004.
  • Hess CA, Olmedo P, Navas-Acien A, Goessler W, Cohen JE, Rule AM. 2017. E-cigarettes as a source of toxic and potentially carcinogenic metals. Environ Res. 152:221–225. doi: 10.1016/j.envres.2016.09.026.
  • King BA, Gammon DG, Marynak KL, Rogers T. 2018. Electronic cigarette sales in the United States, 2013-2017. JAMA. 320(13):1379–1380. doi: 10.1001/jama.2018.10488.
  • Klager S, Vallarino J, MacNaughton P, Christiani DC, Lu Q, Allen JG. 2017. Flavoring chemicals and aldehydes in e-cigarette emissions. Environ Sci Technol. 51(18):10806–10813. doi: 10.1021/acs.est.7b02205.
  • Lenz A-G, Stoeger T, Cei D, Schmidmeir M, Semren N, Burgstaller G, Lentner B, Eickelberg O, Meiners S, Schmid O, et al. 2014. Efficient bioactive delivery of aerosolized drugs to human pulmonary epithelial cells cultured in air-liquid interface conditions. Am J Respir Cell Mol Biol. 51(4):526–535. In eng doi: 10.1165/rcmb.2013-0479OC.
  • Lim CCW, Sun T, Leung J, Chung JYC, Gartner C, Connor J, Hall W, Chiu V, Stjepanovic D, Chan GCK, et al. 2022. Prevalence of adolescent cannabis vaping: a systematic review and meta-analysis of US and Canadian Studies. JAMA Pediatr. 176(1):42–51. doi: 10.1001/jamapediatrics.2021.4102.
  • Love CA, Kim H-YH, Tallman KA, Clapp PW, Porter NA, Jaspers I. 2023. Vaping induced cannabidiol (CBD) oxidation product CBD quinone forms protein adducts with KEAP1 and activates KEAP1-Nrf2 genes. Chem Res Toxicol. 36(4):565–569. doi: 10.1021/acs.chemrestox.3c00038.
  • Muthumalage T, Lucas JH, Wang Q, Lamb T, McGraw MD, Rahman I. 2020. Pulmonary toxicity and inflammatory response of vape cartridges containing medium-chain triglycerides oil and vitamin E acetate: implications in the pathogenesis of EVALI. Toxics. 8(3):46. https://www.mdpi.com/2305-6304/8/3/46.). doi: 10.3390/toxics8030046.
  • Pankow JF, Kim K, McWhirter KJ, Luo W, Escobedo JO, Strongin RM, Duell AK, Peyton DH. 2017. Benzene formation in electronic cigarettes. PLOS One. 12(3):e0173055. doi: 10.1371/journal.pone.0173055.
  • Park-Lee E, Ren C, Sawdey MD, Gentzke AS, Cornelius M, Jamal A, Cullen KA. 2021. Notes from the field: e -cigarette use among middle and high school students - national youth Tobacco Survey, United States, 2021. MMWR Morb Mortal Wkly Rep. 70(39):1387–1389. doi: 10.15585/mmwr.mm7039a4.
  • Pinkston R, Zaman H, Hossain E, Penn AL, Noël A. 2020. Cell-specific toxicity of short-term JUUL aerosol exposure to human bronchial epithelial cells and murine macrophages exposed at the air–liquid interface. Respir Res. 21(1):269. doi: 10.1186/s12931-020-01539-1.
  • Sleiman M, Logue JM, Montesinos VN, Russell ML, Litter MI, Gundel LA, Destaillats H. 2016. Emissions from electronic cigarettes: key Parameters Affecting the Release of Harmful Chemicals. Environ Sci Technol. 50(17):9644–9651. doi: 10.1021/acs.est.6b01741.
  • Smart DJ, Phillips G. 2021. Collecting e-cigarette aerosols for in vitro applications: a survey of the biomedical literature and opportunities to increase the value of submerged cell culture-based assessments. J of Applied Toxicology. 41(1):161–174. DOI: 10.1002/jat.4064. doi: 10.1002/jat.4064).
  • Thorne D, Adamson J, Sticken ET, Wieczorek R, Behrsing H, Steiner S, Majeed S, Frentzel S, Ishikawa S, Ito S, et al. 2021. An interlaboratory in vitro aerosol exposure system reference study. Toxicol Res Appl. 5:239784732199275. doi: 10.1177/2397847321992752.

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