STATISTICAL PROPERTIES OF FITTED ESTIMATES OF APPARENT IN VIVO METABOLIC CONSTANTS OBTAINED FROM GAS UPTAKE DATA. I. LIPOPHILIC AND SLOWLY METABOLIZED VOCs

References

• Andersen, M. E., Clewell, H. J., III, Gargas, M. L., Smith, and Reitz, R. H. 1987a. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. PharmacoL 87:185–205.
   Google Scholar
• Andersen, M. E., Gargas, M. L., Clewell, H. J., III, and Severyn, K. M. 1987b. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1,dichloroethylene in vivo using gas uptake methods. Toxicol. Appl. PharmacoL 89:149–157.
   PubMed Web of Science ®Google Scholar
• Anderson, M. E., Clewell, H. J., III, Mahle, D. A., and Gearhart, J. M. 1994. Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo. ToxicoL Appl. Pharmacol. 128: 158–165.
   Google Scholar
• Beal, S. L., and Sheiner, L. B. 1985. Estimating population kinetics. CRC Crit. Rev. Biomed. Eng. 8:195–222.
   Google Scholar
• Beck, J. V., and Arnold, K. J. 1977. Parameter estimation in engineering & science, pp. 19–24, 349–351. New York: Wiley & Sons.
   Google Scholar
• Bosan, S., and Harris, T. R. 1996. A visualization-based analysis method for multiparameter models of capillary tissue-exchange. Ann. Biomed. Eng. 24:124–138.
   Google Scholar
• Chi, E. M., and Reinsel, G. C. 1989. Models for longitudinal data with random effects and AR(1) errors.]. Am. Stat. Assoc. 84:452–459.
   Web of Science ®Google Scholar
• Corley, R. A., Mendrala, A. L., Smith, F. A., Staats, D. A., Gargas, M. L., Conolly, R. B., Andersen, M. E., and Reitz, R. H. 1990. Development of a physiological based pharmacokinetic model for chloroform. Toxicol. Appl. PharmacoL 103:512–527.
   PubMed Web of Science ®Google Scholar
• Davidian, M., and Giltinan, D. M. 1995. Nonlinear models for repeated measurement data. New York: Chapman & Hall.
   Google Scholar
• Delp, M. D., Manning, R. 0., Bruckner, J. V., and Armstrong, R. B. 1991. Distribution of cardiac out-put during diurnal changes of activity in rats. Am.]. PhysioL 261:H1487–H1493.
   Google Scholar
• Diggle, P. J., Liang, K. Y., and Zeger, S. L. 1994. Analysis of longitudinal data. Oxford: Oxford University Press.
   Google Scholar
• Efron, B., and Tibshirani, R. J. 1993. An introduction to the bootstrap. New York: Chapman & Hall.
   Google Scholar
• Evans, M. A., Crank, W. D., Yang, H., and Simmons, J. E. 1994. Applications of sensitivity analysis to physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicol. Appl. PharmacoL 128:36–44.
   PubMed Web of Science ®Google Scholar
• Evelo, C. T. A., Oostendorp, J. G. M., ten Berge, W. F., and Borm, P. J. A. 1993. Physiologically based toxicokinetic modeling of 1,3-butadiene lung metabolism in mice becomes more impor-tant at low doses. Environ. Health Perspect. 101: 496–502.
   Google Scholar
• Fisher, J. W., Gargas, M. L., Allen, B. C., and Andersen, M. E. 1991. Physiologically based pharmaco-kinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse. Toxicol. AppL PharmacoL 1099:183–195.
   Google Scholar
• Gargas, M. L., Andersen, M. E., and Clewell, H. J., III. 1986. A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. PharmacoL 86:341–352.
   Google Scholar
• Gearhart, J. M., Seckel, C., and Vinegar, A. 1993. In vivo metabolism of chloroform in B6C3F1 mice determined by the method of gas uptake: The effects of body temperature on tissue partition coefficients and metabolism. Toxicol. Appl. Pharmaco1.119:258–266.
   Google Scholar
• Kenyon, M. E., Kraichely, R. E., Hudson, K. T., and Medinsky, A. 1996. Differences in rates of ben-zene metabolism correlate with observed genotoxicity. Toxicol. Appl. PharmacoL 136:49–56.
   PubMed Web of Science ®Google Scholar
• Krishnan, K., Gargas, M. L., Fennell, T. R., and Anderson, M. E. 1992. A physiologically based description of ethylene oxide dosimetry in the rat. Toxicol. Appl. PharmacoL 8:121–140.
   Google Scholar
• Laird, N. M., and Ware, J. H. 1982. Random effects models for longitudinal data. Biometrics 38:963–974.
   PubMed Web of Science ®Google Scholar
• Liang, K. Y., and Zeger, S. L. 1986. Longitudinal data analysis using generalized linear models. Biometrika 73:13–22.
   Web of Science ®Google Scholar
• Palmer, M. J., Phillips, B. F., and Smith, G. T. 1991. Application of nonlinear models with random coefficients to growth data. Biometrics 47:623–635.
   Web of Science ®Google Scholar
• Perkins, R. A., Ward, K. W., and Pollack, G. M. 1996. Ventilation of ambulatory rats exposed to methanol vapor in a flow-through exposure system: Measurement and input to toxicokinetic models. Inhal. Toxicol. 8:143–162.
   Web of Science ®Google Scholar
• Ramsey, J. C., and Anderson, M. E. 1984. A physiologically based description of the inhalation pharmacokinetics of styrene monomer in rats and humans. Toxicol. Appl. PharmacoL 72:159-175. Reilly, P.M. 1976. The numerical computation of posterior distributions in Bayesian statistical inference.]. Stat. Soc. Ser. C25(3).
   Google Scholar
• Seber, G. A. F., and Wild, C. J. 1989. Nonlinear regression. New York: Wiley.
   Google Scholar
• Smith, A. E., and Evans, J. S. 1995. Uncertainty in fitted estimates of apparent in vivo metabolic con-stants for chloroform. Fundam. Appl. Toxicol. 25:29–44.
   PubMedGoogle Scholar
• Smith, A. E., Davidian, M., Evans, M. V., and Evans, J.S. 1995. Issues in estimating apparent in vivo metabolic constants from gas uptake data. Int. Toxicol. Abstr. Int. Cong. Toxicol. VII:89–9–14.
   Google Scholar
• Stott, W. T., Dryzga, M. D., and Ramsey, J. C. 1983. Blood-flow distribution in the mouse.]. Appl. ToxicoL 3:310–312.
   PubMedGoogle Scholar