216
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Evaluation of Keratoconus Disease with Tear Cytokine and Chemokine Levels Before and After Corneal Cross-Linking Treatment

, MDORCID Icon, , MD, , MD, , PhD & , PhD
Pages 269-275 | Received 15 Jul 2022, Accepted 03 Jan 2023, Published online: 06 Feb 2023

References

  • Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28(4):293–322. doi:10.1016/0039-6257(84)90094-8.
  • Razmjoo H, Peyman A, Rahimi A, et al. Cornea collagen cross-linking for keratoconus: a comparison between accelerated and conventional methods. Adv Biomed Res. 2017;6:10. doi:10.4103/2277-9175.200785.
  • Caporossi A, Mazzotta C, Baiocchi S, et al. Long-term results of riboflavin ultraviolet, a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol. 2010;149(4):585–593. doi:10.1016/j.ajo.2009.10.021.
  • O’Brart DP, Patel P, Lascaratos G, et al. Corneal cross-linking to halt the progression of keratoconus and corneal ectasia: seven-year follow-up. Am J Ophthalmol. 2015;160(6):1154–1163. doi:10.1016/j.ajo.2015.08.023.
  • Ameen SS, Mehboob MA, Ali K. Efficacy and safety of transepithelial collagen cross linking for progressive keratoconus. Pak J Med Sci. 2016;32(5):1111–1115. doi:10.12669/pjms.325.10922.
  • Chandler JW. Immunology of the ocular surface. Int Ophthalmol Clin. 1985;25(2):13–23. doi:10.1097/00004397-198502520-00004.
  • Fodor M, Vitályos G, Losonczy G, et al. Tear mediators NGF along with IL-13 predict keratoconus progression. Ocul Immunol Inflamm 29(6):1090 . 2020;1–12 . doi:10.1080/09273948.2020.1716024.
  • Akkaya S, Ulusoy DM. Serum vitamin D levels in patients with keratoconus. Ocul Immunol Inflamm. 2020;28(3):348–353. doi:10.1080/09273948.2019.1604002.
  • Bozkurt E, Ucak T. Serum inflammation biomarkers in patients with keratoconus. Ocul Immunol Inflamm. 2021;29(6):1164–1167. doi:10.1080/09273948.2020.1741648.
  • Loh IP, Sherwin T. Is keratoconus an inflammatory disease? The implication of inflammatory pathways. Ocul Immunol Inflamm. 2022;30(1):246–255. doi:10.1080/09273948.2020.1780271.
  • Zhou L, Sawaguchi S, Twining SS, et al. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest Ophthalmol Vis Sci. 1998;39(7):1117–1124.
  • Collier SA, Madigan MC, Penfold PL. Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas. Curr Eye Res. 2000;21(2):662–668. doi:10.1076/0271-3683(200008)2121-VFT662.
  • Carreño E, Enríquez‐de‐Salamanca A, Tesón M, et al. Cytokine and chemokine levels in tears from healthy subjects. Acta Ophthalmol. 2010;88(7):e250–8. doi:10.1111/j.1755-3768.2010.01978.x.
  • Balasubramanian SA, Mohan S, Pye DC, et al. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol. 2012;90(4):e303–9. doi:10.1111/j.1755-3768.2011.02369.x.
  • Shetty R, Ghosh A, Lim RR, et al. Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci. 2015;56(2):738–750. doi:10.1167/iovs.14-14831.
  • Lema I, Duran JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology. 2005;112(4):654–659. doi:10.1016/j.ophtha.2004.11.050.
  • Ionescu C, Corbu CG, Tanase C, et al. Inflammatory biomarkers profile as microenvironmental expression in keratoconus. Dis Markers. 2016;2016:1243819. doi:10.1155/2016/1243819.
  • Planck SR, Huang XN, Robertson JE, et al. Cytokine mRNA levels in rat ocular tissues after systemic endotoxin treatment. Invest Ophthalmol Vis Sci. 1994;35(3):924–930.
  • Pur DR, Krance SH, Pucchio A, et al. Current uses of artificial intelligence in the analysis of biofluid markers involved in corneal and ocular surface diseases: a systematic review. Eye (Lond). 2022. doi:10.1038/s41433-022-02307-9.
  • Niedźwiedź A, Kawa M, Pius-Sadowska E, et al. Evaluating ocular symptoms and tear film cytokine profiles in symptomatic COVID-19 patients. J Clin Med. 2022;11(9):2647. doi:10.3390/jcm11092647.
  • Kim AY, Moon JY, Jun RM, et al. Ocular surface and tear cytokine changes after cataract surgery in patients with type 2 diabetes. Ocul Immunol Inflamm. 2022;1–8. doi:10.1080/09273948.2022.2088565.
  • Fabre EJ, Bureau J, Pouliquen Y, et al. Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. Curr Eye Res. 1991;10(7):585–592. doi:10.3109/02713689109013850.
  • McMonnies CW. Mechanisms of rubbing-related corneal trauma in keratoconus. Cornea. 2009;28:607–615.
  • Shetty R, Deshmukh R, Ghosh A, et al. Altered tear inflammatory profile in Indian keratoconus patients - the 2015 Col Rangachari Award paper. Indian J Ophthalmol. 2017;65(11):1105–1108. doi:10.4103/ijo.IJO_233_17.
  • Paul WE, Zhu J. How are T(H)2-type immune responses initiated and amplified? Nat Rev Immunol. 2010;10(4):225–235. doi:10.1038/nri2735.
  • Bhogal RK, Bona CA. Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13. Int Rev Immunol. 2008;27(6):472–496. doi:10.1080/08830180802430974.
  • Chwa M, Atilano SR, Reddy V, et al. Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts. Invest Ophthalmol Vis Sci. 2006;47(5):1902–1910. doi:10.1167/iovs.05-0828.
  • Cristina Kenney M, Brown DJ. The cascade hypothesis of keratoconus. Cont Lens Anterior Eye. 2003;26(3):139–146. doi:10.1016/S1367-0484(03)00022-5.
  • Lee HK, Jung EH, Cho BJ. Epidemiological association between systemic diseases and keratoconus in a Korean population: a 10-year nationwide cohort study. Cornea. 2020;39(3):348–353. doi:10.1097/ICO.0000000000002206.
  • Leonardi A, Curnow SJ, Zhan H, et al. Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures. Clin Exp Allergy. 2006;36(6):777–784. doi:10.1111/j.1365-2222.2006.02499.x.
  • Fodor M, Facskó A, Rajnavölgyi E, et al. Enhanced release of IL-6 and IL-8 into tears in various anterior segment eye diseases. Ophthalmic Res. 2006;38(4):182–188. doi:10.1159/000093068.
  • Acar BT, Vural ET, Acar S. Effects of contact lenses on the ocular surface in patients with keratoconus: piggyback versus ClearKone hybrid lenses. Eye Contact Lens. 2012;38(1):43–48. doi:10.1097/ICL.0b013e31823ff181.
  • Jun AS, Cope L, Speck C, et al. Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One. 2011;6(1):e16437. doi:10.1371/journal.pone.0016437.
  • Wisse RP, Kuiper JJ, Gans R, et al. Cytokine expression in keratoconus and its corneal microenvironment: a systematic review. Ocul Surf. 2015;13(4):272–283. doi:10.1016/j.jtos.2015.04.006.
  • Liberman AC, Budziñski ML, Sokn C, et al. Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells. Front Endocrinol (Lausanne). 2018;9:235. doi:10.3389/fendo.2018.00235.
  • Spoerl E, Wollensak G, Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res. 2004;29(1):35–40. doi:10.1080/02713680490513182.
  • Mazzotta C, Traversi C, Baiocchi S, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol. 2008;146(4):527–533. doi:10.1016/j.ajo.2008.05.042.
  • Kolozsvari BL, et al. Alterations of tear mediators in patients with keratoconus after corneal crosslinking are associated with corneal changes. PLoS One. 2013;8(10):e76333. doi:10.1371/journal.pone.0076333.
  • Zaheer N, Khan WA, Khan S, et al. Comparison of changes in central corneal thickness during corneal collagen cross-linking, using isotonic riboflavin solutions with and without dextran, in the treatment of progressive keratoconus. Cornea. 2018;37(3):340–346. doi:10.1097/ICO.0000000000001496.
  • Wollensak G, Aurich H, Wirbelauer C, et al. Significance of the riboflavin film in corneal collagen crosslinking. J Cataract Refract Surg. 2010;36(1):114–120. doi:10.1016/j.jcrs.2009.07.044.
  • Vetter JM, Tubic-Grozdanis M, Faust M, et al. Effect of various compositions of riboflavin eye drops on the intraoperative corneal thickness during UVA-cross-linking in keratoconus eyes. Klin Monbl Augenheilkd. 2011;228(6):509–514. doi:10.1055/s-0031-1273406.
  • Oltulu R, Satirtav G, Donbaloglu M, et al. Intraoperative corneal thickness monitoring during corneal collagen cross-linking with isotonic riboflavin solution with and without dextran. Cornea. 2014;33(11):1164–1167. doi:10.1097/ICO.0000000000000249.
  • Cınar Y, Cingü AK, Şahin A, et al. Intraoperative corneal thickness measurements during corneal collagen cross-linking with isotonic riboflavin solution without dextran in corneal ectasia. Cutan Ocul Toxicol. 2014;33(1):28–31. doi:10.3109/15569527.2013.793700.
  • Soeters N, Wisse RP, Godefrooij DA, et al. Transepithelial versus epithelium-off corneal cross-linking for the treatment of progressive keratoconus: a randomized controlled trial. Am J Ophthalmol. 2015;159(5):821–8.e3. doi:10.1016/j.ajo.2015.02.005.
  • Bonzano C, Cutolo CA, Musetti D, et al. Delayed re-epithelialization after epithelium-off crosslinking: predictors and impact on keratoconus progression. Front Med (Lausanne). 2021;8:657993. doi:10.3389/fmed.2021.657993.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.