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Article

The efficacy and safety of low-dose rituximab in the treatment of pemphigus vulgaris: a cohort study

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Article: 2302071 | Received 27 Sep 2023, Accepted 02 Jan 2024, Published online: 22 Jan 2024

References

  • Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet. 2019;394(10201):1–7. doi:10.1016/s0140-6736(19)31778-7.
  • Lanza A, Cirillo N, Femiano F, et al. How does acantholysis occur in pemphigus vulgaris: a critical review. J Cutan Pathol. 2006;33(6):401–412. doi:10.1111/j.0303-6987.2006.00523.x.
  • Melchionda V, Harman KE. Pemphigus vulgaris and pemphigus foliaceus: an overview of the clinical presentation, investigations and management. Clin Exp Dermatol. 2019;44(7):740–746. doi:10.1111/ced.14041.
  • Bystryn JC, Steinman NM. The adjuvant therapy of pemphigus. Arch Dermatol. 1996;132(2):203–212. doi:10.1001/archderm.1996.03890260105016.
  • Martin LK, Werth VP, Villaneuva EV, et al. A systematic review of randomized controlled trials for pemphigus vulgaris and pemphigus foliaceus. J Am Acad Dermatol. 2011;64(5):903–908. doi:10.1016/j.jaad.2010.04.039.
  • Lever WF, White H. Treatment of pemphigus with corticosteroids. Results obtained in 46 patients over a period of 11 years. Arch Dermatol. 1963;87(1):12–26. doi:10.1001/archderm.1963.01590130018006.
  • Tavakolpour S, Aryanian Z, Seirafianpour F, et al. A systematic review on efficacy, safety, and treatment-durability of low-dose rituximab for the treatment of pemphigus: special focus on COVID-19 pandemic concerns. Immunopharmacol Immunotoxicol. 2021;43(5):507–518. doi:10.1080/08923973.2021.1953063.
  • Zambruno G, Borradori L. Rituximab immunotherapy in pemphigus: therapeutic effects beyond B-cell depletion. J Invest Dermatol. 2008;128(12):2745–2747. doi:10.1038/jid.2008.330.
  • Hertl M, Jedlickova H, Karpati S, et al. Pemphigus. S2 guideline for diagnosis and treatment–guided by the European dermatology forum (EDF) in cooperation with the European academy of dermatology and venereology (EADV). J Eur Acad Dermatol Venereol. 2015;29(3):405–414. doi:10.1111/jdv.12772.
  • Musette P, Bouaziz JD. B cell modulation strategies in autoimmune diseases: new concepts. Front Immunol. 2018;9:622. doi:10.3389/fimmu.2018.00622.
  • Joly P, Maho-Vaillant M, Prost-Squarcioni C, et al. First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial. Lancet. 2017;389(10083):2031–2040. doi:10.1016/s0140-6736(17)30070-3.
  • Alaeen H, Toosi R, Mahmoudi H, et al. Short-term clinical and serological follow-up with conventional and conformational anti-desmoglein antibodies in treatment-naïve and previously treated patients with pemphigus vulgaris after receiving rituximab. Int J Womens Dermatol. 2019;5(5):372–377. doi:10.1016/j.ijwd.2019.05.008.
  • Salopek TG, Logsetty S, Tredget EE. Anti-CD20 chimeric monoclonal antibody (rituximab) for the treatment of recalcitrant, life-threatening pemphigus vulgaris with implications in the pathogenesis of the disorder. J Am Acad Dermatol. 2002;47(5):785–788. doi:10.1067/mjd.2002.126273.
  • Murrell DF, Peña S, Joly P, et al. Diagnosis and management of pemphigus: recommendations of an international panel of experts. J Am Acad Dermatol. 2020;82(3):575–585 e571. doi:10.1016/j.jaad.2018.02.021.
  • Thukral S, Shinde N, Ray DS. Effect of different rituximab doses on B cell count, anti-a/B antibody titer, graft function, and infectious complications in ABO-Incompatible renal transplantation: a prospective study. Transplant Proc. 2021;53(3):970–975. doi:10.1016/j.transproceed.2020.10.008.
  • Schoergenhofer C, Schwameis M, Firbas C, et al. Single, very low rituximab doses in healthy volunteers - a pilot and a randomized trial: implications for dosing and biosimilarity testing. Sci Rep. 2018;8(1):124. doi:10.1038/s41598-017-17934-6.
  • Yancey KB. Commentary regarding clinical and immunological outcomes of high- and low-dose rituximab treatments in patients with pemphigus: a randomized, comparative, observer-blinded study. Dermatol Ther. 2015;28(3):174–175. doi:10.1111/dth.12198.
  • Alaibac M. Ultra-Low dosage regimen of rituximab in autoimmune blistering skin conditions. Front Immunol. 2018;9:810. doi:10.3389/fimmu.2018.00810.
  • Kim JH, Kim YH, Kim MR, et al. Clinical efficacy of different doses of rituximab in the treatment of pemphigus: a retrospective study of 27 patients. Br J Dermatol. 2011;165(3):646–651. doi:10.1111/j.1365-2133.2011.10411.x.
  • Londhe PJ, Kalyanpad Y, Khopkar US. Intermediate doses of rituximab used as adjuvant therapy in refractory pemphigus. Indian J Dermatol Venereol Leprol. 2014;80(4):300–305. doi:10.4103/0378-6323.136832.
  • Kanwar AJ, Vinay K, Sawatkar GU, et al. Clinical and immunological outcomes of high- and low-dose rituximab treatments in patients with pemphigus: a randomized, comparative, observer-blinded study. Br J Dermatol. 2014;170(6):1341–1349. doi:10.1111/bjd.12972.
  • Gupta J, Raval RC, Shah AN, et al. Low-dose rituximab as an adjuvant therapy in pemphigus. Indian J Dermatol Venereol Leprol. 2017;83(3):317–325. doi:10.4103/ijdvl.IJDVL_1078_14.
  • Horváth B, Huizinga J, Pas HH, et al. Low-dose rituximab is effective in pemphigus. Br J Dermatol. 2012;166(2):405–412. doi:10.1111/j.1365-2133.2011.10663.x.
  • Russo I, Miotto S, Saponeri A, et al. Ultra-low dose rituximab for refractory pemghigus vulgaris: a pilot study. Expert Opin Biol Ther. 2020;20(6):673–678. doi:10.1080/14712598.2020.1727440.
  • Shimizu T, Takebayashi T, Sato Y, et al. Grading criteria for disease severity by pemphigus disease area index. J Dermatol. 2014;41(11):969–973. doi:10.1111/1346-8138.12649.
  • Simpson K, Low ZM, Yap T, et al. Ultralow-dose rituximab in pemphigus: a single-Centre experience. Br J Dermatol. 2022;186(3):581–583. doi:10.1111/bjd.20819.
  • Chang Y, Chen X, Wang M, et al. A 10-year retrospective cohort analysis of rituximab for the treatment of pemphigus in a chinese population. J Am Acad Dermatol. 2021;85(6):1643–1645. doi:10.1016/j.jaad.2020.12.062.
  • Zhang J, Huang X, Zhang Z, et al. Clinical observation of different doses of rituximab for the treatment of severe pemphigus: a single-center prospective cohort study. J Am Acad Dermatol. 2022;88(2):500–502. doi:10.1016/j.jaad.2022.06.1187.
  • Cho HH, Jin SP, Chung JH. Clinical experiences of different dosing schedules of rituximab in pemphigus with various disease severities. J Eur Acad Dermatol Venereol. 2014;28(2):186–191. doi:10.1111/jdv.12080.
  • Singh N, Handa S, Mahajan R, et al. Comparison of the efficacy and cost-effectiveness of an immunologically targeted low-dose rituximab protocol with the conventional rheumatoid arthritis protocol in severe pemphigus. Clin Exp Dermatol. 2022;47(8):1508–1516. doi:10.1111/ced.15213.
  • Wang HH, Liu CW, Li YC, et al. Efficacy of rituximab for pemphigus: a systematic review and meta-analysis of different regimens. Acta Derm Venereol. 2015;95(8):928–932. doi:10.2340/00015555-2116.
  • Mohammed R, Milne A, Kayani K, et al. How the discovery of rituximab impacted the treatment of B-cell non-Hodgkin’s lymphomas. J Blood Med. 2019;10:71–84. doi:10.2147/jbm.s190784.
  • Leandro MJ. B-cell subpopulations in humans and their differential susceptibility to depletion with anti-CD20 monoclonal antibodies. Arthritis Res Ther. 2013;15 Suppl 1(Suppl 1):S3. doi:10.1186/ar3908.
  • Didona D, Maglie R, Eming R, et al. Pemphigus: current and future therapeutic strategies. Front Immunol. 2019;10:1418. doi:10.3389/fimmu.2019.01418.
  • Hebert V, Joly P. Rituximab in pemphigus. Immunotherapy. 2018;10(1):27–37. doi:10.2217/imt-2017-0104.
  • Gopal AK, Press OW. Clinical applications of anti-CD20 antibodies. J Lab Clin Med. 1999;134(5):445–450. doi:10.1016/s0022-2143(99)90164-6.
  • Maloney DG, Grillo-López AJ, White CA, et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin’s lymphoma. Blood. 1997;90(6):2188–2195. doi:10.1182/blood.V90.6.2188.