Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway

References

• Ahmadi H, Duddalwar V, Daneshmand S. 2021. Diagnosis and staging of bladder cancer. Hematol Oncol Clin North Am. 35(3):531–541. doi:10.1016/j.hoc.2021.02.004
   PubMed Web of Science ®Google Scholar
• Al-Maghrabi B, Gomaa W, Abdelwahed M, Al-Maghrabi J. 2019. Increased COX-2 immunostaining in urothelial carcinoma of the urinary bladder is associated with invasiveness and poor prognosis. Anal Cell Pathol. 2019:5026939. doi:10.1155/2019/5026939
   Web of Science ®Google Scholar
• Bao T, Ke Y, Wang Y, Wang W, Li Y, Wang Y, Kui X, Zhou Q, Zhou H, Zhang C, et al. 2018. Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression. J Mol Med. 96(7):661–672. doi:10.1007/s00109-018-1652-7
   PubMed Web of Science ®Google Scholar
• Cheki M, Yahyapour R, Farhood B, Rezaeyan A, Shabeeb D, Amini P, Rezapoor S, Najafi M. 2018. COX-2 in radiotherapy: a potential target for radioprotection and radiosensitization. Curr Mol Pharmacol. 11(3):173–183. doi:10.2174/1874467211666180219102520
   PubMed Web of Science ®Google Scholar
• Chen W, Li J, Li C, Fan HN, Zhang J, Zhu JS. 2020. Network pharmacology-based identification of the antitumor effects of taraxasterol in gastric cancer. Int J Immunopathol Pharmacol. 34:2058738420933107. doi:10.1177/2058738420933107
   Web of Science ®Google Scholar
• Cook PJ, Thomas R, Kingsley PJ, Shimizu F, Montrose DC, Marnett LJ, Tabar VS, Dannenberg AJ, Benezra R. 2016. Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma. Neuro Oncol. 18(10):1379–1389. doi:10.1093/neuonc/now049
   PubMed Web of Science ®Google Scholar
• Dobruch J, Oszczudłowski M. 2021. bladder cancer: current challenges and future directions. Medicina. 57(8):749. doi:10.3390/medicina57080749
   PubMedGoogle Scholar
• Ge B, Sang R, Wang W, Yan K, Yu Y, Kong L, Yu M, Liu X, Zhang X. 2023. Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments. Phytomedicine. 116:154872. doi:10.1016/j.phymed.2023.154872
   PubMed Web of Science ®Google Scholar
• Hashemi GN, Najafi M, Salehi E, Farhood B, Mortezaee K. 2019. Cyclooxygenase-2 in cancer: A review. J Cell Physiol. 234(5):5683–5699. doi:10.1002/jcp.27411
   PubMed Web of Science ®Google Scholar
• He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, et al. 2021. Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche. Cell Rep. 36(10):109674. doi:10.1016/j.celrep.2021.109674
   PubMed Web of Science ®Google Scholar
• Jiao F, Tan Z, Yu Z, Zhou B, Meng L, Shi X. 2022. The phytochemical and pharmacological profile of taraxasterol. Front Pharmacol. 13:927365. doi:10.3389/fphar.2022.927365
   PubMed Web of Science ®Google Scholar
• King L, Christie D, Arora D, Anoopkumar-Dukie S. 2020. Cyclooxygenase-2 inhibitors delay relapse and reduce prostate specific antigen (PSA) velocity in patients treated with radiotherapy for nonmetastatic prostate cancer: a pilot study. Prostate Int. 8(1):34–40. doi:10.1016/j.prnil.2019.10.004
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Konishi T. 2018. Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells. J Radiat Res. 59(6):754–759. doi:10.1093/jrr/rry065
   PubMed Web of Science ®Google Scholar
• Kuipers GK, Slotman BJ, Wedekind LE, Stoter TR, Berg J, Sminia P, Lafleur MV. 2007. Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration. Int J Radiat Biol. 83(10):677–685. doi:10.1080/09553000701558985
   PubMed Web of Science ®Google Scholar
• Li H, Qiu Z, Li F, Wang C. 2017. The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis. Oncol Lett. 14(5):5865–5870. doi:10.3892/ol.2017.6924
   PubMed Web of Science ®Google Scholar
• Li Y, Chen Y, Sun-Waterhouse D. 2022. The potential of dandelion in the fight against gastrointestinal diseases: a review. J Ethnopharmacol. 293:115272. doi:10.1016/j.jep.2022.115272
   PubMed Web of Science ®Google Scholar
• Lin F, Luo J, Gao W, Wu J, Shao Z, Wang Z, Meng J, Ou Z, Yang G. 2013. COX-2 promotes breast cancer cell radioresistance via p38/MAPK-mediated cellular anti-apoptosis and invasiveness. Tumour Biol. 34(5):2817–2826. doi:10.1007/s13277-013-0840-x
   PubMedGoogle Scholar
• Liu X, Ji Q, Ye N, Sui H, Zhou L, Zhu H, Fan Z, Cai J, Li Q. 2015. Berberine inhibits invasion and metastasis of colorectal cancer cells via COX-2/PGE2 mediated JAK2/STAT3 signaling pathway. PLOS One. 10(5):e123478. doi:10.1371/journal.pone.0123478
   Web of Science ®Google Scholar
• Mao G, Yao Y, Kong Z. 2018. Long term exposure to gamma‑rays induces radioresistance and enhances the migration ability of bladder cancer cells. Mol Med Rep. 18(6):5834–5840.
   PubMed Web of Science ®Google Scholar
• Najafi M, Mortezaee K, Majidpoor J. 2019. Cancer stem cell (CSC) resistance drivers. Life Sci. 234:116781. doi:10.1016/j.lfs.2019.116781
   PubMed Web of Science ®Google Scholar
• Nissen SE, Yeomans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, Graham DY, Borer JS, Wisniewski LM, Wolski KE, et al. 2016. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 375(26):2519–2529. doi:10.1056/NEJMoa1611593
   PubMed Web of Science ®Google Scholar
• Ohneseit PA, Krebiehl G, Dittmann K, Kehlbach R, Rodemann HP. 2007. Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate cancer cells in vitro. Radiother Oncol. 82(2):229–238. doi:10.1016/j.radonc.2006.11.018
   PubMed Web of Science ®Google Scholar
• Park SY, Lee CJ, Choi JH, Kim JH, Kim JW, Kim JY, Nam JS. 2019. The JAK2/STAT3/CCND2 axis promotes colorectal cancer stem cell persistence and radioresistance. J Exp Clin Cancer Res. 38(1):399. doi:10.1186/s13046-019-1405-7
   PubMed Web of Science ®Google Scholar
• Rempe RG, Hartz AMS, Bauer B. 2016. Matrix metalloproteinases in the brain and blood-brain barrier: versatile breakers and makers. J Cereb Blood Flow Metab. 36(9):1481–1507. doi:10.1177/0271678X16655551
   PubMed Web of Science ®Google Scholar
• Ren M, McGowan E, Li Y, Zhu X, Lu X, Zhu Z, Lin Y, He S. 2019. Saikosaponin-d suppresses COX2 through p-STAT3/C/EBPbeta signaling pathway in liver cancer: a novel mechanism of action. Front Pharmacol. 10:623. doi:10.3389/fphar.2019.00623
   PubMed Web of Science ®Google Scholar
• Scheau C, Badarau IA, Costache R, Caruntu C, Mihai GL, Didilescu AC, Constantin C, Neagu M. 2019. The role of matrix metalloproteinases in the epithelial-mesenchymal transition of hepatocellular carcinoma. Anal Cell Pathol. 2019:9423907. doi:10.1155/2019/9423907
   Web of Science ®Google Scholar
• Shi X, Feng D, Wei W. 2021. A systematic review and meta-analysis protocol of chemoablation vs. transurethral resection of bladder tumor in patients with non-muscle-invasive bladder cancer. Front Surg. 8:753547. doi:10.3389/fsurg.2021.753547
   PubMed Web of Science ®Google Scholar
• Shimura T. 2017. Targeting the AKT/cyclin D1 pathway to overcome intrinsic and acquired radioresistance of tumors for effective radiotherapy. Int J Radiat Biol. 93(4):381–385. doi:10.1080/09553002.2016.1257832
   PubMed Web of Science ®Google Scholar
• Steinauer KK, Gibbs I, Ning S, French JN, Armstrong J, Knox SJ. 2000. Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells. Int J Radiat Oncol Biol Phys. 48(2):325–328. doi:10.1016/s0360-3016(00)00671-4
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Wang F, Ma X, Mao G, Zhang X, Kong Z. 2021. STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer. Mol Med Rep. 23(1):87. doi:10.3892/mmr.2020.11728
   PubMed Web of Science ®Google Scholar
• Wang M, Sun X, Xin H, Wen Z, Cheng Y. 2022. SPP1 promotes radiation resistance through JAK2/STAT3 pathway in esophageal carcinoma. Cancer Med. 11(23):4526–4543. doi:10.1002/cam4.4840
   PubMed Web of Science ®Google Scholar
• Wülfing C, Eltze E, von Struensee D, Wülfing P, Hertle L, Piechota H. 2004. Cyclooxygenase-2 expression in bladder cancer: correlation with poor outcome after chemotherapy. Eur Urol. 45(1):46–52. doi:10.1016/j.eururo.2003.08.007
   PubMed Web of Science ®Google Scholar
• Xu X, Wang X, Fu B, Meng L, Lang B. 2015. Differentially expressed genes and microRNAs in bladder carcinoma cell line 5637 and T24 detected by RNA sequencing. Int J Clin Exp Pathol. 8(10):12678–12687.
   PubMed Web of Science ®Google Scholar
• Xu XT, Hu WT, Zhou JY, Tu Y. 2017. Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. Am J Transl Res. 9(3):1088–1100.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang Q, Zhang R, Kong Z. 2023. DAB2IP-knocking down resulted in radio-resistance of breast cancer cells is associated with increased hypoxia and vasculogenic mimicry formation. Int J Radiat Biol. 99(10):1595–1606. doi:10.1080/09553002.2023.2194390
   PubMed Web of Science ®Google Scholar