Chitinase: a potent biocatalyst and its diverse applications

References

• Abu-Tahon MA, Isaac GS. 2020. Anticancer and antifungal efficiencies of purified chitinase produced from Trichoderma viride under submerged fermentation. J Gen Appl Microbiol. 66(1):32–40.
   PubMed Web of Science ®Google Scholar
• Akeed Y, Atrash F, Naffaa W. 2020. Partial purification and characterization of chitinase produced by Bacillus licheniformis B307. Heliyon. 6(5):e03858.
   PubMed Web of Science ®Google Scholar
• Allonsius CN, Vandenheuvel D, Oerlemans EF, Petrova MI, Donders GG, Cos P, Delputte P, Lebeer S. 2019. Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG. Sci Rep. 9(1):2900.
   PubMedGoogle Scholar
• Al-Qwabah AA, Al-Limoun MO, Al-Mustafa AH, Al-Zereini WA. 2018. Bacillus atrophaeus A7 crude chitinase: characterization and potential role against Drosophila melanogaster larvae. Jordan J Biol Sci. 11(4):451–459.
   Google Scholar
• Alves TB, de Oliveira Ornela PH, de Oliveira AHC, Jorge JA, Guimarães LHS. 2018. Product Annamalai ion and characterization of a thermostable antifungal chitinase secreted by the filamentous fungus Aspergillus niveus under submerged fermentation. 3 Biotech. 8(8):1–10.
   PubMedGoogle Scholar
• Anees M, Abid M, Rehman S, Ahmed N, Ashraf M, Zhang L, Kim KY. 2019. Antifungal activity of various chitinolytic bacteria against Colletotrichum in pepper. Plant Prot Sci. 55(2):109–115.
   Web of Science ®Google Scholar
• Annamalai N, Giji S, Arumugam M, Balasubramanian T. 2010. Purification and characterization of chitinase from Micrococcus sp. AG84 isolated from marine environment. Afr J Microbiol Res. 4(24):2822–2827.
   Google Scholar
• Aronson AI. 1993. The two faces of Bacillus thuringiensis: insecticidal proteins and post‐exponential survival. Mol Microbiol. 7(4):489–496.
   PubMed Web of Science ®Google Scholar
• Asif T, Javed U, Zafar SB, Ansari A, Ul Qader SA, Aman A. 2020. Bioconversion of colloidal chitin using novel chitinase from Glutamicibacter uratoxydans exhibiting anti-fungal potential by hydrolyzing chitin within fungal cell wall. Waste Biomass Valor. 11(8):4129–4143.
   Web of Science ®Google Scholar
• Asmani KL, Bouacem K, Ouelhadj A, Yahiaoui M, Bechami S, Mechri S, Jabeur S, Menguellet KT, Jaouadi B. 2020. Biochemical and molecular characterization of an acido-thermostable endo-chitinase from Bacillus altitudinis KA15 for industrial degradation of chitinous waste. Carbohydr Res. 495:108089.
   PubMed Web of Science ®Google Scholar
• Bargagli E, Maggiorelli C, Rottoli P. 2008. Human chitotriosidase: a potential new marker of sarcoidosis severity. Respiration. 76(2):234–238.
   PubMed Web of Science ®Google Scholar
• Beier S, Bertilsson S. 2013. Bacterial chitin degradation—mechanisms and ecophysiological strategies. Front Microbiol. 4:149.
   PubMed Web of Science ®Google Scholar
• Bekesiova B, Hraska S, Libantova J, Moravcıkova J, Matusıkova I. 2008. Heavy-metal stress induced accumulation of chitinase isoforms in plants. Mol Biol Rep. 35(4):579–588.
   PubMed Web of Science ®Google Scholar
• Berini F, Casartelli M, Montali A, Reguzzoni M, Tettamanti G, Marinelli F. 2019. Metagenome-sourced microbial chitinases as potential insecticide proteins. Front Microbiol. 10:1358.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Das A, Samadder S, Rajan SS. 2016. Biosynthesis and characterization of a thermostable, alkali-tolerant chitinase from Bacillus pumilus JUBCH08 displaying antagonism against phytopathogenic Fusarium oxysporum. 3 Biotech. 6(1):1–8.
   PubMedGoogle Scholar
• Bhattacharya D, Nagpure A, Gupta RK. 2007. Bacterial chitinases: properties and potential. Crit Rev Biotechnol. 27(1):21–28.
   PubMed Web of Science ®Google Scholar
• Bonanomi G, Lorito M, Vinale F, Woo SL. 2018. Organic amendments, beneficial microbes, and soil microbiota: toward a unified framework for disease suppression. Annu Rev Phytopathol. 56:1–20.
   PubMed Web of Science ®Google Scholar
• Boot RG, Blommaart EF, Swart E, Ghauharali-van der Vlugt K, Bijl N, Moe C, Place A, Aerts JM. 2001. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. J Biol Chem. 276(9):6770–6778.
   PubMed Web of Science ®Google Scholar
• Brunner F, Stintzi A, Fritig B, Legrand M. 1998. Substrate specificities of tobacco chitinases. Plant J. 14(2):225–234.
   PubMed Web of Science ®Google Scholar
• Brzezinska MS, Jankiewicz U. 2012. Production of antifungal chitinase by Aspergillus niger LOCK 62 and its potential role in the biological control. Curr Microbiol. 65(6):666–672.
   PubMed Web of Science ®Google Scholar
• Brzezinska MS, Jankiewicz U, Walczak M. 2013. Biodegradation of chitinous substances and chitinase production by the soil actinomycete Streptomyces rimosus. Int Biodeterior Biodegrad. 84:104–110.
   Web of Science ®Google Scholar
• Bulik DA, Olczak M, Lucero HA, Osmond BC, Robbins PW, Specht CA. 2003. Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress. Eukaryot Cell. 2(5):886–900.
   PubMedGoogle Scholar
• Bussink AP, Speijer D, Aerts JM, Boot RG. 2007. Evolution of mammalian chitinase (-like) members of family 18 glycosyl hydrolases. Genetics. 177(2):959–970.
   PubMed Web of Science ®Google Scholar
• Bussink AP, van Eijk M, Renkema GH, Aerts JM, Boot RG. 2006. The biology of the Gaucher cell: the cradle of human chitinases. Int Rev Cytol. 252:71–128.
   PubMedGoogle Scholar
• Castillo BM, Dunn MF, Navarro KG, Meléndez FH, Ortiz MH, Guevara SE, Palacios GH. 2016. Antifungal performance of extracellular chitinases and culture supernatants of Streptomyces galilaeus CFFSUR-B12 against Mycosphaerella fijiensis Morelet. World J Microbiol Biotechnol. 32(3):1–12.
   PubMed Web of Science ®Google Scholar
• Chaiharn M, Lumyong S, Hasan N, Plikomol A. 2013. Solid-state cultivation of Bacillus thuringiensis R 176 with shrimp shells and rice straw as a substrate for chitinase production. Ann Microbiol. 63(2):443–450.
   Web of Science ®Google Scholar
• Chakravarty J, Edwards TA. 2022. Innovation from waste with biomass-derived chitin and chitosan as green and sustainable polymer: a review. Energy Nexus. 8:100149.
   Google Scholar
• Cheba BA, Zaghloul TI, El-Mahdy AR, El-Massry MH. 2018. Effect of nitrogen sources and fermentation conditions on Bacillus sp. R2 chitinase production. Procedia Manuf. 22:280–287.
   Google Scholar
• Chen WM, Chen CS, Jiang ST. 2013. Purification and characterization of an extracellular chitinase from Rhizopus oryzae. J Mar Sci Technol. 21(3):15.
   Web of Science ®Google Scholar
• Chou YT, Yao S, Czerwinski R, Fleming M, Krykbaev R, Xuan D, Zhou H, Brooks J, Strand LFJ, Strand J, et al. 2006. Kinetic characterization of recombinant human acidic mammalian chitinase. Biochemistry. 45(14):4444–4454.
   PubMed Web of Science ®Google Scholar
• Cohen-Kupiec R, Chet I. 1998. The molecular biology of chitin digestion. Curr Opin Biotechnol. 9(3):270–277.
   PubMed Web of Science ®Google Scholar
• Dahiya N, Tewari R, Hoondal GS. 2006. Biotechnological aspects of chitinolytic enzymes: a review. Appl Microbiol Biotechnol. 71(6):773–782.
   PubMed Web of Science ®Google Scholar
• Dahiya N, Tewari R, Tiwari RP, Hoondal GS. 2005. Production of an antifungal chitinase from Enterobacter sp. NRG4 and its application in protoplast production. World J Microbiol Biotechnol. 21(8-9):1611–1616.
   Web of Science ®Google Scholar
• Das SN, Neeraja C, Sarma PVSRN, Prakash JM, Purushotham P, Kaur M, Dutta S, Podile AR. 2012. Microbial chitinases for chitin waste management. In: Microorganisms in environmental management Dordrecht: Springer; p. 135–150.
   Google Scholar
• Deng JJ, Shi D, Mao HH, Li ZW, Liang S, Ke Y, Luo XC. 2019. Heterologous expression and characterization of an antifungal chitinase (Chit46) from Trichoderma harzianum GIM 3.442 and its application in colloidal chitin conversion. Int J Biol Macromol. 134:113–121.
   PubMed Web of Science ®Google Scholar
• Dong X, Zhao Y, Ran X, Guo L, Zhao D-G. 2017. Overexpression of a New Chitinase Gene EuCHIT2 enhances resistance to Erysiphe cichoracearum DC. in Tobacco Plants. IJMS. 18(11):2361.10.3390/ijms18112361.
   Google Scholar
• Du J, Duan S, Miao J, Zhai M, Cao Y. 2021. Purification and characterization of chitinase from Paenibacillus sp. Biotechnol Appl Biochem. 68(1):30–40.
   PubMed Web of Science ®Google Scholar
• Duo-Chuan L. 2006. Review of fungal chitinases. Mycopathologia. 161(6):345–360.
   PubMed Web of Science ®Google Scholar
• Dyachok JV, Wiweger M, Kenne L, Von Arnold S. 2002. Endogenous Nod-factor-like signal molecules promote early somatic embryo development in Norway spruce. Plant Physiol. 128(2):523–533.
   PubMed Web of Science ®Google Scholar
• Ebrahim S, Usha K, Singh B. 2011. Pathogenesis-related (PR)-proteins: chitinase and b-1, 3-glucanase in defense mechanism against malformation in mango (Mangifera indica). Sci Hortic. 130(4):847–852.
   Web of Science ®Google Scholar
• Egan ÁM, Sweeney T, Hayes M, O'Doherty JV. 2015. Prawn shell chitosan has anti-obesogenic properties, influencing both nutrient digestibility and microbial populations in a pig model. PLoS One. 10(12):e0144127.
   PubMed Web of Science ®Google Scholar
• El-Sayed WS, Ibrahim MK, Abu-Shady M, El-Beih F, Ohmura N, Saiki H, Ando A. 2003. Isolation and identification of a novel strain of the genus Ochrobactrum with phenol-degrading activity. J Biosci Bioeng. 96(3):310–312.
   PubMed Web of Science ®Google Scholar
• Evvyernie D, Morimoto K, Karita S, Kimura T, Sakka K, Ohmiya K. 2001. Conversion of chitinous wastes to hydrogen gas by Clostridium paraputrificum M-21. J Biosci Bioeng. 91(4):339–343. 10.1263/jbb.91.339. 16233001
   PubMed Web of Science ®Google Scholar
• Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González Á, Esquivel-Chirino C, Montiel ID, Rivera GS, Vega CV, Morales-González JA. 2011. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 12(5):3117–3132.
   PubMed Web of Science ®Google Scholar
• Fu X, Yan Q, Wang J, Yang S, Jiang Z. 2016. Purification and biochemical characterization of novel acidic chitinase from Paenicibacillus barengoltzii. Int J Biol Macromol. 91:973–979.
   PubMed Web of Science ®Google Scholar
• Funkhouser JD, Aronson NN. 2007. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. BMC Evol Biol. 7(1):1–16.
   PubMedGoogle Scholar
• Gan Z, Yang J, Tao N, Liang L, Mi Q, Li J, Zhang KQ. 2007. Cloning of the gene Lecanicillium psalliotae chitinase Lpchi1 and identification of its potential role in the biocontrol of root-knot nematode Meloidogyne incognita. Appl Microbiol Biotechnol. 76(6):1309–1317.
   PubMed Web of Science ®Google Scholar
• Gangwar M, Singh V, Pandey AK, Tripathi CKM, Mishra BN. 2016. Purification and characterization of chitinase from Streptomyces violascens NRRL B2700. http://nopr.niscpr.res.in/handle/123456789/33576
   Google Scholar
• Ghasemi S, Ahmadian G, Jelodar NB, Rahimian H, Ghandili S, Dehestani A, Shariati P. 2010. Antifungal chitinases from Bacillus pumilus SG2: preliminary report. World J Microbiol Biotechnol. 26(8):1437–1443.
   Web of Science ®Google Scholar
• Gohel V, Chaudhary T, Vyas P, Chhatpar HS. 2006. Statistical screenings of medium components for the production of chitinase by the marine isolate Pantoea dispersa. Biochem Eng J. 28(1):50–56.
   Web of Science ®Google Scholar
• Gohel V, Singh A, Vimal M, Ashwini P, Chhatpar HS. 2006. Bioprospecting and antifungal potential of chitinolytic microorganisms. Afr J Biotechnol. 5(2):54–72.
   Web of Science ®Google Scholar
• Goldman DL, Vicencio AG. 2012. The chitin connection. Mbio. 3(2):e00056–12.
   PubMed Web of Science ®Google Scholar
• Gomaa EZ. 2012. Chitinase production by Bacillus thuringiensis and Bacillus licheniformis: their potential in antifungal biocontrol. J Microbiol. 50(1):103–111.
   PubMed Web of Science ®Google Scholar
• Gomaa EZ. 2021. Microbial chitinases: properties, enhancement and potential applications. Protoplasma. 258(4):695–710.
   PubMed Web of Science ®Google Scholar
• Greenman J, Ieropoulos IA, Melhuish C. 2011. Microbial fuel cells–scalability and their use in robotics. In Eliaz N, editor. Applications of electrochemistry and nanotechnology in biology and medicine I. Cham: Springer; p. 239–290.
   Google Scholar
• Grover A. 2012. Plant chitinases: genetic diversity and physiological roles. Crit Rev Plant Sci. 31(1):57–73.
   Web of Science ®Google Scholar
• Halbedel S, Prager R, Banerji S, Kleta S, Trost E, Nishanth G, Alles G, Holzel G, Schlesiger F, Pietzka A, et al. 2019. A Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis. Emerg Microbes Infect. 8(1):17–28.
   PubMed Web of Science ®Google Scholar
• Halder SK, Pal S, Mondal KC. 2019. Biosynthesis of fungal chitinolytic enzymes and their potent biotechnological appliances. In: Recent advancement in white biotechnology through fungi. Cham: Springer; p. 281–298.
   Google Scholar
• Hamid R, Khan MA, Ahmad M, Ahmad MM, Abdin MZ, Musarrat J, Javed S. 2013. Chitinases: an update. J Pharm Bioallied Sci. 5(1):21–29.
   PubMedGoogle Scholar
• Hammami I, Siala R, Jridi M, Ktari N, Nasri M, Triki MA. 2013. Partial purification and characterization of chi IO 8, a novel antifungal chitinase produced by Bacillus cereus IO 8. J Appl Microbiol. 115(2):358–366.
   PubMed Web of Science ®Google Scholar
• Han Y, Yang B, Zhang F, Miao X, Li Z. 2009. Characterization of antifungal chitinase from marine Streptomyces sp. DA11 associated with South China Sea sponge Craniella australiensis. Mar Biotechnol (NY). 11(1):132–140. 10.1007/s10126-008-9126-5. 18626709
   PubMed Web of Science ®Google Scholar
• Hartl L, Zach S, Seidl-Seiboth V. 2012. Fungal chitinases: diversity, mechanistic properties and biotechnological potential. Appl Microbiol Biotechnol. 93(2):533–543.
   PubMed Web of Science ®Google Scholar
• Hasunuma T, Okazaki F, Okai N, Hara KY, Ishii J, Kondo A. 2013. A review of enzymes and microbes for lignocellulosic biorefinery and the possibility of their application to consolidated bioprocessing technology. Bioresour Technol. 135:513–522.
   PubMed Web of Science ®Google Scholar
• Huang CJ, Wang TK, Chung SC, Chen CY. 2005. Identification of an antifungal chitinase from a potential biocontrol agent, Bacillus cereus 28-9. J Biochem Mol Biol. 38(1):82–88.
   PubMedGoogle Scholar
• Ieropoulos IA, Greenman J, Melhuish C, Horsfield I. 2012. Microbial fuel cells for robotics: energy autonomy through artificial symbiosis. ChemSusChem. 5(6):1020–1026.
   PubMed Web of Science ®Google Scholar
• Islam R, Datta B. 2015. Diversity of chitinases and their industrial potential. Int J Appl Res. 1:55–60.
   Google Scholar
• Itoh T, Kimoto H. 2019. Bacterial chitinase system as a model of chitin biodegradation. Adv Exp Med Biol. 1142:131–151.
   PubMed Web of Science ®Google Scholar
• Jahromi ST, Barzkar N. 2018. Marine bacterial chitinase as sources of energy, eco-friendly agent, and industrial biocatalyst. Int J Biol Macromol. 120(Pt B):2147–2154.
   PubMedGoogle Scholar
• Jankiewicz U, Brzezinska MS, Saks E. 2012. Identification and characterization of a chitinase of Stenotrophomonas maltophilia, a bacterium that is antagonistic towards fungal phytopathogens. J Biosci Bioeng. 113(1):30–35.
   PubMed Web of Science ®Google Scholar
• Juárez-Hernández EO, Casados-Vázquez LE, Del Rincón-Castro MC, Salcedo-Hernández R, Bideshi DK, Barboza-Corona JE. 2015. Bacillus thuringiensis subsp. israelensis producing endochitinase ChiA74Δsp inclusions and its improved activity against Aedes aegypti. J Appl Microbiol. 119(6):1692–1699. 10.1111/jam.12962. 26434743
   PubMed Web of Science ®Google Scholar
• Juárez-Hernández EO, Casados-Vázquez LE, Brieba LG, Torres-Larios A, Jimenez-Sandoval P, Barboza-Corona JE. 2019. The crystal structure of the chitinase ChiA74 of Bacillus thuringiensis has a multidomain assembly. Sci Rep. 9(1):2591.
   PubMedGoogle Scholar
• Junaid JM, Dar NA, Bhat TA, Bhat AH, Bhat MA. 2013. Commercial biocontrol agents and their mechanism of action in the management of plant pathogens. Int J Modern Plant Anim Sci. 1(2):39–57.
   Google Scholar
• Jung WJ, Park RD. 2014. Bioproduction of chitooligosaccharides: present and perspectives. Mar Drugs. 12(11):5328–5356.
   PubMed Web of Science ®Google Scholar
• Jupatanakul N, Pengon J, Selisana SMG, Choksawangkarn W, Jaito N, Saeung A, Bunyong R, Posayapisit N, Thammatinna K, Kalpongnukul N, et al. 2020. Serratia marcescens secretes proteases and chitinases with larvicidal activity against Anopheles dirus. Acta Trop. 212:105686.
   PubMed Web of Science ®Google Scholar
• Karlsson M, Stenlid J. 2008. Comparative evolutionary histories of the fungal chitinase gene family reveal non-random size expansions and contractions due to adaptive natural selection. Evol Bioinform Online. 4: EBO.S604.
   Web of Science ®Google Scholar
• Karthik N, Akanksha K, Binod P, Pandey A. 2014. Production, purification and properties of fungal chitinases- a review. Indian J Exp Biol. 52(11):1025–1035. 0975–1009.
   PubMed Web of Science ®Google Scholar
• Kasprzewska ANNA. 2003. Plant chitinases-regulation and function. Cell Mol Biol Lett. 8(3):809–824.
   PubMed Web of Science ®Google Scholar
• Keyhani NO, Roseman S. 1999. Physiological aspects of chitin catabolism in marine bacteria. Biochim Biophys Acta. 1473(1):108–122.
   PubMed Web of Science ®Google Scholar
• Khan FI, Bisetty K, Singh S, Permaul K, Hassan M. 2015. Chitinase from Thermomyces lanuginosus SSBP and its biotechnological applications. Extremophiles. 19(6):1055–1066.
   PubMed Web of Science ®Google Scholar
• Kidibule PE, Santos-Moriano P, Jiménez-Ortega E, Ramírez-Escudero M, Limón MC, Remacha M, Plou FJ, Aparico JS, Fernández-Lobato M. 2018. Use of chitin and chitosan to produce new chitooligosaccharides by chitinase Chit42: enzymatic activity and structural basis of protein specificity. Microb Cell Fact. 17(1):1–13.
   PubMedGoogle Scholar
• Koga D, Sasaki Y, Uchiumi Y, Hirai N, Arakane Y, Nagamatsu Y. 1997. Purification and characterization of Bombyx mori chitinases. Insect Biochem Mol Biol. 27(8-9):757–767. 10.1016/s0965-1748(97)00058-1. 9443376
   PubMed Web of Science ®Google Scholar
• Kong XF, Zhou XL, Lian GQ, Blachier F, Liu G, Tan BE, Nyachoti CM, Yin YL. 2014. Dietary supplementation with chitooligosaccharides alters gut microbiota and modifies intestinal luminal metabolites in weaned Huanjiang mini-piglets. Livest Sci. 160:97–101.
   Web of Science ®Google Scholar
• Korany SM, Mansour AN, El-Hendawy HH, Kobisi ANA, Aly HH. 2019. Entomopathogenic efficacy of the chitinolytic bacteria: aeromonas hydrophila isolated from Siwa Oasis, Egypt. Egypt J Biol Pest Control. 29(1):1–10.
   Google Scholar
• Kuddus M, Ahmad IZ, Saima, R. 2013. Isolation of novel chitinolytic bacteria and production optimization of extracellular chitinase. J Genet Eng Biotechnol. 11(1):39–46.
   Google Scholar
• Kuepper M, Bratke K, Virchow JC. 2008. Chitinase-like protein and asthma. N Engl J Med. 358(10):1073–1075; author reply 1075. 10.1056/NEJMc073406. 18322291
   PubMed Web of Science ®Google Scholar
• Kumar A, Kumar D, George N, Sharma P, Gupta N. 2018. A process for complete biodegradation of shrimp waste by a novel marine isolate Paenibacillus sp. AD with simultaneous production of chitinase and chitin oligosaccharides. Int J Biol Macromol. 109:263–272.
   PubMed Web of Science ®Google Scholar
• Kumar S, Nehra M, Dilbaghi N, Marrazza G, Hassan AA, Kim KH. 2019. Nano-based smart pesticide formulations: Emerging opportunities for agriculture. J Control Release. 294:131–153.
   PubMed Web of Science ®Google Scholar
• Laribi-Habchi H, Bouacem K, Allala F, Jabeur F, Selama O, Mechri S, Yahiaoui M, Darenfed AB, Jaouadi B. 2020. Characterization of chitinase from Shewanella inventionis HE3 with bio-insecticidal effect against granary weevil, Sitophilus granarius Linnaeus (Coleoptera: curculionidae). Process Biochem. 97:222–233.
   Web of Science ®Google Scholar
• Le B, Yang SH. 2019. Microbial chitinases: properties, current state and biotechnological applications. World J Microbiol Biotechnol. 35(9):144.
   PubMed Web of Science ®Google Scholar
• Lee YG, Chung K-C, Wi SG, Lee JC, Bae H-J. 2009. Purification and properties of a chitinase from Penicillium sp. LYG 0704. Protein Expr Purif. 65(2):244–250. 10.1016/j.pep.2008.12.004. 19116167
   PubMed Web of Science ®Google Scholar
• Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. 2011. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 73:479–501.
   PubMed Web of Science ®Google Scholar
• Li Y, Wilson DB. 2008. Chitin binding by Thermobifida fusca cellulase catalytic domains. Biotechnol Bioeng. 100(4):644–652. 10.1002/bit.21808. 18306418
   PubMed Web of Science ®Google Scholar
• Liang S, Sun Y, Dai X. 2018. A review of the preparation, analysis and biological functions of chitooligosaccharide. IJMS. 19(8):2197.
   Google Scholar
• Liaqat F, Eltem R. 2018. Chitooligosaccharides and their biological activities: a comprehensive review. Carbohydr Polym. 184:243–259.
   PubMed Web of Science ®Google Scholar
• Li H, Greene LH. 2010. Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. PLoS One. 5(1):e8654.
   PubMed Web of Science ®Google Scholar
• Li Y, Lei X, Zhu H, Zhang H, Guan C, Chen Z, Zheng W, Fu L, Zheng T. 2016. Chitinase producing bacteria with direct algicidal activity on marine diatoms. Sci Rep. 6(1):1–13.
   PubMed Web of Science ®Google Scholar
• Li J, Liu JY. 2003. A novel cotton gene encoding a new class of chitinase. Acta Botanica Sinica. 45:1489–1496.
   Google Scholar
• Liu D, Cai J, Xie CC, Liu C, Chen YH. 2010. Purification and partial characterization of a 36-kDa chitinase from Bacillus thuringiensis subsp. colmeri, and its biocontrol potential. Enzyme Microb Technol. 46(3-4):252–256.
   Web of Science ®Google Scholar
• Liu T, Chen L, Zhou Y, Jiang X, Duan Y, Yang Q. 2017. Structure, catalysis, and inhibition of Chi-h, the lepidoptera-exclusive insect chitinase. J Biol Chem. 292(6):2080–2088.
   PubMed Web of Science ®Google Scholar
• Liu J, NanGong Z, Zhang J, Song P, Tang Y, Gao Y, Wang Q. 2019. Expression and characterization of two chitinases with synergistic effect and antifungal activity from Xenorhabdus nematophila. World J Microbiol Biotechnol. 35(7):106.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang J, Zhu KY. 2019. Chitin in arthropods: biosynthesis, modification, and metabolism. Adv Exp Med Biol. 1142:169–207.
   PubMed Web of Science ®Google Scholar
• Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B. 2014. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Res. 42(Database issue):D490–D495.
   PubMedGoogle Scholar
• Madan K, Madan M, Sharma S, Paliwal S. 2020. Chitinases: therapeutic scaffolds for allergy and inflammation. Recent Pat Inflamm Allergy Drug Discov. 14(1):46–57.
   PubMed Web of Science ®Google Scholar
• Mahmood S, Kumar M, Kumari P, Mahapatro GK, Banerjee N, Sarin NB. 2020. Novel insecticidal chitinase from the insect pathogen Xenorhabdus nematophila. Int J Biol Macromol. 159:394–401.
   PubMed Web of Science ®Google Scholar
• Mathew GM, Madhavan A, Arun KB, Sindhu R, Binod P, Singhania RR, Sukumaran RK, Pandey A. 2021. Thermophilic chitinases: structural, functional and engineering attributes for industrial applications. Appl Biochem Biotechnol. 193(1):142–164.
   PubMed Web of Science ®Google Scholar
• Mattaveewong T, Wongkrasant P, Chanchai S, Pichyangkura R, Chatsudthipong V, Muanprasat C. 2016. Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling. Carbohydr Polym. 145:30–36.
   PubMed Web of Science ®Google Scholar
• McDonald AG, Boyce S, Tipton KF. 2009. ExplorEnz: the primary source of the IUBMB enzyme list. Nucleic Acids Res. 37(Database issue):D593–D597.
   PubMedGoogle Scholar
• Merzendorfer H, Zimoch L. 2003. Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases. J Exp Biol. 206(Pt 24):4393–4412.
   PubMed Web of Science ®Google Scholar
• Mishra P, Kshirsagar PR, Nilegaonkar SS, Singh SK. 2012. Statistical optimization of medium components for production of extracellular chitinase by Basidiobolus ranarum: a novel biocontrol agent against plant pathogenic fungi. J Basic Microbiol. 52(5):539–548.
   PubMed Web of Science ®Google Scholar
• Monteiro VN, do Nascimento Silva R, Steindorff AS, Costa FT, Noronha EF, Ricart CAO, Sousa MV, de MH, Vainstein C, Ulhoa J. 2010. New insights in Trichoderma harzianum antagonism of fungal plant pathogens by secreted protein analysis. Curr Microbiol. 61(4):298–305.
   PubMed Web of Science ®Google Scholar
• Mosier N, Wyman C, Dale B, Elander R, Lee YY, Holtzapple M, Ladisch M. 2005. Features of promising technologies for pretreatment of lignocellulosic biomass. Bioresour Technol. 96(6):673–686.
   PubMed Web of Science ®Google Scholar
• Muanprasat C, Chatsudthipong V. 2017. Chitosan oligosaccharide: Biological activities and potential therapeutic applications. Pharmacol Ther. 170:80–97. 10.1016/j.pharmthera.2016.10.013. 27773783
   PubMed Web of Science ®Google Scholar
• Nagpure A, Gupta RK. 2013. Purification and characterization of an extracellular chitinase from antagonistic Streptomyces violaceusniger. J Basic Microbiol. 53(5):429–439.
   PubMed Web of Science ®Google Scholar
• Nakabachi A, Shigenobu S, Miyagishima S. 2010. Chitinase‐like proteins encoded in the genome of the pea aphid, Acyrthosiphon pisum. Insect Molecular Biology. 19:175–185.
   PubMed Web of Science ®Google Scholar
• Nampoothiri KM, Baiju TV, Sandhya C, Sabu A, Szakacs G, Pandey A. 2004. Process optimization for antifungal chitinase production by Trichoderma harzianum. Process Biochem. 39(11):1583–1590.
   Web of Science ®Google Scholar
• Narayana KJ, Vijayalakshmi M. 2009. Chitinase production by Streptomyces sp. ANU 6277. Braz J Microbiol. 40(4):725–733.
   PubMed Web of Science ®Google Scholar
• Nasseri AT, Rasoul-Ami S, Morowvat MH, Ghasemi Y. 2011. Single cell protein: production and process. American J of Food Technology. 6(2):103–116.
   Google Scholar
• Okay S, Özdal M, Kurbanoğlu EB. 2013. Characterization, antifungal activity, and cell immobilization of a chitinase from Serratia marcescens MO-1. Turk J Biol. 37(6):639–644.
   Web of Science ®Google Scholar
• Pan M, Li J, Lv X, Du G, Liu L. 2019. Molecular engineering of chitinase from Bacillus sp. DAU101 for enzymatic production of chitooligosaccharides. Enzyme Microb Technol. 124:54–62.
   PubMed Web of Science ®Google Scholar
• Pan XQ, Shih CC, Harday J. 2005. Chitinase induces lysis of MCF-7 cells in culture and of human breast cancer xenograft B11-2 in SCID mice. Anticancer Res. 25(5):3167–3172.
   PubMed Web of Science ®Google Scholar
• Park JK, Chung MJ, Choi HN, Park YI. 2011. Effects of the molecular weight and the degree of deacetylation of chitosan oligosaccharides on antitumor activity. Int J Mol Sci. 12(1):266–277.
   PubMed Web of Science ®Google Scholar
• Park HJ, Kim D, Kim IH, Lee C-E, Kim I-C, Kim JY, Kim SJ, Lee HK, Yim JH. 2009. Characteristics of cold-adaptive endochitinase from Antarctic bacterium Sanguibacter antarcticus KOPRI 21702. Enzyme Microb Technol. 45(5):391–396.
   Web of Science ®Google Scholar
• Passarinho PA, de Vries SC. 2002. Arabidopsis chitinases: a genomic survey. Arabidopsis Book Am Soc Plant Biol. 1:e0023.
   PubMedGoogle Scholar
• Patil RS, Ghormade V, Deshpande MV. 2000. Chitinolytic enzymes: an exploration. Enzyme Microb Technol. 26(7):473–483.
   PubMed Web of Science ®Google Scholar
• Patil NS, Jadhav JP. 2014a. Enzymatic production of N-acetyl-D-glucosamine by solid state fermentation of chitinase by Penicillium ochrochloron MTCC 517 using agricultural residues. Int Biodeterior Biodegrada. 91:9–17.
   Google Scholar
• Patil NS, Jadhav JP. 2014b. Single cell protein production using Penicillium ochrochloron chitinase and its evaluation in fish meal formulations. J Microbiol Biochem Technol. 4(2):S4.
   Google Scholar
• Patil NS, Jadhav JP. 2015a. Penicillium ochrochloron MTCC 517 chitinase: an effective tool in commercial enzyme cocktail for production and regeneration of protoplasts from various fungi. Saudi J Biol Sci. 22(2):232–236.
   PubMed Web of Science ®Google Scholar
• Patil NS, Jadhav JP. 2015b. Significance of Penicillium ochrochloron chitinase as a biocontrol agent against pest Helicoverpa armigera. Chemosphere. 128:231–235.
   PubMed Web of Science ®Google Scholar
• Placzek S, Schomburg I, Chang A, Jeske L, Ulbrich M, Tillack J, Schomburg D. 2017. BRENDA in 2017: new perspectives and new tools in BRENDA. Nucleic Acids Res. 45(D1):D380–D388.
   PubMed Web of Science ®Google Scholar
• Poria V, Rana A, Kumari A, Grewal J, Pranaw K, Singh S. 2021. Current perspectives on chitinolytic enzymes and their agro-industrial applications. Biology. 10(12):1319.
   PubMedGoogle Scholar
• Prapagdee B, Kuekulvong C, Mongkolsuk S. 2008. Antifungal potential of extracellular metabolites produced by Streptomyces hygroscopicus against phytopathogenic fungi. Int J Biol Sci. 4(5):330–337.
   PubMed Web of Science ®Google Scholar
• Rinaudo M. 2006. Chitin and chitosan: properties and applications. Prog Polym Sci. 31(7):603–632.
   Web of Science ®Google Scholar
• Rishad KS, Rebello S, Shabanamol PS, Jisha MS. 2017. Biocontrol potential of halotolerant bacterial chitinase from high yielding novel Bacillus pumilus MCB-7 autochthonous to mangrove ecosystem. Pestic Biochem Physiol. 137:36–41.
   PubMed Web of Science ®Google Scholar
• Robertus JD, Monzingo AF. 1999. The structure and action of chitinases. Exs. 87:125–135.
   PubMedGoogle Scholar
• Royer V, Fraichard S, Bouhin H. 2002. A novel putative insect chitinase with multiple catalytic domains: hormonal regulation during metamorphosis. Biochem J. 366(Pt 3):921–928.
   PubMedGoogle Scholar
• Sahai AS, Manocha MS. 1993. Chitinases of fungi and plants: their involvement in morphogenesis and host—parasite interaction. FEMS Microbiology Reviews. 11(4):317–338.
   Web of Science ®Google Scholar
• Saini S, Chand M, Sharma HO, Kumar P. 2020. Role of Chitinases as a waste management to control global crisis. Int J Environ Rehabil Conserv. 11:303–313.
   Google Scholar
• Seidl V. 2008. Chitinases of filamentous fungi: a large group of diverse proteins with multiple physiological functions. Fungal Biol Rev. 22(1):36–42.
   Google Scholar
• Selenius O, Korpela J, Salminen S, Gallego CG. 2018. Effect of chitin and chitooligosaccharide on in vitro growth of Lactobacillus rhamnosus GG and Escherichia coli TG. Appl Food Biotechnol. 5(3):163–172.
   Web of Science ®Google Scholar
• Sels J, Mathys J, De Coninck BM, Cammue BP, De Bolle MF. 2008. Plant pathogenesis-related (PR) proteins: a focus on PR peptides. Plant Physiol Biochem. 46(11):941–950.
   PubMed Web of Science ®Google Scholar
• Senol M, Nadaroglu H, Dikbas N, Kotan R. 2014. Purification of Chitinase enzymes from Bacillus subtilis bacteria TV-125, investigation of kinetic properties and antifungal activity against Fusarium culmorum. Ann Clin Microbiol Antimicrob. 13(1):1–7.
   PubMedGoogle Scholar
• Shahbaz U, Yu X. 2020. Cloning, isolation, and characterization of novel chitinase-producing bacterial strain UM01 (Myxococcus fulvus). J Genet Eng Biotechnol. 18(1):1–11.
   PubMed Web of Science ®Google Scholar
• Sharaf EF. 2005. A potent chitinolytic activity of Alternaria alternata isolated from Egyptian black sand. Pol J Microbiol. 54(2):145–151.
   PubMedGoogle Scholar
• Sharma CK, Vishnoi VK, Dubey RC, Maheshwari DK. 2018. A twin rhizospheric bacterial consortium induces systemic resistance to a phytopathogen Macrophomina phaseolina in mung bean. Rhizosphere. 5:71–75.
   Web of Science ®Google Scholar
• Shehata AN, Abd El Aty AA, Darwish DA, Wahab WAA, Mostafa FA. 2018. Purification, physicochemical and thermodynamic studies of antifungal chitinase with production of bioactive chitosan-oligosaccharide from newly isolated Aspergillus griseoaurantiacus KX010988. Int J Biol Macromol. 107(Pt A):990–999.
   PubMedGoogle Scholar
• Simůnek J, Hodrová B, Bartonová H, Kopecný J. 2001. Chitinolytic bacteria of the mammal digestive tract. Folia Microbiol. 46(1):76–78.
   PubMed Web of Science ®Google Scholar
• Singh RV, Sambyal K, Negi A, Sonwani S, Mahajan R. 2021. Chitinases production: a robust enzyme and its industrial applications. Biocatal Biotransform. 39(3):161–189.
   Web of Science ®Google Scholar
• Spiegel Y, Chet I. 1998. Evaluation of Trichoderma spp. as a biocontrol agent against soilborne fungi and plant-parasitic nematodes in Israel. Integr Pest Manage Rev. 3(3):169–175.
   Google Scholar
• Sridevi M, Mallaiah KV. 2008. Factors effecting chitinase activity of Rhizobium sp. from Sesbania sesban. Biologia. 63(3):307–312.
   Web of Science ®Google Scholar
• Stoykov YM, Pavlov AI, Krastanov AI. 2015. Chitinase biotechnology: production, purification, and application. Eng Life Sci. 15(1):30–38.
   Web of Science ®Google Scholar
• Suganthi M, Senthilkumar P, Arvinth S, Chandrashekara KN. 2017. Chitinase from Pseudomonas fluorescens and its insecticidal activity against Helopeltis theivora. J Gen Appl Microbiol. 63(4):222–227.
   PubMed Web of Science ®Google Scholar
• Suma K, Podile AR. 2013. Chitinase A from Stenotrophomonas maltophilia shows transglycosylation and antifungal activities. Bioresour Technol. 133:213–220.
   PubMed Web of Science ®Google Scholar
• Suresh PV, Anil Kumar PK. 2012. Enhanced degradation of α-chitin materials prepared from shrimp processing byproduct and production of N-acetyl-D-glucosamine by thermoactive chitinases from soil mesophilic fungi. Biodegradation. 23(4):597–607.
   PubMed Web of Science ®Google Scholar
• Suryawanshi N, Jujjavarapu SE, Ayothiraman S. 2019. Marine shell industrial wastes–an abundant source of chitin and its derivatives: constituents, pretreatment, fermentation, and pleiotropic applications-a revisit. Int J Environ Sci Technol. 16(7):3877–3898.
   Web of Science ®Google Scholar
• Sutrisno A, Ueda M, Abe Y, Nakazawa M, Miyatake K. 2004. A chitinase with high activity toward partially N-acetylated chitosan from a new, moderately thermophilic, chitin-degrading bacterium, Ralstonia sp. A-471. Appl Microbiol Biotechnol. 63(4):398–406.
   PubMed Web of Science ®Google Scholar
• Takahashi M, Kiuchi M, Kamimura M. 2002. A new chitinase-related gene, BmChiR1, is induced in the Bombyx mori anterior silk gland at molt and metamorphosis by ecdysteroid. Insect Biochem Mol Biol. 32(2):147–151.
   PubMed Web of Science ®Google Scholar
• Teixeira-Costa BE, Andrade CT. 2021. Chitosan as a valuable biomolecule from seafood industry waste in the design of green food packaging. Biomolecules. 11(11):1599.10.3390/biom11111599.
   PubMed Web of Science ®Google Scholar
• Thadathil N, Kuttappan AKP, Vallabaipatel E, Kandasamy M, Velappan SP. 2014. Statistical optimization of solid state fermentation conditions for the enhanced production of thermoactive chitinases by mesophilic soil fungi using response surface methodology and their application in the reclamation of shrimp processing by-products. Ann Microbiol. 64(2):671–681.
   Web of Science ®Google Scholar
• Tom RA, Carroad PA. 1981. Effect of reaction conditions on hydrolysis of chitin by Serratia marcescens QMB 1466 chitinase. J Food Science. 46(2):646–647.
   Web of Science ®Google Scholar
• Udaya Prakash NA, Jayanthi M, Sabarinathan R, Kangueane P, Mathew L, Sekar K. 2010. Evolution, homology conservation, and identification of unique sequence signatures in GH19 family chitinases. J Mol Evol. 70(5):466–478.
   PubMed Web of Science ®Google Scholar
• Vaidya RJ, Shah IM, Vyas PR, Chhatpar HS. 2001. Production of chitinase and its optimization from a novel isolate Alcaligenes xylosoxydans: potential in antifungal biocontrol. World J Microbiol Biotechnol. 17(7):691–696.
   Web of Science ®Google Scholar
• Van Aalten DM, Komander D, Synstad B, Gåseidnes S, Peter MG, Eijsink VG. 2001. Structural insights into the catalytic mechanism of a family 18 exo-chitinase. Proc Natl Acad Sci U S A. 98(16):8979–8984.
   PubMed Web of Science ®Google Scholar
• Van Loon LC, Rep M, Pieterse CM. 2006. Significance of inducible defense-related proteins in infected plants. Annu Rev Phytopathol. 44:135–162.
   PubMed Web of Science ®Google Scholar
• Vega K, Kalkum M. 2012. Chitin, chitinase responses, and invasive fungal infections. Int J Microbiol. 2012:1–10.
   Google Scholar
• Veliz EA, Martínez-Hidalgo P, Hirsch AM. 2017. Chitinase-producing bacteria and their role in biocontrol. AIMS Microbiol. 3(3):689–705.
   PubMed Web of Science ®Google Scholar
• Venkatachalam A, Govinda Rajulu MB, Thirunavukkarasu N, Suryanarayanan TS. 2015. Endophytic fungi of marine algae and seagrasses: a novel source of chitin modifying enzymes. Mycosphere. 6(3):345–355.
   Web of Science ®Google Scholar
• Waghmare SR, Kulkarni SS, Ghosh JS. 2011. Chitinase production in solid-state fermentation from Oerskovia xanthineolytica NCIM 2839 and its application in fungal protoplasts formation. Curr Microbiol. 63(3):295–299.
   PubMed Web of Science ®Google Scholar
• Wang SL, Chen SJ, Wang CL. 2008. Purification and characterization of chitinases and chitosanases from a new species strain Pseudomonas sp. TKU015 using shrimp shells as a substrate. Carbohydr Res. 343(7):1171–1179.
   PubMed Web of Science ®Google Scholar
• Wang D, Li A, Han H, Liu T, Yang Q. 2018. A potent chitinase from Bacillus subtilis for the efficient bioconversion of chitin-containing wastes. Int J Biol Macromol. 116:863–868.
   PubMed Web of Science ®Google Scholar
• Wan J, Jiang F, Xu Q, Chen D, Yu B, Huang Z, Mao X, Yu J, He J. 2017. New insights into the role of chitosan oligosaccharide in enhancing growth performance, antioxidant capacity, immunity and intestinal development of weaned pigs. RSC Adv. 7(16):9669–9679.
   Web of Science ®Google Scholar
• Wan J, Zhang XC, Neece D, Ramonell KM, Clough S, Kim SY, Stacey MG, Stacey G. 2008. A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsi. Plant Cell. 20(2):471–481.
   Google Scholar
• Wasli AS, Salleh MM, Abd-Aziz S, Hassan O, Mahadi NM. 2009. Medium optimization for chitinase production from Trichoderma virens using central composite design. Biotechnol Bioproc E. 14(6):781–787.
   Web of Science ®Google Scholar
• Watanabe T, Kanai R, Kawase T, Tanabe T, Mitsutomi M, Sakuda S, Miyashita K. 1999. Family 19 chitinases of Streptomyces species: characterization and distribution. The GenBank accession numbers for the sequences determined in this work are AB031745–AB031757 inclusive. Microbiology. 145(12):3353–3363.
   PubMedGoogle Scholar
• Webb DC, McKenzie AN, Foster PS. 2001. Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein. J Biol Chem. 276(45):41969–41976.
   PubMed Web of Science ®Google Scholar
• Wu AC, Lasky-Su J, Rogers CA, Klanderman BJ, Litonjua A. 2010. Polymorphisms of chitinases are not associated with asthma. J Allergy Clin Immunol. 125(3):754–757.
   PubMed Web of Science ®Google Scholar
• Yan L, Kim IH. 2011. Evaluation of dietary supplementation of delta-aminolevulinic acid and chitooligosaccharide on growth performance, nutrient digestibility, blood characteristics, and fecal microbial shedding in weaned pigs. Anim Feed Sci Technol. 169(3–4):275–280.
   Web of Science ®Google Scholar
• Yang X, Yang J, Li H, Niu L, Xing G, Zhang Y, Xu W, Zhao Q, Li Q, Dong Y. 2020. Overexpression of the chitinase gene CmCH1 from Coniothyrium minitans renders enhanced resistance to Sclerotinia sclerotiorum in soybean. Transgenic Res. 29(2):187–198.
   PubMed Web of Science ®Google Scholar
• Younes I, Rinaudo M. 2015. Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar Drugs. 13(3):1133–1174. 10.3390/md13031133. 25738328
   PubMed Web of Science ®Google Scholar
• Zhou J, Chen L, Kang L, Liu Z, Bai Y, Yang Y, Yuan S. 2018. ChiE1 from Coprinopsis cinerea is characterized as a processive exochitinase and revealed to have a significant synergistic action with endochitinase ChiIII on chitin degradation. J Agric Food Chem. 66(48):12773–12782.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Zhu Y, Tian Y, Yao JL, Bian S, Zhang H, Zhang R, Gao Q, Yan Z. 2021. MdPR4, a pathogenesis-related protein in apple, is involved in chitin recognition and resistance response to apple replant disease pathogens. J Plant Physiol. 260:153390.
   PubMed Web of Science ®Google Scholar
• Zhu Q, Arakane Y, Banerjee D, Beeman RW, Kramer KJ, Muthukrishnan S. 2008. Domain organization and phylogenetic analysis of the chitinase-like family of proteins in three species of insects. Insect Biochem Mol Biol. 38(4):452–466.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. 2004. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 304(5677):1678–1682.
   PubMed Web of Science ®Google Scholar
• Zong H, Li K, Liu S, Song L, Xing R, Chen X, Li P. 2017. Improvement in cadmium tolerance of edible rape (Brassica rapa L.) with exogenous application of chitooligosaccharide. Chemosphere. 181:92–100.
   PubMed Web of Science ®Google Scholar
• Zou P, Li K, Liu S, He X, Zhang X, Xing R, Li P. 2016. Effect of sulfated chitooligosaccharides on wheat seedlings (Triticum aestivum L.) under salt stress. J Agric Food Chem. 64(14):2815–2821.
   PubMed Web of Science ®Google Scholar
• Zou P, Yuan S, Yang X, Zhai X, Wang J. 2018. Chitosan oligosaccharides with degree of polymerization 2–6 induces apoptosis in human colon carcinoma HCT116 cells. Chem Biol Interact. 279:129–135.
   PubMed Web of Science ®Google Scholar