Treatment response to supplemental nutrients for ADHD is independent of diet quality: the MADDY Study RCT

References

• Danielson ML, Bitsko RH, Ghandour RM, Holbrook JR, Kogan MD, Blumberg SJ. Prevalence of parent-reported ADHD diagnosis and associated treatment among US children and adolescents, 2016. J Clin Child & Adoles Psychol. 2018;47(2):199–212.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington (DC); 2013.
   Google Scholar
• Faraone SV, Rostain AL, Blader J, Busch B, Childress AC, Connor DF, Newcorn JH. Practitioner review: emotional dysregulation in attention-deficit/hyperactivity disorder–implications for clinical recognition and intervention. J Child Psychol Psychiatry. 2019;60(2):133–50.
   PubMed Web of Science ®Google Scholar
• Lange KW, Hauser J, Makulska-Gertruda E, Nakamura Y, Reissmann A, Sakaue Y, et al. The role of nutritional supplements in the treatment of ADHD: what the evidence says. Curr Psychiatry Rep. 2017;19(2):8.
   PubMed Web of Science ®Google Scholar
• Howard AL, Robinson M, Smith GJ, Ambrosini GL, Piek JP, Oddy WH. ADHD is associated with a “western” dietary pattern in adolescents. J Atten Disord. 2011;15(5):403–11.
   PubMed Web of Science ®Google Scholar
• Abbasi K, Beigrezai S, Ghiasvand R, Pourmasoumi M, Mahaki B. Dietary patterns and attention deficit hyperactivity disorder among Iranian children: a case-control study. J Am Coll Nutr. 2019;38(1):76–83.
   PubMed Web of Science ®Google Scholar
• Ríos-Hernández A, Alda JA, Farran-Codina A, Ferreira-García E, Izquierdo-Pulido M. The Mediterranean diet and ADHD in children and adolescents. Pediatrics. 2017;139(2).
   PubMed Web of Science ®Google Scholar
• Mian A, Jansen PW, Nguyen AN, Bowling A, Renders CM, Voortman T. Children's attention-deficit/hyperactivity disorder symptoms predict lower diet quality but not vice versa: results from bidirectional analyses in a population-based cohort. J Nutr. 2019;149(4):642–8.
   PubMed Web of Science ®Google Scholar
• Khoshbakht Y, Moghtaderi F, Bidaki R, Hosseinzadeh M, Salehi-Abargouei A. The effect of dietary approaches to stop hypertension (DASH) diet on attention-deficit hyperactivity disorder (ADHD) symptoms: a randomized controlled clinical trial. Eur J Nutr. 2021;60(7):3647–58.
   PubMed Web of Science ®Google Scholar
• Robinette LM, Hatsu IE, Johnstone JM, Tost G, Bruton AM, Leung BMY, et al. Fruit and vegetable intake is inversely associated with severity of inattention in a pediatric population with ADHD symptoms: the MADDY study. Nutr Neurosci. 2022: 1–10.
   PubMed Web of Science ®Google Scholar
• Brown KA, Samuel S, Patel DR. Pharmacologic management of attention deficit hyperactivity disorder in children and adolescents: a review for practitioners. Transl Pediatr. 2018;7(1):36–47.
   PubMed Web of Science ®Google Scholar
• Charach A. Editorial: time for a new conversation on stimulant use. J Am Acad Child Adolesc Psychiatry. 2020;59(8):929–30.
   PubMed Web of Science ®Google Scholar
• Rucklidge JJ, Frampton CM, Gorman B, Boggis A. Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomised placebo-controlled trial. Br J Psychiatry. 2014;204:306–15.
   PubMed Web of Science ®Google Scholar
• Rucklidge JJ, Eggleston MJF, Johnstone JM, Darling K, Frampton CM. Vitamin-mineral treatment improves aggression and emotional regulation in children with ADHD: a fully blinded, randomized, placebo-controlled trial. J Child Psychol Psychiatry. 2018;59(3):232–46.
   PubMed Web of Science ®Google Scholar
• Johnstone JM, Hatsu I, Tost G, Srikanth P, Eiterman LP, Bruton AM, et al. Micronutrients for attention-deficit/hyperactivity disorder in youths: A placebo-controlled randomized clinical trial. J Am Acad Child Adolesc Psychiatry. 2022;61(5):647–61.
   PubMed Web of Science ®Google Scholar
• Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.
   PubMed Web of Science ®Google Scholar
• Hurt EA, Arnold LE. An integrated dietary/nutritional approach to ADHD. Child Adolesc Psychiatr Clin N Am. 2014;23(4):955–64.
   PubMed Web of Science ®Google Scholar
• Rucklidge JJ, Johnstone J, Gorman B, Boggis A, Frampton CM. Moderators of treatment response in adults with ADHD treated with a vitamin-mineral supplement. Prog Neuropsychopharmacol Biol Psychiatry. 2014;50:163–71.
   PubMed Web of Science ®Google Scholar
• Rucklidge JJ, Eggleston MJF, Darling KA, Stevens AJ, Kennedy MA, Frampton CM. Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables. Prog Neuropsychopharmacol Biol Psychiatry. 2019;89:181–92.
   PubMed Web of Science ®Google Scholar
• Johnstone JM, Leung B, Gracious B, Perez L, Tost G, Savoy A, et al. Rationale and design of an international randomized placebo-controlled trial of a 36-ingredient micronutrient supplement for children with ADHD and irritable mood: the micronutrients for ADHD in youth (MADDY) study. Contem Clin Trials Commun. 2019;16:100478.
   PubMed Web of Science ®Google Scholar
• Kristal AR, Kolar AS, Fisher JL, Plascak JJ, Stumbo PJ, Weiss R, Paskett ED. Evaluation of web-based, self-administered, graphical food frequency questionnaire. J Acad Nutr Diet. 2014;114(4):613–21.
   PubMed Web of Science ®Google Scholar
• Reedy J, Lerman JL, Krebs-Smith SM, Kirkpatrick SI, Pannucci TE, Wilson MM, et al. Evaluation of the healthy eating index-2015. J Acad Nutr Diet. 2018;118(9):1622–33.
   PubMed Web of Science ®Google Scholar
• Department of Health and Human Services. Executive summary. Dietary guidelines for Americans, 2015-2020. Washington (DC): USDA; 2015.
   Google Scholar
• Krebs-Smith SM, Pannucci TE, Subar AF, Kirkpatrick SI, Lerman JL, Tooze JA, et al. Update of the healthy eating index: HEI-2015. J Acad Nutr Diet. 2018;118(9):1591–602.
   PubMed Web of Science ®Google Scholar
• Guy W. ECDEU assessment manual for psychopharmacology; 1976.
   Google Scholar
• Thomson JL, Tussing-Humphreys LM, Goodman MH, Landry AS. Diet quality in a nationally representative sample of American children by sociodemographic characteristics. Am J Clin Nutr. 2019;109(1):127–38.
   PubMed Web of Science ®Google Scholar
• Baker CW, Little TD, Brownell KD. Predicting adolescent eating and activity behaviors: the role of social norms and personal agency. Health Psychol. 2003;22(2):189–98.
   PubMed Web of Science ®Google Scholar
• Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002;75(4):616–58.
   PubMed Web of Science ®Google Scholar
• Cui J, Lian Y, Zhao C, Du H, Han Y, Gao W, et al. Dietary fibers from fruits and vegetables and their health benefits via modulation of Gut microbiota. Compr Rev Food Sci Food Saf. 2019;18(5):1514–32.
   PubMed Web of Science ®Google Scholar
• Wang N, Gao X, Zhang Z, Yang L. Composition of the Gut microbiota in attention deficit hyperactivity disorder: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022;13:838941.
   PubMed Web of Science ®Google Scholar
• Jones LR, Steer CD, Rogers IS, Emmett PM. Influences on child fruit and vegetable intake: sociodemographic, parental and child factors in a longitudinal cohort study. Public Health Nutr. 2010;13(7):1122–30.
   PubMed Web of Science ®Google Scholar
• McClung HL, Ptomey LT, Shook RP, Aggarwal A, Gorczyca AM, Sazonov ES, et al. Dietary intake and physical activity assessment: current tools, techniques, and technologies for use in adult populations. Am J Prev Med. 2018;55(4):e93–e104.
   PubMed Web of Science ®Google Scholar