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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 27, 2024 - Issue 4
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Research Article

Association between the triglyceride-glucose index and cognitive impairment in China: a community population-based cross-sectional study

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References

  • Li X, Feng X, Sun X, Hou N, Han F, Liu Y. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2019. Front Aging Neurosci. 2022;14:937486.doi:10.3389/fnagi.2022.937486
  • Povova J, Ambroz P, Bar M, Pavukova V, Sery O, Tomaskova H, Janout V. Epidemiological of and risk factors for Alzheimer’s disease: a review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012;156(2):108–14. doi:10.5507/bp.2012.055.
  • Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–46. doi:10.1016/s0140-6736(20)30367-6.
  • 2022. Alzheimer’s disease facts and figures. Alzheimers Dement. 2022;18(4):700–89. doi:10.1002/alz.12638.
  • Atri A. The Alzheimer’s disease clinical spectrum: diagnosis and management. Med Clin North Am. 2019;103(2):263–93. doi:10.1016/j.mcna.2018.10.009.
  • Soria Lopez JA, González HM, Léger GC. Alzheimer’s disease. Handb Clin Neurol. 2019;167:231–55. doi:10.1016/b978-0-12-804766-8.00013-3.
  • Crous-Bou M, Minguillón C, Gramunt N, Molinuevo JL. Alzheimer’s disease prevention: from risk factors to early intervention. Alzheimers Res Ther. 2017;9(1):71. doi:10.1186/s13195-017-0297-z.
  • Serrano-Pozo A, Growdon JH. Is Alzheimer’s disease risk modifiable? J Alzheimers Dis. 2019;67(3):795–819. doi:10.3233/jad181028.
  • Ekblad LL, Rinne JO, Puukka P, Laine H, Ahtiluoto S, Sulkava R, et al. Insulin resistance predicts cognitive decline: an 11-year follow-up of a nationally representative adult population sample. Diabetes Care. 2017;40(6):751–8. doi:10.2337/dc16-2001.
  • Ma L, Li Y. Cognitive function and insulin resistance in elderly patients with type 2 diabetes. Neurol Res. 2017;39(3):259–63. doi:10.1080/01616412.2017.1281199.
  • Bosco D, Fava A, Plastino M, Montalcini T, Pujia A. Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis. J Cell Mol Med. 2011;15(9):1807–21. doi:10.1111/j.1582-4934.2011.01318.x.
  • de la Monte SM, Tong M. Brain metabolic dysfunction at the core of Alzheimer’s disease. Biochem Pharmacol. 2014;88(4):548–59. doi:10.1016/j.bcp.2013.12.012.
  • Sherzai AZ, Shaheen M, Yu JJ, Talbot K, Sherzai D. Insulin resistance and cognitive test performance in elderly adults: National Health and Nutrition Examination Survey (NHANES). J Neurol Sci. 2018;388:97–102. doi:10.1016/j.jns.2017.11.031.
  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9. doi:10.1007/bf00280883.
  • Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6(4):299–304. doi:10.1089/met.2008.0034.
  • Jeong S, Lee JH. The verification of the reliability of a triglyceride-glucose index and its availability as an advanced tool. Metabolomics. 2021;17(11):97. doi:10.1007/s11306-021-01837-9.
  • Park HM, Lee HS, Lee YJ, Lee JH. The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance. Diabetes Res Clin Pract. 2021;180:109042. doi:10.1016/j.diabres.2021.109042.
  • Ramdas Nayak VK, Satheesh P, Shenoy MT, Kalra S. Triglyceride Glucose (TyG) index: a surrogate biomarker of insulin resistance. J Pak Med Assoc. 2022;72(5):986–8. doi:10.47391/jpma.22-63.
  • Alizargar J, Bai CH, Hsieh NC, Wu SV. Use of the triglyceride-glucose index (TyG) in cardiovascular disease patients. Cardiovasc Diabetol. 2020;19(1):8. doi:10.1186/s12933-019-0982-2.
  • Qin Z, Zhao J, Geng J, Chang K, Liao R, Su B. Higher triglyceride-glucose index Is associated with increased likelihood of kidney stones. Front Endocrinol (Lausanne). 2021;12:774567. doi:10.3389/fendo.2021.774567.
  • Tutunchi H, Naeini F, Mobasseri M, Ostadrahimi A. Triglyceride glucose (TyG) index and the progression of liver fibrosis: a cross-sectional study. Clin Nutr ESPEN. 2021;44:483–487. doi:10.1016/j.clnesp.2021.04.025.
  • Yang X, Gao Z, Huang X, Zhang M, Chen Z. The correlation of atherosclerosis and triglyceride glucose index: a secondary analysis of a national cross-sectional study of Japanese. BMC Cardiovasc Disord. 2022;22(1):250. doi:10.1186/s12872-022-02685-8.
  • Irace C, Carallo C, Scavelli FB, De Franceschi MS, Esposito T, Tripolino C, Gnasso A. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int J Clin Pract. 2013;67(7):665–72. doi:10.1111/ijcp.12124.
  • Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol. 2017;16(1):108. doi:10.1186/s12933-017-0589-4.
  • Wang S, Shi J, Peng Y, Fang Q, Mu Q, Gu W, et al. Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study. Cardiovasc Diabetol. 2021;20(1):82. doi:10.1186/s12933-021-01274-x.
  • Katzman R, Zhang MY, Ouang Ya Q, Wang ZY, Liu WT, Yu E, et al. A Chinese version of the mini-mental state examination; impact of illiteracy in a Shanghai dementia survey. J Clin Epidemiol. 1988;41(10):971–8. doi:10.1016/0895-4356(88)90034-0.
  • Heizhati M, Li N, Wang L, Hong J, Li M, Yang W, et al. Association of hypertension with mild cognitive impairment in population from less-developed areas of multiethnic northwest China. Neuroepidemiology. 2021;55(5):407–15. doi:10.1159/000517956.
  • James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). Jama. 2014;311(5):507–20. doi:10.1001/jama.2013.284427.
  • Frison E, Proust-Lima C, Mangin JF, Habert MO, Bombois S, Ousset PJ, et al. Diabetes mellitus and cognition: pathway analysis in the MEMENTO cohort. Neurology. 2021;97(8):e836–e848. doi:10.1212/wnl.0000000000012440.
  • 2016 Chinese guideline for the management of dyslipidemia in adults. Zhonghua Xin Xue Guan Bing Za Zhi. 2016;44(10):833–53. doi:10.3760/cma.j.issn.0253-3758.2016.10.005.
  • Zhou BF. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults – study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15(1):83–96.
  • Sherwin BB. Estrogen and cognitive functioning in women. Endocr Rev. 2003;24(2)):133–51. doi:10.1210/er.2001-0016.
  • Zhu D, Montagne A, Zhao Z. Alzheimer’s pathogenic mechanisms and underlying sex difference. Cell Mol Life Sci. 2021;78(11):4907–20. doi:10.1007/s00018-021-03830-w.
  • Hong S, Han K, Park CY. The insulin resistance by triglyceride glucose index and risk for dementia: population-based study. Alzheimers Res Ther. 2021;13(1):9. doi:10.1186/s13195-020-00758-4.
  • Munro CA, Winicki JM, Schretlen DJ, Gower EW, Turano KA, Muñoz B, et al. Sex differences in cognition in healthy elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2012;19(6):759–68. doi:10.1080/13825585.2012.690366.
  • Hooshmand B, Rusanen M, Ngandu T, Leiviskä J, Sindi S, von Arnim CAF, et al. Serum insulin and cognitive performance in older adults: a longitudinal study. Am J Med. 2019;132(3):367–73. doi:10.1016/j.amjmed.2018.11.013.
  • Young SE, Mainous AG, 3rd, Carnemolla M. Hyperinsulinemia and cognitive decline in a middle-aged cohort. Diabetes Care. 2006;29(12):2688–93. doi:10.2337/dc06-0915.
  • Bove RM, Brick DJ, Healy BC, Mancuso SM, Gerweck AV, Bredella MA, et al. Metabolic and endocrine correlates of cognitive function in healthy young women. Obesity (Silver Spring). 2013;21(7):1343–9. doi:10.1002/oby.20212.
  • Bove RM, Gerweck AV, Mancuso SM, Bredella MA, Sherman JC, Miller KK. Association between adiposity and cognitive function in young men: hormonal mechanisms. Obesity (Silver Spring). 2016;24(4):954–61. doi:10.1002/oby.21415.
  • Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2012;69(1):29–38. doi:10.1001/archneurol.2011.233.
  • Freiherr J, Hallschmid M, Frey WH, 2nd, Brünner YF, Chapman CD, Hölscher C, et al. Intranasal insulin as a treatment for Alzheimer’s disease: a review of basic research and clinical evidence. CNS Drugs. 2013;27(7):505–14. doi:10.1007/s40263-013-0076-8.
  • Cai Z, Xiao M, Chang L, Yan LJ. Role of insulin resistance in Alzheimer’s disease. Metab Brain Dis. 2015;30(4):839–51. doi:10.1007/s11011-014-9631-3.
  • Rad SK, Arya A, Karimian H, Madhavan P, Rizwan F, Koshy S, Prabhu G. Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease. Drug Des Devel Ther. 2018;12:3999–4021. doi:10.2147/dddt.S173970.
  • Femminella GD, Livingston NR, Raza S, van der Doef T, Frangou E, Love S, et al. Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects? Alzheimers Res Ther. 2021;13(1):47. doi:10.1186/s13195-021-00784-w.
  • Bonda DJ, Wang X, Lee HG, Smith MA, Perry G, Zhu X. Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass. Neurosci Bull. 2014;30(2):243–52. doi:10.1007/s12264-013-1424-x.
  • Tönnies E, Trushina E. Oxidative stress, synaptic dysfunction, and Alzheimer’s disease. J Alzheimers Dis. 2017;57(4):1105–21. doi:10.3233/jad-161088.
  • Sędzikowska A, Szablewski L. Insulin and insulin resistance in Alzheimer’s disease. Int J Mol Sci. 2021;22(18). doi:10.3390/ijms22189987.
  • Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology. 2010;75(22):1982–7. doi:10.1212/WNL.0b013e3181ffe4f6.
  • Euser SM, Sattar N, Witteman JC, Bollen EL, Sijbrands EJ, Hofman A, et al. A prospective analysis of elevated fasting glucose levels and cognitive function in older people: results from PROSPER and the Rotterdam Study. Diabetes. 2010;59(7):1601–7. doi:10.2337/db09-0568.
  • Sanz CM, Ruidavets JB, Bongard V, Marquié JC, Hanaire H, Ferrières J, Andrieu S. Relationship between markers of insulin resistance, markers of adiposity, HbA1c, and cognitive functions in a middle-aged population-based sample: the MONA LISA study. Diabetes Care. 2013;36(6):1512–21. doi:10.2337/dc12-1017.
  • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214–223. doi:10.1152/ajpendo.1979.237.3.E214.
  • Singh B, Saxena A. Surrogate markers of insulin resistance: a review. World J Diabetes. 2010;1(2):36–47. doi:10.4239/wjd.v1.i2.36.
  • Kang B, Yang Y, Lee EY, Yang HK, Kim HS, Lim SY, et al. Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents. Int J Obes (Lond). 2017;41(5):789–92. doi:10.1038/ijo.2017.14.
  • Jin JL, Cao YX, Wu LG, You XD, Guo YL, Wu NQ, et al. Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease. J Thorac Dis. 2018;10(11):6137–46. doi:10.21037/jtd.2018.10.79.
  • Park K, Ahn CW, Lee SB, Kang S, Nam JS, Lee BK, et al. Elevated TyG index predicts progression of coronary artery calcification. Diabetes Care. 2019;42(8):1569–73. doi:10.2337/dc18-1920.
  • Minh HV, Tien HA, Sinh CT, Thang DC, Chen CH, Tay JC, et al. Assessment of preferred methods to measure insulin resistance in Asian patients with hypertension. J Clin Hypertens (Greenwich). 2021;23(3):529–37. doi:10.1111/jch.14155.
  • Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, Martínez-Abundis E, Ramos-Zavala MG, Hernández-González SO, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347–51. doi:10.1210/jc.2010-0288.
  • Weyman-Vela Y, Simental-Mendía LE, Camacho-Luis A, Gamboa-Gómez CI, Guerrero-Romero F. The triglycerides and glucose index is associated with mild cognitive impairment in older adults. Endocr Res. 2022. 47(2):89–93. https://doi.org/10.1080/07435800.2022.2061508

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