Control of the Serotonergic System by the Medial Prefrontal Cortex: Potential Role in the Etiology of PTSD and Depressive Disorders

References

• Abellán , M.T. , Adell , A. , Honrubia , M.A. , Mengod , G. and Artigas , F. 2000 . "GABA(B)-RI receptors in serotonergic neurons: effects of baclofen on 5-HT output in rat brain" . Neuroreport , 11 : 941 – 945 .
   PubMedGoogle Scholar
• Adell , A. and Artigas , F. 1991 . "Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. An in vivo microdialysis study" . Naunyn-Schmiedeberg's Arch. Pharmacol. , 343 : 237 – 244 .
   Google Scholar
• Adell , A. and Artigas , F. 1998 . "A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat" . Br. J. Pharmacol. , 125 : 361 – 1367 .
   Google Scholar
• Adell , A. , Carceller , A. and Artigas , F. 1993 . "In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat. Effects of 8-hydroxy-2-(di- n -propylamino)tetralin" . J. Neurochem. , 60 : 1673 – 1681 .
   PubMedGoogle Scholar
• Aghajanian , G.K. and Lakoski , J.M. 1984 . "Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K + conductance" . Brain Res. , 305 : 181 – 185 .
   PubMedGoogle Scholar
• Aghajanian , G.K. and Marek , G.J. 1997 . "Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells" . Neuropharmacology , 36 : 589 – 599 .
   PubMed Web of Science ®Google Scholar
• Aghajanian , G.K. and Marek , G.J. 1999 . "Serotonin, via 5-HT 2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release" . Brain Res. , 825 : 161 – 171 .
   PubMed Web of Science ®Google Scholar
• Aghajanian , G.K. and Marek , G.J. 2000 . "Serotonin model of schizophrenia: emerging role of glutamate mechanisms" . Brain Res. Rev. , 31 : 302 – 312 .
   PubMed Web of Science ®Google Scholar
• Aghajanian , G.K. and Wang , R.Y. 1977 . "Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique" . Brain Res. , 122 : 229 – 242 .
   PubMed Web of Science ®Google Scholar
• Andreasen , N.C. , O'Leary , D.S. , Flaum , M. , Nopoulos , P. , Watkins , G.L. , Boles Ponto , L.L. and Hichwa , R.D. 1997 . "Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients" . Lancet , 349 : 1730 – 1734 .
   PubMed Web of Science ®Google Scholar
• Araneda , R. and Andrade , R. 1991 . "5-Hydroxytryptamine 2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex" . Neuroscience , 40 : 399 – 412 .
   PubMed Web of Science ®Google Scholar
• Azmitia , E.C. and Segal , M. 1978 . "An autoradiographic analysis of the differential ascending projections of the dorsal and medial raphe nuclei in the rat" . J. Comp. Neurol. , 179 : 641 – 668 .
   PubMed Web of Science ®Google Scholar
• Baxter , L.R. Jr. , Schwartz , J.M. , Phelps , M.E. , Mazziotta , J.C. , Guze , B.H. , Selin , C.E. , Gerner , R.H. and Sumida , R.M. 1989 . "Reduction of prefrontal cortex glucose metabolism common to three types of depression" . Arch. Gen. Psychiatry , 46 : 243 – 250 .
   PubMed Web of Science ®Google Scholar
• Belin , M.F. , Nanopoulos , D. , Didier , M. , Aguera , M. , Steinbusch , H. , Verhofstad , A. , Maitre , M. and Pujol , J.F. 1983 . "Immunohistochemical evidence for the presence of gamma-aminobutyric acid and serotonin in one nerve cell. A study on the raphe nuclei of the rat using antibodies to glutamate decarboxylase and serotonin" . Brain Res. , 275 : 329 – 339 .
   PubMedGoogle Scholar
• Blier , P. and De Montigny , C. 1987 . "Modification of 5-HT neuron properties by sustained administration of the 5-HT 1A agonist gepirone: electrophysiological studies in the rat brain" . Synapse , 1 : 470 – 480 .
   PubMed Web of Science ®Google Scholar
• Blier , P. and De Montigny , C. 1994 . "Current advances and trends in the treatment of depression" . Trends Pharmacol. Sci. , 15 : 220 – 226 .
   PubMed Web of Science ®Google Scholar
• Blue , M.E. , Yagaloff , K.A. , Mamounas , L.A. , Hartig , P.R. and Molliver , M.E. 1988 . "Correspondence between 5-HT receptors and serotonergic axons in rat neocortex" . Brain Res. , 453 : 315 – 328 .
   PubMedGoogle Scholar
• Bremner , J.D. , Innis , R.B. , Salomon , R.M. , Staib , L.H. , Ng , C.K. , Miller , H.L. , Bronen , R.A. , Krystal , J.H. , Duncan , J. , Rich , D. , Price , L.H. , Malison , R. , Dey , H. , Soufer , R. and Charney , D.S. 1997 . "Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse" . Arch. Gen. Psychiatry , 54 : 364 – 374 .
   PubMed Web of Science ®Google Scholar
• Bremner , J.D. , Staib , L.H. , Kaloupek , D. , Southwick , S.M. , Soufer , R. and Charney , D.S. 1999 . "Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without post-traumatic stress disorder: a positron emission tomography study" . Biol. Psychiatry , 45 : 806 – 816 .
   PubMed Web of Science ®Google Scholar
• Casanovas , J.M. , Hervás , I. and Artigas , F. 1999 . "Postsynaptic 5-HT 1A receptors control 5-HT release in the rat medial prefrontal cortex" . Neuroreport , 10 : 1441 – 1445 .
   PubMed Web of Science ®Google Scholar
• Ceci , A. , Baschirotto , A. and Borsini , F. 1994 . "The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe neurons in rats is attenuated by lesion of the frontal cortex" . Neuropharmacology , 33 : 709 – 713 .
   PubMed Web of Science ®Google Scholar
• Celada , P. , Siuciakm , J.A. , Tranm , T.M. , Altarm , C.A. and Tepper , J.M. 1996 . "Local infusion of brain-derived neurotrophic factor modified the firing pattern of dorsal raphe serotonergic neurons" . Brain Res. , 712 : 293 – 298 .
   PubMed Web of Science ®Google Scholar
• Celada , P. , Puig , M.V. , Casanovas , J.M. , Guillazo , G. and Artigas , F. 2001 . "Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A GABA A and glutamate receptors" . J. Neurosci. , 21 : 9917 – 9929 .
   PubMed Web of Science ®Google Scholar
• Drevets , W.C. 2001 . "Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders" . Curr. Opin. Neurobiol. , 11 : 240 – 249 .
   PubMed Web of Science ®Google Scholar
• Drevets , W.C. , Price , J.L. , Simpson , J.R. Jr. , Todd , R.D. , Reich , T. , Vannier , M. and Raichle , M.E. 1997 . "Subgenual prefrontal cortex abnormalities in mood disorders" . Nature , 386 : 824 – 887 .
   PubMed Web of Science ®Google Scholar
• Fuller , J.H. and Schlag , J.D. 1976 . "Determination of antidromic excitation by the collision test: problems of interpretation" . Brain Res. , 112 : 283 – 298 .
   PubMed Web of Science ®Google Scholar
• Fuster , J.M. 1997 . The Prefrontal Cortex. Anatomy, Physiology and Neuropsychology of the Frontal Lobe , Philadelphia/New York : Lippincott/Raven .
   Google Scholar
• Gallager , D.W. and Aghajanian , G.K. 1976 . "Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin" . Eur. J. Pharmacol. , 39 : 357 – 364 .
   PubMed Web of Science ®Google Scholar
• Hajós , M. , Richards , C.D. , Szekely , A.D. and Sharp , T. 1998 . "An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat" . Neuroscience , 87 : 95 – 108 .
   PubMed Web of Science ®Google Scholar
• Hajós , M. , Hajos-Korsok , E. and Sharp , T. 1999 . "Role of the medial prefrontal cortex in 5-HT 1A receptor-induced inhibition of 5-HT neuronal activity in the rat" . Br. J. Pharmacol. , 126 : 1741 – 1750 .
   PubMedGoogle Scholar
• Hjorth , S. , Carlsson , A. , Magnusson , T. and Arvidsson , L.E. 1987 . "In vivo characterization of 8-OH-DPAT; evidence for 5-HT receptor selectivity and agonist in the rat CNS" ” . In Brain 5-HT 1A Receptors , Edited by: Dourish , C.T. , Ahlenius , S. and Hutson , P.H. 94 – 105 . Chichester : Ellis Horwood Publishers .
   Google Scholar
• Hutson , P.H. , Sarna , G.S. , O'Connell , M.T. and Curzon , G. 1989 . "Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OH-DPAT into the nucleus raphe dorsalis" . Neurosci. Lett. , 100 : 276 – 280 .
   PubMed Web of Science ®Google Scholar
• Invernizzi , R. , Carli , M. , Di Clemente , A. and Samanin , R. 1991 . "Administration of 8-hydroxy-2-(di- n -propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: differences in potency and regional sensitivity" . J. Neurochem. , 56 : 243 – 247 .
   PubMedGoogle Scholar
• Jacobs , B.L. and Azmitia , E.C. 1992 . "Structure and function of the brain serotonin system" . Physiol. Rev. , 72 : 165 – 229 .
   PubMed Web of Science ®Google Scholar
• Jakab , R.L. and Goldman-Rakic , P.S. 1998 . "5-Hydroxytryptamine 2A serotonin receptors in the primate cerebral cortex. Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites" . Proc. Natl Acad. Sci. USA , 95 : 735 – 740 .
   PubMed Web of Science ®Google Scholar
• Jakab , R.L. and Goldman-Rakic , P.S. 2000 . "Segregation of serotonin 5-HT 2A and 5-HT 3 receptors in inhibitory circuits of the primate cerebral cortex" . J. Comp. Neurol. , 417 : 337 – 348 .
   PubMedGoogle Scholar
• Jodo , E. , Chiang , C. and Aston-Jones , G. 1998 . "Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons" . Neuroscience , 83 : 63 – 79 .
   PubMed Web of Science ®Google Scholar
• Jolas , T. and Aghajanian , G.K. 1997 . "Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro" . Brain Res. , 755 : 229 – 245 .
   PubMedGoogle Scholar
• Kalén , P. , Strecker , R.E. , Rosengren , E. and Bjorklund , A. 1989 . "Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA" . Brain Res. , 492 : 187 – 202 .
   PubMedGoogle Scholar
• Kennedy , S.H. , Evans , K.R. , Kruger , S. , Mayberg , H.S. , Meyer , J.H. , McCann , S. , Arifuzzman , A.I. , Houle , S. and Vaccarino , F.J. 2001 . "Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression" . Am. J. Psychiatry , 158 : 899 – 905 .
   PubMed Web of Science ®Google Scholar
• Kia , H.K. , Miquel , M.C. , Brisorgueil , M.J. , Daval , G. , Riad , M. , El Mestikawy , S. , Hamon , M. and Vergé , D. 1996 . "Immunocytochemical localization of serotonin(1A) receptors in the rat central nervous system" . J. Comp. Neurol. , 365 : 289 – 305 .
   PubMed Web of Science ®Google Scholar
• Kroeze , W.K. and Roth , B.L. 1998 . "The molecular biology of serotonin receptors: therapeutic implications for the interface of mood disorders and psychosis" . Biol. Psychiatry , 44 : 1128 – 1142 .
   PubMed Web of Science ®Google Scholar
• Liberzon , I. , Taylor , S.F. , Amdur , R. , Jung , T.D. , Chamberlain , K.R. , Minoshima , S. , Koeppe , R.A. and Fig , L.M. 1999 . "Brain activation in PTSD in response to trauma-related stimuli" . Biol. Psychiatry , 45 : 817 – 826 .
   PubMed Web of Science ®Google Scholar
• Marek , G.J. , Wright , R.A. , Schoepp , D.D. , Monn , J.A. and Aghajanian , G.K. 2000 . "Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex" . J. Pharmacol. Exp. Ther. , 292 : 76 – 87 .
   PubMed Web of Science ®Google Scholar
• Marek , G.J. , Wright , R.A. , Gewitz , J.C. and Schoepp , D.D. 2001 . "A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in neocortex" . Neuroscience , 105 : 379 – 392 .
   PubMedGoogle Scholar
• Martinot , J.L. , Hardy , P. , Feline , A. , Huret , J.D. , Mazoyer , B. , Attar-Levy , D. , Pappata , S. and Syrota , A. 1990 . "Left prefrontal glucose hypometabolism in the depressed state: a confirmation" . Am. J. Psychiatry , 147 : 1313 – 1317 .
   PubMed Web of Science ®Google Scholar
• Martín-Ruiz , R. , Puig , M.V. , Celada , P. , Shapiro , D.A. , Roth , B.L. , Mengod , G. and Artigas , F. 2001 . "Control of serotonergic function in medial prefrontal cortex by 5-HT 2A receptors through a glutamate-dependent mechanism" . J. Neurosci. , 21 : 9856 – 9866 .
   PubMed Web of Science ®Google Scholar
• Meltzer , H.Y. 1999 . "The role of serotonin in antipsychotic drug action" . Neuropsychopharmacology , 21 : S106 – S115 .
   PubMed Web of Science ®Google Scholar
• Miner , L.H. , Schroeter , S. , Blakely , R.D. and Sesack , S.R. 2000 . "Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals" . J. Comp. Neurol. , 427 : 220 – 234 .
   PubMedGoogle Scholar
• Montgomery , S.A. 1994 . "Long-term treatment of depression" . Br. J. Phychiatry , 26 ( Suppl. ) : 31 – 36 .
   Google Scholar
• Murase , S. , Grenhoff , J. , Chouvet , G. , Gonon , F.G. and Svensson , T.H. 1993 . "Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo" . Neurosci. Lett. , 157 : 53 – 56 .
   PubMed Web of Science ®Google Scholar
• Nanopoulos , D. , Belin , M.F. , Maitre , M. , Vincendon , G. and Pujol , J.F. 1982 . "Immunocytochemical evidence for the existence of GABAergic neurons in the nucleus raphe dorsalis. Possible existence of neurons containing serotonin and GABA" . Brain Res. , 232 : 375 – 389 .
   PubMed Web of Science ®Google Scholar
• Paxinos , G. and Watson , C. 1986 . The Rat Brain in Stereotaxic Coordinates , Sydney : Academic Press .
   Google Scholar
• Pazos , A. and Palacios , J.M. 1985 . "Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors" . Brain Res. , 346 : 205 – 230 .
   PubMed Web of Science ®Google Scholar
• Peyron , C. , Petit , J.M. , Rampon , C. , Jouvet , M. and Luppi , P.H. 1998 . "Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods" . Neuroscience , 82 : 443 – 468 .
   PubMed Web of Science ®Google Scholar
• Pompeiano , M. , Palacios , J.M. and Mengod , G. 1992 . "Distribution and cellular localization of mRNA coding for 5-HT 1A receptor in the rat brain: correlation with receptor binding" . J. Neurosci. , 12 : 440 – 453 .
   PubMed Web of Science ®Google Scholar
• Pompeiano , M. , Palacios , J.M. and Mengod , G. 1994 . "Distribution of the serotonin 5-HT 2 receptor family mRNAs: comparison between 5-HT 2A and 5-HT 2C receptors" . Mol. Brain Res. , 23 : 163 – 178 .
   PubMedGoogle Scholar
• Rauch , S.L. , Van der Kolk , B.A. , Fisler , R.E. , Alpert , N.M. , Orr , S.P. , Savage , C.R. , Fischman , A.J. , Jenike , M.A. and Pitman , R.K. 1996 . "A symptom provocation study of post-traumatic stress disorder using positron emission tomography and script-driven imagery" . Arch. Gen. Psychiatry , 53 : 380 – 387 .
   PubMed Web of Science ®Google Scholar
• Romero , L. , Celada , P. and Artigas , F. 1994 . "Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/Go proteins in dorsal raphe nucleus" . Eur. J. Pharmacol. , 265 : 103 – 106 .
   PubMedGoogle Scholar
• Sawyer , S.F. , Tepper , J.M. , Young , S.J. and Groves , P.M. 1985 . "Antidromic activation of dorsal raphe neurons from neostriatum: physiological characterization and effects of terminal autoreceptor activation" . Brain Res. , 332 : 15 – 28 .
   PubMedGoogle Scholar
• Sesack , S.R. and Pickel , V.M. 1992 . "Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area" . J. Comp. Neurol. , 320 : 145 – 160 .
   PubMed Web of Science ®Google Scholar
• Sesack , S.R. , Deutch , A.Y. , Roth , R.H. and Bunney , B.S. 1989 . "Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin" . J. Comp. Neurol. , 290 : 213 – 242 .
   PubMed Web of Science ®Google Scholar
• Shim , S.S. , Bunney , B.S. and Shi , W.X. 1996 . "Effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons" . Neuropsychopharmacology , 15 : 437 – 441 .
   PubMedGoogle Scholar
• Smiley , J.F. and Goldman-Rakic , P.S. 1996 . "Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy" . J. Comp. Neurol. , 367 : 431 – 443 .
   PubMedGoogle Scholar
• Sprouse , J.S. and Aghajanian , G.K. 1987 . "Electrophysiological responses of serotonergic dorsal raphe neurons to 5-HT 1A and 5-HT 1B agonists" . Synapse , 1 : 3 – 9 .
   PubMed Web of Science ®Google Scholar
• Steinbusch , H.W.M. 1981 . "Distribution of serotonin-immunoreactivity in the central nervous system of the rat. Cell bodies and terminals" . Neuroscience , 6 : 557 – 618 .
   PubMed Web of Science ®Google Scholar
• Stern , W.C. , Johnson , A. , Bronzino , J.D. and Morgane , P.J. 1981 . "Neuropharmacology of the afferent projections from the lateral habenula and substantia nigra to the anterior raphe in the rat" . Neuropharmacology , 20 : 979 – 989 .
   PubMedGoogle Scholar
• Takagishi , M. and Chiba , T. 1991 . "Efferent projections of the infralimbic (area 25) region of the medial prefrontal cortex in the rat: an anterograde tracer PHA-L study" . Brain Res. , 566 : 26 – 39 .
   PubMedGoogle Scholar
• Thierry , A.M. , Deniau , J.M. , Chevalier , G. , Ferron , A. and Glowinski , J. 1983 . "An electrophysiological analysis of some afferent and efferent pathways of the rat prefrontal cortex" . Prog. Brain Res. , 58 : 257 – 261 .
   PubMedGoogle Scholar
• Wang , R.Y. and Aghajanian , G.K. 1977 . "Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition" . Brain Res. , 132 : 186 – 193 .
   PubMedGoogle Scholar
• Willins , D.L. , Deutch , A.Y. and Roth , B.L. 1997 . "Serotonin 5HT 2A receptors are expressed on pyramidal neurons and interneurons in the rat cortex" . Synapse , 27 : 79 – 82 .
   PubMed Web of Science ®Google Scholar
• Xu , T.J. and Pandey , S.C. 2000 . "Cellular localization of serotonin 2A (5HT 2A) receptors in the rat brain" . Brain Res. Bull. , 51 : 499 – 505 .
   PubMed Web of Science ®Google Scholar
• Zhou , F.C. , Taocheng , J.H. , Segu , L. , Patel , T. and Wang , Y. 1998 . "Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence" . Brain Res. , 805 : 241 – 254 .
   PubMed Web of Science ®Google Scholar
• Zubieta , J.K. , Chinitz , J.A. , Lombardi , U. , Fig , L.M. , Cameron , O.G. and Liberzon , I. 1999 . "Medial frontal cortex involvement in PTSD symptoms: a SPECT study" . J. Psychiatr. Res. , 33 : 259 – 264 .
   PubMed Web of Science ®Google Scholar