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Polyphenols and inflammatory bowel disease: Natural products with therapeutic effects?

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References

  • Alatab, S., Sepanlou, S. G., Ikuta, K., Vahedi, H., Bisignano, C., Safiri, S., Sadeghi, A., Nixon, M. R., Abdoli, A., et al. 2020. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: A systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol 5 (1):17–30.
  • Abdallah, D. M, and N. R. Ismael. 2011. Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats. Canadian Journal of Physiology and Pharmacology 89 (11): 811–8.
  • Abraham, C, and J. H. Cho. 2009. Inflammatory bowel disease. The New England Journal of Medicine 361 (21):2066–78. doi: 10.1056/NEJMra0804647.
  • Aggarwal, B. B., C. Sundaram, N. Malani, and H. Ichikawa. 2007. Curcumin: The Indian solid gold. Advances in Experimental Medicine and Biology 595:1–75.
  • Ahluwalia, B., L. Moraes, M. K. Magnusson, and L. Öhman. 2018. Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies. Scandinavian Journal of Gastroenterology 53 (4):379–89.
  • Ahmad, S. F., K. M. Zoheir, H. E. Abdel-Hamied, A. E. Ashour, S. A. Bakheet, S. M. Attia, and A. R. Abd-Allah. 2014. Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines. Cellular Immunology 287 (2):112–20.
  • Al-Bawardy, B., R. Shivashankar, and D. D. Proctor. 2021. Novel and emerging therapies for inflammatory bowel disease. Frontiers in Pharmacology 12:651415.
  • Al-Rejaie, S. S., H. M. Abuohashish, M. M. Al-Enazi, A. H. Al-Assaf, M. Y. Parmar, and M. M. Ahmed. 2013. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World Journal of Gastroenterology 19 (34):5633–44. doi: 10.3748/wjg.v19.i34.5633.
  • Al-Sadi, R., P. Nighot, M. Nighot, M. Haque, M. Rawat, and T. Y. Ma. 2021. Lactobacillus acidophilus induces a strain-specific and toll-like receptor 2-dependent enhancement of intestinal epithelial tight junction barrier and protection against intestinal inflammation. The American Journal of Pathology 191 (5):872–84. doi: 10.1016/j.ajpath.2021.02.003.
  • Alam, M. A., N. Subhan, M. M. Rahman, S. J. Uddin, H. M. Reza, and S. D. Sarker. 2014. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition (Bethesda, Md.) 5 (4):404–17.
  • Almofarreh, A., H. A. Sheerah, A. Arafa, S. S. Ahamed, O. Alzeer, W. Al-Hunaishi, M. M. Mhimed, A. Al-Hazmi, and S. H. Lim. 2022. Beverage consumption and ulcerative colitis: A case-control study from Saudi Arabia. Int J Environ Res Public Health. 19 (4): 2287–98
  • Alrafas, H. R., P. B. Busbee, M. Nagarkatti, and P. S. Nagarkatti. 2019. Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells. Journal of Leukocyte Biology 106 (2):467–80. doi: 10.1002/JLB.3A1218-476RR.
  • Alrafas, H. R., P. B. Busbee, M. Nagarkatti, and P. S. Nagarkatti. 2020. Resveratrol downregulates miR-31 to promote t regulatory cells during prevention of TNBS-induced colitis. Molecular Nutrition & Food Research 64 (1):e1900633.
  • Askari, G., R. Ghiasvand, A. Feizi, S. M. Ghanadian, and J. Karimian. 2012. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. Journal of Research in Medical Sciences 17:7: 637–41.
  • Azuma, T., M. Shigeshiro, M. Kodama, S. Tanabe, and T. Suzuki. 2013. Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice. The Journal of Nutrition 143 (6):827–34.
  • Bai, W., C. Wang, and C. Ren. 2014. Intakes of total and individual flavonoids by us adults. International Journal of Food Sciences and Nutrition 65 (1):9–20.
  • Bansal, M., N. Singh, S. Pal, I. Dev, K. M., and Ansari, Jc. 2018. Chapter three – Chemopreventive role of dietary phytochemicals in colorectal cancer. In Advances in molecular toxicology, eds FishbeinHeilman, J. M., 69–121. Elsevier.
  • Bian, X., W. Wu, L. Yang, L. Lv, Q. Wang, Y. Li, J. Ye, D. Fang, J. Wu, X. Jiang, et al. 2019. Administration of Akkermansia muciniphila ameliorates dextran sulfate sodium-induced ulcerative colitis in mice. Frontiers in Microbiology 10:2259.
  • Bian, Y., P. Liu, J. Zhong, Y. Hu, S. Zhuang, K. Fan, and Z. Liu. 2018. Quercetin attenuates adhesion molecule expression in intestinal microvascular endothelial cells by modulating multiple pathways. Digestive Diseases and Sciences 63 (12):3297–304.
  • Bibiloni, R., R. N. Fedorak, G. W. Tannock, K. L. Madsen, P. Gionchetti, M. Campieri, C. De Simone, and R. B. Sartor. 2005. VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. The American Journal of Gastroenterology 100 (7):1539–46. doi: 10.1111/j.1572-0241.2005.41794.x.
  • Bing, X., L. Xuelei, D. Wanwei, L. Linlang, and C. Keyan. 2017. EGCG maintains Th1/Th2 balance and mitigates ulcerative colitis induced by dextran sulfate sodium through TLR4/MyD88/NF-κB signaling pathway in rats. Canadian Journal of Gastroenterology & Hepatology 2017:3057268. doi: 10.1155/2017/3057268.
  • Byun, E. B., H. G. Choi, N. Y. Sung, and E. H. Byun. 2012. Green tea polyphenol epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa laminin receptor on lipopolysaccharide-stimulated dendritic cells. Biochemical and Biophysical Research Communications 426 (4):4: 480–5.
  • Byun, E. B., W. S. Kim, N. Y. Sung, and E. H. Byun. 2018. Epigallocatechin-3-gallate regulates anti-inflammatory action through 67-kDa laminin receptor-mediated tollip signaling induction in lipopolysaccharide-stimulated human intestinal epithelial cells. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 46 (5):2072–81. doi: 10.1159/000489447.
  • Cai, Z., S. Wang, and J. Li. 2021. Treatment of inflammatory bowel disease: A comprehensive review. Frontiers in Medicine 8:765474.
  • Cao, R., X. Wu, H. Guo, X. Pan, R. Huang, G. Wang, and J. Liu. 2021. Naringin exhibited therapeutic effects against DSS-induced mice ulcerative colitis in intestinal barrier-dependent manner. Molecules 26 (21):6604. doi: 10.3390/molecules26216604.
  • Cao, Y., J. Shen, and Z. H. Ran. 2014. Association between Faecalibacterium prausnitzii reduction and inflammatory bowel disease: A meta-analysis and systematic review of the literature. Gastroenterology Research and Practice 2014:872725. doi: 10.1155/2014/872725.
  • Cao, Z., Y. Wang, W. Zheng, L. Yin, Y. Tang, W. Miao, S. Liu, and B. Yang. 2022. The algorithm of stereo vision and shape from shading based on endoscope imaging. Biomedical Signal Processing and Control 76:103658. doi: 10.1016/j.bspc.2022.103658.
  • Capitán-Cañadas, F., B. Ocón, C. J. Aranda, A. Anzola, M. D. Suárez, A. Zarzuelo, F. S. De Medina, and O. Martínez-Augustin. 2016. Fructooligosaccharides exert intestinal anti-inflammatory activity in the CD4+ CD62L + T cell transfer model of colitis in C57BL/6J mice. European Journal of Nutrition 55 (4):1445–54. doi: 10.1007/s00394-015-0962-6.
  • Carroll, M. W., M. E. Kuenzig, D. R. Mack, A. R. Otley, A. M. Griffiths, G. G. Kaplan, C. N. Bernstein, A. Bitton, S. K. Murthy, G. C. Nguyen, et al. 2019. The impact of inflammatory bowel disease in Canada 2018: Children and adolescents with IBD. Journal of the Canadian Association of Gastroenterology 2 (Suppl 1):S49–S67.
  • Cătană, C. S., I. Berindan Neagoe, V. Cozma, C. Magdaş, F. Tăbăran, and D. L. Dumitraşcu. 2015. Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease. World Journal of Gastroenterology 21 (19):5823–30. doi: 10.3748/wjg.v21.i19.5823.
  • Chaen, Y., Y. Yamamoto, and T. Suzuki. 2019. Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-α production and induction of M2-type macrophages in colitic mice. Nutrition Research (New York, N.Y.) 64:82–92. doi: 10.1016/j.nutres.2019.01.004.
  • Chen, L., Y. Huang, X. Yu, J. Lu, W. Jia, J. Song, L. Liu, Y. Wang, Y. Huang, J. Xie, et al. 2021a. Corynoxine protects dopaminergic neurons through inducing autophagy and diminishing neuroinflammation in rotenone-induced animal models of Parkinson’s disease. Frontiers in Pharmacology 12:642900. doi: 10.3389/fphar.2021.642900.
  • Chen, Y., B. Yang, C. Stanton, R. P. Ross, J. Zhao, H. Zhang, and W. Chen. 2021b. Bifidobacterium pseudocatenulatum ameliorates DSS-induced colitis by maintaining intestinal mechanical barrier, blocking proinflammatory cytokines, inhibiting TLR4/NF-κB signaling, and altering gut microbiota. Journal of Agricultural and Food Chemistry 69 (5):1496–512. doi: 10.1021/acs.jafc.0c06329.
  • Chen, Y., Z. Zheng, C. Li, Y. Pan, X. Tang, and X. J. Wang. 2019. Synthetic imine resveratrol analog 2-methoxyl-3,6-dihydroxyl-IRA ameliorates colitis by activating protective Nrf2 pathway and inhibiting NLRP3 expression. Oxidative Medicine and Cellular Longevity 2019:7180284.
  • Chen, Y. M., W. C. Chiu, Y. S. Chiu, T. Li, H. C. Sung, and C. Y. Hsiao. 2020. Supplementation of nano-bubble curcumin extract improves gut microbiota composition and exercise performance in mice. Food & Function 11 (4):4: 3574–3584.
  • Cheng, F. S., D. Pan, B. Chang, M. Jiang, and L. X. Sang. 2020. Probiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases. World Journal of Clinical Cases 8 (8):1361–84. doi: 10.12998/wjcc.v8.i8.1361.
  • Choy, M. C., K. Visvanathan, and P. D. Cruz. 2017. An overview of the innate and adaptive immune system in inflammatory bowel disease. Inflammatory Bowel Diseases 23 (1):2–13.
  • Chudy-Onwugaje, K. O., K. E. Christian, F. A. Farraye, and R. K. Cross. 2019. A state-of-the-art review of new and emerging therapies for the treatment of IBD. Inflammatory Bowel Diseases 25 (5):820–30. doi: 10.1093/ibd/izy327.
  • Comalada, M., D. Camuesco, S. Sierra, I. Ballester, J. Xaus, J. Gálvez, and A. Zarzuelo. 2005. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappab pathway. European Journal of Immunology 35 (2):584–92.
  • Cong, Y., L. Wang, A. Konrad, T. Schoeb, and C. O. Elson. 2009. Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells. European Journal of Immunology 39 (11):3134–46.
  • Coward, S., M. E. Kuenzig, G. Hazlewood, F. Clement, K. Mcbrien, R. Holmes, R. Panaccione, S. Ghosh, C. H. Seow, A. Rezaie, et al. 2017. Comparative effectiveness of mesalamine, sulfasalazine, corticosteroids, and budesonide for the induction of remission in Crohn’s disease: A Bayesian network meta-analysis. Inflammatory Bowel Diseases 23 (3):461–72. doi: 10.1097/MIB.0000000000001023.
  • Crooks, B., T. Barnes, and J. K. Limdi. 2020. Vedolizumab in the treatment of inflammatory bowel disease: Evolving paradigms. Drugs Context 9: 2019–23
  • Cui, X., Y. Jin, A. B. Hofseth, E. Pena, J. Habiger, A. Chumanevich, D. Poudyal, M. Nagarkatti, P. S. Nagarkatti, U. P. Singh, et al. 2010. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prevention Research (Philadelphia, Pa.) 3 (4):4: 549–59.
  • Deguchi, Y., A. Andoh, O. Inatomi, Y. Yagi, S. Bamba, Y. Araki, K. Hata, T. Tsujikawa, and Y. Fujiyama. 2007. Curcumin prevents the development of dextran sulfate sodium (DSS)-induced experimental colitis. Digestive Diseases and Sciences 52 (11):2993–8.
  • Diez-Echave, P., A. J. Ruiz-Malagón, J. A. Molina-Tijeras, L. Hidalgo-García, T. Vezza, L. Cenis-Cifuentes, M. J. Rodríguez-Sojo, J. L. Cenis, M. E. Rodríguez-Cabezas, A. Rodríguez-Nogales, et al. 2021. Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis. International Journal of Pharmaceutics 606:120935. doi: 10.1016/j.ijpharm.2021.120935.
  • Dodda, D., R. Chhajed, J. Mishra, and M. Padhy. 2014. Targeting oxidative stress attenuates trinitrobenzene sulphonic acid induced inflammatory bowel disease like symptoms in rats: Role of quercetin. Indian Journal of Pharmacology 46 (3):286–91. doi: 10.4103/0253-7613.132160.
  • Dong, Y., J. Lei, and B. Zhang. 2020. Dietary quercetin alleviated DSS-induced colitis in mice through several possible pathways by transcriptome analysis. Current Pharmaceutical Biotechnology 21 (15):1666–73. doi: 10.2174/1389201021666200711152726.
  • Dou, W., J. Zhang, A. Sun, E. Zhang, L. Ding, S. Mukherjee, X. Wei, G. Chou, Z. T. Wang, and S. Mani. 2013. Protective effect of naringenin against experimental colitis via suppression of toll-like receptor 4/NF-κB signalling. The British Journal of Nutrition 110 (4):599–608.
  • Dryden, G. W., A. Lam, K. Beatty, H. H. Qazzaz, and C. J. Mcclain. 2013. A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis. Inflamm Bowel Dis 19 (9):1904–12.
  • Du, Y., H. Ding, K. Vanarsa, S. Soomro, S. Baig, J. Hicks, and C. Mohan. 2019. Low dose epigallocatechin gallate alleviates experimental colitis by subduing inflammatory cells and cytokines, and improving intestinal permeability. Nutrients 11 (8):1743. doi: 10.3390/nu11081743.
  • Du, Y., J. Ma, Y. Fan, X. Wang, S. Zheng, J. Feng, J. Li, Z. Fan, G. Li, and Q. Ye. 2021. Naringenin: A promising therapeutic agent against organ fibrosis. Oxidative Medicine and Cellular Longevity 2021:1210675. doi: 10.1155/2021/1210675.
  • Fang, D., D. Shi, L. Lv, S. Gu, W. Wu, Y. Chen, J. Guo, A. L. X. Hu, F. Guo, J. Ye, et al. 2017. Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota. Scientific Reports 7 (1):8770.
  • Feagan, B. G., W. J. Sandborn, G. D’haens, J. Panés, A. Kaser, M. Ferrante, E. Louis, D. Franchimont, O. Dewit, U. Seidler, et al. 2017. Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn’s disease: A randomised, double-blind, placebo-controlled phase 2 study. Lancet (London, England) 389 (10080):1699–709. doi: 10.1016/S0140-6736(17)30570-6.
  • Firrman, J., L. Liu, G. A. Argoty, L. Zhang, P. Tomasula, M. Wang, S. Pontious, M. Kobori, and W. Xiao. 2018. Analysis of temporal changes in growth and gene expression for commensal gut microbes in response to the polyphenol naringenin. Microbiology Insights 11:1178636118775100. doi: 10.1177/1178636118775100.
  • Freeman, K., R. Ryan, N. Parsons, S. Taylor-Phillips, B. H. Willis, and A. Clarke. 2021. The incidence and prevalence of inflammatory bowel disease in UK primary care: A retrospective cohort study of the iqvia medical research database. BMC Gastroenterology 21 (1):139. doi: 10.1186/s12876-021-01716-6.
  • Galleggiante, V., S. De Santis, M. Liso, G. Verna, E. Sommella, M. Mastronardi, P. Campiglia, M. Chieppa, and G. Serino. 2019. Quercetin-induced miR-369-3p suppresses chronic inflammatory response targeting C/EBP-β. Molecular Nutrition & Food Research 63 (19):e1801390.
  • Ganji-Arjenaki, M, and M. Rafieian-Kopaei. 2018. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. Journal of Cellular Physiology 233 (3):2091–103.
  • Gerlach, K., A. N. Mckenzie, M. F. Neurath, and B. Weigmann. 2015. IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis. Tissue Barriers 3 (1–2):e983777.
  • Godos, J., F. Caraci, S. Castellano, W. Currenti, F. Galvano, R. Ferri, and G. Grosso. 2020. Association between dietary flavonoids intake and cognitive function in an Italian cohort. Biomolecules 10 (9):1300. doi: 10.3390/biom10091300.
  • Gong, Y., Y. Lin, N. Zhao, X. He, A. Lu, W. Wei, and M. Jiang. 2016. The Th17/Treg immune imbalance in ulcerative colitis disease in a Chinese Han population. Mediators of Inflammation 2016:7089137. doi: 10.1155/2016/7089137.
  • Gong, Z., S. Zhao, J. Zhou, J. Yan, L. Wang, X. Du, H. Li, Y. Chen, W. Cai, and J. Wu. 2018. Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production. Molecular Immunology 104:11–9. doi: 10.1016/j.molimm.2018.09.004.
  • Guazelli, C. F., V. Fattori, B. B. Colombo, S. R. Georgetti, F. T. Vicentini, R. Casagrande, M. M. Baracat, and W. A. Verri. Jr. 2013. Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms. Journal of Natural Products 76 (2):: 200–8.
  • Guo, X., Y. Xu, R. Geng, J. Qiu, and X. He. 2022. Curcumin alleviates dextran sulfate sodium-induced colitis in mice through regulating gut microbiota. Molecular Nutrition & Food Research 66 (8):e2100943. doi: 10.1002/mnfr.202100943.
  • Hanai, H., T. Iida, K. Takeuchi, F. Watanabe, Y. Maruyama, A. Andoh, T. Tsujikawa, Y. Fujiyama, K. Mitsuyama, M. Sata, et al. 2006. Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association 4 (12):1502–6.
  • He, X., Y. Zhu, L. Yang, Z. Wang, Z. Wang, J. Feng, X. Wen, L. Cheng, and R. Zhu. 2021. MgFe‐LDH nanoparticles: A promising leukemia inhibitory factor replacement for self‐renewal and pluripotency maintenance in cultured mouse embryonic stem cells. Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 8 (9):2003535. doi: 10.1002/advs.202003535.
  • Hong, Z, and M. Piao. 2018. Effect of quercetin monoglycosides on oxidative stress and gut microbiota diversity in mice with dextran sodium sulphate-induced colitis. BioMed Research International 2018:8343052. doi: 10.1155/2018/8343052.
  • Hu, Y., J. Gu, J. Lin, Y. Wang, F. Yang, J. Yin, Z. Yu, S. Wu, H. Lv, X. Ji, et al. 2021. (-)-epigallocatechin-3-gallate (EGCG) modulates polarized macrophages to suppress M1 phenotype and promote M2 polarization in vitro and in vivo. Journal of Functional Foods 87:104743. doi: 10.1016/j.jff.2021.104743.
  • Huang, S., L. Zhao, K. Kim, D. S. Lee, and D. H. Hwang. 2008. Inhibition of NOD2 signaling and target gene expression by curcumin. Molecular Pharmacology 74 (1):274–81.
  • Iqbal, U., H. Anwar, and A. A. Quadri. 2018. Use of curcumin in achieving clinical and endoscopic remission in ulcerative colitis: A systematic review and meta-analysis. The American Journal of the Medical Sciences 356 (4):350–6.
  • Ivanov, I. I., R. d L. Frutos, N. Manel, K. Yoshinaga, D. B. Rifkin, R. B. Sartor, B. B. Finlay, and D. R. Littman. 2008. Specific microbiota direct the differentiation of IL-17-producing t-helper cells in the mucosa of the small intestine. Cell Host & Microbe 4 (4):337–49.
  • Izzo, C., M. Annunziata, G. Melara, R. Sciorio, M. Dallio, M. Masarone, A. Federico, and M. Persico. 2021. The role of resveratrol in liver disease: A comprehensive review from in vitro to clinical trials. Nutrients 13 (3):933. doi: 10.3390/nu13030933.
  • Jian, Y. T., G. F. Mai, J. D. Wang, Y. L. Zhang, R. C. Luo, and Y. X. Fang. 2005. Preventive and therapeutic effects of NF-kappab inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid. World Journal of Gastroenterology 11 (12):1747–52.
  • Jiang, W., J. Su, X. Zhang, X. Cheng, J. Zhou, R. Shi, and H. Zhang. 2014. Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease. Inflammation Research: Official Journal of the European Histamine Research Society. [et al.] 63 (11):943–50. doi: 10.1007/s00011-014-0768-7.
  • Joo, S. Y., Y. A. Song, Y. L. Park, E. Myung, C. Y. Chung, K. J. Park, S. B. Cho, W. S. Lee, H. S. Kim, J. S. Rew, et al. 2012. Epigallocatechin-3-gallate inhibits LPS-induced NF-κB and MAPK signaling pathways in bone marrow-derived macrophages. Gut and Liver 6 (2):188–96.
  • Ju, S., Y. Ge, P. Li, X. Tian, H. Wang, X. Zheng, and S. Ju. 2018. Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway. Cell Cycle (Georgetown, Tex.) 17 (1):53–63. doi: 10.1080/15384101.2017.1387701.
  • Junyuan, Z., X. Hui, H. Chunlan, F. Junjie, M. Qixiang, L. Yingying, L. Lihong, W. Xingpeng, and Z. Yue. 2018. Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ers inhibition. Pancreatology: Official Journal of the International Association of Pancreatology (IAP). [et al.] 18 (7):742–52. doi: 10.1016/j.pan.2018.08.001.
  • Justesen, U., P. Knuthsen, N. Lyhne Andersen, and T. Leth. 2000. Estimation of daily intake distribution of flavonols and flavanones in Denmark. Näringsforskning 44 (1):1: 158–160. doi: 10.3402/fnr.v44i0.1781.
  • Kang, Z. P., M. X. Wang, T. T. Wu, D. Y. Liu, H. Y. Wang, J. Long, H. M. Zhao, and Y. B. Zhong. 2021. Curcumin alleviated dextran sulfate sodium-induced colitis by regulating M1/M2 macrophage polarization and TLRs signaling pathway. Evidence-Based Complementary and Alternative Medicine : eCAM 2021:3334994. doi: 10.1155/2021/3334994.
  • Kedia, S., V. Bhatia, S. Thareja, S. Garg, V. P. Mouli, S. Bopanna, V. Tiwari, G. Makharia, and V. Ahuja. 2017. Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial. World Journal of Gastrointestinal Pharmacology and Therapeutics 8 (2):147–54. doi: 10.4292/wjgpt.v8.i2.147.
  • Kim, G. Y., H. Cho, S. C. Ahn, Y. H. Oh, C. M. Lee, and Y. M. Park. 2004. Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells. International Immunopharmacology 4 (2):245–53.
  • Kim, H., Y. Jeong, S. Kang, H. J. You, and G. E. Ji. 2020. Co-culture with Bifidobacterium catenulatum improves the growth, gut colonization, and butyrate production of Faecalibacterium prausnitzii: In vitro and in vivo studies. Microorganisms 8 (5):788. doi: 10.3390/microorganisms8050788.
  • Kmieć, Z., M. Cyman, and T. J. Ślebioda. 2017. Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease. Advances in Medical Sciences 62 (1):1–16.
  • Kumar Singh, A., C. Cabral, R. Kumar, R. Ganguly, H. Kumar Rana, A. Gupta, M. R. Lauro, C. Carbone, F. Reis, and A. K. Pandey. 2019. Beneficial effects of dietary polyphenols on gut microbiota and strategies to improve delivery efficiency. Nutrients 11 (9):2216. doi: 10.3390/nu11092216.
  • Kwak, M. S., J. M. Cha, H. H. Lee, Y. S. Choi, S. I. Seo, K. J. Ko, D. I. Park, S. H. Kim, and T. J. Kim. 2019. Emerging trends of inflammatory bowel disease in South Korea: A nationwide population-based study. Journal of Gastroenterology and Hepatology 34 (6):1018–26.
  • Kwon, Y. 2014. Estimation of curcumin intake in Korea based on the korea national health and nutrition examination survey (2008–2012). Nutrition Research and Practice 8 (5):589–94. doi: 10.4162/nrp.2014.8.5.589.
  • Lang, A., N. Salomon, J. C. Wu, U. Kopylov, A. Lahat, O. Har-Noy, J. Y. Ching, P. K. Cheong, B. Avidan, D. Gamus, et al. 2015. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology and Hepatology 13 (8):1444–9 e1. doi: 10.1016/j.cgh.2015.02.019.
  • Larmonier, C. B., M. T. Midura-Kiela, R. Ramalingam, D. Laubitz, N. Janikashvili, N. Larmonier, F. K. Ghishan, and P. R. Kiela. 2011. Modulation of neutrophil motility by curcumin: Implications for inflammatory bowel disease. Inflammatory Bowel Diseases 17 (2):503–15.
  • Larmonier, C. B., J. K. Uno, K. M. Lee, T. Karrasch, D. Laubitz, R. Thurston, M. T. Midura-Kiela, F. K. Ghishan, R. B. Sartor, C. Jobin, et al. 2008. Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection. American Journal of Physiology. Gastrointestinal and Liver Physiology 295 (5):G1079–91.
  • Larrosa, M., M. J. Yañéz-Gascón, M. V. Selma, A. González-Sarrías, S. Toti, J. J. Cerón, F. Tomás-Barberán, P. Dolara, and J. C. Espín. 2009. Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model. Journal of Agricultural and Food Chemistry 57 (6):2211–20. doi: 10.1021/jf803638d.
  • Le, Z., Z. He, H. Liu, L. Liu, Z. Liu, and Y. Chen. 2021. Antioxidant enzymes sequestered within lipid-polymer hybrid nanoparticles for the local treatment of inflammatory bowel disease. ACS Applied Materials & Interfaces 13 (47):55966–77.
  • Lee, J. G., D. S. Han, S. V. Jo, A. R. Lee, C. H. Park, C. S. Eun, and Y. Lee. 2019. Characteristics and pathogenic role of adherent-invasive Escherichia coli in inflammatory bowel disease: Potential impact on clinical outcomes. PloS One 14 (4):e0216165.
  • Li, B., R. Alli, P. Vogel, and T. L. Geiger. 2014. IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis. Mucosal Immunology 7 (4):869–78.
  • Li, C. P., J. H. Li, S. Y. He, O. Chen, and L. Shi. 2015a. Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis. Genetics and Molecular Research: GMR 14 (2):3450–8.
  • Li, H., H. Che, J. Xie, X. Dong, L. Song, W. Xie, and J. Sun. 2022. Supplementary selenium in the form of selenylation α-D-1,6-glucan ameliorates dextran sulfate sodium induced colitis in vivo. International Journal of Biological Macromolecules 195:67–74.
  • Li, Y., J. Yao, C. Han, J. Yang, M. T. Chaudhry, S. Wang, H. Liu, and Y. Yin. 2016. Quercetin, inflammation and immunity. Nutrients 8 (3):167.
  • Li, Y.-R., D.-Y. Chen, C.-L. Chu, S. Li, Y.-K. Chen, C.-L. Wu, and C.-C. Lin. 2015b. Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis. J Nutr Biochem. 26 (12):1467–78. doi: 10.1016/j.jnutbio.2015.07.016.
  • Liu, F., X. Wang, Y. Cui, Y. Yin, D. Qiu, S. Li, and X. Li. 2021a. Apple polyphenols extract (APE) alleviated dextran sulfate sodium induced acute ulcerative colitis and accompanying neuroinflammation via inhibition of apoptosis and pyroptosis. Foods 10 (11):2711. doi: 10.3390/foods10112711.
  • Liu, L., Y. L. Liu, G. X. Liu, X. Chen, K. Yang, Y. X. Yang, Q. Xie, H. K. Gan, X. L. Huang, and H. T. Gan. 2013. Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway. International Immunopharmacology 17 (2):314–20.
  • Liu, P., Y. Li, R. Wang, F. Ren, and X. Wang. 2021b. Oxidative stress and antioxidant nanotherapeutic approaches for inflammatory bowel disease. Biomedicines 10 (1):85. doi: 10.3390/biomedicines10010085.
  • Liu, Y., J. Tian, R. Hu, B. Yang, S. Liu, L. Yin, and W. Zheng. 2022. Improved feature point pair purification algorithm based on SIFT during endoscope image stitching. Frontiers in Neurorobotics 16:840594. doi: 10.3389/fnbot.2022.840594.
  • Liu, Y., X. Tian, B. He, T. K. Hoang, C. M. Taylor, E. Blanchard, J. Freeborn, S. Park, M. Luo, J. Couturier, et al. 2019. Lactobacillus reuteri DSM 17938 feeding of healthy newborn mice regulates immune responses while modulating gut microbiota and boosting beneficial metabolites. American Journal of Physiology. Gastrointestinal and Liver Physiology 317 (6):G824–G838.
  • Lobo De Sá, F. D., M. M. Heimesaat, S. Bereswill, P. K. Nattramilarasu, J. D. Schulzke, and R. Bücker. 2021. Resveratrol prevents Campylobacter jejuni-induced leaky gut by restoring occludin and claudin-5 in the paracellular leak pathway. Frontiers in Pharmacology 12:640572.
  • Loguercio, C., G. D’argenio, M. Delle Cave, V. Cosenza, N. D. Valle, G. Mazzacca, and C. D. V. Blanco. 2003. Glutathione supplementation improves oxidative damage in experimental colitis. Digestive and Liver Disease: Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 35 (9):635–41. doi: 10.1016/s1590-8658(03)00379-7.
  • López-Sanromán, A., J. V. Esplugues, and E. Domènech. 2021. Pharmacology and safety of tofacitinib in ulcerative colitis. Gastroenterologia y Hepatologia 44 (1):39–48. doi: 10.1016/j.gastrohep.2020.04.012.
  • Lu, L., X. Zhai, X. Li, S. Wang, L. Zhang, L. Wang, X. Jin, L. Liang, Z. Deng, Z. Li, et al. 2022. Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains. Nature Communications 13 (1):1–14. doi: 10.1038/s41467-022-32364-3.
  • Lubbad, A., M. A. Oriowo, and I. Khan. 2009. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Molecular and Cellular Biochemistry 322 (1-2):127–35.
  • Martinez-Medina, M, and L. J. Garcia-Gil. 2014. Escherichia coli in chronic inflammatory bowel diseases: An update on adherent invasive Escherichia coli pathogenicity. World Journal of Gastrointestinal Pathophysiology 5 (3):213–27.
  • Martínez-Montiel, M. D. P., G. J. Gómez-Gómez, and A. I. Flores. 2014. Therapy with stem cells in inflammatory bowel disease. World Journal of Gastroenterology 20 (5):1211–27. doi: 10.3748/wjg.v20.i5.1211.
  • Masnadi Shirazi, K., S. Sotoudeh, A. Masnadi Shirazi, S. Y. Moaddab, Z. Nourpanah, and Z. Nikniaz. 2021. Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial. Clinics and Research in Hepatology and Gastroenterology 45 (4):101532.
  • Mayangsari, Y, and T. Suzuki. 2018. Resveratrol ameliorates intestinal barrier defects and inflammation in colitic mice and intestinal cells. Journal of Agricultural and Food Chemistry 66 (48):12666–74.
  • Mcfadden, R. M., C. B. Larmonier, K. W. Shehab, M. Midura-Kiela, R. Ramalingam, C. A. Harrison, D. G. Besselsen, J. H. Chase, J. G. Caporaso, C. Jobin, et al. 2015. The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory Bowel Diseases 21 (11):2483–94.
  • Mishra, J., M. Stubbs, L. Kuang, N. Vara, P. Kumar, and N. Kumar. 2022. Inflammatory bowel disease therapeutics: A focus on probiotic engineering. Mediators of Inflammation 2022:9621668. doi: 10.1155/2022/9621668.
  • Mochizuki, M, and N. Hasegawa. 2010. (-)-epigallocatechin-3-gallate reduces experimental colon injury in rats by regulating macrophage and masT cell. Phytotherapy Research: PTR 24 (Suppl 1):S120–S2. doi: 10.1002/ptr.2862.
  • Moein, S. 2015. Polyphenols and cancer: A review. Mol. Med. J 1:6–12.
  • Moein, S., D. Qujeq, M. Vaghari Tabari, M. Kashifard, and K. Hajian-Tilaki. 2017. Diagnostic accuracy of fecal calprotectin in assessing the severity of inflammatory bowel disease: From laboratory to clinic. Caspian Journal of Internal Medicine 8 (3):178–82.
  • Moein, S., M. Vaghari-Tabari, D. Qujeq, M. Kashifard, J. Shokri-Shirvani, and K. Hajian-Tilaki. 2020. Association between serum folate with inflammatory markers, disease clinical activity and serum homocysteine in patients with inflammatory bowel disease. Does folate level have an effect on maintaining clinical remission? Acta Bio-Medica: Atenei Parmensis 91 (4):e2020106.
  • Moein, S., M. Vaghari-Tabari, D. Qujeq, M. Majidinia, S. M. Nabavi, and B. Yousefi. 2019. Mirnas and inflammatory bowel disease: An interesting new story. Journal of Cellular Physiology 234 (4):3277–93.
  • Mohammadi, E., D. Qujeq, H. Taheri, and K. Hajian-Tilaki. 2017. Evaluation of serum trace element levels and superoxide dismutase activity in patients with inflammatory bowel disease: Translating basic research into clinical application. Biological Trace Element Research 177 (2):235–40. doi: 10.1007/s12011-016-0891-0.
  • Mouzaoui, S., I. Rahim, and B. Djerdjouri. 2012. Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice. International Immunopharmacology 12 (1):302–11.
  • Mukhopadhya, I., R. Hansen, E. M. El-Omar, and G. L. Hold. 2012. IBD-what role do proteobacteria play? Nature Reviews. Gastroenterology & Hepatology 9 (4):219–30.
  • Myung, D.-S., Y.-L. Park, S.-Y. Joo, E. Myung, C.-Y. Chung, H.-C. Park, J.-S. Kim, S.-B. Cho, W.-S. Lee, H.-S. Kim, et al. 2013. Epigallocatechin-3-gallate inhibits the expression of adhesion molecules by blocking nuclear factor kappa B signaling in intestinal epithelial cells. Intestinal Research 11 (4):261–7. doi: 10.5217/ir.2013.11.4.261.
  • Nishimura, F. d C. Y., A. C. de Almeida, B. A. Ratti, T. Ueda-Nakamura, C. V. Nakamura, V. F. Ximenes, and S. d O. Silva. 2013. Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity. Evidence-Based Complementary and Alternative Medicine: eCAM 2013:795916. doi: 10.1155/2013/795916.
  • Nishimuro, H., H. Ohnishi, M. Sato, M. Ohnishi-Kameyama, I. Matsunaga, S. Naito, K. Ippoushi, H. Oike, T. Nagata, H. Akasaka, et al. 2015. Estimated daily intake and seasonal food sources of quercetin in Japan. Nutrients 7 (4):2345–58.
  • Ogawa, A., A. Andoh, Y. Araki, T. Bamba, and Y. Fujiyama. 2004. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clinical Immunology (Orlando, Fla.) 110 (1):55–62.
  • Ogura, Y., D. K. Bonen, N. Inohara, D. L. Nicolae, F. F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, R. H. Duerr, et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411 (6837):603–6.
  • Ohno, M., A. Nishida, Y. Sugitani, K. Nishino, O. Inatomi, M. Sugimoto, M. Kawahara, and A. Andoh. 2017. Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. PloS One 12 (10):e0185999.
  • Pan, H. H., X. X. Zhou, Y. Y. Ma, W. S. Pan, F. Zhao, M. S. Yu, and J. Q. Liu. 2020. Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy. World Journal of Gastroenterology 26 (33):4945–59.
  • Qu, S., L. Fan, Y. Qi, C. Xu, Y. Hu, S. Chen, W. Liu, W. Liu, and J. Si. 2021. Akkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced acute colitis by NLRP3 activation. Microbiology Spectrum 9 (2):e0073021.
  • Ran, Z. H., C. Chen, and S. D. Xiao. 2008. Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 62 (3):189–96.
  • Ren, G., L. Zhang, X. Zhao, G. Xu, Y. Zhang, A. I. Roberts, R. C. Zhao, and Y. Shi. 2008. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2 (2):141–50.
  • Riemschneider, S., M. Hoffmann, U. Slanina, K. Weber, S. Hauschildt, and J. Lehmann. 2021. Indol-3-carbinol and quercetin ameliorate chronic DSS-induced colitis in C57BL/6 mice by ahr-mediated anti-inflammatory mechanisms. Int J Environ Res Public Health. 18 (5): 2262
  • Rutgeerts, P. 2004. Review article: Treatment of perianal fistulizing Crohn’s disease. Alimentary Pharmacology & Therapeutics 20 Suppl 4:106–10. doi: 10.1111/j.1365-2036.2004.02060.x.
  • Sabzevary-Ghahfarokhi, M., A. Soltani, F. Luzza, T. Larussa, G. Rahimian, H. Shirzad, and N. Bagheri. 2020. The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein. Molecular Biology Reports 47 (9):9: 6941–6947.
  • Sadeghi, N., A. Mansoori, A. Shayesteh, and S. J. Hashemi. 2020. The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytotherapy Research: PTR 34 (5):1123–33.
  • Samsami-Kor, M., N. E. Daryani, P. R. Asl, and A. Hekmatdoost. 2015. Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: A randomized, double-blind, placebo-controlled pilot study. Archives of Medical Research 46 (4):280–5. doi: 10.1016/j.arcmed.2015.05.005.
  • Samsamikor, M., N. E. Daryani, P. R. Asl, and A. Hekmatdoost. 2016. Resveratrol supplementation and oxidative/anti-oxidative status in patients with ulcerative colitis: A randomized, double-blind, placebo-controlled pilot study. Archives of Medical Research 47 (4):304–9. doi: 10.1016/j.arcmed.2016.07.003.
  • Sandborn, W. J., B. G. Feagan, G. D’haens, D. C. Wolf, I. Jovanovic, S. B. Hanauer, S. Ghosh, A. Petersen, S. Y. Hua, J. H. Lee, et al. 2021. Ozanimod as induction and maintenance therapy for ulcerative colitis. The New England Journal of Medicine 385 (14):1280–91.,
  • Schoepfer, A. M., C. Beglinger, A. Straumann, E. Safroneeva, Y. Romero, D. Armstrong, C. Schmidt, M. Trummler, V. Pittet, and S. R. Vavricka. 2013. Fecal calprotectin more accurately reflects endoscopic activity of ulcerative colitis than the lichtiger index, C-reactive protein, platelets, hemoglobin, and blood leukocytes. Inflamm Bowel Dis 19 (2):332–41.
  • Seyedizade, S. S., K. Afshari, S. Bayat, F. Rahmani, S. Momtaz, N. Rezaei, and A. H. Abdolghaffari. 2020. Current status of M1 and M2 macrophages pathway as drug targets for inflammatory bowel disease. Archivum Immunologiae et Therapiae Experimentalis 68 (2):10.
  • Shahrokh, S., R. Qobadighadikolaei, M. Abbasinazari, M. Haghazali, H. Asadzadeh Aghdaei, S. Abdi, H. Balaii, N. Khanzadeh-Moghaddam, and M. R. Zali. 2021. Efficacy and safety of melatonin as an adjunctive therapy on clinical, biochemical, and quality of life in patients with ulcerative colitis. Iran J Pharm Res 20 (2):197–205.
  • Shawki, A, and D. F. Mccole. 2017. Mechanisms of intestinal epithelial barrier dysfunction by adherent-invasive Escherichia coli. Cellular and Molecular Gastroenterology and Hepatology 3 (1):41–50.
  • Shih, D. Q, and S. R. Targan. 2008. Immunopathogenesis of inflammatory bowel disease. World Journal of Gastroenterology 14 (3):390–400. doi: 10.3748/wjg.14.390.
  • Sido, B., V. Hack, A. Hochlehnert, H. Lipps, C. Herfarth, and W. Dröge. 1998. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 42 (4):485–92.
  • Simon, E. G., S. Ghosh, M. Iacucci, and G. W. Moran. 2016. Ustekinumab for the treatment of Crohn’s disease: Can it find its niche? Therapeutic Advances in Gastroenterology 9 (1):26–36. doi: 10.1177/1756283X15618130.
  • Singh, U. P., N. P. Singh, B. Singh, L. J. Hofseth, R. L. Price, M. Nagarkatti, and P. S. Nagarkatti. 2010. Resveratrol (trans-3,5,4’-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappa B activation to abrogate dextran sulfate sodium-induced colitis. The Journal of Pharmacology and Experimental Therapeutics 332 (3):829–39.
  • Singh, U. P., N. P. Singh, B. Singh, L. J. Hofseth, D. D. Taub, R. L. Price, M. Nagarkatti, and P. S. Nagarkatti. 2012. Role of resveratrol-induced CD11b(+) GR-1(+) myeloid derived suppressor cells (MDSCS) in the reduction of CXCR3(+) T cells and amelioration of chronic colitis in IL-10(-/-) mice. Brain, Behavior, and Immunity 26 (1):72–82. doi: 10.1016/j.bbi.2011.07.236.
  • Sokol, H., P. Seksik, J. P. Furet, O. Firmesse, I. Nion-Larmurier, L. Beaugerie, J. Cosnes, G. Corthier, P. Marteau, and J. Doré. 2009. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflammatory Bowel Diseases 15 (8):1183–9.
  • Song, K, and D. Wu. 2022. Shared decision-making in the management of patients with inflammatory bowel disease. World Journal of Gastroenterology 28 (26):3092–100.
  • Stillman, A., M. Mohammad, G. Dryden, and H. Qazzaz. 2013. Epigallocatechin-3-gallate inhibits production and modulates expression of LPS-stimulated cytokines and their transcriptional factors in human colon epithelial Caco-2 cells: 1829. American Journal of Gastroenterology 108:S552–S553. doi: 10.14309/00000434-201310001-01829.
  • Sugimoto, K., K. Ikeya, S. Bamba, A. Andoh, H. Yamasaki, K. Mitsuyama, M. Nasuno, H. Tanaka, A. Matsuura, M. Kato, et al. 2020. Highly bioavailable curcumin derivative ameliorates Crohn’s disease symptoms: A randomized, double-blind, multicenter study. Journal of Crohn’s & Colitis 14 (12):1693–701. doi: 10.1093/ecco-jcc/jjaa097.
  • Sugimoto, K., A. Ogawa, E. Mizoguchi, Y. Shimomura, A. Andoh, A. K. Bhan, R. S. Blumberg, R. J. Xavier, and A. Mizoguchi. 2008. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. Journal of Clinical Investigation 118 (2):534–44.
  • Taxonera, C., D. Olivares, and C. Alba. 2022. Real-world effectiveness and safety of tofacitinib in patients with ulcerative colitis: Systematic review with meta-analysis. Inflammatory Bowel Diseases 28 (1):32–40.
  • Thomazini, C. M., D. A. Samegima, M. A. Rodrigues, C. R. Victoria, and J. Rodrigues. 2011. High prevalence of aggregative adherent Escherichia coli strains in the mucosa-associated microbiota of patients with inflammatory bowel diseases. International Journal of Medical Microbiology : IJMM 301 (6):475–9.
  • Ukil, A., S. Maity, S. Karmakar, N. Datta, J. R. Vedasiromoni, and P. K. Das. 2003. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. British Journal of Pharmacology 139 (2): 209–18.
  • Vaghari-Tabari, M., D. Jafari-Gharabaghlou, F. Sadeghsoltani, P. Hassanpour, D. Qujeq, N. Rashtchizadeh, and A. Ghorbanihaghjo. 2021. Zinc and selenium in inflammatory bowel disease: Trace elements with key roles? Biological Trace Element Research 199 (9):3190–204. doi: 10.1007/s12011-020-02444-w.
  • Vaghari-Tabari, M., S. Moein, D. Qujeq, M. Kashifard, and K. Hajian-Tilaki. 2018. Positive correlation of fecal calprotectin with serum antioxidant enzymes in patients with inflammatory bowel disease: Accidental numerical correlation or a new finding? The American Journal of the Medical Sciences 355 (5):449–55. doi: 10.1016/j.amjms.2017.12.009.
  • Vaghari-Tabari, M., N. Targhazeh, S. Moein, D. Qujeq, F. Alemi, M. Majidina, S. Younesi, Z. Asemi, and B. Yousefi. 2022. From inflammatory bowel disease to colorectal cancer: What’s the role of mirnas? Cancer Cell International 22 (1):146.
  • Van Herk, E. H, and A. A. Te Velde. 2016. Treg subsets in inflammatory bowel disease and colorectal carcinoma: Characteristics, role, and therapeutic targets. Journal of Gastroenterology and Hepatology 31 (8):1393–404.
  • Veldhoen, M., C. Uyttenhove, J. Van Snick, H. Helmby, A. Westendorf, J. Buer, B. Martin, C. Wilhelm, and B. Stockinger. 2008. Transforming growth factor-beta ‘reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nature Immunology 9 (12):1341–6.
  • Viola, A., M. Muscianisi, F. S. Macaluso, M. Ventimiglia, M. Cappello, A. C. Privitera, A. Magnano, D. Pluchino, G. Magrì, C. Ferracane, et al. 2021. Ustekinumab in Crohn’s disease: Real-world outcomes from the sicilian network for inflammatory bowel diseases. JGH Open: An Open Access Journal of Gastroenterology and Hepatology 5 (3):364–70., doi: 10.1002/jgh3.12502.
  • Wang, G., Z. Hu, Q. Fu, X. Song, Q. Cui, R. Jia, Y. Zou, C. He, L. Li, and Z. Yin. 2017a. Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade. Scientific Reports 7:45006. doi: 10.1038/srep45006.
  • Wang, J., S. S. Ghosh, and S. Ghosh. 2017b. Curcumin improves intestinal barrier function: Modulation of intracellular signaling, and organization of tight junctions. American Journal of Physiology. Cell Physiology 312 (4):C438–C445.
  • Wang, J., M. Pae, S. N. Meydani, and D. Wu. 2013. Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4+ T cells into specific lineage effector cells. Journal of Molecular Medicine (Berlin, Germany) 91 (4):485–95.
  • Wang, J., Y. Qi, X. Niu, H. Tang, S. N. Meydani, and D. Wu. 2018a. Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice. The Journal of Nutritional Biochemistry 54:130–9. doi: 10.1016/j.jnutbio.2017.12.004.
  • Wang, L., L. Tang, Y. Feng, S. Zhao, M. Han, C. Zhang, G. Yuan, J. Zhu, S. Cao, Q. Wu, et al. 2020. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice. Gut 69 (11):1988–97. doi: 10.1136/gutjnl-2019-320105.
  • Wang, M. R., L. Deng, G. C. Liu, L. Wen, J. G. Wang, K. B. Huang, H. T. Tang, and Y. M. Pan. 2019. Porous organic polymer-derived nanopalladium catalysts for chemoselective synthesis of antitumor benzofuro[2,3- b]pyrazine from 2-bromophenol and isonitriles. Organic Letters 21 (13):4929–32. doi: 10.1021/acs.orglett.9b01230.
  • Wang, N., G. Wang, J. Hao, J. Ma, Y. Wang, X. Jiang, and H. Jiang. 2012. Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells. Digestive Diseases and Sciences 57 (7):1792–801.
  • Wang, R., Q. Yao, W. Chen, F. Gao, P. Li, J. Wu, J. Yu, and H. Cao. 2021. Stem cell therapy for Crohn’s disease: Systematic review and meta-analysis of preclinical and clinical studies. Stem Cell Research & Therapy 12 (1):463.
  • Wang, Y., Y. Gu, K. Fang, K. Mao, J. Dou, H. Fan, C. Zhou, and H. Wang. 2018b. Lactobacillus acidophilus and Clostridium butyricum ameliorate colitis in murine by strengthening the gut barrier function and decreasing inflammatory factors. Beneficial Microbes 9 (5):775–87. doi: 10.3920/BM2017.0035.
  • Wang, Y., Q. Tang, P. Duan, and L. Yang. 2018c. Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis. Immunopharmacology and Immunotoxicology 40 (6): 476–82.
  • Wei, C., J. Y. Wang, F. Xiong, B. H. Wu, M. H. Luo, Z. C. Yu, T. T. Liu, D. F. Li, Q. Tang, Y. X. Li, et al. 2021. Curcumin ameliorates DSS‑induced colitis in mice by regulating the Treg/Th17 signaling pathway. Mol Med Rep. 23 (1): 34–42
  • Wine, E., J. C. Ossa, S. D. Gray-Owen, and P. M. Sherman. 2009. Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia. BMC Microbiology 9:180.
  • Wu, Z., S. Huang, T. Li, N. Li, D. Han, B. Zhang, Z. Z. Xu, S. Zhang, J. Pang, S. Wang, et al. 2021. Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis. Microbiome 9 (1):184.
  • Xiao, Y. T., W. H. Yan, Y. Cao, J. K. Yan, and W. Cai. 2016. Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis. Cytokine 83:189–92. doi: 10.1016/j.cyto.2016.04.012.
  • Xu, B., W. Qin, Y. Xu, W. Yang, Y. Chen, J. Huang, J. Zhao, and L. Ma. 2021. Dietary quercetin supplementation attenuates diarrhea and intestinal damage by regulating gut microbiota in weanling piglets. Oxidative Medicine and Cellular Longevity 2021:6221012. doi: 10.1155/2021/6221012.
  • Xu, Z., C. Wei, R. U. Zhang, J. Yao, D. Zhang, and L. Wang. 2015. Epigallocatechin-3-gallate-induced inhibition of interleukin-6 release and adjustment of the regulatory T/T helper 17 cell balance in the treatment of colitis in mice. Experimental and Therapeutic Medicine 10 (6):2231–8. doi: 10.3892/etm.2015.2824.
  • Yamada, A., R. Arakaki, M. Saito, T. Tsunematsu, Y. Kudo, and N. Ishimaru. 2016. Role of regulatory T cell in the pathogenesis of inflammatory bowel disease. World Journal of Gastroenterology 22 (7):2195–205. doi: 10.3748/wjg.v22.i7.2195.
  • Yan, B., X. Li, L. Zhou, Y. Qiao, J. Wu, L. Zha, P. Liu, S. Peng, B. Wu, X. Yu, et al. 2022a. Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/NF-κB pathway and protecting the intestinal barrier. Bosn J Basic Med Sci
  • Yan, L., M. Vaghari-Tabari, F. Malakoti, S. Moein, D. Qujeq, B. Yousefi, and Z. Asemi. 2022b. Quercetin: An effective polyphenol in alleviating diabetes and diabetic complications. Critical Reviews in Food Science and Nutrition 62:1–24. doi: 10.1080/10408398.2022.2067825.
  • Yang, X. O., S. H. Chang, H. Park, R. Nurieva, B. Shah, L. Acero, Y. H. Wang, K. S. Schluns, R. R. Broaddus, Z. Zhu, et al. 2008. Regulation of inflammatory responses by IL-17f. The Journal of Experimental Medicine 205 (5):1063–75. doi: 10.1084/jem.20071978.
  • Yang, Y., X. Zhang, M. Xu, X. Wu, F. Zhao, and C. Zhao. 2018. Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of heme oxygenase 1-mediated anti-inflammatory effect. International Immunopharmacology 54:153–62. doi: 10.1016/j.intimp.2017.11.013.
  • Yao, J., C. Wei, J. Y. Wang, R. Zhang, Y. X. Li, and L. S. Wang. 2015. Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice. World Journal of Gastroenterology 21 (21):6572–81.
  • Yao, Z., Y. G. Q. Zhang, L. Liu, G. Meng, H. Wu, Y. Xia, X. Bao, H. Shi, S. Sun, X. Wang, et al. 2019. Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults. European Journal of Nutrition 58 (2):819–30.
  • Yasukawa, K., H. Tokuda, X. Tun, H. Utsumi, and K. Yamada. 2012. The detrimental effect of nitric oxide on tissue is associated with inflammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis. Free Radical Research 46 (12):1427–36. doi: 10.3109/10715762.2012.732698.
  • Yokota, Y., A. Shikano, T. Kuda, M. Takei, H. Takahashi, and B. Kimura. 2018. Lactobacillus plantarum AN1 cells increase caecal L. Reuteri in an ICR mouse model of dextran sodium sulphate-induced inflammatory bowel disease. International Immunopharmacology 56:119–27. doi: 10.1016/j.intimp.2018.01.020.
  • Youn, J., J. S. Lee, H. K. Na, J. K. Kundu, and Y. J. Surh. 2009. Resveratrol and piceatannol inhibit inos expression and NF-kappab activation in dextran sulfate sodium-induced mouse colitis. Nutrition and Cancer 61 (6):847–54.
  • Yu, E. S., H. J. Min, S. Y. An, H. Y. Won, J. H. Hong, and E. S. Hwang. 2008. Regulatory mechanisms of IL-2 and ifngamma suppression by quercetin in T helper cells. Biochem Pharmacol. 76 (1):70–8. doi: 10.1016/j.bcp.2008.03.020.
  • Zamora-Ros, R., C. Andres-Lacueva, R. M. Lamuela-Raventós, T. Berenguer, P. Jakszyn, C. Martínez, M. J. Sánchez, C. Navarro, M. D. Chirlaque, M. J. Tormo, et al. 2008. Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European prospective investigation into cancer and nutrition (epic)-spain cohort. The British Journal of Nutrition 100 (1):188–96. doi: 10.1017/S0007114507882997.
  • Zamora-Ros, R., V. Knaze, J. A. Rothwell, B. Hémon, A. Moskal, K. Overvad, A. Tjønneland, C. Kyrø, G. Fagherazzi, M. C. Boutron-Ruault, et al. 2016. Dietary polyphenol intake in Europe: The european prospective investigation into cancer and nutrition (epic) study. European Journal of Nutrition 55 (4):1359–75. doi: 10.1007/s00394-015-0950-x.
  • Zhang, M., C. S. Deng, J. J. Zheng, and J. Xia. 2006. Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis. Acta Pharmacologica Sinica 27 (8):1071–7.
  • Zhang, Z., L. Wang, W. Zheng, L. Yin, R. Hu, and B. Yang. 2022. Endoscope image mosaic based on pyramid ORB. Biomedical Signal Processing and Control 71:103261. doi: 10.1016/j.bspc.2021.103261.
  • Zhao, H., H. Xu, S. Chen, J. He, Y. Zhou, and Y. Nie. 2021. Systematic review and meta-analysis of the role of Faecalibacterium prausnitzii alteration in inflammatory bowel disease. Journal of Gastroenterology and Hepatology 36 (2): 320–8.
  • Zhao, H. M., R. Xu, X. Y. Huang, S. M. Cheng, M. F. Huang, H. Y. Yue, X. Wang, Y. Zou, A. P. Lu, and D. Y. Liu. 2016. Curcumin suppressed activation of dendritic cells via JAK/STAT/SOCS signal in mice with experimental colitis. Frontiers in Pharmacology 7:455. doi: 10.3389/fphar.2016.00455.
  • Zhong, Y.-B., Z.-P. Kang, M.-X. Wang, J. Long, H.-Y. Wang, J.-Q. Huang, S.-Y. Wei, W. Zhou, H.-M. Zhao, and D.-Y. Liu. 2021. Curcumin ameliorated dextran sulfate sodium-induced colitis via regulating the homeostasis of DCs and Treg and improving the composition of the gut microbiota. Journal of Functional Foods 86:104716. doi: 10.1016/j.jff.2021.104716.
  • Zhong, Y. B., Z. P. Kang, B. G. Zhou, H. Y. Wang, J. Long, W. Zhou, H. M. Zhao, and D. Y. Liu. 2020. Curcumin regulated the homeostasis of memory T cell and ameliorated dextran sulfate sodium-induced experimental colitis. Frontiers in Pharmacology 11:630244.
  • Zhou, X., M. Ren, J. Yang, H. Pan, M. Yu, and F. Ji. 2021a. Curcumin improves epithelial barrier integrity of Caco-2 monolayers by inhibiting endoplasmic reticulum stress and subsequent apoptosis. Gastroenterology Research and Practice 2021:5570796. doi: 10.1155/2021/5570796.
  • Zhou, Y., H. Xu, J. Xu, X. Guo, H. Zhao, Y. Chen, Y. Zhou, and Y. Nie. 2021b. F. prausnitzii and its supernatant increase scfas-producing bacteria to restore gut dysbiosis in TNBS-induced colitis. AMB Express 11 (1):33.
  • Zhu, L., T. Shi, C. Zhong, Y. Wang, M. Chang, and X. Liu. 2017. IL-10 and IL-10 receptor mutations in very early onset inflammatory bowel disease. Gastroenterology Research 10 (2):65–9.
  • Zocco, M. A., L. Z. Dal Verme, F. Cremonini, A. C. Piscaglia, E. C. Nista, M. Candelli, M. Novi, D. Rigante, I. A. Cazzato, V. Ojetti, et al. 2006. Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis. Alimentary Pharmacology & Therapeutics 23 (11):1567–74.

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