Quality evaluation of commercial herbal products using chemical methods

References

• Abourashed, E. A., and I. A. Khan. 2001. High-performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal. Journal of Pharmaceutical Sciences 90 (7):817–22. doi: 10.1002/jps.1035.
   PubMed Web of Science ®Google Scholar
• Alvarenga, F. C. R., E. D. F. Garcia, E. Bastos, T. S. M. Grandi, and M. G. R. Duarte. 2009. Evaluation of the quality of commercial samples of leaves and tinctures of guaco. Revista Brasileira de Farmacognosia 19 (2a):442–8. doi: 10.1590/S0102-695X2009000300018.
   Google Scholar
• Attimarad, M., K. K. Mueen Ahmed, B. E. Aldhubaib, and S. Harsha. 2011. High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery. Pharmaceutical Methods 2 (2):71–5. doi: 10.4103/2229-4708.84436.
   PubMedGoogle Scholar
• Avula, B., P. A. Cohen, Y. H. Wang, S. Sagi, W. Feng, M. Wang, J. Zweigenbaum, M. Shuangcheng, and I. A. Khan. 2014. Chemical profiling and quantification of monacolins and citrinin in red yeast rice commercial raw materials and dietary supplements using liquid chromatography-accurate QToF mass spectrometry: Chemometrics application. Journal of Pharmaceutical and Biomedical Analysis 100:243–53. doi: 10.1016/j.jpba.2014.07.039.
   PubMed Web of Science ®Google Scholar
• Awortwe, C., M. Makiwane, H. Reuter, C. Muller, J. Louw, and B. Rosenkranz. 2018. Critical evaluation of causality assessment of herb–drug interactions in patients. British Journal of Clinical Pharmacology 84 (4):679–93. doi: 10.1111/bcp.13490.
   PubMed Web of Science ®Google Scholar
• Bailey, N. J. C., J. Sampson, P. J. Hylands, J. K. Nicholson, and E. Holmes. 2002. Multi-component metabolic classification of commercial feverfew preparations via high-field 1H-NMR spectroscopy and chemometrics. Planta Medica 68 (8):734–8. doi: 10.1055/s-2002-33793.
   PubMed Web of Science ®Google Scholar
• Baker, J. I., X. Zhang, T. A. Boucher, and D. E. Keyler. 2003. Investigation of quality in ephedrine-containing dietary supplements. Journal of Herbal Pharmacotherapy 3 (2):5–17. doi: 10.1080/J157v03n02_02.
   PubMedGoogle Scholar
• Balekundri, A., and V. Mannur. 2020. Quality control of the traditional herbs and herbal products: A review. Future Journal of Pharmaceutical Sciences 6 (67).
   Google Scholar
• Bansal, A., V. Chhabra, R. K. Rawal, and S. Sharma. 2014. Chemometrics: A new scenario in herbal drug standardization. Journal of Pharmaceutical Analysis 4 (4):223–33. doi: 10.1016/j.jpha.2013.12.001.
   PubMedGoogle Scholar
• Başaran, N., D. Paslı, and A. A. Başaran. 2022. Unpredictable adverse effects of herbal products. Food and Chemical Toxicology 159:112762. doi: 10.1016/j.fct.2021.112762.
   PubMed Web of Science ®Google Scholar
• Beltrame, F. L., D. C. Ferroni, B. R. V. Alves, A. V. Pereira, and L. A. Esmerino. 2009. Quality evaluation of commercial samples of Baccharis trimera L. (Carqueja) sold in Paraná State. Acta Scientiarum - Health Sciences 31:37–43.
   Google Scholar
• Bilia, A. R., G. Flamini, V. Taglioli, I. Morelli, and F. F. Vincieri. 2002. GC-MS analysis of essential oil of some commercial Fennel teas. Food Chemistry 76 (3):307–10. doi: 10.1016/S0308-8146(01)00277-1.
   Web of Science ®Google Scholar
• Booker, A., D. Johnston, and M. Heinrich. 2012. Value chains of herbal medicines - Research needs and key challenges in the context of ethnopharmacology. Journal of Ethnopharmacology 140 (3):624–33. doi: 10.1016/j.jep.2012.01.039.
   PubMed Web of Science ®Google Scholar
• Booker, A., A. Suter, A. Krnjic, B. Strassel, M. Zloh, M. Said, and M. Heinrich. 2014. A phytochemical comparison of saw palmetto products using gas chromatography and 1H nuclear magnetic resonance spectroscopy metabolomic profiling. The Journal of Pharmacy and Pharmacology 66 (6):811–22. doi: 10.1111/jphp.12198.
   PubMed Web of Science ®Google Scholar
• Boudesocque-Delaye, L., A. Lanoue, J. Dorat, F. Bruyère, A. Gueiffier, and C. Enguehard-Gueiffier. 2018. Quality control of commercial cranberry products: HPTLC-densitometry a new deal. Food Control 86:214–23. doi: 10.1016/j.foodcont.2017.11.017.
   Web of Science ®Google Scholar
• British Pharmacopoeia Commission. 2018. DNA barcoding as a tool for botanical identification of herbal drugs. British Pharmacopoeia supplementary chapter SC VII D.
   Google Scholar
• Cielecka-Piontek, J., P. Zalewski, A. Jelińska, and P. Garbacki. 2013. UHPLC: The greening face of liquid chromatography. Chromatographia 76:1429–37. doi: 10.1007/s10337-013-2434-6.
   PubMed Web of Science ®Google Scholar
• Deng, F., and S. W. Zito. 2003. Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations. Journal of Chromatography, A 986 (1):121–7.
   PubMed Web of Science ®Google Scholar
• Dias, E. G. E., V. C. T. Valenzuela, M. R. Alves, M. G. R. Duarte, and E. F. Garcia. 2013. Quality and authenticity of leaves of “chapéu-de-couro” (Echinodorus grandiflorus) from suppliers in São Paulo. Revista Brasileira de Plantas Medicinais 15 (2):250–6. doi: 10.1590/S1516-05722013000200013.
   Google Scholar
• Ding, S., E. Dudley, S. Plummer, J. Tang, R. P. Newton, and A. G. Brenton. 2006. Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry: RCM 20 (18):2753–60. doi: 10.1002/rcm.2646.
   PubMed Web of Science ®Google Scholar
• Duan, S. N., W. Qi, S. W. Zhang, K. K. Huang, and D. Yuan. 2019. Simultaneous quantification combined with multivariate statistical analysis of multiple chemical markers of Wu Ji Bai Feng Pill by UHPLC–MS/MS. Journal of Food and Drug Analysis 27 (1):275–83. doi: 10.1016/j.jfda.2018.10.004.
   PubMed Web of Science ®Google Scholar
• Dubber, M. J., and I. Kanfer. 2004. High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms. Journal of Pharmacy & Pharmaceutical Sciences 7 (3):303–9.
   PubMed Web of Science ®Google Scholar
• Dubber, M. J., and I. Kanfer. 2006. Application of reverse-flow micellar electrokinetic chromatography for the simultaneous determination of flavonols and terpene trilactones in Ginkgo biloba dosage forms. Journal of Chromatography, A 1122 (1–2):266–74. doi: 10.1016/j.chroma.2006.04.062.
   PubMed Web of Science ®Google Scholar
• Farag, M. A., and L. A. Wessjohann. 2012. Metabolome classification of commercial hypericum perforatum (St. John’s Wort) preparations via UPLC-qTOF-MS and chemometrics. Planta Medica 78 (5):488–96. doi: 10.1055/s-0031-1298170.
   PubMed Web of Science ®Google Scholar
• Fenclova, M., A. Novakova, J. Viktorova, P. Jonatova, Z. Dzuman, T. Ruml, V. Kren, J. Hajslova, L. Vitek, and M. Stranska-Zachariasova. 2019. Poor chemical and microbiological quality of the commercial milk thistle-based dietary supplements may account for their reported unsatisfactory and non-reproducible clinical outcomes. Scientific Reports 9 (1):11118.
   PubMedGoogle Scholar
• Gao, J., A. Sanchez-Medina, B. A. Pendry, M. J. Hughes, G. P. Webb, and O. Corcoran. 2008. Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. Journal of Pharmacy & Pharmaceutical Sciences 11 (1):77–87. doi: 10.18433/j39g6v.
   PubMed Web of Science ®Google Scholar
• Gouws, C., and J. H. Hamman. 2020. What are the dangers of drug interactions with herbal medicines? Expert Opinion on Drug Metabolism & Toxicology 16 (3):165–7. doi: 10.1080/17425255.2020.1733969.
   PubMed Web of Science ®Google Scholar
• Govindan, M., and G. Govindan. 2000. A convenient method for the determination of the quality of goldenseal. Fitoterapia 71 (3):232–5. doi: 10.1016/S0367-326X(99)00162-8.
   PubMed Web of Science ®Google Scholar
• Grosu, E., and M. C. Ichim. 2020. Turning meadow weeds into valuable species for the Romanian ethnomedicine while complying with the environmentally friendly farming requirements of the European Union’s common agricultural policy. Frontiers in Pharmacology 11:529. doi: 10.3389/fphar.2020.00529.
   PubMed Web of Science ®Google Scholar
• Gurley, B. J., P. Wang, and S. F. Gardner. 1998. Ephedrine-type alkaloid content of nutritional supplements containing Ephedra sinica (Ma-huang) as determined by high performance liquid chromatography. Journal of Pharmaceutical Sciences 87 (12):1547–53. doi: 10.1021/js9801844.
   PubMed Web of Science ®Google Scholar
• Gurley, B. J., S. F. Gardner, and M. A. Hubbard. 2000. Content versus label claims in ephedra-containing dietary supplements. American Journal of Health-System Pharmacy: AJHP 57 (10):963–9. doi: 10.1093/ajhp/57.10.963.
   PubMed Web of Science ®Google Scholar
• Harkey, M. R., G. L. Henderson, M. E. Gershwin, J. S. Stern, and R. M. Hackman. 2001. Variability in commercial ginseng products: An analysis of 25 preparations. The American Journal of Clinical Nutrition 73 (6):1101–6. doi: 10.1093/ajcn/73.6.1101.
   PubMed Web of Science ®Google Scholar
• Harnly, J., P. Chen, J. Sun, H. Huang, K. L. Colson, J. Yuk, J.-A. H. McCoy, D. T. H. Reynaud, P. B. Harrington, and E. J. Fletcher. 2016. Comparison of flow injection MS, NMR, and DNA sequencing: Methods for identification and authentication of black cohosh (Actaea racemosa). Planta Medica 82 (3):250–62.
   PubMed Web of Science ®Google Scholar
• Heptinstall, S., D. V. C. Awang, B. A. Dawson, D. Kindack, D. W. Knight, and J. May. 1992. Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.). estimation of commercial and authenticated feverfew products. The Journal of Pharmacy and Pharmacology 44 (5):391–5. doi: 10.1111/j.2042-7158.1992.tb03631.x.
   PubMed Web of Science ®Google Scholar
• Hess, A. V. I. 2007. Digitally enhanced thin-layer chromatography: An inexpensive, new technique for qualitative and quantitative analysis. Journal of Chemical Education 84 (5):842–7. doi: 10.1021/ed084p842.
   Web of Science ®Google Scholar
• Ichim, M. C. 2019. The DNA-based authentication of commercial herbal products reveals their globally widespread adulteration. Frontiers in Pharmacology 10:1227. doi: 10.3389/fphar.2019.01227.
   PubMed Web of Science ®Google Scholar
• Ichim, M. C., and H. de Boer. 2021. A review of authenticity and authentication of commercial ginseng herbal medicines and food supplements. Frontiers in Pharmacology 11:612071. doi: 10.3389/fphar.2020.612071.
   PubMed Web of Science ®Google Scholar
• Ichim, M. C., and A. Booker. 2021. Chemical authentication of botanical ingredients: A review of commercial herbal products. Frontiers in Pharmacology 12:666850. doi: 10.3389/fphar.2021.666850.
   PubMed Web of Science ®Google Scholar
• Ichim, M. C., A. Häser, and P. Nick. 2020. Microscopic authentication of commercial herbal products in the globalized market: Potential and limitations. Frontiers in Pharmacology 11:876. doi: 10.3389/fphar.2020.00876.
   PubMed Web of Science ®Google Scholar
• Indrayanto, G. 2018. Recent development of quality control methods for herbal derived drug preparations. Natural Products Communications 13 (12):1934578X1801301. doi: 10.1177/1934578X1801301208.
   Web of Science ®Google Scholar
• Jiao, P., Q. Jia, G. Randel, B. Diehl, S. Weaver, and G. Milligan. 2010. Quantitative 1H-NMR spectrometry method for quality control of aloe vera products. Journal of AOAC International 93 (3):842–8.
   PubMed Web of Science ®Google Scholar
• Jordan, S. A., D. G. Cunningham, and R. J. Marles. 2010. Assessment of herbal medicinal products: Challenges, and opportunities to increase the knowledge base for safety assessment. Toxicology and Applied Pharmacology 243 (2):198–216. doi: 10.1016/j.taap.2009.12.005.
   PubMed Web of Science ®Google Scholar
• Khattab, A. R., M. Abou-Shoer, F. M. Harraz, and M. G. El-Ghazouly. 2010. Hiearchiral clustering of commercial chamomile oil, a quality assessment approach. Egyptian Journal of Biomedical Sciences 34:1–12.
   Google Scholar
• Kim, J. H., C. S. Seo, S. S. Kim, and H. K. Shin. 2015. Quality assessment of Ojeok-San, a traditional herbal formula, using high-performance liquid chromatography combined with chemometric analysis. Journal of Analytical Methods in Chemistry. 2015:1–11. doi: 10.1155/2015/607252.
   Web of Science ®Google Scholar
• Kressmann, S., W. E. Müller, and H. H. Blume. 2002. Pharmaceutical quality of different Ginkgo biloba brands. The Journal of Pharmacy and Pharmacology 54 (5):661–9. doi: 10.1211/0022357021778970.
   PubMed Web of Science ®Google Scholar
• Kustrin, S. A., and C. G. Hettiarachchi. 2014. Quantitative high performance thin layer chromatography for the analysis of herbal medicines: Problems and advantages. Modern Chemistry and Applications 02:1000e118.
   Google Scholar
• Li, C., S. Chu, S. Tan, X. Yin, Y. Jiang, X. Dai, X. Gong, X. Fang, and D. Tian. 2021. Towards higher sensitivity of mass spectrometry: A perspective from the mass analyzers. Frontiers in Chemistry 9:813359. doi: 10.3389/fchem.2021.813359.
   PubMed Web of Science ®Google Scholar
• Lin, Y. K., Y. L. Ho, Y. Zhao, and Y. S. Chang. 2015. Quality assessment of Fritillariae Thunbergii Bulbus sold in Taiwan markets using a validated HPLC-UV method combined with hierarchical clustering analysis. Journal of Food and Drug Analysis 23 (1):130–5. doi: 10.1016/j.jfda.2014.06.004.
   PubMed Web of Science ®Google Scholar
• López-Gutiérrez, N., R. Romero-González, J. L. M. Vidal, and A. G. Frenich. 2016. Quality control evaluation of nutraceutical products from Ginkgo biloba using liquid chromatography coupled to high resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 121:151–60. doi: 10.1016/j.jpba.2016.01.021.
   PubMed Web of Science ®Google Scholar
• Low, T. Y., K. O. Wong, A. L. L. Yap, L. H. J. Haan, I. M. De, and C. M. Rietjens. 2017. The regulatory framework across international jurisdictions for risks associated with consumption of botanical food supplements. Comprehensive Reviews in Food Science and Food Safety 16 (5):821–34. doi: 10.1111/1541-4337.12289.
   PubMed Web of Science ®Google Scholar
• Lucas, D., J. Neal-Kababick, and J. Zweigenbaum. 2015. Characterization and quantitation of yohimbine and its analogs in botanicals and dietary supplements using LC/QTOF-MS and LC/QQQ-MS for determination of the presence of bark extract and yohimbine adulteration. Journal of AOAC International 98 (2):330–5. doi: 10.5740/jaoacint.14-246.
   PubMed Web of Science ®Google Scholar
• Manthorpe, D. P., and W. J. S. Lockley. 2013. Digitally enhanced thin layer chromatography: Further development and some applications in isotopic chemistry. Journal of Labelled Compounds & Radiopharmaceuticals 56 (11):544–52. doi: 10.1002/jlcr.3052.
   PubMed Web of Science ®Google Scholar
• Meier, B., and D. Spriano. 2010. Modern HPTLC - A perfect tool for quality control of herbals and their preparations. Journal of AOAC International 93 (5):1399–409. doi: 10.1093/jaoac/93.5.1399.
   PubMed Web of Science ®Google Scholar
• MHRA. 2014. https://www.gov.uk/drug-safety-update/herbal-products-safety-update. Accessed April 6, 2022.
   Google Scholar
• Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman; PRISMA Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine 6 (7):e1000097. doi: 10.1371/journal.pmed.1000097.
   PubMed Web of Science ®Google Scholar
• Morgan, A., and M. J. Cupp. 2000. Panax Ginseng. In Toxicology and clinical pharmacology of herbal products, ed. M. J. Cupp, 141–53. Totowa, NJ: Humana Press.
   Google Scholar
• Muyumba, N. W., S. C. Mutombo, H. Sheridan, A. Nachtergael, and P. Duez. 2021. Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications. Talanta Open 4:100070. doi: 10.1016/j.talo.2021.100070.
   Google Scholar
• Ömür Demirezer, L., A. Büyükkaya, E. Uçaktürk, A. Kuruüzüm-Uz, Z. Güvenalp, and E. Palaska. 2014. Adulteration determining of pharmaceutical forms of Ginkgo biloba extracts from different international manufacturers. Records of Natural Products 8:394–400.
   Web of Science ®Google Scholar
• Osathanunkul, M., R. Osathanunkul, and P. Madesis. 2018. Species identification approach for both raw materials and end products of herbal supplements from Tinospora species. BMC Complementary and Alternative Medicine 18 (1):111.
   PubMedGoogle Scholar
• Osowski, S., M. Rostock, H.-H. Bartsch, and U. Massing. 2000. Zur pharmazeutischen Vergleichbarkeit von therapeutisch verwendeten Echinacea-Präparaten. Forschende Komplementarmedizin Und Klassische Naturheilkunde = Research in Complementary and Natural Classical Medicine 7 (6):294–300. doi: 10.1159/000057177.
   PubMedGoogle Scholar
• Pawar, R. S., E. Grundel, A. R. Fardin-Kia, and J. I. Rader. 2014. Determination of selected biogenic amines in Acacia rigidula plant materials and dietary supplements using LC-MS/MS methods. Journal of Pharmaceutical and Biomedical Analysis 88:457–66. doi: 10.1016/j.jpba.2013.09.012.
   PubMed Web of Science ®Google Scholar
• Pawar, R. S., S. Sagi, and D. Leontyev. 2020. Analysis of bitter orange dietary supplements for natural and synthetic phenethylamines by LC–MS/MS. Drug Testing and Analysis 12 (9):1241–51. doi: 10.1002/dta.2871.
   PubMed Web of Science ®Google Scholar
• Pharmacopoeia Committee of P. R. China. 2015. Pharmacopoeia of People’s Republic of China. Vol. I, China Medical Science Press, Beijing.
   Google Scholar
• Posadzki, P., L. Watson, and E. Ernst. 2013. Contamination and adulteration of herbal medicinal products (HMPs): An overview of systematic reviews. European Journal of Clinical Pharmacology 69 (3):295–307. doi: 10.1007/s00228-012-1353-z.
   PubMed Web of Science ®Google Scholar
• Raal, A., A. Orav, T. Püssa, C. Valner, B. Malmiste, and E. Arak. 2012. Content of essential oil, terpenoids and polyphenols in commercial chamomile (Chamomilla recutita L. Rauschert) teas from different countries. Food Chemistry 131 (2):632–8. doi: 10.1016/j.foodchem.2011.09.042.
   Web of Science ®Google Scholar
• Raclariu, A. C., M. Heinrich, M. C. Ichim, and H. de Boer. 2018. Benefits and limitations of DNA barcoding and metabarcoding in herbal product authentication. Phytochemical Analysis: PCA 29 (2):123–8. doi: 10.1002/pca.2732.
   PubMed Web of Science ®Google Scholar
• Rasmussen, B., O. Cloarec, H. Tang, D. Staerk, and J. W. Jaroszewski. 2006. Multivariate analysis of integrated and full-resolution1H-NMR spectral data from complex pharmaceutical preparations: St. John’s wort. Planta Medica 72 (6):556–63. doi: 10.1055/s-2006-931567.
   PubMed Web of Science ®Google Scholar
• Sánchez-Patán, F., B. Bartolomé, P. J. Martín-Alvarez, M. Anderson, A. Howell, and M. Monagas. 2012. Comprehensive assessment of the quality of commercial cranberry products. Phenolic characterization and in vitro bioactivity. Journal of Agricultural and Food Chemistry 60 (13):3396–408. doi: 10.1021/jf204912u.
   PubMed Web of Science ®Google Scholar
• Schmidt, B., J. W. Jaroszewski, R. Bro, M. Witt, and D. Staerk. 2008. Combining PARAFAC analysis of HPLC-PDA profiles and structural characterization using HPLC-PDA-SPE-NMR-MS experiments: Commercial preparations of St. John’s wort. Analytical Chemistry 80 (6):1978–87. doi: 10.1021/ac702064p.
   PubMed Web of Science ®Google Scholar
• Scotti, F., K. Löbel, A. Booker, and M. Heinrich. 2019. St. John’s Wort (Hypericum perforatum) products – How variable is the primary material? Frontiers in Plant Science 9:1973. doi: 10.3389/fpls.2018.01973.
   PubMed Web of Science ®Google Scholar
• Seethapathy, G. S., M. Tadesse, S. K. J. Urumarudappa, S. V. Gunaga, R. Vasudeva, K. E. Malterud, R. U. Shaanker, H. de Boer, G. Ravikanth, and H. Wangensteen. 2018. Authentication of Garcinia fruits and food supplements using DNA barcoding and NMR spectroscopy. Scientific Reports 8 (1):10561.
   PubMedGoogle Scholar
• Sharma, S., M. Gupta, and R. Bhadauria. 2015. Quality evaluation of commercially available Triphala powder: A renown dietary supplement of Indian system of medicines. Quality Assurance and Safety of Crops & Foods 7 (5):599–611. doi: 10.3920/QAS2014.0391.
   Web of Science ®Google Scholar
• Shetti, S., C. D. Kumar, N. K. Sriwastava, and I. P. Sharma. 2011. Pharmacovigilance of herbal medicines: Current state and future directions. Pharmacognosy Magazine 7 (25):69–73. doi: 10.4103/0973-1296.75905.
   PubMed Web of Science ®Google Scholar
• Sima, I. A., M. Andrási, and C. Sârbu. 2018. Chemometric assessment of chromatographic methods for herbal medicines authentication and fingerprinting. Journal of Chromatographic Science 56 (1):49–55. doi: 10.1093/chromsci/bmx080.
   PubMed Web of Science ®Google Scholar
• Simmler, C., J. G. Graham, S.-N. Chen, and G. F. Pauli. 2018. Integrated analytical assets aid botanical authenticity and adulteration management. Fitoterapia 129:401–14. doi: 10.1016/j.fitote.2017.11.017.
   PubMed Web of Science ®Google Scholar
• Sun, W., S. Yan, J. Li, C. Xiong, Y. Shi, L. Wu, L. Xiang, B. Deng, W. Ma, and S. Chen. 2017. Study of commercially available Lobelia chinensis products using Bar-HRM technology. Frontiers in Plant Science 8:351. doi: 10.3389/fpls.2017.00351.
   PubMed Web of Science ®Google Scholar
• Thakkar, S., E. Anklam, A. Xu, F. Ulberth, J. Li, B. Li, M. Hugas, N. Sarma, S. Crerar, S. Swift, et al. 2020. Regulatory landscape of dietary supplements and herbal medicines from a global perspective. Regulatory Toxicology and Pharmacology: RTP 114:104647. doi: 10.1016/j.yrtph.2020.104647.
   PubMed Web of Science ®Google Scholar
• Tistaert, C., B. Dejaegher, and Y. V. Heyden. 2011. Chromatographic separation techniques and data handling methods for herbal fingerprints: A review. Analytica Chimica Acta 690 (2):148–61. doi: 10.1016/j.aca.2011.02.023.
   PubMed Web of Science ®Google Scholar
• Wang, M., N. Zhu, Y. Jin, N. Belkowitz, and C.-T. Ho. 2001. A quantitative HPLC method for the quality assurance of goldenseal products in the U.S. market. In Quality management of nutraceuticals, ed. C.-T. Ho and Q. Yi Zheng, 199–213. New York: American Chemical Society.
   Google Scholar
• Wheatley, V. M., and J. Spink. 2013. Defining the public health threat of dietary supplement fraud. Comprehensive Reviews in Food Science and Food Safety 12 (6):599–613. doi: 10.1111/1541-4337.12033.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2004. WHO guidelines on safety monitoring of herbal medicines in pharmacovigilance systems. Geneva.
   Google Scholar
• World Health Organization. 2017. Fifty-first report of the WHO expert committee on specifications for pharmaceutical preparations. Geneva.
   Google Scholar
• World Health Organization. 2018. A study on the public health and socioeconomic impact of substandard and falsified medical products. Geneva.
   Google Scholar
• Wurglics, M., K. Westerhoff, A. Kaunzinger, A. Wilke, A. Baumeister, J. Dressman, and M. Schubert-Zsilavecz. 2001. Comparison of German St. John’s wort products according to hyperforin and total hypericin content. Journal of the American Pharmacists Association 41 (4):560–6. doi: 10.1016/S1086-5802(16)31280-3.
   Google Scholar
• Xu, X., J. Jiang, Y. Liang, L. Yi, and J. Cheng. 2010. Chemical fingerprint analysis for quality control of Fructus Aurantii Immaturus based on HPLC-DAD combined with chemometric methods. Analytical Methods 2 (12):2002–10. doi: 10.1039/c0ay00455c.
   Web of Science ®Google Scholar
• Yao, C., W. Yang, W. Si, H. Pan, S. Qiu, J. Wu, X. Shi, R. Feng, W. Wu, and D. Guo. 2016. A strategy for establishment of practical identification methods for Chinese patent medicine from systematic multi-component characterization to selective ion monitoring of chemical markers: Shuxiong tablet as a case study. RSC Advances 6 (69):65055–66. doi: 10.1039/C6RA10883K.
   Web of Science ®Google Scholar
• Ye, F., H. Wang, S. Jiang, J. Wu, J. Shao, X. Cheng, Y. Tu, and D. Y. Zhang. 2004. Quality evaluation of commercial extracts of Scutellaria baicalensis. Nutrition and Cancer 49 (2):217–22. doi: 10.1207/s15327914nc4902_14.
   PubMed Web of Science ®Google Scholar
• Zhou, J. L., L. W. Qi, and P. Li. 2009. Herbal medicine analysis by liquid chromatography/time-of-flight mass spectrometry. Journal of Chromatography, A 1216 (44):7582–94. doi: 10.1016/j.chroma.2009.05.054.
   PubMed Web of Science ®Google Scholar
• Zhu, M. Z., G. L. Chen, J. L. Wu, N. Li, Z. H. Liu, and M. Q. Guo. 2018. Recent development in mass spectrometry and its hyphenated techniques for the analysis of medicinal plants. Phytochemical Analysis: PCA 29 (4):365–74. doi: 10.1002/pca.2763.
   PubMed Web of Science ®Google Scholar
• Zöllner, T., and M. Schwarz. 2013. Herbal reference standards: Applications, definitions and regulatory requirements. Revista Brasileira de Farmacognosia 23 (1):1–21. doi: 10.1590/S0102-695X2012005000144.
   Google Scholar