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Journal of Drug Targeting Volume 15, 2007 - Issue 3
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Research Article

Synthesis and in vitro evaluation of N-nicotinoylglycyl-2-(5-fluorouracil-1-yl)-d,l-glycine as a colon-specific prodrug of 5-fluorouracil

Jeoungsoo Lee Bioengineering Department, Clemson University, Clemson, SC29634, USA
,
Joohyun Rho Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
,
Youngwook Yang Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
,
Hyesik Kong Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
,
Yunjin Jung Department of Biomedicinal Chemistry, College of Pharmacy, Pusan National University, Busan, 609-735, South Korea
&
Youngmi Kim Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
Pages 199-205 | Received 18 Aug 2006, Accepted 04 Jan 2007, Published online: 08 Oct 2008

References

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