MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan

References

• George EM, Granger JP. Recent insights into the pathophysiology of preeclampsia. Expert Rev Obstet Gynecol. 2010 Sep 1;5(5):557–10.
   PubMedGoogle Scholar
• Osungbade KO, Ige OK. public health perspectives of preeclampsia in developing countries: implication for health system strengthening. J Pregnancy. 2011;2011:e481095. Apr 4; 2011. DOI:10.1155/2011/481095
   PubMedGoogle Scholar
• Unicef. Trends in maternal mortality: 1990 to 2013. Geneva: World Health Organization; 2014.
   Google Scholar
• Goldenberg RL, Rouse DJ. Prevention of premature birth. N Engl J Med. 1998 Jul 30;339(5):313–320.
   PubMed Web of Science ®Google Scholar
• Mou AD, Barman Z, Hasan M, et al. Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Sci Rep. 2021 Oct 29;11(1):21339. DOI:10.1038/s41598-021-00839-w
   PubMed Web of Science ®Google Scholar
• Kovo M, Schreiber L, Ben-Haroush A, et al. The placental component in early-onset and late-onset preeclampsia in relation to fetal growth restriction. Prenat Diagn. 2012;32(7):632–637.
   PubMed Web of Science ®Google Scholar
• Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003 Jul;69(1):1–7.
   PubMed Web of Science ®Google Scholar
• Brosens I. A study of the spiral arteries of the decidua basalis in normotensive and hypertensive pregnancies. J Obstet Gynaecol Br Commonw. 1964 Apr;71(2):222–230.
   PubMedGoogle Scholar
• Sibai B, Lindheimer M, Hauth J, et al. Risk factors for preeclampsia, abruptio placentae, and adverse neonatal outcomes among women with chronic hypertension. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. New Engl J Med. 1998 Oct 1;339(10):667–671. DOI:10.1056/NEJM199809033391004
   PubMed Web of Science ®Google Scholar
• Shiozaki A, Matsuda Y, Satoh S, et al. Impact of fetal sex in pregnancy-induced hypertension and preeclampsia in Japan. J Reprod Immunol. 2011;89(2):133–139.
   PubMed Web of Science ®Google Scholar
• Yang J, Pearl M, DeLorenze GN, et al. Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors. Am J Clin Exp Obstet Gynecol. 2016;215(3): 359-e1. doi:10.1016/j.ajog.2016.04.002.
   Google Scholar
• Shamsi U, Hatcher J, Shamsi A, et al. A multicentre matched case control study of risk factors for preeclampsia in healthy women in Pakistan. BMC Women’s Health. 2010 Dec;10(1):1–7.
   PubMed Web of Science ®Google Scholar
• Ahmed T, Ali S, Aliaga A, et al. Pakistan demographic and health survey 1990/91. Pakistan: National Institute of Population Studies Islamabad; 1992.
   Google Scholar
• Skjaerven R, Wilcox AJ, Lie RT. The interval between pregnancies and the risk of preeclampsia. N Engl J Med. 2002;346(1):33–38.
   PubMed Web of Science ®Google Scholar
• Endeshaw M, Ambaw F, Aragaw A, et al. Effect of maternal nutrition and dietary habits on preeclampsia: a case-control study. Int J Clin Med. 2014 Dec 4;05(21):1405.
   Google Scholar
• Esplin MS, Fausett MB, Fraser A, et al. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med. 2001;344(12):867–872. DOI:10.1056/NEJM200103223441201
   PubMed Web of Science ®Google Scholar
• Leclerc D, Sibani S, Rozen R Molecular biology of methylenetetrahydrofolate reductase (MTHFR) and overview of mutations/polymorphisms [Internet]. Madame Curie Bioscience Database [Internet]. Landes Bioscience; 2013 [cited 2021 Dec 25]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6561/
   Google Scholar
• Canbakan B, Keven K, Tutkak H, et al. Circulating endothelial cells in preeclampsia. J Hum Hypertens. 2007 Jul;21(7):558–563.
   PubMed Web of Science ®Google Scholar
• Kharb S, Aggarwal D, Nanda JB, et al., Evaluation of homocysteine, vitamin B12 and folic acid levels during all the trimesters in pregnant and preeclamptic womens [internet]. Curr Hypertens Rev 2016;12:234–238. Available from: cited 2020 Aug 26 10.2174/1573402112666161010151632.
   PubMed Web of Science ®Google Scholar
• Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet. 1995;10(1):111–113. DOI:10.1038/ng0595-111
   PubMed Web of Science ®Google Scholar
• Der Put Nmj V, Gabreëls F, Stevens EMB, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 1998 May;62(5):1044–1051.
   PubMed Web of Science ®Google Scholar
• Khidri FF, Waryah YM, Ali FK, et al. MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study. BMC Med Gene. 2019;20(1):163.
   PubMed Web of Science ®Google Scholar
• Sambrook J, Fritsch EF, Maniatis T Molecular cloning: a laboratory manual. molecular cloning: a laboratory manual [Internet]. 1989 [cited 2021 Apr 6];(Ed. 2). Available from: https://www.cabdirect.org/cabdirect/abstract/19901616061
   Google Scholar
• Harmon DL, Woodside JV, Yarnell JWG, et al. The common ‘thermolabile’variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. QJM. 1996;89(8):571–578. DOI:10.1093/qjmed/89.8.571
   PubMedGoogle Scholar
• Markan S, Sachdeva M, Sehrawat BS, et al. MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem. 2007;302(1):125–131.
   PubMed Web of Science ®Google Scholar
• Alghasham A, Settin AA, Ali A, et al. Association of MTHFR C677T and A1298C gene polymorphisms with hypertension. Int J Health Sci (Qassim). 2012;6(1):3.
   PubMedGoogle Scholar
• Poduri A, Kumari S, Jain S, et al. A case–control study of the association between the MTHFR gene and essential hypertension in Asian Indians. J Hum Hypertens. 2009 Feb;23(2):140–142.
   PubMed Web of Science ®Google Scholar
• Yang B, Liu Y, Li Y, et al. Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of han nationality. PLoS ONE. 2013 Mar 5;8(3):e57917. DOI:10.1371/journal.pone.0057917
   PubMed Web of Science ®Google Scholar
• Saraswathy KN, Asghar M, Samtani R, et al. Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India. Mol Biol Rep. 2012 Apr 1;39(4):5025–5031. DOI:10.1007/s11033-011-1299-8
   PubMed Web of Science ®Google Scholar
• Sabbagh AS, Mahfoud Z, Taher A, et al. High Prevalence of MTHFR gene A1298C polymorphism in Lebanon. Genet Test. 2008 Mar 1;12(1):75–80.
   PubMedGoogle Scholar
• Roje S, Chan SY, Kaplan F, et al. Metabolic engineering in yeast demonstrates thatS-Adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo*. J Biol Chem. 2002 Feb 8;277(6):4056–4061. DOI:10.1074/jbc.M110651200
   PubMed Web of Science ®Google Scholar
• Wiemels JL, Smith RN, Taylor GM, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. PNAS. 2001;98(7): 4004–4009.
   PubMed Web of Science ®Google Scholar
• Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004 Jan 1;103(1):252–257. DOI:10.1182/blood-2003-06-1794
   PubMed Web of Science ®Google Scholar
• De Mattia E, Toffoli G. C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation. Eur J Cancer. 2009 May 1;45(8):1333–1351.
   PubMed Web of Science ®Google Scholar
• Zusterzeel PLM, Visser W, Bolm HJ, et al. Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the hellp syndrome. Hypertens Pregnancy. 2000 Jan 1;19(3):299–307. DOI:10.1081/PRG-100101991
   PubMed Web of Science ®Google Scholar
• Othman G, Badawy AE, Elbaz R, et al. Thrombophilic genes mutations in preeclampsia. Bulletin Egyptian Soc Physiol Sci. 2010;30(2):21–34.
   Google Scholar
• Azimi-Nezhad M, Teymoori A, Salmaninejad A, et al. Association of MTHFR C677T polymorphism with preeclampsia in north east of Iran (khorasan province). Fetal Pediatr Pathol. 2019 Aug 26;0(0):1–8.
   Google Scholar
• Chedraui P, Salazar-Pousada D, Villao A, et al. Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia. Gynecological Endocrinol. 30(5). Internet. 392–396. 2014 Apr 15[cited 2020 Aug 27]; Available from. https://www.tandfonline.com/doi/abs/10.3109/09513590.2014.895807.
   PubMed Web of Science ®Google Scholar
• Salimi S, Saravani M, Yaghmaei M, et al. The early-onset preeclampsia is associated with MTHFR and FVL polymorphisms. Arch Gynecol Obstetrics. 2015;291(6):1303–1312. DOI:10.1007/s00404-014-3561-5
   PubMed Web of Science ®Google Scholar
• Butler S, Young A, Akam EC, et al. Association of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with coronary artery disease (CAD) in a North Indian population. Schumacher U, editor. Cogent Med. 2018 Jan 1;5(1):1478477. 10.1080/2331205X.2018.1478477
   Google Scholar
• Kamel AM, Moussa HS, Ebid GT et al. Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Natl Canc Inst. 2007 Jun;19(2): 96–105.
   PubMedGoogle Scholar
• Agarwal R, Light RP. GFR, proteinuria and circadian blood pressure. Nephrol Dialysis Transplantation. 2009;24(8):2400–2406.
   PubMed Web of Science ®Google Scholar
• Belogolovkin V, Eddleman KA, Malone FD, et al. The effect of low body mass index on the development of gestational hypertension and preeclampsia. J Matern Fetal Neonatal Med. 2007 Jan;20(7):509–513.
   PubMed Web of Science ®Google Scholar
• Andraweera PH, Gatford KL, Care AS, et al. Mechanisms linking exposure to preeclampsia in utero and the risk for cardiovascular disease. J Dev Orig Health Dis. 2020 Jun;11(3):235–242.
   PubMed Web of Science ®Google Scholar
• van Guldener C, Nanayakkara PW, Stehouwer CD. Homocysteine and blood pressure. Curr Hypertens Rep. 2003;5(1):26–31.
   PubMed Web of Science ®Google Scholar
• Also-Rallo E, Lopez-Quesada E, Urreizti R, et al. Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies. Eur J Obstet Gynecol Reprod Biol. 2005 May;120(1):45–52.
   PubMed Web of Science ®Google Scholar
• Bdolah Y, Elchalal U, Natanson-Yaron S, et al. Relationship between nulliparity and preeclampsia may be explained by altered circulating soluble fms-like tyrosine kinase 1. Hypertens Pregnancy. 2014 May 1;33(2):250–259. DOI:10.3109/10641955.2013.858745
   PubMed Web of Science ®Google Scholar
• Bezerra PCFM, Leão MD, Queiroz JW, et al. Family history of hypertension as an important risk factor for the development of severe preeclampsia. Acta Obstet Gynecol Scand. 2010 May 1;89(5):612–617. DOI:10.3109/00016341003623720
   PubMed Web of Science ®Google Scholar