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Research Article

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway

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Article: 2178659 | Received 28 Dec 2022, Accepted 02 Feb 2023, Published online: 16 Feb 2023

References

  • Zhou J, Zhou Z, Liu X, Yin HY, Tang Y, Cao X. P2X7 receptor-mediated inflammation in cardiovascular disease. Front Pharmacol. 2021;12:654425.doi:10.3389/fphar.2021.654425.
  • Shokoples BG, Paradis P, Schiffrin EL. P2X7 receptors: an untapped target for the management of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2021;41(1):186–10.doi:10.1161/ATVBAHA.120.315116.
  • Gu M, Wang Z, Feng F, Yang Y, Sun X, Yang D. Inhibition of PIKfyve ameliorates the proliferation, migration of vascular smooth muscle cells and vascular intima hyperplasia via reducing mTORC1 activity. J Cardiovasc Pharmacol. 2022;79(5):739–48.doi:10.1097/FJC.0000000000001243.
  • Tripathi M, Singh BK, Liehn EA, Lim, SY, Tikno, K, David, CM, Rattanasopa, C, Nilcham, P, Ghani, SABA, Wu, Z, et al. Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. Autophagy. 2022 ;18 (9): ;2150–2160.
  • Spadaccio C, Antoniades C, Nenna A, Chung C, Will R, Chello M, Gaudino MFL . Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries? Cardiovasc Res. 2020;116(3):505–19.doi:10.1093/cvr/cvz214.
  • Buglak NE, Jiang W, Bahnson ESM. Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker diabetic fatty rats. Redox Biol. 2018;19:166–78.doi:10.1016/j.redox.2018.08.013.
  • Chang H, Lei H, Zhao Y, Yang R, Wu A, Mao Y, Huang Y, Lv X, Zhao J, Lou L, et al. Yiqihuoxuejiedu formula restrains vascular remodeling by reducing the inflammation reaction and Cx43 expression in the adventitia after balloon injury. Evid Based Complement Alternat Med. 2015;2015:904273.
  • Han X, Wu A, Wang J, Chang H, Zhao Y, Zhang Y, Mao Y, Lou L, Gao Y, Zhang D, et al. Activation and migration of adventitial fibroblasts contributes to vascular remodeling. Anat Rec (Hoboken). 2018;301(7):1216–23.doi:10.1002/ar.23793.
  • Schilperoort M, van den Berg R, Bosmans LA, Os BW, Dollé MET, Smits NAM, Guichelaar T, Baarle D, Koemans L, Berbée JFP, et al. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. J Pineal Res. 2020;68(1):e12614.doi:10.1111/jpi.12614.
  • Wang Q, Sundar IK, Lucas JH, Muthumalage T, Rahman I. Molecular clock REV-ERBalpha regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal transition. JCI Insight. 2021;6:12.doi:10.1172/jci.insight.145200.
  • Allada R, Bass J, Longo DL. Circadian mechanisms in medicine. N Engl J Med. 2021;384(6):550–61.doi:10.1056/NEJMra1802337.
  • Gillis SP, Yao H, Rizal S, Maeda H, Chang J, Dennery PA. Loss of the transcriptional repressor Rev-erbalpha upregulates metabolism and proliferation in cultured mouse embryonic fibroblasts. Sci Rep. 2021;11(1):12356.doi:10.1038/s41598-021-91516-5.
  • Chu G, Zhou X, Hu Y, Shi S, Yang G. Rev-erbα inhibits proliferation and promotes apoptosis of preadipocytes through the agonist GSK4112. Int J Mol Sci. 2019;20:18.doi:10.3390/ijms20184524.
  • Woldt E, Sebti Y, Solt LA, Duhem C, Lancel S, Eeckhoute J, Hesselink MKC, Paquet C, Delhaye S, Shin Y, et al. Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. 2013;19(8):1039–46.doi:10.1038/nm.3213.
  • Wu Z, Liao F, Luo G, Qian Y, He X, Xu W, Ding S, Pu J . NR1D1 deletion induces rupture-prone vulnerable plaques by regulating macrophage pyroptosis via the NF-kappaB/NLRP3 inflammasome pathway. Oxid Med Cell Longev. 2021;2021:5217572.
  • Zhang L, Zhang R, Tien CL, Chan RE, Sugi K, Fu C, Griffin AC, Shen Y, Burris TP, Liao X, et al. REV-ERBalpha ameliorates heart failure through transcription repression. JCI Insight. 2017;2(17):e95177.doi:10.1172/jci.insight.95177.
  • Stujanna EN, Murakoshi N, Tajiri K, Xu D, Kimura T, Qin R, Feng D, Yonebayashi S, Ogura Y, Yamagami F, et al. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. PLoS One. 2017;12(12):e0189330.doi:10.1371/journal.pone.0189330.
  • Wang Y, Kojetin D, Burris TP. Anti-proliferative actions of a synthetic REV-ERBalpha/beta agonist in breast cancer cells. Biochem Pharmacol. 2015;96(4):315–22.doi:10.1016/j.bcp.2015.06.010.
  • Wang H, Fu Y. NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway. BMC Cancer. 2021;21(1):871.doi:10.1186/s12885-021-08597-8.
  • Zou DP, Chen YM, Zhang LZ, Yuan X-H, Zhang Y-J, Inggawati A, Kieu Nguyet PT, Gao T-W, Chen J . SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/beta-catenin signaling. Genes Dis. 2021;8(5):677–88.doi:10.1016/j.gendis.2020.06.003.
  • Liang T, Ye X, Liu Y, Qiu X, Li Z, Tian B, Yan D . FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of beta-catenin. Exp Mol Med. 2018;50(12):1–12.doi:10.1038/s12276-018-0184-0.
  • DiRenzo DM, Chaudhary MA, Shi X, Franco SR, Zent J, Wang K, Guo L-W, Kent KC . A crosstalk between TGF-beta/Smad3 and Wnt/beta-catenin pathways promotes vascular smooth muscle cell proliferation. Cell Signal. 2016;28(5):498–505.doi:10.1016/j.cellsig.2016.02.011.
  • Wu X, Liu W, Jiang H, CHEN J, WANG J, ZHU R, LI B . Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling. Int J Mol Med. 2016;37(2):436–44.doi:10.3892/ijmm.2015.2429.
  • He Y, Lin F, Chen Y, Tan Z, Bai D, Zhao Q. Overexpression of the circadian clock gene rev-erbalpha affects murine bone mesenchymal stem cell proliferation and osteogenesis. Stem Cells Dev. 2015;24(10):1194–204.doi:10.1089/scd.2014.0437.
  • Yue J, He J, Wei Y, Shen K, Wu K, Yang X, Liu S, Zhang C, Yang H . Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model. J Neuroinflammation. 2020;17(1):43.doi:10.1186/s12974-020-1718-7.
  • Fu C, Liu P, Li P, Liu W, Huang X, Liang Y. FSP1 promotes the biofunctions of adventitial fibroblast through the crosstalk among RAGE, JAK2/STAT3 and Wnt3a/beta-catenin signalling pathways. J Cell Mol Med. 2019;23(11):7246–60.doi:10.1111/jcmm.14518.
  • Wang L, Wu T, Si C, Wang H, Yue K, Shang S, Li X, Chen Y, Guan H . Danlou tablet activates autophagy of vascular adventitial fibroblasts through PI3K/Akt/mTOR to protect cells from damage caused by atherosclerosis. Front Pharmacol. 2021;12:730525.
  • Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J, Wu W . SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing beta-catenin biosynthesis. EMBO Mol Med. 2013;5(5):737–50.doi:10.1002/emmm.201202218.
  • Sciarretta S, Volpe M, Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 2014;114(3):549–64.doi:10.1161/CIRCRESAHA.114.302022.
  • Zhang L, Li Y, Liu Y, Wang X, Chen M, Xing Y, Zhu D . STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration. J Steroid Biochem Mol Biol. 2015;149:106–17.
  • Dutzmann J, Koch A, Weisheit S, Sonnenschein K, Korte L, Haertlé M, Thum T, Bauersachs J, Sedding DG, Daniel J-M, et al. Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation. Cardiovasc Res. 2017;113(13):1653–63.doi:10.1093/cvr/cvx158.
  • Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B. Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration. Thromb Haemost. 2014;111(5):951–59.doi:10.1160/TH13-09-0748.
  • Ma H, Zhong W, Jiang Y, Fontaine C, Li S, Fu J, Olkkonen VM, Staels B, Yan D . Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor rev-erbα knock- down. J Am Heart Assoc. 2013;2(4):e000235.doi:10.1161/JAHA.113.000235.
  • Sun LY, Lyu YY, Zhang HY, Shen Z, Lin G-Q, Geng N, Wang Y-L, Huang L, Feng Z-H, Guo X, et al. Nuclear receptor NR1D1 regulates abdominal aortic aneurysm development by targeting the mitochondrial tricarboxylic acid cycle enzyme aconitase-2. Circulation. 2022;146(21):1591–609.doi:10.1161/CIRCULATIONAHA.121.057623.
  • Tong Y, Ye C, Ren XS, Qiu Y, Zang Y-H, Xiong X-Q, Wang -J-J, Chen Q, Li Y-H, Kang Y-M, et al. Exosome-mediated transfer of ACE (angiotensin-converting enzyme) from adventitial fibroblasts of spontaneously hypertensive rats promotes vascular smooth muscle cell migration. Hypertension. 2018;72(4):881–88.doi:10.1161/HYPERTENSIONAHA.118.11375.
  • Tinajero MG, Gotlieb AI. Recent developments in vascular adventitial pathobiology: the dynamic adventitia as a complex regulator of vascular disease. Am J Pathol. 2020;190(3):520–34.doi:10.1016/j.ajpath.2019.10.021.
  • Ka NL, Na TY, Na H, Lee M-H, Park H-S, Hwang S, Kim IY, Seong JK, Lee M-O . NR1D1 recruitment to sites of DNA damage inhibits repair and is associated with chemosensitivity of breast cancer. Cancer Res. 2017;77(9):2453–63.doi:10.1158/0008-5472.CAN-16-2099.
  • Lei Q, Yu Z, Li H, Cheng J, Wang Y. Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/beta-catenin pathway. J Adv Res. 2022;40:197–206.doi:10.1016/j.jare.2021.11.011.
  • An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K, Luo J, Zhang C, et al. Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling. Cardiovasc Res. 2022;118(2):638–53.doi:10.1093/cvr/cvab056.
  • Maiese K. Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and cancer. Curr Neurovasc Res. 2017;14(3):299–304.doi:10.2174/1567202614666170718092010.
  • Lu QB, Wan MY, Wang PY, Zhang C-X, Xu D-Y, Liao X, Sun H-J . Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFkappaB/mTOR/P70S6K signaling cascade. Redox Biol. 2018;14:656–68.