FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction

References

• Wang Z, Chen Z, Zhang L, Wang X, Hao G, Zhang Z. Status of hypertension in China: results from the China hypertension survey, 2012-2015. Circulation. 2018;137(22):2344–10.
   PubMed Web of Science ®Google Scholar
• Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, Chen J, He J. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. 2016;134(6):441–50. doi:10.1161/CIRCULATIONAHA.115.018912.
   PubMed Web of Science ®Google Scholar
• Wang S, Ding Z. Fibroblast growth factor receptors in breast cancer. Tumour Biol. 2017;39(5):1010428317698370. doi:10.1177/1010428317698370.
   Google Scholar
• Wang B, Wu W, Xu K, Wu H. MicroRNA-223-3p is involved in fracture healing by regulating fibroblast growth factor receptor 2. Bioengineered. 2021;12(2):12040–48. doi:10.1080/21655979.2021.2002498.
   PubMed Web of Science ®Google Scholar
• Narla ST, Bushnell DS, Schaefer CM, Nouraie M, Tometich JT, Hand TW, Bates CM. Loss of fibroblast growth factor receptor 2 (FGFR2) leads to defective bladder urothelial regeneration after cyclophosphamide injury. Am J Pathol. 2021;191(4):631–51. doi:10.1016/j.ajpath.2020.12.011.
   PubMed Web of Science ®Google Scholar
• Chen X, Song D. LncRNA MEG3 participates in caerulein-induced inflammatory injury in human pancreatic cells via regulating miR-195-5p/FGFR2 axis and Inactivating NF-κB pathway. Inflammation. 2021;44(1):160–73. doi:10.1007/s10753-020-01318-6.
   PubMed Web of Science ®Google Scholar
• Xu Z, Zhu X, Wang M, Lu Y, Dai C. FGF/FGFR2 protects against tubular cell death and acute kidney injury involving Erk1/2 signaling activation. Kidney Dis (Basel). 2020;6(3):181–94. doi:10.1159/000505661.
   PubMed Web of Science ®Google Scholar
• Korkor MT, Meng FB, Xing SY, Zhang MC, Guo JR, Zhu XX, Zhu XX, Yang P. Microarray analysis of differential gene expression profile in peripheral blood cells of patients with human essential hypertension. Int J Med Sci. 2011;8(2):168–79. doi:10.7150/ijms.8.168.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Trautz B, Kračun D, Vogel F, Weitnauer M, Hochkogler K, Petry A, Görlach A. Stabilization of p22phox by hypoxia promotes pulmonary hypertension. Antioxid Redox Signal. 2019;30(1):56–73. doi:10.1089/ars.2017.7482.
   PubMed Web of Science ®Google Scholar
• Ding J, Yu M, Jiang J, Luo Y, Zhang Q, Wang S, Yang F, Wang A, Wang L, Zhuang M, et al. Angiotensin II decreases endothelial nitric oxide synthase phosphorylation via AT(1)R Nox/ROS/PP2A pathway. Front Physiol. 2020;11:566410.
   PubMed Web of Science ®Google Scholar
• Yu Q, Zhao J, Liu B. Bazedoxifene activates the angiotensin II-induced HUVEC hypertension model by targeting SIRT1. Exp Ther Med. 2022;23(2):120. doi:10.3892/etm.2021.11043.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–08. doi:10.1006/meth.2001.1262.
   PubMed Web of Science ®Google Scholar
• Lawes CM, Vander Hoorn S, Rodgers A. Global burden of blood-pressure-related disease, 2001. Lancet. 2008;371(9623):1513–18. doi:10.1016/S0140-6736(08)60655-8.
   PubMed Web of Science ®Google Scholar
• Gerage AM, Benedetti TRB, Ritti-Dias RM, Dos Santos ACO, de Souza BCC, Almeida FA, de Souza BCC. Effectiveness of a behavior change program on physical activity and eating habits in patients with hypertension: a randomized controlled trial. J Phys Act Health. 2017;14(12):943–52. doi:10.1123/jpah.2016-0268.
   PubMed Web of Science ®Google Scholar
• Ambrozova G, Fidlerova T, Verescakova H, Koudelka A, Rudolph TK, Woodcock SR, Freeman BA, Kubala L, Pekarova M. Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition. Biochim Biophys Acta. 2016;1860(11):2428–37. doi:10.1016/j.bbagen.2016.07.010.
   PubMed Web of Science ®Google Scholar
• Souza PS, Gonçalves ED, Pedroso GS, Farias HR, Junqueira SC, Marcon R, Tuon T, Cola M, Silveira PCL, Santos AR, et al. Physical exercise attenuates experimental autoimmune encephalomyelitis by inhibiting peripheral immune response and blood-brain barrier disruption. Mol Neurobiol. 2017;54(6):4723–37. doi:10.1007/s12035-016-0014-0.
   PubMed Web of Science ®Google Scholar
• Vaillancourt M, Ruffenach G, Meloche J, Bonnet S. Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension. Can J Cardiol. 2015;31(4):407–15. doi:10.1016/j.cjca.2014.10.023.
   PubMed Web of Science ®Google Scholar
• Reynolds JA, Rosenberg AZ, Smith CK, Sergeant JC, Rice GI, Briggs TA, Bruce IN, Kaplan MJ. Brief report: vitamin D deficiency is associated with endothelial dysfunction and increases type i interferon gene expression in a murine model of systemic lupus erythematosus. Arthritis Rheumatol. 2016;68(12):2929–35. doi:10.1002/art.39803.
   PubMed Web of Science ®Google Scholar
• Wesche J, Haglund K, Haugsten EM. Fibroblast growth factors and their receptors in cancer. Biochem J. 2011;437(2):199–213. doi:10.1042/BJ20101603.
   PubMed Web of Science ®Google Scholar
• Du X, Xie Y, Xian CJ, Chen L. Role of FGFs/FGFRs in skeletal development and bone regeneration. J Cell Physiol. 2012;227(12):3731–43. doi:10.1002/jcp.24083.
   PubMed Web of Science ®Google Scholar
• Katoh M. Therapeutics targeting FGF signaling network in human diseases. Trends Pharmacol Sci. 2016;37(12):1081–96. doi:10.1016/j.tips.2016.10.003.
   PubMed Web of Science ®Google Scholar
• Allouche M, Bikfalvi A. The role of fibroblast growth factor-2 (FGF-2) in hematopoiesis. Prog Growth Factor Res. 1995;6(1):35–48. doi:10.1016/0955-2235(95)00041-0.
   PubMedGoogle Scholar
• Zhang Q, Chen L, Huang L, Cheng H, Wang L, Xu L, Hu D, He C, Fu C, Wei Q. CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction. Mol Med. 2022;28(1):145. doi:10.1186/s10020-022-00575-5.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Wang Z, Chen X, Wang W, Wang X. ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress. Drug Des Devel Ther. 2018;12:4181–89. doi:10.2147/DDDT.S181312.
   PubMed Web of Science ®Google Scholar
• Tian M, Yang J, Yan X, Cao Y, Liu Y, Lei Y, Lv H. Knockdown of lncRNA TUG1 alleviates diabetic retinal vascular dysfunction through regulating miR-524-5p/FGFR2. Bioengineered. 2022;13(5):12661–72. doi:10.1080/21655979.2022.2075306.
   PubMed Web of Science ®Google Scholar
• Altaany Z, Moccia F, Munaron L, Mancardi D, Wang R. Hydrogen sulfide and endothelial dysfunction: relationship with nitric oxide. Curr Med Chem. 2014;21(32):3646–61. doi:10.2174/0929867321666140706142930.
   PubMed Web of Science ®Google Scholar
• Liu H, Chen T, Li N, Wang S, Bu P. Role of SIRT3 in Angiotensin II-induced human umbilical vein endothelial cells dysfunction. BMC Cardiovasc Disord. 2015;15(1):81. doi:10.1186/s12872-015-0075-4.
   PubMedGoogle Scholar
• Cui J, Zhuang S, Qi S, Li L, Zhou J, Zhang W, Zhao Y, Qi N, Yin Y, Huang L. Hydrogen sulfide facilities production of nitric oxide via the Akt/endothelial nitric oxide synthases signaling pathway to protect human umbilical vein endothelial cells from injury by angiotensin II. Mol Med Rep. 2017;16(5):6255–61. doi:10.3892/mmr.2017.7328.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang Q, Xie C, Cai Y, Chen X, Hou Y, He L, Li J, Yao M, Chen S, et al. Peptide ligands targeting FGF receptors promote recovery from dorsal root crush injury via AKT/mTOR signaling. Theranostics. 2021;11(20):10125–47. doi:10.7150/thno.62525.
   PubMed Web of Science ®Google Scholar
• Hu H, Hao L, Tang C, Zhu Y, Jiang Q, Yao J. Activation of KGFR-Akt-Mtor-Nrf2 signaling protects human retinal pigment epithelium cells from ultra-violet. Biochem Biophys Res Commun. 2018;495(3):2171–77. doi:10.1016/j.bbrc.2017.12.078.
   PubMed Web of Science ®Google Scholar
• Sato A, Nishioka S, Kiuchi M, Imada Y, Makino K, Nakagawa K, Tanaka R, Matsumura Y, Ohkita M. Grape Extract from Chardonnay Seeds Restores Deoxycorticosterone Acetate–Salt-Induced endothelial dysfunction and hypertension in rats. Biol Pharm Bull. 2020;43(1):59–67. doi:10.1248/bpb.b19-00540.
   PubMed Web of Science ®Google Scholar
• Chen YP, Sivalingam K, Shibu MA, Peramaiyan R, Day CH, Shen CY, Lai C-H, Chen R-J, Viswanadha VP, Chen Y-F, et al. Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats. Phytomedicine. 2019;57:1–8.
   PubMed Web of Science ®Google Scholar
• Chen XY, Yang LP, Zheng YL, Li YX, Zhong DL, Jin RJ, Li J. Electroacupuncture attenuated phenotype transformation of vascular smooth muscle cells via PI3K/Akt and MAPK signaling pathways in spontaneous hypertensive rats. Chin J Integr Med. 2022;28(4):357–65. doi:10.1007/s11655-021-2883-y.
   PubMed Web of Science ®Google Scholar
• Ho JH, Baskaran R, Wang MF, Mohammedsaleh ZM, Yang HS, Balasubramanian B. Dipeptide if and exercise training attenuate hypertension in SHR rats by inhibiting fibrosis and hypertrophy and activating AMPKα1, SIRT1, and PGC1α. Int J Mol Sci. 2022;23(15):8167.
   PubMed Web of Science ®Google Scholar
• Lopes RA, Neves KB, Tostes RC, Montezano AC, Touyz RM. Downregulation of nuclear factor erythroid 2-related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension. 2015;66(6):1240–50. doi:10.1161/HYPERTENSIONAHA.115.06163.
   PubMed Web of Science ®Google Scholar
• Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, Zhu Y, Guo C, Jia Y, Li Y, et al. Neuroprotection by Acetyl-11-Keto-β-Boswellic Acid, in ischemic brain injury involves the Nrf2/HO-1 defense Pathway. Sci Rep. 2014;4(1):7002. doi:10.1038/srep07002.
   PubMedGoogle Scholar
• Yao J, Long H, Zhao J, Zhong G, Li J. Nifedipine inhibits oxidative stress and ameliorates osteoarthritis by activating the nuclear factor erythroid-2-related factor 2 pathway. Life Sci. 2020;253:117292. doi:10.1016/j.lfs.2020.117292.
   PubMed Web of Science ®Google Scholar
• Meephat S, Prasatthong P, Potue P, Bunbupha S, Pakdeechote P, Maneesai P. Diosmetin ameliorates vascular dysfunction and remodeling by modulation of Nrf2/HO-1 and p-JNK/p-NF-κB expression in hypertensive rats. Antioxid (Basel). 2021;10(9):1487. doi:10.3390/antiox10091487.
   PubMedGoogle Scholar