1,158
Views
0
CrossRef citations to date
0
Altmetric
Research Article

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

, , , , , , , , & show all
Article: 2272062 | Received 24 Jul 2023, Accepted 10 Oct 2023, Published online: 29 Oct 2023

References

  • Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, Williams PG, Souza R. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53(1):1801913. doi:10.1183/13993003.01913-2018. Cited in: PMID: 30545968.
  • Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol. 2009;297(6):L1013–15. doi: 10.1152/ajplung.00217.2009. Cited in: PMID: 19748998.
  • Ghigna MR, Dorfmüller P. Pulmonary vascular disease and pulmonary hypertension. Diagn Histopathol. 2019;25(8):304–12. doi:10.1016/j.mpdhp.2019.05.002.
  • Colvin KL, Yeager ME. Animal models of pulmonary hypertension: matching disease mechanisms to etiology of the human disease. J Pulm Respir Med. 2014;4(4):198. doi:10.4172/2161-105X.1000198. Cited in: PMID: 25705569.
  • Stevens T, Phan S, Frid MG, Alvarez D, Herzog E, Stenmark KR. Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts. Proc Am Thorac Soc. 2008;5(7):783–91. doi: 10.1513/pats.200803-027HR. Cited in: PMID: 18757318.
  • Adachi T, Weisbrod RM, Pimentel DR, Ying J, Sharov VS, Schöneich C, Cohen RA. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med. 2004;10(11):1200–07. doi:10.1038/nm1119. Cited in: PMID: 15489859.
  • Yu W, Xu G, Chen H, Xiao L, Liu G, Hu P, Li S, Kasim V, Zeng C, Tong X. The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway. Acta Pharm Sin B. 2022;12(5):2315–29. doi:10.1016/j.apsb.2021.12.025. Cited in: PMID: 35646520.
  • Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014;289(29):19907–16. doi: 10.1074/jbc.M114.554451. Cited in: PMID: 24920669.
  • He RL, Wu ZJ, Liu XR, Gui LX, Wang RX, Lin MJ. Calcineurin/NFAT signaling modulates pulmonary artery smooth muscle cell proliferation, migration and apoptosis in monocrotaline-induced pulmonary arterial hypertension rats. Cell Physiol Biochem. 2018;49(1):172–89. doi:10.1159/000492852. Cited in: PMID: 30134231.
  • Kang S, Dahl R, Hsieh W, Shin A, Zsebo KM, Buettner C, Hajjar RJ, Lebeche D. Small Molecular allosteric Activator of the Sarco/endoplasmic reticulum Ca2±ATPase (SERCA) attenuates diabetes and metabolic disorders. J Biol Chem. 2016;291(10):5185–98. doi: 10.1074/jbc.M115.705012. Cited in: MID: 26702054.
  • Wagenvoort CA, Nauta J, van der Schaar P J, Weeda HW, Wagenvoort N. The pulmonary vasculature in complete transposition of the great vessels, judged from lung biopsies. Circulation. 1968;38(4):746–54. doi:10.1161/01.cir.38.4.746. Cited in: PMID: 5677959.
  • Thenappan T, Chan SY, Weir EK. Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2018;315(5):H1322–H31. doi: 10.1152/ajpheart.00136.2018. Cited in: PMID: 30141981.
  • Meng L, Liu X, Teng X, Gu H, Yuan W, Meng J, Li J, Zheng Z, Wei Y, Hu S. Osteopontin plays important roles in pulmonary arterial hypertension induced by systemic-to-pulmonary shunt. FASEB J. 2019;33(6):7236–51. doi: 10.1096/fj.201802121RR. Cited in: PMID: 30893567.
  • Mura M, Cecchini MJ, Joseph M, Granton JT. Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension. Respirology. 2019;24(11):1104–10. doi:10.1111/resp.13557. Cited in: PMID: 30963672.
  • Firth AL, Won JY, Park WS. Regulation of ca(2+) signaling in pulmonary hypertension. Korean J Physiol Pharmacol. 2013;17(1):1–8. doi: 10.4196/kjpp.2013.17.1.1. Cited in: PMID: 23439762.
  • Masaki T, Shimada M. Decoding the phosphatase code: regulation of cell proliferation by Calcineurin. Int J Mol Sci. 2022;23(3):1122. doi: 10.3390/ijms23031122. Cited in: PMID: 35163061.
  • Chen R, Yan J, Liu P, Wang Z, Wang C, Zhong W, Xu L. The role of nuclear factor of activated T cells in pulmonary arterial hypertension. Cell Cycle. 2017;16(6):508–14. doi:10.1080/15384101.2017.1281485. Cited in: PMID: 28103134.
  • Stevenson AS, Gomez MF, Hill-Eubanks DC, Nelson MT. NFAT4 movement in native smooth muscle. A role for differential Ca(2+) signaling. J Biol Chem. 2001;276(18):15018–24. doi: 10.1074/jbc.M011684200. Cited in: PMID: 11278965.
  • Chemaly ER, Troncone L, Lebeche D. SERCA control of cell death and survival. Cell Calcium. 2018;69:46–61. doi:10.1016/j.ceca.2017.07.001. Cited in: PMID: 28747251.
  • Que Y, Shu X, Wang L, Hu P, Wang S, Xiong R, Liu J, Chen H, Tong X. Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm. J Mol Cell Cardiol. 2020;139:213–24. doi:10.1016/j.yjmcc.2020.02.003. Cited in: PMID: 32035136.
  • Tong X, Hou X, Jourd’heuil D, Weisbrod RM, Cohen RA. Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res. 2010;107(8):975–83. doi: 10.1161/CIRCRESAHA.110.221242. Cited in: PMID: 20724704.
  • Liu B, Wang D, Luo E, Hou J, Qiao Y, Yan G, Wang Q, Tang C. Role of TG2-mediated SERCA2 serotonylation on hypoxic pulmonary vein remodeling. Front Pharmacol. 2020;10:1611. doi:10.3389/fphar.2019.01611. Cited in: PMID: 32116663.
  • Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmüller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, et al. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation. 2013;128(5):512–23. doi:10.1161/CIRCULATIONAHA.113.001585. Cited in: PMID: 23804254.
  • Sordi G, Goti A, Young HS, Palchetti I, Tadini-Buoninsegni F. Stimulation of Ca2+ -ATPase transport activity by a small-molecule drug. ChemMedchem. 2021;16(21):3293–99. doi:10.1002/cmdc.202100350. PMID: 34297466.
  • Cornea RL, Gruber SJ, Lockamy EL, Muretta JM, Jin D, Chen J, Dahl R, Bartfai T, Zsebo KM, Gillispie GD, et al. High-throughput FRET assay yields allosteric SERCA activators. J Biomol Screen. 2013;18(1):97–107. doi:10.1177/1087057112456878. Cited in: PMID: 22923787.
  • Koulmann N, Novel-Chaté V, Peinnequin A, Chapot R, Serrurier B, Simler N, Richard H, Ventura-Clapier R, Bigard X. Cyclosporin a inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy. Am J Respir Crit Care Med. 2006;174(6):699–705. doi:10.1164/rccm.200512-1976OC. Cited in: PMID: 16799071.
  • Kudryavtseva O, Aalkjaer C, Matchkov VV. Vascular smooth muscle cell phenotype is defined by Ca2±dependent transcription factors. FEBS J. 2013;280(21):5488–99. doi:10.1111/febs.12414. Cited in: PMID: 23848563.
  • Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A. 2007;104(27):11418–23. doi: 10.1073/pnas.0610467104. Cited in: PMID: 17596340.
  • Zhao FY, Xu SL, Zhang CF, Liu J, Zhang Y, Yang J, Xing XQ. PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2. Mol Med Rep. 2021;23(1):39. doi:10.3892/mmr.2021.11833. Cited in: PMID: 33179105.
  • Li M, Liu Y, Sun X, Li Z, Liu Y, Fang P, He P, Shi H, Xie M, Wang X, et al. Sildenafil inhibits calcineurin/NFATc2-mediated cyclin a expression in pulmonary artery smooth muscle cells. Life Sci. 2011;89(17–18):644–49. doi:10.1016/j.lfs.2011.07.023. Cited in: PMID: 21851826.
  • Bierer R, Nitta CH, Friedman J, Codianni S, de Frutos S, Dominguez-Bautista JA, Howard TA, Resta TC, Bosc LV. NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2011;301(6):L872–80. doi: 10.1152/ajplung.00405.2010. Cited in: PMID: 21908592.
  • Ramiro-Diaz JM, Nitta CH, Maston LD, Codianni S, Giermakowska W, Resta TC, Gonzalez Bosc LV. NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice. Am J Physiol Lung Cell Mol Physiol. 2013;304(9):L613–25. doi: 10.1152/ajplung.00408.2012. Cited in: PMID: 23475768.
  • Huang X, Lin X, Wang L, Xie Y, Que Y, Li S, Hu P, Tong X. Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts. Biochem Pharmacol. 2022;203:115164. doi:10.1016/j.bcp.2022.115164. Cited in: PMID: 35809651.
  • Mognol GP, Carneiro FR, Robbs BK, Faget DV, Viola JP. Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player. Cell Death Disease. 2016;7(4):e2199. doi:10.1038/cddis.2016.97. Cited in: PMID: 27100893.
  • Yu W, Xiao L, Que Y, Li S, Chen L, Hu P, Xiong R, Seta F, Chen H, Tong X. Smooth muscle NADPH oxidase 4 promotes angiotensin II-induced aortic aneurysm and atherosclerosis by regulating osteopontin. Biochim Biophys Acta Mol Basis Dis. 2020;1866(12):165912. doi: 10.1016/j.bbadis.2020.165912. Cited in: PMID: 32777344.
  • Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, et al. Substitution of SERCA2 Cys674 accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis. Br J Pharmacol. 2022;179(17):4423–39. doi:10.1111/bph.15864. Cited in: PMID: 35491240.
  • Yan X, Wang J, Zhu Y, Feng W, Zhai C, Liu L, Shi W, Wang Q, Zhang Q, Chai L, et al. S1P induces pulmonary artery smooth muscle cell proliferation by activating calcineurin/NFAT/OPN signaling pathway. Biochem Biophys Res Commun. 2019;516(3):921–27. doi: 10.1016/j.bbrc.2019.06.160. Cited in: PMID: 31277946.