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Research Article

Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis

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Article: 2321148 | Received 16 Oct 2023, Accepted 15 Feb 2024, Published online: 12 Mar 2024

References

  • Wheeler SM, Myers SO, Swamy GK, Myers ER. Estimated prevalence of risk factors for preeclampsia among individuals giving birth in the US in 2019. JAMA Netw Open. 2022;5(1):e2142343. doi:10.1001/jamanetworkopen.2021.42343.
  • Roell KR, Harmon QE, Klungsøyr K, Bauer AE, Magnus P, Engel SM. Clustering longitudinal blood pressure trajectories to examine heterogeneity in outcomes among preeclampsia cases and controls. Hypertension (Dallas, Tex: 1979). 2021;77(6):2034–10. doi:10.1161/hypertensionaha.120.16239.
  • Lv L, Tan X, Peng X, Bai R, Xiao Q, Zou T, Tan J, Zhang H, Wang C. The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease. Transl Neurodegener. 2020;9(1):34. doi:10.1186/s40035-020-00213-2.
  • Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelić M, Ganz T, Nemeth E. Effects of maternal iron status on placental and fetal iron homeostasis. J Clin Invest. 2020;130(2):625–40. doi:10.1172/jci127341.
  • Wiegersma AM, Dalman C, Lee BK, Karlsson H, Gardner RM. Association of prenatal maternal anemia with neurodevelopmental disorders. JAMA Psychiarty. 2019;76(12):1294–304. doi:10.1001/jamapsychiatry.2019.2309.
  • Romero-Afrima L, Zelmanovich V, Abergel Z, Zuckerman B, Shaked M, Abergel R, Livshits L, Smith Y, Gross E. Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans. Redox Biol. 2020;28:101359.
  • Erlandsson L, Masoumi Z, Hansson LR, Hansson SR. The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha-1-microglobulin in preeclampsia and fetal growth restriction. J Intern Med. 2021;290(5):952–68. doi:10.1111/joim.13349.
  • Chen Z, Gan J, Zhang M, Du Y, Zhao H. Ferroptosis and its emerging role in pre-eclampsia. Antioxid (Basel). 2022;11(7):1282. doi:10.3390/antiox11071282.
  • Alahari S, Farrell A, Ermini L, Park C, Sallais J, Roberts S, Gillmore T, Litvack M, Post M, Caniggia I, et al. JMJD6 dysfunction due to iron deficiency in preeclampsia disrupts fibronectin homeostasis resulting in diminished trophoblast migration. Front Cell Dev Biol. 2021;9:652607.
  • Kim J, Kim YJ, Lee R, Moon JH, Jo I. Serum levels of zinc, calcium, and iron are associated with the risk of preeclampsia in pregnant women. Nutr Res. 2012;32(10):764–9. doi:10.1016/j.nutres.2012.09.007.
  • Liu JX, Chen D, Li MX, Hua Y. Increased serum iron levels in pregnant women with preeclampsia: a meta-analysis of observational studies. J Obstet Gynaecol. 2019;39(1):11–16. doi:10.1080/01443615.2018.1450368.
  • Fang Z, Zheng S, Xie Y, Lin S, Zhang H, Yan J. Correlation between serum ferritin in early pregnancy and hypertensive disorders in pregnancy. Front Nutr. 2023;10:1151410. doi:10.3389/fnut.2023.1151410.
  • Serdar Z, Gür E, Develioğlu O. Serum iron and copper status and oxidative stress in severe and mild preeclampsia. Cell Biochem Funct. 2006;24(3):209–15. doi:10.1002/cbf.1235.
  • Rayman MP, Barlis J, Evans RW, Redman CW, King LJ. Abnormal iron parameters in the pregnancy syndrome preeclampsia. Am J Obstet Gynecol. 2002;187(2):412–18. doi:10.1067/mob.2002.123895.
  • Gómez-Gutiérrez AM, Parra-Sosa BE, Bueno-Sánchez JC. Glycosylation profile of the transferrin receptor in gestational iron deficiency and early-onset severe preeclampsia. J Pregnancy. 2019;2019:9514546. doi:10.1155/2019/9514546.
  • Peters TM, Holmes MV, Richards JB, Palmer T, Forgetta V, Lindgren CM, Asselbergs FW, Nelson CP, Samani NJ, McCarthy MI, et al. Sex differences in the risk of coronary heart disease associated with type 2 diabetes: a Mendelian randomization analysis. Diabetes Care. 2021;44(2):556–62. doi:10.2337/dc20-1137.
  • Nazarzadeh M, Pinho-Gomes AC, Smith Byrne K, Canoy D, Raimondi F, Ayala Solares JR, Otto CM, Rahimi K. Systolic blood pressure and risk of valvular heart disease: a Mendelian randomization study. JAMA Cardiol. 2019;4(8):788–95. doi:10.1001/jamacardio.2019.2202.
  • Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, et al. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun. 2014;5(1):4926. doi:10.1038/ncomms5926.
  • Yang M, Xu J, Zhang F, Luo P, Xu K, Feng R, Xu P. Large-scale genetic correlation analysis between spondyloarthritis and human blood metabolites. J Clin Med. 2023;12(3):1201. doi:10.3390/jcm12031201.
  • McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, Broer L, Guo X, Jeong A, Jung J, et al. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol. 2021;22(1):194. doi:10.1186/s13059-021-02398-9.
  • van de Luitgaarden IAT, van Oort S, Bouman EJ, Schoonmade LJ, Schrieks IC, Grobbee DE, van de Luitgaarden IAT, van Oort S, van der Schouw YT, Larsson SC, et al. Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies. Eur J Epidemiol. 2022;37(7):655–69. doi:10.1007/s10654-021-00799-5.
  • Bowden J, Spiller W, Del Greco MF, Sheehan N, Thompson J, Minelli C, Davey Smith G. Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression. Int J Epidemiol. 2018;47(4):1264–78. doi:10.1093/ije/dyy101.
  • Stender S, Kozlitina J, Nordestgaard BG, Tybjærg-Hansen A, Hobbs HH, Cohen JC. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. Nat Genet. 2017;49(6):842–7. doi:10.1038/ng.3855.
  • Chiang KM, Tsay YC, Vincent Ng TC, Yang HC, Huang YT, Chen CH, Pan W-H. Is hyperuricemia, an early-onset metabolic disorder, causally associated with cardiovascular disease events in Han Chinese? J Clin Med. 2019;8(8):1202. doi:10.3390/jcm8081202.
  • Demanelis K, Tong L, Pierce BL. Genetically increased telomere length and aging-related traits in the U.K. Biobank. J Gerontol: Series A. 2021;76(1):15–22. doi:10.1093/gerona/glz240.
  • Barone BB, Yeh HC, Snyder CF, Peairs KS, Stein KB, Derr RL, Wolff AC, Brancati FL. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA. 2008;300(23):2754–64. doi:10.1001/jama.2008.824.
  • Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, et al. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat Commun. 2020;11(1):597. doi:10.1038/s41467-020-14389-8.
  • Cubro H, Nath KA, Suvakov S, Garcia-Valencia O, Parashuram S, White WM, Weissgerber TL, Nath MC, Milic NM, Sontag F, et al. Mechanisms of vascular dysfunction in the interleukin-10–deficient murine model of preeclampsia indicate nitric oxide dysregulation. Kidney Int. 2021;99(3):646–56. doi:10.1016/j.kint.2020.09.034.
  • Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr. 2005;81(5):1218s–22. doi:10.1093/ajcn/81.5.1218.
  • Cerit ET, Cerit M. A case of pregnancy and lactation associated osteoporosis in the third pregnancy; robust response to teriparatide despite delayed administration. Bone Rep. 2020;13:100706. doi:10.1016/j.bonr.2020.100706.
  • Feng S, Yin H, Zhang K, Shan M, Ji X, Luo S, Shen Y. Integrated clinical characteristics and omics analysis identifies a ferroptosis and iron-metabolism-related lncRNA signature for predicting prognosis and therapeutic responses in ovarian cancer. J Ovarian Res. 2022;15(1):10. doi:10.1186/s13048-022-00944-y.
  • Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet (London, England). 2016;387(10021):907–16. doi:10.1016/s0140-6736(15)60865-0.
  • Ng SW, Norwitz SG, Norwitz ER. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int J Mol Sci. 2019;20(13). doi:10.3390/ijms20133283.
  • Liu J-X, Chen D, Li M-X, Hua Y. Increased serum iron levels in pregnant women with preeclampsia: a meta-analysis of observational studies. J Obstet Gynaecol. 2018;39(1):11–16. doi:10.1080/01443615.2018.1450368.