Reduced hydrogen sulfide production contributes to adrenal insufficiency induced by hypoxia via modulation of NLRP3 inflammasome activation

References

• Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8:383–395.
   PubMedGoogle Scholar
• Carrasco GA, van de Kar LD. Neuroendocrine pharmacology of stress. Eur J Pharmacol. 2003;463:235–272.
   PubMed Web of Science ®Google Scholar
• Timmermans S, Souffriau J, Libert C. A general introduction to glucocorticoid biology. Front Immunol. 2019;10:1545.
   PubMed Web of Science ®Google Scholar
• Bollaert PE, Fieux F, Charpentier C, et al. Baseline cortisol levels, cortisol response to corticotropin, and prognosis in late septic shock. Shock. 2003;19:13–15.
   PubMed Web of Science ®Google Scholar
• Husebye ES, Pearce SH, Krone NP, et al. Adrenal insufficiency. Lancet. 2021;397(10274):613–629.
   PubMed Web of Science ®Google Scholar
• Martin-Grace J, Dineen R, Sherlock M, et al. Adrenal insufficiency: physiology, clinical presentation and diagnostic challenges. Clin Chim Acta. 2020;505:78–91.
   PubMed Web of Science ®Google Scholar
• Marik PE. Mechanisms and clinical consequences of critical illness associated adrenal insufficiency. Curr Opin Crit Care. 2007;13:363–369.
   PubMed Web of Science ®Google Scholar
• Michiels C. Physiological and pathological responses to hypoxia. Am J Pathol. 2004;164:1875–1882.
   PubMed Web of Science ®Google Scholar
• Ward DS, Karan SB, Pandit JJ. Hypoxia: developments in basic science, physiology and clinical studies. Anaesthesia. 2011;66(Suppl. 2):19–268.
   PubMedGoogle Scholar
• Kimura H. Hydrogen sulfide: from brain to gut. Antioxid Redox Signal. 2010;12:1111–1123.
   PubMed Web of Science ®Google Scholar
• Li L, Rose P, Moore PK. Hydrogen sulfide and cell signaling. Annu Rev Pharmacol Toxicol. 2011;51:169–187.
   PubMed Web of Science ®Google Scholar
• Calvert JW, Coetzee WA, Lefer DJ. Novel insights into hydrogen sulfide–mediated cytoprotection. Antioxid Redox Signal. 2010;12:1203–1217.
   PubMed Web of Science ®Google Scholar
• Skovgaard N, Gouliaev A, Aalling M, et al. The role of endogenous H2S in cardiovascular physiology. Curr Pharm Biotechnol. 2011;12:1385–1393.
   PubMed Web of Science ®Google Scholar
• Papapetropoulos A, Pyriochou A, Altaany Z, et al. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci USA. 2009;106:21972–21977.
   PubMed Web of Science ®Google Scholar
• Wallace JL, Ferraz JG, Muscara MN. Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury. Antioxid Redox Signal. 2012;17:58–67.
   PubMed Web of Science ®Google Scholar
• Wang CN, Liu YJ, Duan GL, et al. CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex. Antioxid Redox Signal. 2014;21:2192–2207.
   PubMed Web of Science ®Google Scholar
• Wang G, Huang Y, Zhang N, et al. Hydrogen sulfide is a regulator of hemoglobin oxygen-carrying capacity via controlling 2,3-BPG production in erythrocytes. Oxid Med Cell Longev. 2021;2021:8877691.
   PubMed Web of Science ®Google Scholar
• Wang C, Du J, Du S, et al. Endogenous H2S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice. Mol Cell Endocrinol. 2018;474:65–73.
   PubMed Web of Science ®Google Scholar
• Ni J, Jiang L, Shen G, et al. Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion-induced acute kidney injury by inhibiting NLRP3 inflammasome. Life Sci. 2021;284:119466.
   PubMed Web of Science ®Google Scholar
• Lin Z, Altaf N, Li C, et al. Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages. Biochim Biophys Acta Mol Basis Dis. 2018;1864(9 Pt B):2890–2900.
   PubMed Web of Science ®Google Scholar
• Qiu Z, He Y, Ming H, et al. Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia/reoxygenation-induced injury through activating ROS-dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019;2019:8151836.
   PubMed Web of Science ®Google Scholar
• Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18:2114–2127.
   PubMed Web of Science ®Google Scholar
• Jia Y, Song T, Wei C, et al. Negative regulation of MAVS-mediated innate immune response by PSMA7. J Immunol. 2009;183:4241–4248.
   PubMed Web of Science ®Google Scholar
• Park S, Juliana C, Hong S, et al. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol. 2013;191:4358–4366.
   PubMed Web of Science ®Google Scholar
• Xie ZZ, Shi MM, Xie L, et al. Sulfhydration of p66Shc at cysteine59 mediates the antioxidant:effect of hydrogen sulfide. Antioxid Redox Signal. 2014;21:2531–2542.
   PubMed Web of Science ®Google Scholar
• Myers DA, Ducsay CA. Altitude, attitude and adaptation. Adv Exp Med Biol. 2014;814:147–157.
   PubMed Web of Science ®Google Scholar
• Swenson ER, Bärtsch P. High-altitude pulmonary edema. Compr Physiol. 2011;2:2753–2773.
   Web of Science ®Google Scholar
• Liu Y, Yang R, Liu X, et al. Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration. Cell Stem Cell. 2014;15:66–78.
   PubMed Web of Science ®Google Scholar
• Zhao S, Song T, Gu Y, et al. Hydrogen sulfide alleviates liver injury through the S-sulfhydrated-kelch-like ECH-associated protein 1/nuclear erythroid 2-related factor 2/low-density lipoprotein receptor-related protein 1 pathway. Hepatology. 2021;73:282–302.
   PubMed Web of Science ®Google Scholar
• Filipovic MR. Persulfidation (S-sulfhydration) and H2S. Handb Exp Pharmacol. 2015;230:29–59.
   PubMedGoogle Scholar
• Li D, Dong Q, Tao Q, et al. c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit. Cell Rep. 2015;10:484–496.
   PubMed Web of Science ®Google Scholar
• McGarry T, Biniecka M, Veale DJ, et al. Hypoxia, oxidative stress and inflammation. Free Radic Biol Med. 2018;125:15–24.
   PubMed Web of Science ®Google Scholar
• Wang J, Chen X, Huang W. MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3. Braz J Med Biol Res. 2021;54:e10550.
   PubMed Web of Science ®Google Scholar
• Wang L, Hauenstein AV. The NLRP3 inflammasome: mechanism of action, role in disease and therapies. Mol Aspects Med. 2020;76:100889.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Geng X, Warren J, et al. Hypoxia inducible factor-1α (HIF-1α) mediates NLRP3 inflammasome-dependent-pyroptotic and apoptotic cell death following ischemic stroke. Neuroscience. 2020;448:126–139.
   PubMed Web of Science ®Google Scholar
• Yang K, Xu S, Zhao H, et al. Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts. Int Immunopharmacol. 2021;94:107456.
   PubMed Web of Science ®Google Scholar
• Dubois H, Sorgeloos F, Sarvestani ST, et al. Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection. PLoS Pathog. 2019;15:e1007709.
   PubMed Web of Science ®Google Scholar
• Zheng M, Kanneganti TD. The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev. 2020;297:26–38.
   PubMed Web of Science ®Google Scholar