The consumption of Sechium edule (chayote) has antioxidant effect and prevents telomere attrition in older adults with metabolic syndrome

References

• Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5–6):231–237.
   PubMed Web of Science ®Google Scholar
• Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. 2018;20(2):1–8.
   PubMed Web of Science ®Google Scholar
• Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am. 2004;33(2):351–375.
   PubMed Web of Science ®Google Scholar
• The IDF consensus worldwide definition of the metabolic syndrome. Available online: https://www.idf.org/our-activities/advocacy-awareness/resources-and-tools/60:idfconsensus-worldwide-definitionof-the-metabolic-syndrome.html. (accessed on 1 March 2022).
   Google Scholar
• Bechtold M, Palmer J, Valtos J, et al. Metabolic syndrome in the elderly. Curr Diab Rep. 2006;6(1):64–71.
   PubMedGoogle Scholar
• Nam GE, Kim SM, Han K, et al. Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study. PLoS Med. 2018;15:e1002640.
   PubMed Web of Science ®Google Scholar
• Morrison JA, Friedman LA, Wang P, et al. Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr. 2008;152(2):201–206.
   PubMed Web of Science ®Google Scholar
• Vona R, Gambardella L, Cittadini C, et al. Biomarkers of oxidative stress in metabolic syndrome and associated diseases. Oxid Med Cell Longev. 2019;2019:8267234.
   PubMed Web of Science ®Google Scholar
• Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–772.
   PubMed Web of Science ®Google Scholar
• Libertini G, Shubernetskaya O, Corbi G, et al. Is evidence supporting the subtelomere-telomere theory of aging? Biochemistry Mosc. 2021;86(12):1526–1539.
   PubMed Web of Science ®Google Scholar
• Iglesias MAE, Panero J, Dos Santos PC, et al. Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome. PLoS One. 2017;12:e0174945.
   PubMed Web of Science ®Google Scholar
• von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27(7):339–344.
   PubMed Web of Science ®Google Scholar
• Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27–31.
   PubMedGoogle Scholar
• Aguiñiga-Sánchez I, Cadena-Íñiguez J, Santiago-Osorio E, et al. Chemical analyses and in vitro and in vivo toxicity of fruit methanol extract of Sechium edule var. nigrum spinosum. Pharm Biol. 2017;55(1):1638–1645.
   PubMed Web of Science ®Google Scholar
• Al Shoyaib A, Archie SR, Karamyan VT. Intraperitoneal route of drug administration: should it be used in experimental animal studies? Pharm Res. 2019;37(1):12.
   PubMed Web of Science ®Google Scholar
• Rosado-Pérez J, Aguiñiga-Sánchez I, Santiago-Osorio E, et al. Effect of Sechium edule var. nigrum spinosum (Chayote) on oxidative stress and pro-inflammatory markers in older adults with metabolic syndrome: an exploratory study. Antioxidants. 2019;8(5):146.
   Web of Science ®Google Scholar
• Arista-Ugalde TL, Santiago-Osorio E, Monroy-García A, et al. Antioxidant and anti-inflammatory effect of the consumption of powdered concentrate of Sechium edule var. nigrum spinosum in Mexican older adults with metabolic syndrome. Antioxidants. 2022;11(6):1076.
   Web of Science ®Google Scholar
• Orozco-Sota AU. Análisis fitoquímico y efecto antioxidante in vitro E in vivo de dos genotipos de Sechium edule (Jacq.) Sw. Tesis (Maestría en Ciencias, especialista en Botánica). Colegio de Postgraduados, Campus Montecillo, 2022.
   Google Scholar
• NCEP. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA. 2001;285(19):2486–2497.
   PubMed Web of Science ®Google Scholar
• Secretaría de Salud. Toma de medidas clínicas y antropométricas en el adulto mayor. Mexico City, (Mexico): Subsecretaría de prevención y Protección de la Salud; 2002.
   Google Scholar
• Secretaría de Salud. Norma Oficial Mexicana NOM-030-SSA-1999. Para la prevención, tratamiento y control de la hipertensión arterial. Mexico City, (Mexico): Secretaría de Salud; 1999.
   Google Scholar
• Jentzsch AM, Bachmann H, Fürst P, et al. Improved analysis of malondialdehyde in human body fluids. Free Radic Biol Med. 1996;20(2):251–256.
   PubMed Web of Science ®Google Scholar
• Mesquita CS, Oliveira R, Bento F, et al. Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins. Anal Biochem. 2014;458:59–71.
   Web of Science ®Google Scholar
• Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121–126.
   PubMed Web of Science ®Google Scholar
• Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881–887.
   PubMed Web of Science ®Google Scholar
• Veronika S, Siahaan JM. The effect of ethanol extract and fruit fraction of chayote (Sechium Edule (Jacq.) Swartz) on oxidative stress and leptin leptins in wistar brain white rats (Rattus Novergicus Sp.) high-fatty diet induced obesity. IJBHM. 2021;1(2021):10–14.
   Google Scholar
• Gavia-García G, Rosado-Pérez J, Aguiñiga-Sánchez I, et al. Effect of Sechium edule var. nigrum spinosum (chayote) on telomerase levels and antioxidant capacity in older adults with metabolic syndrome. Antioxidants. 2020;9(7):634.
   Web of Science ®Google Scholar
• Modgil M, Modgil R, Kumar R. Carbohydrate and mineral content of Chayote (Sechium edule) and Bottle Gourd (Lagenaria Siceraria). J Hum Ecol. 2004;15(2):157–159.
   Google Scholar
• Yu-Ting P, Qing L, Lin-Hong W, et al. Origin, evolution, breeding, and omics of Chayote, an important cucurbitaceae vegetable. Crop Front Plant Sci. 2021;12:739091.
   PubMed Web of Science ®Google Scholar
• Cheng-Hsun W, Ting-Tsz O, Chun-Hua C, et al. The polyphenol extract from Sechium edule shoots inhibits lipogenesis and stimulates lipolysis via activation of AMPK signals in HepG2 cells. J Agric Food Chem. 2014;62(3):750–759.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Guideline for the pharmacological treatment of hypertension in adults: summary, Geneva; 2022.
   Google Scholar
• Sakung JM, Sirajuddin S, Zulkifli A, et al. Influence of nutrition education and provision of instant chayote to change in blood pressure. Pakistan J Nutr. 2018;17(8):386–391.
   Google Scholar
• Hastuti H, Mardiana E. The effect of chayote juice (Sechium Edule) to reduce blood pressure in elderly with hypertension. In 1st International Conference on Community Health (ICCH 2019), Purwokerto, Indonesia. 2020.
   Google Scholar
• Lombardo-Earl G, Roman-Ramos R, Zamilpa A, et al. Extracts and fractions from edible roots of Sechium edule (Jacq.) Sw. with antihypertensive activity. Evid Based Complement Alternat Med. 2014;2014:594326.
   PubMed Web of Science ®Google Scholar
• Maity S, Firdous SM, Debnath R. Evaluation of antidiabetic activity of ethanolic extract of sechium edule fruits in alloxan-induced diabetic rats. World J Pharm Sci. 2013;2:3612–3621.
   Google Scholar
• Sakung S, Saifuddin S, Zulkifli A, et al. The effect of chayote (Sechium Edule) on blood glucose level of high school teachers of pre-diabetes. Indian J Public Heal Res Dev. 2018;9(5):245–250.
   Google Scholar
• Loizzo MR, Bonesi M, Menichini F, et al. Antioxidant and carbohydrate-hydrolysing enzymes potential of Sechium edule (Jacq.) Swartz (Cucurbitaceae) peel, leaves and pulp fresh and processed. Plant Foods Hum Nutr. 2016;71(4):381–387.
   PubMed Web of Science ®Google Scholar
• Sevilla-Asencio OA, Dublán-García O, Gómez-Oliván LM, et al. Actividad inhibitoria sobre α-glucosidasa y α-amilasa de extractos acuosos de algunas especias utilizados en la cocina mexicana. Ciencia UAT. 2013;8(1):42–47.
   Google Scholar
• Millar CL, Duclos Q, Blesso CN. Effects of dietary flavonoids on reverse cholesterol transport, HDL metabolism, and HDL function. Adv Nutr. 2017;8(2):226–239.
   PubMed Web of Science ®Google Scholar
• Neeraja K, Debnath R, Firdous SM. Cardioprotective activity of fruits of Sechium edule. Bangladesh J Pharmacol. 2015;10(1):125–130.
   Web of Science ®Google Scholar
• Mumtaz SF, Paul S, Bag AK. Effect of Sechium edule on chemical induced kidney damage in experimental animals. Bangladesh J Pharmacol. 2013;8(1):28–35.
   Web of Science ®Google Scholar
• Afanas’ ev IB, Dcrozhko AI, Brodskii AV, et al. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem Pharmacol. 1989;38(11):1763–1769.
   PubMed Web of Science ®Google Scholar
• Utrera M, Estévez M. Impact of trolox, quercetin, genistein and gallic acid on the oxidative damage to myofibrillar proteins: The carbonylation pathway. Food Chem. 2013;141(4):4000–4009.
   PubMed Web of Science ®Google Scholar
• Díaz-Acosta AE, Membrillo-Hernández J. Consecuencias fisiológicas de la oxidación de proteínas por carbonilación en diversos sistemas biológicos. Tip Revista Especializada en Ciencias Químico-Biológicas. 2006;9(1):34–44.
   Google Scholar
• Caimi G, Hopps E, Noto D, et al. Protein oxidation in a group of subjects with metabolic syndrome. Diabetes Metab Syndr. 2013;7(1):38–41.
   PubMedGoogle Scholar
• Venereo GJ. Daño oxidativo, radicales libres y antioxidantes. Rev Cubana Med Milit. 2002;31(2):126–133.
   Google Scholar
• Gelen V, Yıldırım S, Şengül E, et al. Naringin attenuates oxidative stress, inflammation, apoptosis, and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats. Asian Pac J Trop Biomed. 2022;12(5):223–232.
   Web of Science ®Google Scholar
• Caglayan C, Temel Y, Kandemir FM, et al. Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage. Environ Sci Pollut Res Int. 2018;25(21):20968–20984.
   PubMed Web of Science ®Google Scholar
• Kanazawa K, Uehara M, Yanagitani H, et al. Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. Arch Biochem Biophys. 2006;455(2):197–203.
   PubMed Web of Science ®Google Scholar
• Cadena-Iñiguez J, Soto-Hernández M, Torres-Salas A, et al. The antiproliferative effect of chayote varieties (Sechium edule (Jacq.) Sw.) on tumour cell lines. Med Plants Res. 2013;7(8):455–460.
   Google Scholar
• Weng CJ, Chen MJ, Yeh CT, et al. Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity. N Biotechnol. 2011;28(6):767–777.
   PubMed Web of Science ®Google Scholar
• Dreger H, Westphal K, Weller A, et al. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res. 2009;83(2):354–361.
   PubMed Web of Science ®Google Scholar
• Escorza MAQ, Salinas JVC. La capacidad antioxidante total. Bases y aplicaciones. REB. 2009;28(3):89–101.
   Google Scholar
• Motor S, Ozturk S, Ozcan O, et al. Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata. Int J Clin Exp Med. 2014;7(4):1089–1093.
   PubMed Web of Science ®Google Scholar
• Lin Y, Kotakeyama Y, Li J, et al. Cucurbitacin B exerts antiaging effects in yeast by regulating autophagy and oxidative stress. Oxid Med Cell Longev. 2019;2019:4517091.
   PubMed Web of Science ®Google Scholar
• Liu Z, Kumar M, Kabra A. Cucurbitacin B exerts neuroprotection in a murine Alzheimer's disease model by modulating oxidative stress, inflammation, and neurotransmitter levels. Front Biosci (Landmark Ed). 2022;27(2):71.
   PubMed Web of Science ®Google Scholar
• Ranjan A, Ramachandran S, Gupta N, et al. Role of phytochemicals in cancer prevention. Int J Mol Sci. 2019;20(20):4981.
   PubMed Web of Science ®Google Scholar
• Park SY, Kim YH, Park G. Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition. Neurosci Lett. 2015;609:129–136.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang J, Zhao G, et al. Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway. Cell Stress Chaperones. 2020;25(2):277–285.
   PubMed Web of Science ®Google Scholar
• Arredondo F, Echeverry C, Abin-Carriquiry JA, et al. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic Biol Med. 2010;49(5):738–747.
   PubMed Web of Science ®Google Scholar
• Qin S, Chen J, Tanigawa S, et al. Microarray and pathway analysis highlight Nrf2/ARE-mediated expression profiling by polyphenolic myricetin. Mol Nutr Food Res. 2013;57(3):435–446.
   PubMed Web of Science ®Google Scholar
• Liao HH, Zhu JX, Feng H, et al. Myricetin possesses potential protective effects on diabetic cardiomyopathy through inhibiting IκBα/NFκB and enhancing Nrf2/HO-1. Oxid Med Cell Longev. 2017;2017:8370593.
   PubMed Web of Science ®Google Scholar
• Ma C, Deng Y, Xiao R, et al. Anti-fatigue effect of phlorizin on exhaustive exercise-induced oxidative injury mediated by Nrf2/ARE signaling pathway in mice. Eur J Pharmacol. 2022;918:174563.
   PubMed Web of Science ®Google Scholar
• Wang K, Chen Z, Huang L, et al. Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons. Int J Mol Med. 2017;40(5):1582–1590.
   PubMed Web of Science ®Google Scholar
• Bao L, Li J, Zha D, et al. Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways. Int Immunopharmacol. 2018;54:245–253.
   PubMed Web of Science ®Google Scholar
• Juurlink BH, Azouz HJ, Aldalati AM, et al. Hydroxybenzoic acid isomers and the cardiovascular system. Nutr J. 2014;13:63.
   PubMed Web of Science ®Google Scholar
• Sabitha R, Nishi K, Gunasekaran VP, et al. p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models. Chem Biol Interact. 2020;321:109044.
   PubMed Web of Science ®Google Scholar
• Yoon JH, Youn K, Ho CT, et al. p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25–35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. J Agric Food Chem. 2014;62(21):4911–4916.
   PubMed Web of Science ®Google Scholar
• Kassab RB, Lokman MS, Daabo HMA, et al. Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium-induced oxidative challenge, inflammation, and apoptosis in rats. J Food Biochem. 2020;44(12):e13505.
   PubMed Web of Science ®Google Scholar
• Somade IT, Ajiboye BO, Osukoya OA, et al. Syringic acid ameliorates testicular oxidative stress via the conservation of endogenous antioxidant markers and inhibition of the activated Nrf2-Keap1-NQO1-HO1 signaling in methyl cellosolve-administered rats. Pharmacol Res (Modern Chinese Medicine). 2023;6:100207.
   Google Scholar
• Pang C, Zheng Z, Shi L, et al. Caffeic acid prevents Acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system. Free Radic Biol Med. 2016;91:236–246.
   PubMed Web of Science ®Google Scholar
• da Cunha FM, Duma D, Assreuy J, et al. Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties. Free Radic Res. 2004;38(11):1241–1253.
   PubMed Web of Science ®Google Scholar
• Yeh CT, Yen GC. Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells. Carcinogenesis. 2006;27(5):1008–1007.
   PubMed Web of Science ®Google Scholar
• Saavedra RG, Vásquez DGM, González NLA. Interleucina-6: ¿amiga o enemiga? Bases para comprender su utilidad como objetivo terapéutico. Iatreia. 2011;24(2):157–166.
   Google Scholar
• Marasco MR, Conteh AM, Reissaus CA, et al. Interleukin-6 reduces β-Cell oxidative stress by linking autophagy with the antioxidant response. Diabetes. 2018;67(8):1576–1588.
   PubMed Web of Science ®Google Scholar
• Matsuoka Y, Nakayama H, Yoshida R, et al. IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma. Br J Cancer. 2016;115(110):1234–1244.
   PubMedGoogle Scholar
• Lim YJ, Kim JH, Pan JH, et al. Naringin protects pancreatic β-Cells against oxidative stress-induced apoptosis by inhibiting both intrinsic and extrinsic pathways in Insulin-Deficient Diabetic Mice. Mol Nutr Food Res. 2018;62(5):1700810.
   Web of Science ®Google Scholar
• Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol. 2006;6(4):379–386.
   PubMed Web of Science ®Google Scholar
• Pérez-Fernández R, Kaski JC. Interleucina-10 y enfermedad coronaria. Rev Esp Cardiol. 2002;55(7):738–750.
   PubMedGoogle Scholar
• Hutchins AP, Diez D, Miranda-Saavedra D. The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Brief Funct Genomics. 2013;12(6):489–498.
   PubMed Web of Science ®Google Scholar
• Naz S, Shafique N, Sharif S, et al. Association of Interleukin 10 (IL-10) gene with type 2 diabetes mellitus by single nucleotide polymorphism of its promotor region G/A 1082. Crit Rev Eukaryot Gene Expr. 2020;30(4):285–289.
   PubMed Web of Science ®Google Scholar
• Comalada M, Ballester I, Bailón E, et al. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure activity relationship. Biochem Pharmacol. 2006;72(8):1010–1021.
   PubMed Web of Science ®Google Scholar
• Révész D, Milaneschi Y, Verhoeven JE, et al. Longitudinal associations between metabolic syndrome components and telomere shortening. J Clin Endocrinol Metab. 2015;100:3050–3059.
   PubMed Web of Science ®Google Scholar
• Gavia-García G, Rosado-Pérez J, Arista-Ugalde TL, et al. Telomere length and oxidative stress and its relation with metabolic syndrome components in the aging. Biology (Basel). 2021;10(4):253.
   PubMedGoogle Scholar
• Cheng YY, Kao TW, Chang YW, et al. Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length. PLoS One. 2017;12(7):e0180687.
   PubMed Web of Science ®Google Scholar
• Rehkopf DH, Needham BL, Lin J, et al. Leukocyte telomere length in relation to 17 biomarkers of cardiovascular disease risk: a cross-sectional study of us adults. PLoS Med. 2016;13(11):e1002188.
   PubMed Web of Science ®Google Scholar
• Neuner B, Lenfers A, Kelsch R, et al. Telomere length is not related to established cardiovascular risk factors but does correlate with red and white blood cell counts in a German blood donor population. PLoS One. 2015;10(10):e0139308.
   PubMed Web of Science ®Google Scholar
• Révész D, Milaneschi Y, Verhoeven JE, et al. Telomere length as a marker of cellular aging is associated with prevalence and progression of metabolic syndrome. J Clin Endocrinol Metab. 2014;99:4607–4615.
   PubMed Web of Science ®Google Scholar
• Huzen J, Wong LS, van Veldhuisen DJ, et al. Telomere length loss due to smoking and metabolic traits. J Intern Med. 2014;275(2):155–163.
   PubMed Web of Science ®Google Scholar
• Rentoukas E, Tsarouhas K, Kaplanis I, et al. Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome. PLoS ONE. 2012;7(4):e35739.
   PubMed Web of Science ®Google Scholar
• Garlichs CD, Eskafi S, Cicha I, et al. Delay of neutrophil apoptosis in acute coronary syndromes. J Leukoc Biol. 2004;75(5):828–835.
   PubMed Web of Science ®Google Scholar
• Wang JC, Warner JK, Erdmann N, et al. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. Proc Natl Acad Sci U S A. 2005;102(40):14398–14403.
   PubMed Web of Science ®Google Scholar
• Gürünlüoğlu K, Demircan M, Koç A, et al. The effects of different burn dressings on length of telomere and expression of telomerase in children with thermal burns. J Burn Care Res. 2019;40(3):302–311.
   PubMed Web of Science ®Google Scholar
• Bozkus F, Guler S, Sımsek S. Serum telomerase levels and COPD exacerbations. Respir Care. 2016;61(3):359–365.
   PubMed Web of Science ®Google Scholar
• McAninch D, Bianco-Miotto T, Gatford KL, et al. The metabolic syndrome in pregnancy and its association with child telomere length. Diabetologia. 2020;63(10):2140–2149.
   PubMed Web of Science ®Google Scholar
• Qi A, Zhou H, Zhou Z, et al. Telomerase activity increased and telomere length shortened in peripheral blood cells from patients with immune thrombocytopenia. J Clin Immu-nol. 2013;33(3):577–585.
   PubMed Web of Science ®Google Scholar
• Wu K, Higashi N, Hansen ER, et al. Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis. J Immunol. 2000;165(8):4742–4747.
   PubMed Web of Science ®Google Scholar
• Akhtar N, Anand V, Verma KK, et al. Augmented telomerase activity and reduced telomere length in parthenium-induced contact dermatitis. J Eur Acad Dermatol Venereol. 2013;27(10):1222–1227.
   PubMed Web of Science ®Google Scholar
• Wu KD, Hansen ER. Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis. Exp Dermatol. 2001;10(5):329–336.
   PubMed Web of Science ®Google Scholar
• Bjørge T, Lukanova A, Jonsson H, et al. Metabolic syndrome and breast cancer in the me-can (metabolic syndrome and cancer) project. Cancer Epidemiol Biomarkers Prev. 2010;19(7):1737–1745.
   PubMed Web of Science ®Google Scholar
• Russo A, Autelitano M, Bisanti L. Metabolic syndrome and cancer risk. Eur J Cancer. 2008;44(2):293–297.
   PubMed Web of Science ®Google Scholar
• Holt SE, Glinsky VV, Ivanova AB, et al. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol Carcinog. 1999;25(4):241–248.
   PubMed Web of Science ®Google Scholar
• Aguiar SS, Rosa TS, Sousa CV, et al. Influence of body fat on oxidative stress and telomere length of master athletes. J Strength Cond Res. 2021;35(6):1693–1699.
   PubMed Web of Science ®Google Scholar
• Canudas S, Becerra-Tomás N, Hernández-Alonso P, et al. Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis.
   Google Scholar