Publication Cover
Redox Report
Communications in Free Radical Research
Volume 29, 2024 - Issue 1
2,271
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis

, , , , , , , & ORCID Icon show all

References

  • Hoste EA, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015;41(8):1411–1423. doi:10.1007/s00134-015-3934-7
  • Linkermann A, et al. Regulated cell death in AKI. J Am Soc Nephrol. 2014;25(12):2689–2701. doi:10.1681/ASN.2014030262
  • Peerapornratana S, et al. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019;96(5):1083–1099. doi:10.1016/j.kint.2019.05.026
  • Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
  • Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369–379. doi:10.1038/cdd.2015.158
  • Belavgeni A, et al. Ferroptosis and necroptosis in the kidney. Cell Chem Biol. 2020;27(4):448–462. doi:10.1016/j.chembiol.2020.03.016
  • Wehbe R, et al. Bee venom: overview of main compounds and bioactivities for therapeutic interests. Molecules. 2019;24(16):2997. doi:10.3390/molecules24162997
  • Kim JY, et al. Melittin ameliorates endotoxin-induced acute kidney injury by inhibiting inflammation, oxidative stress, and cell death in mice. Oxid Med Cell Longev. 2021;2021:8843051.
  • Lee G, Bae H. Anti-inflammatory applications of melittin, a major component of Bee venom: detailed mechanism of action and adverse effects. Molecules. 2016;21(5):616.
  • Li J, et al. Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses. Cell Mol Biol Lett. 2022;27(1):29, doi:10.1186/s11658-022-00318-8
  • Bellomo R, et al. Acute kidney injury. Lancet. 2012;380(9843):756–766. doi:10.1016/S0140-6736(11)61454-2
  • Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185(14):2401–2421. doi:10.1016/j.cell.2022.06.003
  • Jaganjac M, et al. Oxidative stress and regeneration. Free Radic Biol Med. 2022;181:154–165. doi:10.1016/j.freeradbiomed.2022.02.004
  • Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 2016;26(3):165–176. doi:10.1016/j.tcb.2015.10.014
  • Sun X, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63(1):173–184. doi:10.1002/hep.28251
  • Dodson M, et al. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019;23:101107. doi:10.1016/j.redox.2019.101107
  • Fleischmann C, et al. Assessment of global incidence and mortality of hospital-treated sepsis. current estimates and limitations. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–272. doi:10.1164/rccm.201504-0781OC
  • Memariani H, et al. Melittin: a venom-derived peptide with promising anti-viral properties. Eur J Clin Microbiol Infect Dis. 2020;39(1):5–17. doi:10.1007/s10096-019-03674-0
  • Tang D, et al. The molecular machinery of regulated cell death. Cell Res. 2019;29(5):347–364. doi:10.1038/s41422-019-0164-5
  • Stockwell BR, et al. Emerging mechanisms and disease relevance of ferroptosis. Trends Cell Biol. 2020;30(6):478–490. doi:10.1016/j.tcb.2020.02.009
  • Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331. doi:10.1016/j.cell.2013.12.010
  • Ingold I, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172(3):409–422.e421. doi:10.1016/j.cell.2017.11.048
  • Anandhan A, et al. Breakdown of an ironclad defense system: the critical role of NRF2 in mediating ferroptosis. Cell Chem Biol. 2020;27(4):436–447. doi:10.1016/j.chembiol.2020.03.011
  • Loboda A, et al. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(16):3221–3247. doi:10.1007/s00018-016-2223-0.