Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation

References

• Zawada AE, Moszak M, Skrzypczak D, et al. Gastrointestinal complications in patients with diabetes mellitus. Adv Clin Exp Med. 2018 Apr;27(4):567–572. doi:10.17219/acem/67961
   PubMed Web of Science ®Google Scholar
• Umathe SN, Kochar NI, Jain NS, et al. Gastrointestinal dysfunction in diabetic rats relates with a decline in tissue L-arginine content and consequent low levels of nitric oxide. Nitric Oxide. 2009 Mar;20(2):129–133. doi:10.1016/j.niox.2008.10.007
   PubMed Web of Science ®Google Scholar
• Hu W, Feng P. Myosin light chain kinase is involved in the mechanism of gastrointestinal dysfunction in diabetic rats. Dig Dis Sci. 2012 May;57(5):1197–1202. doi:10.1007/s10620-012-2041-7
   PubMed Web of Science ®Google Scholar
• Lake JI, Heuckeroth RO. Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G1–24. doi:10.1152/ajpgi.00452.2012
   PubMed Web of Science ®Google Scholar
• Yarandi SS, Srinivasan S. Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions. Neurogastroenterol Motil. 2014 May;26(5):611–624. doi:10.1111/nmo.12330
   PubMed Web of Science ®Google Scholar
• Seguella L, Gulbransen BD. Enteric glial biology, intercellular signalling and roles in gastrointestinal disease. Nat Rev Gastroenterol Hepatol. 2021 Aug;18(8):571–587. doi:10.1038/s41575-021-00423-7
   PubMed Web of Science ®Google Scholar
• Yu YB, Li YQ. Enteric glial cells and their role in the intestinal epithelial barrier. World J Gastroenterol. 2014 Aug 28;20(32):11273–11280. doi:10.3748/wjg.v20.i32.11273
   PubMed Web of Science ®Google Scholar
• Qi R, Yang W, Chen J. Role of enteric glial cells in gastric motility in diabetic rats at different stages. J Huazhong Univ Sci Technolog Med Sci. 2013 Aug;33(4):496–500. doi:10.1007/s11596-013-1148-1
   PubMedGoogle Scholar
• Zhu X, Li Y, Zhu X, et al. Circular RNA-VPS13A attenuates diabetes-induced enteric glia damage by targeting miR-182/GDNF Axis. Acta Biochim Biophys Sin (Shanghai). 2022 Jun 25;54(7):999–1007. doi:10.3724/abbs.2022073
   PubMed Web of Science ®Google Scholar
• Luo P, Liu D, Li C, et al. Enteric glial cell activation protects enteric neurons from damage due to diabetes in part via the promotion of neurotrophic factor release. Neurogastroenterol Motil. 2018 Oct;30(10):e13368. doi:10.1111/nmo.13368
   PubMed Web of Science ®Google Scholar
• Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180–183. doi:10.1016/j.redox.2015.01.002
   PubMed Web of Science ®Google Scholar
• Ramos-Riera KP. Pérez-Severiano F,López-Meraz ML. Oxidative stress: a common imbalance in diabetes and epilepsy. Metab Brain Dis. 2023 Mar;38(3):767–782. doi:10.1007/s11011-022-01154-7
   PubMed Web of Science ®Google Scholar
• Kashyap P, Farrugia G. Oxidative stress: key player in gastrointestinal complications of diabetes. Neurogastroenterol Motil. 2011 Feb;23(2):111–114. doi:10.1111/j.1365-2982.2010.01659.x
   PubMed Web of Science ®Google Scholar
• Spencer NY, Engelhardt JF. The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies. Biochemistry. 2014 Mar 18;53(10):1551–1564. doi:10.1021/bi401719r
   PubMed Web of Science ®Google Scholar
• Zou W, Lu Q, Zhu X, et al. Procyanidin B2 protects TR-iBRB2 cells against hyperglycemia stress by attenuating oxidative stress and inflammasome activation via regulation of Redoxosomes/NF-kB signaling. Curr Mol Med. 2022 Oct 17;23(10):1095–1103. doi:10.2174/1566524023666221017120334
   Web of Science ®Google Scholar
• Yin J, Wang K, Zhu X, et al. Procyanidin B2 suppresses hyperglycemia-induced renal mesangial cell dysfunction by modulating CAV-1-dependent signaling. Exp Ther Med. 2022 Aug;24(2):496. doi:10.3892/etm.2022.11423
   PubMed Web of Science ®Google Scholar
• Wang K, Chen Y, Zhu X, et al. Ginkgo biloba extract attenuates light-induced photoreceptor degeneration by modulating CAV-1-Redoxosome signaling. Antioxidants (Basel). 2022 Jun 27;11(7):1268. doi:10.3390/antiox11071268
   PubMedGoogle Scholar
• Kumar P, Nagarajan A, Uchil PD. Analysis of cell viability by the MTT assay. Cold Spring Harb Protoc. 2018 Jun 1;2018(6). doi:10.1101/pdb.prot095505
   Google Scholar
• Rasooly R, Do P, He X, et al. A sensitive, cell-based assay for measuring low-level biological activity of α-Amanitin. Int J Mol Sci. 2023 Nov;24(22):16402.
   PubMed Web of Science ®Google Scholar
• Kyrylkova K, Kyryachenko S, Leid M, et al. Detection of apoptosis by TUNEL assay. Methods Mol Biol. 2012;887:41–47. doi:10.1007/978-1-61779-860-3_5
   PubMedGoogle Scholar
• Aranda A, Sequedo L, Tolosa L, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells. Toxicol In Vitro. 2013 Mar;27(2):954–963. doi:10.1016/j.tiv.2013.01.016
   PubMed Web of Science ®Google Scholar
• Wang Y, Lou MF. The regulation of NADPH oxidase and its association with cell proliferation in human lens epithelial cells. Invest Ophthalmol Vis Sci. 2009 May;50(5):2291–2300. doi:10.1167/iovs.08-2568
   PubMed Web of Science ®Google Scholar
• Walker JM. The bicinchoninic acid (BCA) assay for protein quantitation. Methods Mol Biol. 1994;32:5–8. doi:10.1385/0-89603-268-x:5
   PubMedGoogle Scholar
• Jindal RM, Karanam M, Shah R. Prevention of diabetes in the NOD mouse by intra-muscular injection of recombinant adeno-associated virus containing the preproinsulin II gene. Int J Exp Diabetes Res. 2001;2(2):129–138. doi:10.1155/EDR.2001.129
   PubMedGoogle Scholar
• Tasfaout H, Lionello VM, Kretz C, et al. Single intramuscular injection of AAV-shRNA reduces DNM2 and prevents myotubular myopathy in mice. Mol Ther. 2018 Apr 4;26(4):1082–1092. doi:10.1016/j.ymthe.2018.02.008
   PubMed Web of Science ®Google Scholar
• Li MY, Duan JQ, Wang XH, et al. Inulin inhibits the inflammatory response through modulating enteric glial cell function in type 2 diabetic mellitus mice by reshaping intestinal flora. ACS Omega. 2023 Oct 10;8(40):36729–36743. doi:10.1021/acsomega.3c03055
   PubMed Web of Science ®Google Scholar
• Jiang Q, Yuan S, Wang K, et al. Ginkgo biloba extract ameliorates hyperglycaemia-induced enteric glial cell injury via regulation of the TLR2-related pathway. J Pharm Pharmacol. 2023 Nov 23;75(11):1430–1441. doi:10.1093/jpp/rgad075
   PubMed Web of Science ®Google Scholar
• Shahin WS, Engelhardt JF. Isolation of redox-active endosomes (redoxosomes) and assessment of NOX activity. Methods Mol Biol. 2019;1982:461–472. doi:10.1007/978-1-4939-9424-3_27
   PubMedGoogle Scholar
• Mir HA, Ali R, Mushtaq U, et al. Structure-functional implications of longevity protein p66Shc in health and disease. Ageing Res Rev. 2020 Nov;63:101139. doi:10.1016/j.arr.2020.101139
   PubMed Web of Science ®Google Scholar
• Mousavi S, Khazeei Tabari MA, Bagheri A, et al. The role of p66Shc in diabetes: a comprehensive review from bench to bedside. J Diabetes Res. 2022;2022:7703520. doi:10.1155/2022/7703520
   PubMed Web of Science ®Google Scholar
• Minami Y, Sonoda N, Hayashida E, et al. p66Shc signaling mediates diabetes-related cognitive decline. Sci Rep. 2018 Feb 16;8(1):3213. doi:10.1038/s41598-018-21426-6
   PubMedGoogle Scholar
• Albiero M, Ciciliot S, Tedesco S, et al. Diabetes-associated myelopoiesis drives stem cell mobilopathy through an OSM-p66Shc signaling pathway. Diabetes. 2019 Jun;68(6):1303–1314. doi:10.2337/db19-0080
   PubMed Web of Science ®Google Scholar