Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway

References

• Lanvers-Kaminsky C, Zehnhoff-Dinnesen AA, Parfitt R, et al. Drug-induced ototoxicity: mechanisms, pharmacogenetics, and protective strategies. Clin Pharmacol Ther. 2017 Apr;101(4):491–500. doi:10.1002/cpt.603
   PubMed Web of Science ®Google Scholar
• Durante-Mangoni E, Grammatikos A, Utili R, et al. Do we still need the aminoglycosides? Int J Antimicrob Agents. 2009;33(3):201–205. doi:10.1016/j.ijantimicag.2008.09.001
   PubMed Web of Science ®Google Scholar
• Zhou M, Sun G, Zhang L, et al. STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells. J Cell Mol Med. 2018 Nov;22(11):5286–5299. doi:10.1111/jcmm.13792
   PubMed Web of Science ®Google Scholar
• Abdel-Fattah MM, Elgendy A, Mohamed WR. Xanthenone, ACE2 activator, counteracted gentamicin-induced nephrotoxicity in rats: Impact on oxidative stress and ACE2/Ang-(1–7) signaling. Life Sci. 2021;275:119387. doi:10.1016/j.lfs.2021.119387
   PubMed Web of Science ®Google Scholar
• Sharma I, Liao Y, Zheng X, et al. Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway. JCI Insight. 2022 Mar 22;7(6):e155487. doi:10.1172/jci.insight.155487
   PubMed Web of Science ®Google Scholar
• Wu P, Wu X, Zhang C, et al. Hair cell protection from ototoxic drugs. Neural Plast. 2021;2021:1. doi:10.1155/2021/4909237
   Web of Science ®Google Scholar
• Kucharava K, Sekulic-Jablanovic M, Horvath L, et al. Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway. Cell Death Dis. 2019 Feb 6;10(2):110. doi:10.1038/s41419-019-1386-7
   PubMedGoogle Scholar
• Xie J, Talaska AE, Schacht J. New developments in aminoglycoside therapy and ototoxicity. Hear Res. 2011 Nov;281(1-2):28–37. doi:10.1016/j.heares.2011.05.008
   PubMed Web of Science ®Google Scholar
• Xie L, Jiang Y, Zhou Q. Theophylline alleviates gentamicin-induced cytotoxicity to sensory hair cells by maintaining HDAC2 expression. Acta Histochem. 2021 Apr;123(3):151696. doi:10.1016/j.acthis.2021.151696
   PubMed Web of Science ®Google Scholar
• He Z, Guo L, Shu Y, et al. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy. 2017;13(11):1884–1904. doi:10.1080/15548627.2017.1359449
   PubMed Web of Science ®Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014 Jul;94(3):909–950. doi:10.1152/physrev.00026.2013
   PubMed Web of Science ®Google Scholar
• Forrester SJ, Kikuchi DS, Hernandes MS, et al. Reactive oxygen species in metabolic and inflammatory signaling. Circ Res. 2018 Mar 16;122(6):877–902. doi:10.1161/CIRCRESAHA.117.311401
   PubMed Web of Science ®Google Scholar
• Somdas MA, Korkmaz F, Gurgen SG, et al. N-acetylcysteine prevents gentamicin ototoxicity in a Rat model. J Int Adv Otol. 2015 Apr;11(1):12–18. doi:10.5152/iao.2015.650
   PubMed Web of Science ®Google Scholar
• Yang Y, Chen X, Tian K, et al. Heme oxygenase-1 protects hair cells from gentamicin-induced death. Front Cell Neurosci. 2022;16:783346. doi:10.3389/fncel.2022.783346
   PubMed Web of Science ®Google Scholar
• Quan Y, Xia L, Shao J, et al. Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway. Sci Rep. 2015 Feb 2;5:8181. doi:10.1038/srep08181
   PubMed Web of Science ®Google Scholar
• Elborn JS. Cystic fibrosis. Lancet. 2016;388(10059):2519–2531. doi:10.1016/S0140-6736(16)00576-6
   PubMed Web of Science ®Google Scholar
• Wong FH, AbuArish A, Matthes E, et al. Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells. Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C118–C134. doi:10.1152/ajpcell.00099.2017
   PubMed Web of Science ®Google Scholar
• Moliteo E, Sciacca M, Palmeri A, et al. Cystic fibrosis and oxidative stress: the role of CFTR. Molecules. 2022;275:119387. doi:10.3390/molecules27165324
   Google Scholar
• Simoes F, Ousingsawat J, Wanitchakool P, et al. CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6). Pflugers Arch. 2018 Feb;470(2):305–314. doi:10.1007/s00424-017-2065-0
   PubMed Web of Science ®Google Scholar
• Zhang YP, Zhang Y, Xiao ZB, et al. CFTR prevents neuronal apoptosis following cerebral ischemia reperfusion via regulating mitochondrial oxidative stress. J Mol Med (Berl). 2018;96(7):611–620. doi:10.1007/s00109-018-1649-2
   PubMed Web of Science ®Google Scholar
• Homma K, Miller KK, Anderson CT, et al. Interaction between CFTR and prestin (SLC26A5). 2010 Jun;1798(6):1029–1040. doi:10.1016/j.bbamem.2010.02.001
   Google Scholar
• Borcherding DC, Siefert ME, Lin S, et al. Clinically approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia. J Clin Invest. 2019 May 30;129(8):3448–3463. doi:10.1172/JCI96273
   PubMed Web of Science ®Google Scholar
• Hoshino T, Tabuchi K, Nishimura B, et al. Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. Biochem Biophys Res Commun. 2011;415(1):94–98. doi:10.1016/j.bbrc.2011.10.019
   PubMed Web of Science ®Google Scholar
• Yu Y, Cao L, Guan N, et al. Acupuncture attenuates ototoxicity induced by gentamicin in mice. Altern Ther Health Med. 2022 Feb;28(2):78–83.
   PubMed Web of Science ®Google Scholar
• Ulasov AV, Rosenkranz AA, Georgiev GP, et al. Nrf2/Keap1/ARE signaling: towards specific regulation. Life Sci. 2022 Feb 15;291:120111. doi:10.1016/j.lfs.2021.120111
   PubMed Web of Science ®Google Scholar
• Liu S, Pi J, Zhang Q. Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway. Redox Biol. 2022 Aug;54:102389. doi:10.1016/j.redox.2022.102389
   PubMed Web of Science ®Google Scholar
• Zhang W, Xiong H, Pang J, et al. Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production. Toxicol Lett. 2020;331:1–10. doi:10.1016/j.toxlet.2020.04.005
   PubMed Web of Science ®Google Scholar
• Xie S, Deng W, Chen J, et al. Andrographolide protects against adverse cardiac remodeling after myocardial infarction through enhancing Nrf2 signaling pathway. Int J Biol Sci. 2020;16(1):12–26. doi:10.7150/ijbs.37269
   PubMed Web of Science ®Google Scholar
• Wu F, Hu R, Huang X, et al. CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress. Biomed Pharmacother. 2023 Oct;166:115399. doi:10.1016/j.biopha.2023.115399
   PubMed Web of Science ®Google Scholar
• He Z, Zhang S, Ma D, et al. HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia. J Transl Med. 2019 Nov 11;17(1):366. doi:10.1186/s12967-019-2115-9
   PubMed Web of Science ®Google Scholar
• Sha SH, Schacht J. Formation of reactive oxygen species following bioactivation of gentamicin. Free Radic Biol Med. 1999;26(3-4):341–347. doi:10.1016/S0891-5849(98)00207-X
   PubMed Web of Science ®Google Scholar
• Niwa K, Matsunobu T, Kurioka T, et al. The beneficial effect of Hangesha-shin-to (TJ-014) in gentamicin-induced hair cell loss in the rat cochlea. Auris Nasus Larynx. 2016;43(5):507–513. doi:10.1016/j.anl.2015.12.012
   PubMed Web of Science ®Google Scholar
• Kim SJ, Park C, Han AL, et al. Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells. Hear Res. 2009 May;251(1–2):70–82. doi:10.1016/j.heares.2009.03.003
   PubMed Web of Science ®Google Scholar
• So HS, Kim HJ, Lee JH, et al. Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin. Cell Death Differ. 2006 Oct;13(10):1763-1775. doi:10.1038/sj.cdd.4401863
   PubMed Web of Science ®Google Scholar
• Choudhury C, Mazumder R, Kumar R, et al. Cadmium induced oxystress alters Nrf2-Keap1 signaling and triggers apoptosis in piscine head kidney macrophages. Aquat Toxicol. 2021 Feb;231:105739. doi:10.1016/j.aquatox.2020.105739
   PubMed Web of Science ®Google Scholar
• Ashino T, Yamamoto M, Numazawa S. Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep. 2016 May 20;6:26291. doi:10.1038/srep26291
   PubMed Web of Science ®Google Scholar
• Li J, Hu R, Xu S, et al. Xiaochaihutang attenuates liver fibrosis by activation of Nrf2 pathway in rats. Biomed Pharmacother. 2017;96:847–853. doi:10.1016/j.biopha.2017.10.065.
   PubMed Web of Science ®Google Scholar
• Hu R, Jia W-y, Xu S-f, et al. Xiaochaihutang inhibits the activation of hepatic stellate cell line T6 through the Nrf2 pathway. Front Pharmacol. 2019 Jan 7;9:1516. doi:10.3389/fphar.2018.01516
   PubMed Web of Science ®Google Scholar
• Khalaf M, Scott-Ward T, Causer A, et al. Cystic fibrosis transmembrane conductance regulator (CFTR) in human lung microvascular endothelial cells controls oxidative stress, reactive oxygen-mediated cell signaling and inflammatory responses. Front Physiol. 2020;11:879. doi:10.3389/fphys.2020.00879.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Leir SH, Harris A. Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Am J Respir Cell Mol Biol. 2015 Mar;52(3):387–396. doi:10.1165/rcmb.2014-0263OC.
   PubMed Web of Science ®Google Scholar
• Ross D, Siegel D. The diverse functionality of NQO1 and its roles in redox control. Redox Biol. 2021 May;41:101950. doi:10.1016/j.redox.2021.101950.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Qu J, Zheng C, et al. Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis. Cell Death Dis. 2018 Jan 23;9(2):83. doi:10.1038/s41419-017-0198-x
   PubMedGoogle Scholar
• Hao Y, Miao J, Liu W, et al. Formononetin protects against cisplatin-induced acute kidney injury through activation of the PPARalpha/Nrf2/HO-1/NQO1 pathway. Int J Mol Med. 2021 Feb;47(2):511-522. doi:10.3892/ijmm.2020.4805
   PubMed Web of Science ®Google Scholar
• Zhang X, Yu J. Baicalin attenuates gentamicin-induced cochlear hair cell ototoxicity. J Appl Toxicol. 2019;39(8):1208–1214. doi:10.1002/jat.3806
   PubMed Web of Science ®Google Scholar
• Jung HH, Chang J, Yang JY, et al. Protective role of antidiabetic drug metformin against gentamicin induced apoptosis in auditory cell line. Hear Res. 2011;282(1–2):92–96. doi:10.1016/j.heares.2011.09.005
   PubMed Web of Science ®Google Scholar