Liuwei Dihuang pills attenuate ovariectomy-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis

References

• Adami G, Fassio A, Gatti D, Viapiana O, Benini C, Danila MI, Saag KG, Rossini M. 2022. Osteoporosis in 10 years time: a glimpse into the future of osteoporosis. Ther Adv Musculoskelet Dis. 14:1759720X221083541. doi: 10.1177/1759720X221083541.
   PubMed Web of Science ®Google Scholar
• Barron RL, Oster G, Grauer A, Crittenden DB, Weycker D. 2020. Determinants of imminent fracture risk in postmenopausal women with osteoporosis. Osteoporos Int. 31(11):2103–2111. doi: 10.1007/s00198-020-05294-3.
   PubMed Web of Science ®Google Scholar
• Bi Y, Guo X, Zhang M, Zhu K, Shi C, Fan B, Wu Y, Yang Z, Ji G. 2021. Bone marrow derived-mesenchymal stem cell improves diabetes-associated fatty liver via mitochondria transformation in mice. Stem Cell Res Ther. 12(1):602. doi: 10.1186/s13287-021-02663-5.
   PubMed Web of Science ®Google Scholar
• Chen M, Hu Y, Hou Y, Li M, Chen M, Tan L, Mu C, Tao B, Luo Z, Cai K. 2020. Osteogenesis regulation of mesenchymal stem cells via autophagy induced by silica–titanium composite surfaces with different mechanical moduli. J Mater Chem B. 8(40):9314–9324. doi: 10.1039/d0tb01412e.
   PubMed Web of Science ®Google Scholar
• Chen Q, Chao Y, Zhang W, Zhang Y, Bi Y, Fu Y, Cai D, Meng Q, Li Y, Bian H. 2020. Activation of estrogen receptor alpha (ERalpha) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation. Life Sci. 258:118030. doi: 10.1016/j.lfs.2020.118030.
   PubMed Web of Science ®Google Scholar
• Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, et al. 2016. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differ. 12(10):1128–1139. doi: 10.1038/cdd.2015.168.
   Google Scholar
• Chen X, Wang L, Hou J, Li J, Chen L, Xia J, Wang Z, Xiao M, Wang Y. 2019. Study on the dynamic biological characteristics of human bone marrow mesenchymal stem cell senescence. Stem Cells Int. 2019:9271595–9271599. doi: 10.1155/2019/9271595.
   PubMed Web of Science ®Google Scholar
• Chen XD, Tan JL, Feng Y, Huang LJ, Zhang M, Cheng B. 2020. Autophagy in fate determination of mesenchymal stem cells and bone remodeling. World J Stem Cells. 12(8):776–786. doi: 10.4252/wjsc.v12.i8.776.
   PubMed Web of Science ®Google Scholar
• Devlin MJ, Rosen CJ. 2015. The bone–fat interface: basic and clinical implications of marrow adiposity. Lancet Diabetes Endocrinol. 3(2):141–147. doi: 10.1016/S2213-8587(14)70007-5.
   PubMed Web of Science ®Google Scholar
• el-Deiry WS, Harper JW, O’Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54(5):1169–1174.
   PubMed Web of Science ®Google Scholar
• el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell. 75(4):817–825. doi: 10.1016/0092-8674(93)90500-p.
   PubMed Web of Science ®Google Scholar
• García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, et al. 2016. Autophagy maintains stemness by preventing senescence. Nature. 529(7584):37–42. doi: 10.1038/nature16187.
   PubMed Web of Science ®Google Scholar
• Han Y, Zhang L, Xing Y, Zhang L, Chen X, Tang P, Chen Z. 2018. Autophagy relieves the function inhibition and apoptosis promoting effects on osteoblast induced by glucocorticoid. Int J Mol Med. 41(2):800–808. doi: 10.3892/ijmm.2017.3270.
   PubMed Web of Science ®Google Scholar
• Hong-Rong L. 2012. Point of ‘none kidney excess syndrome’ of QIAN Yi and Liu Wei Di Huang Wan. China J Tradit Chin Med Pharm. 27:2512–2513.
   Google Scholar
• Jia L, Gu W, Zhang Y, Jiang B, Qiao X, Wen Y. 2018. Activated Yes-associated protein accelerates cell cycle, inhibits apoptosis, and delays senescence in human periodontal ligament stem cells. Int J Med Sci. 15(11):1241–1250. doi: 10.7150/ijms.25115.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Zhang P, Zhang X, Lv L, Zhou Y. 2021. Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis. Cell Prolif. 54(1):e12956. doi: 10.1111/cpr.12956.
   PubMed Web of Science ®Google Scholar
• Kim M, Kim C, Choi YS, Kim M, Park C, Suh Y. 2012. Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Mech Ageing Dev. 133(5):215–225. doi: 10.1016/j.mad.2012.03.014.
   PubMed Web of Science ®Google Scholar
• Lange U, Classen K, Muller-Ladner U, Richter M. 2017. Weekly oral bisphosphonates over 2 years prevent bone loss in cardiac transplant patients. Clin Transplant. 31(11):e13122.
   Web of Science ®Google Scholar
• Lee CG, Kim DW, Kim J, Uprety LP, Oh KI, Singh S, Yoo J, Jin HS, Choi TH, Park E, et al. 2022. Effects of loganin on bone formation and resorption in vitro and in vivo. Int J Mol Sci. 23:141128.
   Web of Science ®Google Scholar
• Lee CG, Kim J, Yun SH, Hwang S, Jeon H, Park E, Jeong SY. 2021. Anti-osteoporotic effect of morroniside on osteoblast and osteoclast differentiation in vitro and ovariectomized mice in vivo. Int J Mol Sci. 22(19):10642. doi: 10.3390/ijms221910642.
   PubMed Web of Science ®Google Scholar
• Lewis CE, Wellons MF. 2017. Menopausal hormone therapy for primary prevention of chronic disease. JAMA. 318(22):2187–2189. doi: 10.1001/jama.2017.16974.
   PubMed Web of Science ®Google Scholar
• Li Y, Wu Q, Wang Y, Li L, Bu H, Bao J. 2017. Senescence of mesenchymal stem cells. Int J Mol Med. 39(4):775–782. doi: 10.3892/ijmm.2017.2912.
   PubMed Web of Science ®Google Scholar
• Liu F, Yuan Y, Bai L, Yuan L, Li L, Liu J, Chen Y, Lu Y, Cheng J, Zhang J. 2021. LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss. Redox Biol. 43:101963. doi: 10.1016/j.redox.2021.101963.
   PubMed Web of Science ®Google Scholar
• Liu Y, Song A, Wu H, Sun Y, Dai M. 2021. Paeonol inhibits apoptosis of vascular smooth muscle cells via up-regulation of autophagy by activating class III PI3K/Beclin-1 signaling pathway. Life Sci. 264:118714. doi: 10.1016/j.lfs.2020.118714.
   PubMed Web of Science ®Google Scholar
• Ma Y, Qi M, An Y, Zhang L, Yang R, Doro DH, Liu W, Jin Y. 2018. Autophagy controls mesenchymal stem cell properties and senescence during bone aging. Aging Cell. 17(1):e12709. doi: 10.1111/acel.12709.
   PubMed Web of Science ®Google Scholar
• Mohamad NV, Ima-Nirwana S, Chin KY. 2020. Are oxidative stress and inflammation mediators of bone loss due to estrogen deficiency? A review of current evidence. Endocr Metab Immune Disord Drug Targets. 20(9):1478–1487. doi: 10.2174/1871530320666200604160614.
   PubMed Web of Science ®Google Scholar
• Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N. 2019. Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci. 76(17):3323–3348. doi: 10.1007/s00018-019-03125-1.
   PubMed Web of Science ®Google Scholar
• Pan H, Xie Y, Zhang Z, Li K, Hu D, Zheng X, Fan Q, Tang T. 2017. YAP-mediated mechanotransduction regulates osteogenic and adipogenic differentiation of BMSCs on hierarchical structure. Colloids Surf B Biointerfaces. 152:344–353. doi: 10.1016/j.colsurfb.2017.01.039.
   PubMed Web of Science ®Google Scholar
• Pavel M, Renna M, Park SJ, Menzies FM, Ricketts T, Füllgrabe J, Ashkenazi A, Frake RA, Lombarte AC, Bento CF, et al. 2018. Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis. Nat Commun. 9(1):2961. doi: 10.1038/s41467-018-05388-x.
   PubMed Web of Science ®Google Scholar
• Perry B, Zhang J, Saleh T, Wang Y. 2014. Liuwei Dihuang, a traditional Chinese herbal formula, suppresses chronic inflammation and oxidative stress in obese rats. J Integr Med. 12(5):447–454. doi: 10.1016/S2095-4964(14)60044-3.
   PubMedGoogle Scholar
• Salemi S, Yousefi S, Constantinescu MA, Fey MF, Simon HU. 2012. Autophagy is required for self-renewal and differentiation of adult human stem cells. Cell Res. 22(2):432–435. doi: 10.1038/cr.2011.200.
   PubMed Web of Science ®Google Scholar
• Sui BD, Hu CH, Zheng CX, Jin Y. 2016. Microenvironmental views on mesenchymal stem cell differentiation in aging. J Dent Res. 95(12):1333–1340. doi: 10.1177/0022034516653589.
   PubMed Web of Science ®Google Scholar
• The NAMS 2017 Hormone Therapy Position Statement Advisory Panel. 2017. The 2017 hormone therapy position statement of The North American Menopause Society. Menopause. 24(7):728–753. doi: 10.1097/GME.0000000000000921.
   PubMed Web of Science ®Google Scholar
• Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S. 2019. Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction. Proc Natl Acad Sci U S A. 116(36):17848–17857. doi: 10.1073/pnas.1908228116.
   PubMed Web of Science ®Google Scholar
• Tseng YT, Chang FR, Lo YC. 2014. The Chinese herbal formula Liuwei Dihuang protects dopaminergic neurons against Parkinson’s toxin through enhancing antioxidative defense and preventing apoptotic death. Phytomedicine. 21(5):724–733. doi: 10.1016/j.phymed.2013.11.001.
   PubMed Web of Science ®Google Scholar
• Wang D, He J, Huang B, Liu S, Zhu H, Xu T. 2020. Emerging role of the Hippo pathway in autophagy. Cell Death Dis. 11(10):880. doi: 10.1038/s41419-020-03069-6.
   PubMed Web of Science ®Google Scholar
• Wu G, Xu R, Zhang P, Xiao T, Fu Y, Zhang Y, Du Y, Ye J, Cheng J, Jiang H. 2018. Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERbeta–SATB2 pathway. J Cell Physiol. 233(5):4194–4204. doi: 10.1002/jcp.26233.
   PubMed Web of Science ®Google Scholar
• Wu W, Fu J, Gu Y, Wei Y, Ma P, Wu J. 2020. JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells. J Endocrinol. 245(1):141–153. doi: 10.1530/JOE-19-0518.
   PubMed Web of Science ®Google Scholar
• Xia B, Xu B, Sun Y, Xiao L, Pan J, Jin H, Tong P. 2014. The effects of Liuwei Dihuang on canonical Wnt/beta-catenin signaling pathway in osteoporosis. J Ethnopharmacol. 153(1):133–141. doi: 10.1016/j.jep.2014.01.040.
   PubMed Web of Science ®Google Scholar
• Xu H, Cai L, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y, Nie H. 2018. Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-kappaB signalling pathway in osteoclast differentiation. Immunology. 154(4):593–603. doi: 10.1111/imm.12907.
   PubMed Web of Science ®Google Scholar
• Zhou SB, Chiang CA, Liu K, Li QF. 2015. Intravenous transplantation of bone marrow mesenchymal stem cells could effectively promote vascularization and skin regeneration in mechanically stretched skin. Br J Dermatol. 172(5):1278–1285. doi: 10.1111/bjd.13251.
   PubMed Web of Science ®Google Scholar